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AU2024238668A1 - Substituted pyridyl/pyrazidyl dihydrobenzothiazepine compounds for combatting phytopathogenic fungi - Google Patents

Substituted pyridyl/pyrazidyl dihydrobenzothiazepine compounds for combatting phytopathogenic fungi

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AU2024238668A1
AU2024238668A1 AU2024238668A AU2024238668A AU2024238668A1 AU 2024238668 A1 AU2024238668 A1 AU 2024238668A1 AU 2024238668 A AU2024238668 A AU 2024238668A AU 2024238668 A AU2024238668 A AU 2024238668A AU 2024238668 A1 AU2024238668 A1 AU 2024238668A1
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alkyl
alkenyl
phenyl
halogen
alkynyl
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AU2024238668A
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Jochen Dietz
Wassilios Grammenos
Andreas Koch
Ronan Le Vezouet
Jan Klaas Lohmann
Benjamin Juergen MERGET
Nadine RIEDIGER
Philipp Georg Werner SEEBERGER
Aymane SELMANI
Christian Winter
Dorothee Sophia ZIEGLER
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BASF SE
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BASF SE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The present invention relates to the compounds of formula (I) wherein the variables are defined as given in the description and claims. The invention further relates to their use and composition.

Description

230124 Substituted pyridyl/pyrazidyl dihydrobenzothiazepine compounds for combatting phytopatho- genic fungi The present invention relates to new pyridyl/pyrazidyl dihydrobenzothiazepine compounds and the N-oxides and the salts thereof as well as to their use as fungicides. The invention also re- lates to the composition comprising at least one compound I, to the method for combating phy- topathogenic fungi and to the seed coated with at least one compound of the formula I. WO 2010018686 discloses some dihydrobenzothiazepine compounds. However, in many cases, in particular at low application rates, the fungicidal activity of the known compounds is unsatisfactory. Based on this, it was an objective of the present invention to provide compounds having improved activity and/or a broader activity spectrum against phytopathogenic fungi. An- other object of the present invention is to provide fungicides with improved toxicological proper- ties or with improved environmental fate properties. These and further objectives are achieved by the dihydrobenzothiazepine compounds of for- mula (I), as defined below, and by their agriculturally suitable salts. Accordingly, the present invention relates to the compounds of formula I Y is N, CR1; Z is S, SO or SO2 R1 is in each case independently selected from H, halogen, CN, C1-C4-alkyl, C1-C4-halogen- alkyl; R2 is in each case independently selected from halogen, CN, C1-C6-alkyl, C1-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, O-C1-C6-alkyl, O-C2-C6-alkenyl, O-C2-C6-alkynyl, C3-C6-cycloalkyl, S-C1-C6-alkyl, S-C2-C6-alkenyl, S-C2- C6-alkynyl; 230124 2 R3 is in each case independently selected from halogen, CN, C1-C6-alkyl, C1-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, O-C1-C6-alkyl, O-C2-C6-alkenyl, O-C2-C6-alkynyl, C3-C6-cycloalkyl, S-C1-C6-alkyl, S-C2-C6-alkenyl, S-C2- C6-alkynyl; R4 is in each case independently selected from H, halogen, CN, C1-C4-alkyl, C1-C4-halogen- alkyl; R5 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6- haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2 -heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substit- uents R5a; where each R5a is independently halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl or O-C1-C6-alkyl; R6 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6- haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, ben- zyl, five- or six-membered heteroaryl or five- or six-membered CH2- heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substituents R6a; where each R6a is independently halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl or O-C1-C6-alkyl; or R5 and R6 form together an oxo group (=O); or a thioxo group (=S); or R5 and R6 together with the carbon atom to which they are bound, form a 3-, 4-, 5- or 6-mem- bered saturated carbocyclic ring or a 3-, 4-, 5- or 6-membered saturated heterocyclic ring containing 1, 2 or 3 heteroatoms selected from O and S as ring members; where the car- bocyclic or heterocyclic ring is unsubstituted or carries 1, 2 or 3 substituents R56; where each R56 is independently halogen, C1-C6-alkyl or C1-C6-haloalkyl; 230124 3 R7 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6- haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, ben- zyl, five- or six-membered heteroaryl or five- or six-membered CH2heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substituents R7a; where each R7a is independently halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl or O-C1-C6-alkyl; R8 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6- haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, ben- zyl, five- or six-membered heteroaryl or five- or six-membered CH2heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substituents R8a; where each R8a is independently halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl or O-C1-C6-alkyl; or R7 and R8 together with the carbon atom to which they are bound, form a 3-, 4-, 5- or 6-mem- bered saturated carbocyclic ring or a 3-, 4-, 5- or 6-membered saturated heterocyclic ring containing 1, 2 or 3 heteroatoms selected from O and S as ring members; X is in each case independently selected from halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C6-alkoxy or C1-C6-haloalkoxy, phenyl, benzyl, phenoxy, benzoxy, C1-C6-thioalkyl;wherein phenyl, benzyl, phenoxy, benzoxy can be unsubstituted or substituted by halogen, CN, C1-C6-alkyl or C1-C6-haloalkyl; n is 0, 1, 2 or 3; with the proviso that if Y is CR1, R5, R6, R7 and R8 cannot all be H; or the N-oxides, tautomers, stereoisomers or agriculturally acceptable salts thereof. The N-oxides may be prepared from the inventive compounds according to conventional oxida- tion methods, e. g. by treating compounds I with an organic peracid such as metachloroper- 230124 4 benzoic acid (cf. WO 03/64572 or J. Med. Chem.38(11), 1892-903, 1995); or with inorganic oxi- dizing agents such as hydrogen peroxide (cf. J. Heterocyc. Chem.18(7), 1305-8, 1981) or ox- one (cf. J. Am. Chem. Soc.123(25), 5962-5973, 2001). The oxidation may lead to pure mono- N-oxides or to a mixture of different N-oxides, which can be separated by conventional methods such as chromatography. Agriculturally acceptable salts of the compounds of the formula I encompass especially the salts of those cations or the acid addition salts of those acids whose cations and anions, respectively, have no adverse effect on the fungicidal action of the compounds I. Suitable cations are thus in particular the ions of the alkali metals, preferably sodium and potassium, of the alkaline earth metals, preferably calcium, magnesium and barium, of the transition metals, preferably manga- nese, copper, zinc and iron, and also the ammonium ion which, if desired, may be substituted with one to four C1-C4-alkyl substituents and/or one phenyl or benzyl substituent, preferably diisopropylammonium, tetramethylammonium, tetrabutylammonium, trimethylbenzylammonium, furthermore phosphonium ions, sulfonium ions, preferably tri(C1-C4-alkyl)sulfonium, and sulfoxo- nium ions, preferably tri(C1-C4-alkyl)sulfoxonium. Anions of acceptable acid addition salts are primarily chloride, bromide, fluoride, hydrogensul- fate, sulfate, dihydrogenphosphate, hydrogenphosphate, phosphate, nitrate, bicarbonate, car- bonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of C1-C4-alkanoic acids, preferably formate, acetate, propionate and butyrate. They can be formed by reacting a compound I with an acid of the corresponding anion, preferably of hydrochloric acid, hydrobro- mic acid, sulfuric acid, phosphoric acid or nitric acid. Compounds of the formula I can exist as one or more stereoisomers. The various stereoisomers include enantiomers, diastereomers, atropisomers arising from restricted rotation about a single bond of asymmetric groups and geometric isomers. They also form part of the subject matter of the present invention. One skilled in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). Additionally, the skilled artisan knows how to separate, enrich, and/or to selectively prepare said stereoisomers. The compounds of the invention may be present as a mixture of stereoisomers, e.g. a racemate, individual stereoisomers, or as an optically active form. Compounds of the formula I can be present in different crystal modifications whose biological activity may differ. They also form part of the subject matter of the present invention. In respect of the variables, the embodiments of the intermediates obtained during preparation of compounds I correspond to the embodiments of the compounds of formula I. The term “com- pounds I” refers to compounds of the formula I. In the following, the intermediate compounds are further described. A skilled person will readily 230124 5 understand that the preferences for the substituents, also in particular the ones given in the ta- bles below for the respective substituents, given herein in connection with compounds I apply for the intermediates accordingly. Thereby, the substituents in each case have independently of each other or more preferably in combination the meanings as defined herein. If the synthesis yields mixtures of isomers, a separation is generally not necessarily required since in some cases the individual isomers can be interconverted during work-up for use or dur- ing application (e. g. under the action of light, acids or bases). Such conversions may also take place after use, e. g. in the treatment of plants in the treated plant, or in the harmful fungus to be controlled. In the definitions of the variables given above, collective terms are used which are generally representative for the substituents in question. The term "Cn-Cm" indicates the number of carbon atoms possible in each case in the substituent or substituent moiety in question. The term "halogen" refers to fluorine, chlorine, bromine and iodine. The term "C1-C6-alkyl" refers to a straight-chained or branched saturated hydrocarbon group having 1 to 6 carbon atoms, e.g. methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2- methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dime- thylpropyl, 1-ethylpropyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, hexyl, 1-methylpentyl, 2- methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethyl- butyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-tri- methylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl. Likewise, the term "C2-C4-alkyl" refers to a straight-chained or branched alkyl group having 2 to 4 carbon atoms, such as ethyl, propyl (n-propyl), 1-methylethyl (iso-propoyl), butyl, 1-methylpropyl (sec.- butyl), 2-methylpropyl (iso-butyl), 1,1-dimethylethyl (tert.-butyl). The term "C1-C6-halogenalkyl" refers to an alkyl group having 1 or 6 carbon atoms as defined above, wherein some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as mentioned above. Examples are "C1-C2-halogenalkyl" groups such as chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlor- ofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoro- ethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro- 2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl or pentafluoroethyl. The term "C2-C6-alkenyl" refers to a straight-chain or branched unsaturated hydrocarbon radical having 2 to 6 carbon atoms and a double bond in any position. Examples are "C2-C4-alkenyl" groups, such as ethenyl, 1-propenyl, 2-propenyl (allyl), 1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl. The term "C2-C6-halogenalkenyl" refers to an alkyl group having 2 or 6 carbon atoms as defined above, wherein some or all of the hydrogen atoms in these groups may be replaced by halogen 230124 6 atoms as mentioned above. The term "C2-C6-alkynyl" refers to a straight-chain or branched unsaturated hydrocarbon radical having 2 to 6 carbon atoms and containing at least one triple bond. Examples are "C2-C4-al- kynyl" groups, such as ethynyl, prop-1-ynyl, prop-2-ynyl (propargyl), but-1-ynyl, but-2-ynyl, but- 3-ynyl, 1-methyl-prop-2-ynyl. The term "C2-C6-halogenalkynyl" refers to an alkyl group having 2 or 6 carbon atoms as defined above, wherein some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as mentioned above. The term "C3-C6-cycloalkyl" refers to monocyclic saturated hydrocarbon radicals having 3 to 6 carbon ring members, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl. Accordingly, a saturated three-, four-, five-, six-, seven-, eight-, nine or ten-membered carbocyclyl or carbo- cycle is a "C3-C10-cycloalkyl". The term "C3-C8-cycloalkyl-C1-C4-alkyl" refers to alkyl having 1 to 4 carbon atoms (as defined above), where at least one hydrogen atom of the alkyl radical is replaced by a cycloalkyl radical having 3 to 8 carbon atoms (as defined above). The term “saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine or ten- membered heterocyclyl or heterocycle, wherein the heterocyclyl or heterocycle contains 1, 2, 3 or 4 heteroatoms selected from N, O and S” is to be understood as meaning both saturated and partially unsaturated heterocycles, wherein the ring member atoms of the heterocycle include besides carbon atoms 1, 2, 3 or 4 heteroatoms independently selected from the group of O, N and S. For example: a 3- or 4-membered saturated heterocycle which contains 1 or 2 heteroatoms from the group consisting of O, N and S as ring members such as oxirane, aziridine, thiirane, oxetane, azet- idine, thiethane, [1,2]dioxetane, [1,2]dithietane, [1,2]diazetidine; and a 5- or 6-membered saturated or partially unsaturated heterocycle which contains 1, 2 or 3 het- eroatoms from the group consisting of O, N and S as ring members such as 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3-tetrahydrothienyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-isox- azolidinyl, 4-isoxazolidinyl, 5-isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl, 5-isothiazoli- dinyl, 3-pyrazolidinyl, 4-pyrazolidinyl, 5-pyrazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5-oxazoli- dinyl, 2-thiazolidinyl, 4-thiazolidinyl, 5-thiazolidinyl, 2-imidazolidinyl, 4-imidazolidinyl, 1,2,4-oxadiazolidin-3-yl, 1,2,4-oxadiazolidin-5-yl, 1,2,4-thiadiazolidin-3-yl, 1,2,4-thiadiazolidin-5- yl, 1,2,4-triazolidin-3-yl, 1,3,4-oxadiazolidin-2-yl, 1,3,4-thiadiazolidin-2-yl, 1,3,4-triazolidin-2-yl, 2,3-dihydrofur-2-yl, 2,3-dihydrofur-3-yl, 2,4-dihydrofur-2-yl, 2,4-dihydrofur-3-yl, 2,3-dihydrothien- 2-yl, 2,3-dihydrothien-3-yl, 2,4-dihydrothien-2-yl, 2,4-dihydrothien-3-yl, 2-pyrrolin-2-yl, 2-pyrrolin- 3-yl, 3-pyrrolin-2-yl, 3-pyrrolin-3-yl, 2-isoxazolin-3-yl, 3-isoxazolin-3-yl, 4-isoxazolin-3-yl, 2-isoxa- zolin-4-yl, 3-isoxazolin-4-yl, 4-isoxazolin-4-yl, 2-isoxazolin-5-yl, 3-isoxazolin-5-yl, 4-isoxazolin-5- 230124 7 yl, 2-isothiazolin-3-yl, 3-isothiazolin-3-yl, 4-isothiazolin-3-yl, 2-isothiazolin-4-yl, 3-isothiazolin-4- yl, 4-isothiazolin-4-yl, 2-isothiazolin-5-yl, 3-isothiazolin-5-yl, 4-isothiazolin-5-yl, 2,3-dihydropyra- zol-1-yl, 2,3-dihydropyrazol-2-yl, 2,3-dihydropyrazol-3-yl, 2,3-dihydropyrazol-4-yl, 2,3-dihydropy- razol-5-yl, 3,4-dihydropyrazol-1-yl, 3,4-dihydropyrazol-3-yl, 3,4-dihydropyrazol-4-yl, 3,4-dihydro- pyrazol-5-yl, 4,5-dihydropyrazol-1-yl, 4,5-dihydropyrazol-3-yl, 4,5-dihydropyrazol-4-yl, 4,5-dihy- dropyrazol-5-yl, 2,3-dihydrooxazol-2-yl, 2,3-dihydrooxazol-3-yl, 2,3-dihydrooxazol-4-yl, 2,3-dihy- drooxazol-5-yl, 3,4-dihydrooxazol-2-yl, 3,4-dihydrooxazol-3-yl, 3,4-dihydrooxazol-4-yl, 3,4-dihy- drooxazol-5-yl, 3,4-dihydrooxazol-2-yl, 3,4-dihydrooxazol-3-yl, 3,4-dihydrooxazol-4-yl, 2-piperidi- nyl, 3-piperidinyl, 4-piperidinyl, 1,3–dioxan–5–yl, 2-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tet- rahydrothienyl, 3-hexahydropyridazinyl, 4-hexahydropyridazinyl, 2-hexahydropyrimidinyl, 4-hex- ahydropyrimidinyl, 5-hexahydropyrimidinyl, 2-piperazinyl, 1,3,5-hexahydrotriazin-2-yl and 1,2,4- hexahydrotriazin-3-yl and also the corresponding –ylidene radicals; and a 7-membered saturated or partially unsaturated heterocycle such as tetra- and hexahydroaze- pinyl, such as 2,3,4,5-tetrahydro[1H]azepin-1-,-2-,-3-,-4-,-5-,-6- or-7-yl, 3,4,5,6-tetrahy- dro[2H]azepin-2-,-3-,-4-,-5-,-6- or-7-yl, 2,3,4,7-tetrahydro[1H]azepin-1-,-2-,-3-,-4-,-5-,-6- or-7-yl, 2,3,6,7-tetrahydro[1H]azepin-1-,-2-,-3-,-4-,-5-,-6- or-7-yl, hexahydroazepin-1-,-2-,-3- or-4-yl, tetra- and hexahydrooxepinyl such as 2,3,4,5-tetrahydro[1H]oxepin-2-,-3-,-4-,-5-,-6- or-7-yl, 2,3,4,7-tetrahydro[1H]oxepin-2-,-3-,-4-,-5-,-6- or-7-yl, 2,3,6,7-tetrahydro[1H]oxepin-2-, -3-,-4-,-5- ,-6- or-7-yl, hexahydroazepin-1-,-2-,-3- or-4-yl, tetra- and hexahydro-1,3-diazepinyl, tetra- and hexahydro-1,4-diazepinyl, tetra- and hexahydro-1,3-oxazepinyl, tetra- and hexahydro-1,4-oxa- zepinyl, tetra- and hexahydro-1,3-dioxepinyl, tetra- and hexahydro-1,4-dioxepinyl and the corre- sponding -ylidene radicals. The term “substituted” refers to substitued with 1, 2, 3 or up to the maximum possible number of substituents. The term “5-or 6-membered heteroaryl” or “5-or 6-membered heteroaromatic” refers to aromatic ring systems incuding besides carbon atoms, 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, O and S, for example, a 5-membered heteroaryl such as pyrrol-1-yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan- 2-yl, furan-3-yl, pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, 1,2,4-triazolyl-1-yl, 1,2,4-triazol-3-yl 1,2,4-triazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl and 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl; or a 6-membered heteroaryl, such as pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyri- dazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrazin-2-yl and 1,3,5-triazin-2-yl and 1,2,4-triazin-3-yl. 230124 8 In the following, particular embodiments of the inventive compounds are described. Therein, specific meanings of the respective substituents are further detailed, wherein the meanings are in each case on their own but also in any combination with one another, particular embodiments of the present invention. Furthermore, in respect of the variables, generally, the embodiments of the compounds I also apply to the intermediates. According to one embodiment of the compound of formula I, Y is N, According to one embodiment of the compound of formula I, Y is CR1. According to one embodiment of the compound of formula I, Z is S. According to one embodiment of the compound of formula I, Z is SO. According to one embodiment of the compound of formula I, Z is SO2. According to one embodiment of the compound of formula I, R1 is in each case independently selected from H, halogen, CN, C1-C4-alkyl, C1-C4-halogenalkyl, preferred R1 is in each case in- dependently selected from H, C1-C4-alkyl, C1-C4-halogenalkyl, more preferred R1 is in each case independently selected from H, C1-C4-alkyl, most preferred R1 is in each case H. According to one embodiment of the compound of formula I, R2 is selected from halogen, CN, C1-C6-alkyl, C1-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halo- genalkynyl, O-C1-C6-alkyl, O-C2-C6-alkenyl, O-C2-C6-alkynyl, C3-C6-cycloalkyl, S-C1-C6-alkyl, S- C2-C6-alkenyl, S-C2-C6-alkynyl. According to one embodiment of the compound of formula I, R2 is in each case independently selected from C1-C4-alkyl and C1-C4-halogenalkyl, preferred R2 is in each case independently selected from H, C1-C4-alkyl, C1-C4-halogenalkyl, more preferred R2 is in each case inde- pendently selected from CH3 and CF2H, most preferred R2 is in each case CH3. According to still another embodiment of formula I, R2 is halogen, in particular F, Cl, Br or l, more specifically F, Cl or Br, in particular F or Cl. According to still another embodiment of formula I, R2 is F. According to still another embodiment of formula I, R2 is Cl. According to still another embodiment of formula I, R2 is Br. According to still another embodiment of formula I, R2 is CN. According to still another embodiment of formula I, R2 is C1-C6-alkyl, in particular C1-C4-alkyl, such as CH3 or C2H5, in particular CH3 or CH2CH3. 230124 9 According to still another embodiment of formula I, R2 is C1-C6-halogenalkyl, in particular C1-C4- halogenalkyl, such as CF3. According to still a further embodiment of formula I, R2 is C2-C6-alkenyl, in particular C2-C4-alk- enyl, such as CH=CH2, C(CH3)=CH2, CH2CH=CH2. According to a further specific embodiment of formula I, R2 is C2-C6-halogenalkenyl, in particular C2-C4-halogenalkenyl, more specifically C2-C3-halogenalkenyl such as CH=CHF, CH=CHCl, CH=CF2, CH=CCl2, CH2CH=CHF, CH2CH=CHCl, CH2CH=CF2, CH2CH=CCl2, CF2CH=CF2, CCl2CH=CCl2, CF2CF=CF2, CCl2CCl=CCl2. According to still a further embodiment of formula I, R2 is C2-C6-alkynyl or C2-C6-halogenalkynyl, in particular C2-C4-alkynyl or C2-C4-halogenalkynyl, such as CΞCH, CH2CΞCH, CΞCCl, CH2CΞCCl, or CCl2CΞCCl. According to a further specific embodiment of formula I, R2 is O-C1-C6-alkyl, in particular C1-C4- alkyl, more specifically C1-C2-alkoxy. R2 is such as OCH3 or OCH2CH3. According to a further specific embodiment of formula I, R2 is O-C1-C6-alkyl, According to a further specific embodiment of formula I, R2 is O-C2-C6-alkenyl in particular C2- C4-alkenyl, more specifically C2-C3-alkenyl. R2 is such as OCH=CH2, OCH2CH=CH2. According to a further specific embodiment of formula I, R2 is O-C2-C6-alkynyl, in particular C2- C6-alkynyl, in particular C2-C4-alkynyl, more specifically C2-C3-alkynyl. R2 is such as O-CH2- CΞCH. According to still another embodiment of formula I, R2 is C3-C6-cycloalkyl, in particular cyclopro- pyl or cyclobutyl. According to a further specific embodiment of formula I, R2 is S-C1-C6-alkyl, in particular C1-C4- alkyl, more specifically C1-C2-alkoxy. R2 is such as SCH3 or SCH2CH3. According to a further specific embodiment of formula I, R2 is S-C1-C6-alkyl, According to a further specific embodiment of formula I, R2 is S-C2-C6-alkenyl in particular C2- C4-alkenyl, more specifically C2-C3-alkenyl. R2 is such as SCH=CH2, SCH2CH=CH2. According to a further specific embodiment of formula I, R2 is S-C2-C6-alkynyl, in particular C2- C6-alkynyl, in particular C2-C4-alkynyl, more specifically C2-C3-alkynyl. R2 is such as S-CH2- CΞCH. Particularly preferred embodiments of R2 according to the invention are in Table P2 below, wherein each line of lines P2-1 to P2-21 corresponds to one particular embodiment of the inven- tion, wherein P2-1 to P2-21 are also in any combination with one another a preferred embodi- ment of the present invention. The connection point to the carbon atom, to which R2 is bound is marked with “#” in the drawings. 230124 10 Table P2: No. R2 No. R2 P2-1 CH3 P2-13 OCH3 P2-2 CH2F P2-14 OCHF2 P2-3 CHF2 P2-15 OC2H5 P2-4 CF3 P2-16 CN P2-5 C2H5 P2-17 F P2-6 CH(CH3)2 P2-18 Cl P2-7 CH2CH2CH3 P2-19 Br P2-8 CH=CH2 P2-20 P2-9 CH2CH=CH2 P2-10 CΞCH P2-11 CH2CΞCH P2-21 P2-12 OCF3 According to one embodiment of formula I, R3 is selected from the group consisting of C1-C6- alkyl, C1-C6-halogenalkyl, C3-C6-cycloalkyl, in particular CH3, C2H5, CF3, CH2F, CHF2, cyclopro- pyl, cyclobutyl, more specifically CH3, CH2F, CF2H, CF3, cyclopropyl, cyclobutyl most preferred CH3, CF2H. According to still another embodiment of formula I, R3 is C1-C6-alkyl, in particular C1-C4-alkyl, such as CH3 or C2H5, in particular CH3 or CH2CH3. According to still another embodiment of formula I, R3 is C1-C6-halogenalkyl, in particular C1-C4- halogenalkyl, such as CF3, FCH2, F2CH, CF3CH2. According to still a further embodiment of formula I, R3 is C2-C6-alkenyl, in particular C2-C4-alk- enyl, such as CH=CH2, C(CH3)=CH2, CH2CH=CH2. According to still a further embodiment of formula I, R3 is C2-C6-alkynyl or C2-C6-halogenalkynyl, in particular C2-C4-alkynyl or C2-C4-halogenalkynyl, such as CΞCH, CH2CΞCH, CΞCCl, CH2CΞCCl, or CCl2CΞCCl. According to a further specific embodiment of formula I, R3 is O-C1-C6-alkyl, in particular C1-C4- alkyl, more specifically C1-C2-alkoxy. R3 is such as OCH3 or OCH2CH3. 230124 11 According to a further specific embodiment of formula I, R3 is O-C2-C6-alkenyl in particular C2- C4-alkenyl, more specifically C2-C3-alkenyl. R3 is such as OCH=CH2, OCH2CH=CH2. According to a further specific embodiment of formula I, R3 is O-C2-C6-alkynyl, in particular C2- C6-alkynyl, in particular C2-C4-alkynyl, more specifically C2-C3-alkynyl. R3 is such as O-CH2- CΞCH. According to a further specific embodiment of formula I, R3 is O-C1-C6-halogenalkyl, in particular OCF3, OCCl3, OFCH2, OClCH2, OF2CH, OCl2CH, OCF3CH2, OCCl3CH2 or OCF2CHF2, more specifically OCF3, OF2CH, OFCH2. According to still another embodiment of formula I, R3 is C3-C6-cycloalkyl, in particular cyclopro- pyl, cyclobutyl. According to a further specific embodiment of formula I, R3 is S-C1-C6-alkyl, in particular C1-C4- alkyl, more specifically C1-C2-alkoxy. R2 is such as SCH3 or SCH2CH3. According to a further specific embodiment of formula I, R3 is S-C1-C6-alkyl, According to a further specific embodiment of formula I, R3 is S-C2-C6-alkenyl in particular C2-C4- alkenyl, more specifically C2-C3-alkenyl. R2 is such as SCH=CH2, SCH2CH=CH2. According to a further specific embodiment of formula I, R3 is S-C2-C6-alkynyl, in particular C2- C6-alkynyl, in particular C2-C4-alkynyl, more specifically C2-C3-alkynyl. R2 is such as S-CH2- CΞCH. Particularly preferred embodiments of R3 according to the invention are in Table P3 below, wherein each line of lines P3-1 to P3-17 corresponds to one particular embodiment of the inven- tion, wherein P3-1 to P3-17 are also in any combination with one another a preferred embodi- ment of the present invention. The connection point to the carbon atom, to which R3 is bound is marked with “#” in the drawings. Table P3: No. R3 No. R3 P3-1 CH3 P3-7 CH2CH2CH3 P3-2 CH2F P3-8 CH=CH2 P3-3 CHF2 P3-9 CH2CH=CH2 P3-4 CF3 P3-10 CΞCH P3-5 C2H5 P3-11 CH2CΞCH P3-6 CH(CH3)2 P3-12 OCHF3 No. R3 No. R3 P3-13 OCH3 P3-16 P3-14 OCHF2 P3-15 OC2H5 P3-17 According to one embodiment of the compound of formula I, R4 is in each case independently selected from H, halogen, CN, C1-C4-alkyl, C1-C4-halogenalkyl, preferred R4 is in each case in- dependently selected from H, C1-C4-alkyl, C1-C4-halogenalkyl, more preferred R4 is in each case independently selected from H, C1-C4-alkyl, most preferred R4 is in each case H. According to one embodiment of the compound of formula I, R5 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloal- kenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substituents R5a; where each R5a is independently halogen, CN, C1-C6-alkyl, C1- C6-haloalkyl or O-C1-C6-alkyl. According to one embodiment of the compound of formula I, R5 is in each case independently selected from C1-C6-alkyl (embodiment 5.1), C1-C6-halogenalkyl (embodiment 5.2), C1-C6-alkyl- O-C1-C6-alkyl (embodiment 5.3), phenyl, CH2-phenyl (embodiment 5.4), wherein phenyl and CH2-phenyl is unsubstituted or substituted by one or two halogen. According to one further embodiment of the compound of formula I, R5 is CH3 or CF3. According to one further embodiment of the compound of formula I, R5 is CH3. According to one further embodiment of the compound of formula I, R5 is CH2CH3, CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, CH2-CH(CH3)2, CH2-C(CH3)3, CH2-O-CH3. According to one further embodiment of the compound of formula I, R5 is CH=CH2, CH2CH=CH2. According to one further embodiment of the compound of formula I, R5 is phenyl, 2-F-phenyl, 4- F-phenyl, 2,4-F2-phenyl, 2-Cl-phenyl, 4-Cl-phenyl, CH2-phenyl, CH2-2-F-phenyl, CH2-4-F-phe- nyl. 13 According to one embodiment of the compound of formula I, R6 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloal- kenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substituents R6a; where each R6a is independently halogen, CN, C1-C6-alkyl, C1- C6-haloalkyl or O-C1-C6-alkyl. According to one embodiment of the compound of formula I, R6 is in each case independently selected from C1-C6-alkyl (embodiment 6.1), C1-C6-alkyl-O-phenyl (embodiment 6.2), C1-C6-al- kyl-O-C1-C6-alkyl (embodiment 6.3). According to one further embodiment of the compound of formula I, R6 is CH2CH3, CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, CH2-CH(CH3)2, CH2-C(CH3)3, CH2-CH(CH3)-C(CH3)3, CH2-CH2- C(CH3)3, CH2-O-CH3, CH2-O-(CH3)3, CH2-O-phenyl, is CH=CH2, CH2CH=CH2, CH2-phenyl. According to one further embodiment of the compound of formula I, R5 and R6 form together with the C atoms to which they are bound a C3-C6-cycloalkyl or a a 3 - to 6-membered satu- rated heterocycle which contains 1, 2 or 3 heteroatoms from the group consisting of O and S, wherein the cycloalkyl or heterocycle can be unsubsituted or substitued by halogene, C1-C6- alkyl, C1-C6-halogenalkyl. According to one further embodiment of the compound of formula I, R5 and R6 form C3-C6-cy- cloalkyl (embodiment 6.4). According to one further embodiment of the compound of formula I, R5 and R6 form 3- to 6- membered saturated heterocycle which contains 1, 2 or 3 heteroatoms from the group consist- ing of O and S. According to one further embodiment of the compound of formula I, R5 and R6 form together a (=O) group (embodiment 6.5). Prefferred embodiments of R5, R6 according to the invention are in Table P5 below, wherein each line of lines P5-1 to P5-19 corresponds to one particular embodiment of the invention, wherein P5-1 to P5-19 are also in any combination with one another a preferred embodiment of the present invention. The connection point to the carbon atom, to which R5 and R6 is bound is marked with “#” in the drawings. Table P5,6: No. R5 R6 No. R5 R6 P5-1 P5-2 BASF SE 220928 EP01 14 No. R5 R6 No. R5 R6 P5-3 P5-12 P5-4 P5-13 P5-5 P5-14 P5-6 P5-15 P5-7 P5-16 P5-8 P5-9 P5-17 P5-10 P5-18 P5-19 =O P5-11 According to one embodiment of the compound of formula I, R7 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloal- kenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substituents R7a; where each R7a is independently halogen, CN, C1-C6-alkyl, C1- C6-haloalkyl or O-C1-C6-alkyl. According to one embodiment of the compound of formula I, R7 is in each case independently selected from C1-C6-alkyl (embodiment 7.1), C1-C6-halogenalkyl (embodiment 7.2), C1-C6-alkyl- 230124 15 O-C1-C6-alkyl (embodiment 7.3), phenyl, CH2-phenyl (embodiment 7.4), wherein phenyl and CH2-phenyl is unsubstituted or substituted by one or two halogen. According to one further embodiment of the compound of formula I, R7 is CH3 or CF3. According to one further embodiment of the compound of formula I, R7 is CH3. According to one further embodiment of the compound of formula I, R7 is CH2CH3, CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, CH2-CH(CH3)2, CH2-C(CH3)3, CH2-O-CH3, CH=CH2, CH2CH=CH2. According to one further embodiment of the compound of formula I, R7 is phenyl, 2-F-phenyl, 4- F-phenyl, 2,4-F2-phenyl, 2-Cl-phenyl, 4-Cl-phenyl, CH2-phenyl, CH2-2-F-phenyl, CH2-4-F-phe- nyl. According to one embodiment of the compound of formula I, R8 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloal- kenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substituents R8a; where each R8a is independently halogen, CN, C1-C6-alkyl, C1- C6-haloalkyl or O-C1-C6-alkyl. According to one embodiment of the compound of formula I, R8 is in each case independently selected from C1-C6-alkyl (embodiment 8.1), C1-C6-alkyl-O-phenyl (embodiment 8.2), C1-C6-al- kyl-O-C1-C6-alkyl (embodiment 8.3). According to one further embodiment of the compound of formula I, R8 is CH2CH3, CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, CH2-CH(CH3)2, CH2-C(CH3)3, CH2-CH(CH3)-C(CH3)3, CH2-CH2- C(CH3)3, CH2-O-CH3, CH2-O-(CH3)3, CH2-O-phenyl CH=CH2, CH2CH=CH2, CH2-phenyl. According to one further embodiment of the compound of formula I, R7 and R8 form together with the C atoms to which they are bound a C3-C6-cycloalkyl or a a 3 - to 6-membered satu- rated heterocycle which contains 1, 2 or 3 heteroatoms from the group consisting of O and S, wherein the cycloalkyl or heterocycle can be unsubsituted or substitued by halogene, C1-C6- alkyl, C1-C6-halogenalkyl. According to one further embodiment of the compound of formula I, R7 and R8 form C3-C6-cy- cloalkyl (embodiment 8.4). According to one further embodiment of the compound of formula I, R7 and R8 form 3- to 6- membered saturated heterocycle which contains 1, 2 or 3 heteroatoms from the group consist- ing of O and S. Prefferred embodiments of R7, R8 according to the invention are in Table P78 below, wherein each line of lines P7-1 to P7-19 corresponds to one particular embodiment of the invention, 230124 16 wherein P7-1 to P7-19 are also in any combination with one another a preferred embodiment of the present invention. The connection point to the carbon atom, to which R7 and R8 is bound is marked with “#” in the drawings. Table P7,8: No. R7 R8 No. R7 R8 P7-1 P7-12 P7-2 P7-13 P7-3 P7-14 P7-4 P7-15 P7-5 P7-6 P7-16 P7-7 P7-17 P7-8 P7-18 P7-19 =O P7-9 P7-10 P7-11 230124 17 According to one embodiment of the compound of formula I, X is in each case independently selected from halogen (embodiment X.1), CN, C1-C6-alkyl (embodiment X.2), C1-C6-halogen- alkyl (embodiment X.3), O-C1-C6-alkyl (embodiment X.4), O-C1-C6-halogenalkyl (embodiment X.5). According to one embodiment of the compound of formula I, X is in each case independently selected from halogen, O-C1-C6-alkyl. According to one embodiment of the compound of formula I, X is in each case independently selected from F or Cl. According to one embodiment of the compound of formula I, X is C3-C6-cycloalkyl. According to one embodiment of the compound of formula I, n is 0. According to one embodiment of the compound of formula I, n is 1. According to one embodiment of the compound of formula I, n is 2. According to one embodiment Xn is as defined below: and X is selected from F, Cl, I, CH3, cyclopropyl, CH=CH2, CΞCH, OCH3, OCHF2, CF3, CHF2, CH2CH3, CN, OPh. According to one embodiment Xn is as defined below: According to one embodiment Xn is as defined below: 230124 18 and X is selected from F, Cl, I, CH3, cyclopropyl, CH=CH2, CΞCH, OCH3, OCHF2, CF3, CHF2, CH2CH3, CN, OPh. According to one embodiment Xn is as defined below: and X is F. According to one embodiment n is 0. Therefore, according to the present invention, the compound of the formula I having one chiral center can be used in form of − a racemic mixture of the of the (R)-enantiomer and the (S)-enantiomer; − a mixture with any other proportions of the (R)-enantiomer and the (S)-enantiomer; − pure (R)-enantiomer or − pure (S)-enantiomer. According to one specific embodiment, the compound of the formula I is provided and used as (R)-enantiomer with an enantiomeric excess (e.e.) of at least 40%, for example, at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, yet more preferably at least 98% and most preferably at least 99%. According to one specific embodiment, the compound of the formula I is provided and used as (S)-enantiomer with an enantiomeric excess (e.e.) of at least 40%, for example, at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, yet more preferably at least 98% and most preferably at least 99%. 230124 19 Therefore, according to the present invention, the compound of the formula I having two chiral centers can be used in form of − a racemic mixture of the of the (R,R)-enantiomer and the (S,S)-enantiomer, − a mixture with any other proportions of the (R,R)-enantiomer and the (S,S)-enantiomer; − pure (R,R)-enantiomer or − pure (S,S)-enantiomer. According to one specific embodiment, the compound of the formula I is provided and used as (R,R)-enantiomer with an enantiomeric excess (e.e.) of at least 40%, for example, at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, yet more preferably at least 98% and most preferably at least 99%. According to one specific embodiment, the compound of the formula I is provided and used as (S,S)-enantiomer with an enantiomeric excess (e.e.) of at least 40%, for example, at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, yet more preferably at least 98% and most preferably at least 99%. Therefore, according to the present invention, the compound of the formula I having two chiral centers can be used in form of − a racemic mixture of the of the (R,S)-enantiomer and the (S,R)-enantiomer, − a mixture with any other proportions of the (R,S)-enantiomer and the (S, R)-enantiomer; − pure (R,S)-enantiomer or − pure (S,R)-enantiomer. According to one specific embodiment, the compound of the formula I is provided and used as (R,S)-enantiomer with an enantiomeric excess (e.e.) of at least 40%, for example, at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, yet more preferably at least 98% and most preferably at least 99%. According to one specific embodiment, the compound of the formula I is provided and used as (S,R)-enantiomer with an enantiomeric excess (e.e.) of at least 40%, for example, at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, yet more preferably at least 98% and most preferably at least 99%. Therefore, according to the present invention, the compound of the formula I having two chiral centers can be used in form of - a mixture with any proportions of the (R,S)-diastereoisomer and the (S,S)-diastereoiso- mer, According to one specific embodiment, the compound of the formula I is provided and used as (R,S)-diastereoisomer with an diastereomeric excess (d.e.) of at least 40%, for example, at least 230124 20 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, yet more prefer- ably at least 98% and most preferably at least 99%. According to one specific embodiment, the compound of the formula I is provided and used as (S,S)-diastereoisomer with an diastereomeric excess (d.e.) of at least 40%, for example, at least 50%, 60%, 70% or 80%, preferably at least 90%, more preferably at least 95%, yet more prefer- ably at least 98% and most preferably at least 99%. This applies to the mixtures with any other proportions of a mixture A (composed by any propor- tion of (R,R)-enantiomer and the (S,S)-enantiomer) and a mixture B (composed by any propor- tion of (R,S)-enantiomer and the (S,R)-enantiomer). This applies also to the compound of the formula I having three, four and five chiral centers. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, which represent preferred combinations of embodiments that are defined above for each of the variables R2, R3 and X (represented by embodiments X.1 to X.6), n in compounds of formula I as defined below. Table E: Embodiment X n R2 R3 E.1 (X.1) 0, 1, or 2 C1-C6-alkyl C1-C6-alkyl E.2 (X.2) 0, 1, or 2 C1-C6-alkyl C1-C6-alkyl E.3 (X.3) 0, 1, or 2 C1-C6-alkyl C1-C6-alkyl E.4 (X.4) 0, 1, or 2 C1-C6-alkyl C1-C6-alkyl E.5 (X.5) 0, 1, or 2 C1-C6-alkyl C1-C6-alkyl E.6 (X.1) 0, 1, or 2 halogen C1-C6-alkyl E.7 (X.2) 0, 1, or 2 halogen C1-C6-alkyl E.8 (X.3) 0, 1, or 2 halogen C1-C6-alkyl E.9 (X.4) 0, 1, or 2 halogen C1-C6-alkyl E.10 (X.5) 0, 1, or 2 halogen C1-C6-alkyl E.11 (X.1) 0, 1, or 2 C1-C6-halogenalkyl C1-C6-alkyl 230124 21 Embodiment X n R2 R3 E.12 (X.2) 0, 1, or 2 C1-C6-halogenalkyl C1-C6-alkyl E.13 (X.3) 0, 1, or 2 C1-C6-halogenalkyl C1-C6-alkyl E.14 (X.4) 0, 1, or 2 C1-C6-halogenalkyl C1-C6-alkyl E.15 (X.5) 0, 1, or 2 C1-C6-halogenalkyl C1-C6-alkyl E.16 (X.1) 0, 1, or 2 C2-C6-alkenyl C1-C6-alkyl E.17 (X.2) 0, 1, or 2 C2-C6-alkenyl C1-C6-alkyl E.18 (X.3) 0, 1, or 2 C2-C6-alkenyl C1-C6-alkyl E.19 (X.4) 0, 1, or 2 C2-C6-alkenyl C1-C6-alkyl E.20 (X.5) 0, 1, or 2 C2-C6-alkenyl C1-C6-alkyl E.21 (X.1) 0, 1, or 2 C2-C6-halogenalkenyl C1-C6-alkyl E.22 (X.2) 0, 1, or 2 C2-C6-halogenalkenyl C1-C6-alkyl E.23 (X.3) 0, 1, or 2 C2-C6-halogenalkenyl C1-C6-alkyl E.24 (X.4) 0, 1, or 2 C2-C6-halogenalkenyl C1-C6-alkyl E.25 (X.5) 0, 1, or 2 C2-C6-halogenalkenyl C1-C6-alkyl E.26 (X.1) 0, 1, or 2 C2-C6-alkynyl C1-C6-alkyl E.27 (X.2) 0, 1, or 2 C2-C6-alkynyl C1-C6-alkyl E.28 (X.3) 0, 1, or 2 C2-C6-alkynyl C1-C6-alkyl E.29 (X.4) 0, 1, or 2 C2-C6-alkynyl C1-C6-alkyl E.30 (X.5) 0, 1, or 2 C2-C6-alkynyl C1-C6-alkyl E.31 (X.1) 0, 1, or 2 C2-C6-halogenalkynyl C1-C6-alkyl E.32 (X.2) 0, 1, or 2 C2-C6-halogenalkynyl C1-C6-alkyl E.33 (X.3) 0, 1, or 2 C2-C6-halogenalkynyl C1-C6-alkyl E.34 (X.4) 0, 1, or 2 C2-C6-halogenalkynyl C1-C6-alkyl E.35 (X.5) 0, 1, or 2 C2-C6-halogenalkynyl C1-C6-alkyl E.36 (X.1) 0, 1, or 2 O-C1-C6-alkyl C1-C6-alkyl E.37 (X.2) 0, 1, or 2 O-C1-C6-alkyl C1-C6-alkyl E.38 (X.3) 0, 1, or 2 O-C1-C6-alkyl C1-C6-alkyl E.39 (X.4) 0, 1, or 2 O-C1-C6-alkyl C1-C6-alkyl E.40 (X.5) 0, 1, or 2 O-C1-C6-alkyl C1-C6-alkyl E.41 (X.1) 0, 1, or 2 O-C2-C6-alkenyl C1-C6-alkyl E.42 (X.2) 0, 1, or 2 O-C2-C6-alkenyl C1-C6-alkyl E.43 (X.3) 0, 1, or 2 O-C2-C6-alkenyl C1-C6-alkyl E.44 (X.4) 0, 1, or 2 O-C2-C6-alkenyl C1-C6-alkyl E.45 (X.5) 0, 1, or 2 O-C2-C6-alkenyl C1-C6-alkyl E.46 (X.1) 0, 1, or 2 O-C2-C6-alkynyl C1-C6-alkyl 230124 22 Embodiment X n R2 R3 E.47 (X.2) 0, 1, or 2 O-C2-C6-alkynyl C1-C6-alkyl E.48 (X.3) 0, 1, or 2 O-C2-C6-alkynyl C1-C6-alkyl E.49 (X.4) 0, 1, or 2 O-C2-C6-alkynyl C1-C6-alkyl E.50 (X.5) 0, 1, or 2 O-C2-C6-alkynyl C1-C6-alkyl E.51 (X.1) 0, 1, or 2 C3-C6-cycloalkyl C1-C6-alkyl E.52 (X.2) 0, 1, or 2 C3-C6-cycloalkyl C1-C6-alkyl E.53 (X.3) 0, 1, or 2 C3-C6-cycloalkyl C1-C6-alkyl E.54 (X.4) 0, 1, or 2 C3-C6-cycloalkyl C1-C6-alkyl E.55 (X.5) 0, 1, or 2 C3-C6-cycloalkyl C1-C6-alkyl E.56 (X.1) 0, 1, or 2 C1-C6-alkyl C1-C6-halogenalkyl E.57 (X.2) 0, 1, or 2 C1-C6-alkyl C1-C6-halogenalkyl E.58 (X.3) 0, 1, or 2 C1-C6-alkyl C1-C6-halogenalkyl E.59 (X.4) 0, 1, or 2 C1-C6-alkyl C1-C6-halogenalkyl E.60 (X.5) 0, 1, or 2 C1-C6-alkyl C1-C6-halogenalkyl E.61 (X.1) 0, 1, or 2 halogen C1-C6-halogenalkyl E.62 (X.2) 0, 1, or 2 halogen C1-C6-halogenalkyl E.63 (X.3) 0, 1, or 2 halogen C1-C6-halogenalkyl E.64 (X.4) 0, 1, or 2 halogen C1-C6-halogenalkyl E.65 (X.5) 0, 1, or 2 halogen C1-C6-halogenalkyl E.66 (X.1) 0, 1, or 2 C1-C6-halogenalkyl C1-C6-halogenalkyl E.67 (X.2) 0, 1, or 2 C1-C6-halogenalkyl C1-C6-halogenalkyl E.68 (X.3) 0, 1, or 2 C1-C6-halogenalkyl C1-C6-halogenalkyl E.69 (X.4) 0, 1, or 2 C1-C6-halogenalkyl C1-C6-halogenalkyl E.70 (X.5) 0, 1, or 2 C1-C6-halogenalkyl C1-C6-halogenalkyl E.71 (X.1) 0, 1, or 2 C2-C6-alkenyl C1-C6-halogenalkyl E.72 (X.2) 0, 1, or 2 C2-C6-alkenyl C1-C6-halogenalkyl E.73 (X.3) 0, 1, or 2 C2-C6-alkenyl C1-C6-halogenalkyl E.74 (X.4) 0, 1, or 2 C2-C6-alkenyl C1-C6-halogenalkyl E.75 (X.5) 0, 1, or 2 C2-C6-alkenyl C1-C6-halogenalkyl E.76 (X.1) 0, 1, or 2 C2-C6-halogenalkenyl C1-C6-halogenalkyl E.77 (X.2) 0, 1, or 2 C2-C6-halogenalkenyl C1-C6-halogenalkyl E.78 (X.3) 0, 1, or 2 C2-C6-halogenalkenyl C1-C6-halogenalkyl E.79 (X.4) 0, 1, or 2 C2-C6-halogenalkenyl C1-C6-halogenalkyl E.80 (X.5) 0, 1, or 2 C2-C6-halogenalkenyl C1-C6-halogenalkyl E.81 (X.1) 0, 1, or 2 C2-C6-alkynyl C1-C6-halogenalkyl Embodiment X n R2 R3 E.82 (X.2) 0, 1, or 2 C2-C6-alkynyl C1-C6-halogenalkyl E.83 (X.3) 0, 1, or 2 C2-C6-alkynyl C1-C6-halogenalkyl E.84 (X.4) 0, 1, or 2 C2-C6-alkynyl C1-C6-halogenalkyl E.85 (X.5) 0, 1, or 2 C2-C6-alkynyl C1-C6-halogenalkyl E.86 (X.1) 0, 1, or 2 C2-C6-halogenalkynyl C1-C6-halogenalkyl E.87 (X.2) 0, 1, or 2 C2-C6-halogenalkynyl C1-C6-halogenalkyl E.88 (X.3) 0, 1, or 2 C2-C6-halogenalkynyl C1-C6-halogenalkyl E.89 (X.4) 0, 1, or 2 C2-C6-halogenalkynyl C1-C6-halogenalkyl E.90 (X.5) 0, 1, or 2 C2-C6-halogenalkynyl C1-C6-halogenalkyl E.91 (X.1) 0, 1, or 2 O-C1-C6-alkyl C1-C6-halogenalkyl E.92 (X.2) 0, 1, or 2 O-C1-C6-alkyl C1-C6-halogenalkyl E.93 (X.3) 0, 1, or 2 O-C1-C6-alkyl C1-C6-halogenalkyl E.94 (X.4) 0, 1, or 2 O-C1-C6-alkyl C1-C6-halogenalkyl E.95 (X.5) 0, 1, or 2 O-C1-C6-alkyl C1-C6-halogenalkyl E.96 (X.1) 0, 1, or 2 O-C2-C6-alkenyl C1-C6-halogenalkyl E.97 (X.2) 0, 1, or 2 O-C2-C6-alkenyl C1-C6-halogenalkyl E.98 (X.3) 0, 1, or 2 O-C2-C6-alkenyl C1-C6-halogenalkyl E.99 (X.4) 0, 1, or 2 O-C2-C6-alkenyl C1-C6-halogenalkyl E.100 (X.5) 0, 1, or 2 O-C2-C6-alkenyl C1-C6-halogenalkyl E.101 (X.1) 0, 1, or 2 O-C2-C6-alkynyl C1-C6-halogenalkyl E.102 (X.2) 0, 1, or 2 O-C2-C6-alkynyl C1-C6-halogenalkyl E.103 (X.3) 0, 1, or 2 O-C2-C6-alkynyl C1-C6-halogenalkyl E.104 (X.4) 0, 1, or 2 O-C2-C6-alkynyl C1-C6-halogenalkyl E.105 (X.5) 0, 1, or 2 O-C2-C6-alkynyl C1-C6-halogenalkyl E.106 (X.1) 0, 1, or 2 C3-C6-cycloalkyl C1-C6-halogenalkyl E.107 (X.2) 0, 1, or 2 C3-C6-cycloalkyl C1-C6-halogenalkyl E.108 (X.3) 0, 1, or 2 C3-C6-cycloalkyl C1-C6-halogenalkyl E.109 (X.4) 0, 1, or 2 C3-C6-cycloalkyl C1-C6-halogenalkyl E.110 (X.5) 0, 1, or 2 C3-C6-cycloalkyl C1-C6-halogenalkyl E.111 (X.1) 0, 1, or 2 C1-C6-alkyl O-C1-C6-alkyl E.112 (X.2) 0, 1, or 2 C1-C6-alkyl O-C1-C6-alkyl E.113 (X.3) 0, 1, or 2 C1-C6-alkyl O-C1-C6-alkyl E.114 (X.4) 0, 1, or 2 C1-C6-alkyl O-C1-C6-alkyl E.115 (X.5) 0, 1, or 2 C1-C6-alkyl O-C1-C6-alkyl E.116 (X.1) 0, 1, or 2 halogen O-C1-C6-alkyl Embodiment X n R2 R3 E.117 (X.2) 0, 1, or 2 halogen O-C1-C6-alkyl E.118 (X.3) 0, 1, or 2 halogen O-C1-C6-alkyl E.119 (X.4) 0, 1, or 2 halogen O-C1-C6-alkyl E.120 (X.5) 0, 1, or 2 halogen O-C1-C6-alkyl E.121 (X.1) 0, 1, or 2 C1-C6-halogenalkyl O-C1-C6-alkyl E.122 (X.2) 0, 1, or 2 C1-C6-halogenalkyl O-C1-C6-alkyl E.123 (X.3) 0, 1, or 2 C1-C6-halogenalkyl O-C1-C6-alkyl E.124 (X.4) 0, 1, or 2 C1-C6-halogenalkyl O-C1-C6-alkyl E.125 (X.5) 0, 1, or 2 C1-C6-halogenalkyl O-C1-C6-alkyl E.126 (X.1) 0, 1, or 2 C2-C6-alkenyl O-C1-C6-alkyl E.127 (X.2) 0, 1, or 2 C2-C6-alkenyl O-C1-C6-alkyl E.128 (X.3) 0, 1, or 2 C2-C6-alkenyl O-C1-C6-alkyl E.129 (X.4) 0, 1, or 2 C2-C6-alkenyl O-C1-C6-alkyl E.130 (X.5) 0, 1, or 2 C2-C6-alkenyl O-C1-C6-alkyl E.131 (X.1) 0, 1, or 2 C2-C6-halogenalkenyl O-C1-C6-alkyl E.132 (X.2) 0, 1, or 2 C2-C6-halogenalkenyl O-C1-C6-alkyl E.133 (X.3) 0, 1, or 2 C2-C6-halogenalkenyl O-C1-C6-alkyl E.134 (X.4) 0, 1, or 2 C2-C6-halogenalkenyl O-C1-C6-alkyl E.135 (X.5) 0, 1, or 2 C2-C6-halogenalkenyl O-C1-C6-alkyl E.136 (X.1) 0, 1, or 2 C2-C6-alkynyl O-C1-C6-alkyl E.137 (X.2) 0, 1, or 2 C2-C6-alkynyl O-C1-C6-alkyl E.138 (X.3) 0, 1, or 2 C2-C6-alkynyl O-C1-C6-alkyl E.139 (X.4) 0, 1, or 2 C2-C6-alkynyl O-C1-C6-alkyl E.140 (X.5) 0, 1, or 2 C2-C6-alkynyl O-C1-C6-alkyl E.141 (X.1) 0, 1, or 2 C2-C6-halogenalkynyl O-C1-C6-alkyl E.142 (X.2) 0, 1, or 2 C2-C6-halogenalkynyl O-C1-C6-alkyl E.143 (X.3) 0, 1, or 2 C2-C6-halogenalkynyl O-C1-C6-alkyl E.144 (X.4) 0, 1, or 2 C2-C6-halogenalkynyl O-C1-C6-alkyl E.145 (X.5) 0, 1, or 2 C2-C6-halogenalkynyl O-C1-C6-alkyl E.146 (X.1) 0, 1, or 2 O-C1-C6-alkyl O-C1-C6-alkyl E.147 (X.2) 0, 1, or 2 O-C1-C6-alkyl O-C1-C6-alkyl E.148 (X.3) 0, 1, or 2 O-C1-C6-alkyl O-C1-C6-alkyl E.149 (X.4) 0, 1, or 2 O-C1-C6-alkyl O-C1-C6-alkyl E.150 (X.5) 0, 1, or 2 O-C1-C6-alkyl O-C1-C6-alkyl E.151 (X.1) 0, 1, or 2 O-C2-C6-alkenyl O-C1-C6-alkyl 25 Embodiment X n R2 R3 E.152 (X.2) 0, 1, or 2 O-C2-C6-alkenyl O-C1-C6-alkyl E.153 (X.3) 0, 1, or 2 O-C2-C6-alkenyl O-C1-C6-alkyl E.154 (X.4) 0, 1, or 2 O-C2-C6-alkenyl O-C1-C6-alkyl E.155 (X.5) 0, 1, or 2 O-C2-C6-alkenyl O-C1-C6-alkyl E.156 (X.1) 0, 1, or 2 O-C2-C6-alkynyl O-C1-C6-alkyl E.157 (X.2) 0, 1, or 2 O-C2-C6-alkynyl O-C1-C6-alkyl E.158 (X.3) 0, 1, or 2 O-C2-C6-alkynyl O-C1-C6-alkyl E.159 (X.4) 0, 1, or 2 O-C2-C6-alkynyl O-C1-C6-alkyl E.160 (X.5) 0, 1, or 2 O-C2-C6-alkynyl O-C1-C6-alkyl E.161 (X.1) 0, 1, or 2 C3-C6-cycloalkyl O-C1-C6-alkyl E.162 (X.2) 0, 1, or 2 C3-C6-cycloalkyl O-C1-C6-alkyl E.163 (X.3) 0, 1, or 2 C3-C6-cycloalkyl O-C1-C6-alkyl E.164 (X.4) 0, 1, or 2 C3-C6-cycloalkyl O-C1-C6-alkyl E.165 (X.5) 0, 1, or 2 C3-C6-cycloalkyl O-C1-C6-alkyl E.166 (X.1) 0, 1, or 2 C1-C6-alkyl C3-C6-cycloalkyl E.167 (X.2) 0, 1, or 2 C1-C6-alkyl C3-C6-cycloalkyl E.168 (X.3) 0, 1, or 2 C1-C6-alkyl C3-C6-cycloalkyl E.169 (X.4) 0, 1, or 2 C1-C6-alkyl C3-C6-cycloalkyl E.170 (X.5) 0, 1, or 2 C1-C6-alkyl C3-C6-cycloalkyl E.171 (X.1) 0, 1, or 2 halogen C3-C6-cycloalkyl E.172 (X.2) 0, 1, or 2 halogen C3-C6-cycloalkyl E.173 (X.3) 0, 1, or 2 halogen C3-C6-cycloalkyl E.174 (X.4) 0, 1, or 2 halogen C3-C6-cycloalkyl E.175 (X.5) 0, 1, or 2 halogen C3-C6-cycloalkyl E.176 (X.1) 0, 1, or 2 C1-C6-halogenalkyl C3-C6-cycloalkyl E.177 (X.2) 0, 1, or 2 C1-C6-halogenalkyl C3-C6-cycloalkyl E.178 (X.3) 0, 1, or 2 C1-C6-halogenalkyl C3-C6-cycloalkyl E.179 (X.4) 0, 1, or 2 C1-C6-halogenalkyl C3-C6-cycloalkyl E.180 (X.5) 0, 1, or 2 C1-C6-halogenalkyl C3-C6-cycloalkyl E.181 (X.1) 0, 1, or 2 C2-C6-alkenyl C3-C6-cycloalkyl E.182 (X.2) 0, 1, or 2 C2-C6-alkenyl C3-C6-cycloalkyl E.183 (X.3) 0, 1, or 2 C2-C6-alkenyl C3-C6-cycloalkyl E.184 (X.4) 0, 1, or 2 C2-C6-alkenyl C3-C6-cycloalkyl E.185 (X.5) 0, 1, or 2 C2-C6-alkenyl C3-C6-cycloalkyl E.186 (X.1) 0, 1, or 2 C2-C6-halogenalkenyl C3-C6-cycloalkyl 230124 26 Embodiment X n R2 R3 E.187 (X.2) 0, 1, or 2 C2-C6-halogenalkenyl C3-C6-cycloalkyl E.188 (X.3) 0, 1, or 2 C2-C6-halogenalkenyl C3-C6-cycloalkyl E.189 (X.4) 0, 1, or 2 C2-C6-halogenalkenyl C3-C6-cycloalkyl E.190 (X.5) 0, 1, or 2 C2-C6-halogenalkenyl C3-C6-cycloalkyl E.191 (X.1) 0, 1, or 2 C2-C6-alkynyl C3-C6-cycloalkyl E.192 (X.2) 0, 1, or 2 C2-C6-alkynyl C3-C6-cycloalkyl E.193 (X.3) 0, 1, or 2 C2-C6-alkynyl C3-C6-cycloalkyl E.194 (X.4) 0, 1, or 2 C2-C6-alkynyl C3-C6-cycloalkyl E.195 (X.5) 0, 1, or 2 C2-C6-alkynyl C3-C6-cycloalkyl E.196 (X.1) 0, 1, or 2 C2-C6-halogenalkynyl C3-C6-cycloalkyl E.197 (X.2) 0, 1, or 2 C2-C6-halogenalkynyl C3-C6-cycloalkyl E.198 (X.3) 0, 1, or 2 C2-C6-halogenalkynyl C3-C6-cycloalkyl E.199 (X.4) 0, 1, or 2 C2-C6-halogenalkynyl C3-C6-cycloalkyl E.200 (X.5) 0, 1, or 2 C2-C6-halogenalkynyl C3-C6-cycloalkyl E.201 (X.1) 0, 1, or 2 O-C1-C6-alkyl C3-C6-cycloalkyl E.202 (X.2) 0, 1, or 2 O-C1-C6-alkyl C3-C6-cycloalkyl E.203 (X.3) 0, 1, or 2 O-C1-C6-alkyl C3-C6-cycloalkyl E.204 (X.4) 0, 1, or 2 O-C1-C6-alkyl C3-C6-cycloalkyl E.205 (X.5) 0, 1, or 2 O-C1-C6-alkyl C3-C6-cycloalkyl E.206 (X.1) 0, 1, or 2 O-C2-C6-alkenyl C3-C6-cycloalkyl E.207 (X.2) 0, 1, or 2 O-C2-C6-alkenyl C3-C6-cycloalkyl E.208 (X.3) 0, 1, or 2 O-C2-C6-alkenyl C3-C6-cycloalkyl E.209 (X.4) 0, 1, or 2 O-C2-C6-alkenyl C3-C6-cycloalkyl E.210 (X.5) 0, 1, or 2 O-C2-C6-alkenyl C3-C6-cycloalkyl E.211 (X.1) 0, 1, or 2 O-C2-C6-alkynyl C3-C6-cycloalkyl E.212 (X.2) 0, 1, or 2 O-C2-C6-alkynyl C3-C6-cycloalkyl E.213 (X.3) 0, 1, or 2 O-C2-C6-alkynyl C3-C6-cycloalkyl E.214 (X.4) 0, 1, or 2 O-C2-C6-alkynyl C3-C6-cycloalkyl E.215 (X.5) 0, 1, or 2 O-C2-C6-alkynyl C3-C6-cycloalkyl E.216 (X.1) 0, 1, or 2 C3-C6-cycloalkyl C3-C6-cycloalkyl E.217 (X.2) 0, 1, or 2 C3-C6-cycloalkyl C3-C6-cycloalkyl E.218 (X.3) 0, 1, or 2 C3-C6-cycloalkyl C3-C6-cycloalkyl E.219 (X.4) 0, 1, or 2 C3-C6-cycloalkyl C3-C6-cycloalkyl E.220 (X.5) 0, 1, or 2 C3-C6-cycloalkyl C3-C6-cycloalkyl E.221 (X.1) 0, 1, or 2 C1-C6-alkyl C2-C6-alkenyl 230124 27 Embodiment X n R2 R3 E.222 (X.2) 0, 1, or 2 C1-C6-alkyl C2-C6-alkenyl E.223 (X.3) 0, 1, or 2 C1-C6-alkyl C2-C6-alkenyl E.224 (X.4) 0, 1, or 2 C1-C6-alkyl C2-C6-alkenyl E.225 (X.5) 0, 1, or 2 C1-C6-alkyl C2-C6-alkenyl E.226 (X.1) 0, 1, or 2 halogen C2-C6-alkenyl E.227 (X.2) 0, 1, or 2 halogen C2-C6-alkenyl E.228 (X.3) 0, 1, or 2 halogen C2-C6-alkenyl E.229 (X.4) 0, 1, or 2 halogen C2-C6-alkenyl E.230 (X.5) 0, 1, or 2 halogen C2-C6-alkenyl E.231 (X.1) 0, 1, or 2 C1-C6-halogenalkyl C2-C6-alkenyl E.232 (X.2) 0, 1, or 2 C1-C6-halogenalkyl C2-C6-alkenyl E.233 (X.3) 0, 1, or 2 C1-C6-halogenalkyl C2-C6-alkenyl E.234 (X.4) 0, 1, or 2 C1-C6-halogenalkyl C2-C6-alkenyl E.235 (X.5) 0, 1, or 2 C1-C6-halogenalkyl C2-C6-alkenyl E.236 (X.1) 0, 1, or 2 C2-C6-alkenyl C2-C6-alkenyl E.237 (X.2) 0, 1, or 2 C2-C6-alkenyl C2-C6-alkenyl E.238 (X.3) 0, 1, or 2 C2-C6-alkenyl C2-C6-alkenyl E.239 (X.4) 0, 1, or 2 C2-C6-alkenyl C2-C6-alkenyl E.240 (X.5) 0, 1, or 2 C2-C6-alkenyl C2-C6-alkenyl E.241 (X.1) 0, 1, or 2 C2-C6-halogenalkenyl C2-C6-alkenyl E.242 (X.2) 0, 1, or 2 C2-C6-halogenalkenyl C2-C6-alkenyl E.243 (X.3) 0, 1, or 2 C2-C6-halogenalkenyl C2-C6-alkenyl E.244 (X.4) 0, 1, or 2 C2-C6-halogenalkenyl C2-C6-alkenyl E.245 (X.5) 0, 1, or 2 C2-C6-halogenalkenyl C2-C6-alkenyl E.246 (X.1) 0, 1, or 2 C2-C6-alkynyl C2-C6-alkenyl E.247 (X.2) 0, 1, or 2 C2-C6-alkynyl C2-C6-alkenyl E.248 (X.3) 0, 1, or 2 C2-C6-alkynyl C2-C6-alkenyl E.249 (X.4) 0, 1, or 2 C2-C6-alkynyl C2-C6-alkenyl E.250 (X.5) 0, 1, or 2 C2-C6-alkynyl C2-C6-alkenyl E.251 (X.1) 0, 1, or 2 C2-C6-halogenalkynyl C2-C6-alkenyl E.252 (X.2) 0, 1, or 2 C2-C6-halogenalkynyl C2-C6-alkenyl E.253 (X.3) 0, 1, or 2 C2-C6-halogenalkynyl C2-C6-alkenyl E.254 (X.4) 0, 1, or 2 C2-C6-halogenalkynyl C2-C6-alkenyl E.255 (X.5) 0, 1, or 2 C2-C6-halogenalkynyl C2-C6-alkenyl E.256 (X.1) 0, 1, or 2 O-C1-C6-alkyl C2-C6-alkenyl 230124 28 Embodiment X n R2 R3 E.257 (X.2) 0, 1, or 2 O-C1-C6-alkyl C2-C6-alkenyl E.258 (X.3) 0, 1, or 2 O-C1-C6-alkyl C2-C6-alkenyl E.259 (X.4) 0, 1, or 2 O-C1-C6-alkyl C2-C6-alkenyl E.260 (X.5) 0, 1, or 2 O-C1-C6-alkyl C2-C6-alkenyl E.261 (X.1) 0, 1, or 2 O-C2-C6-alkenyl C2-C6-alkenyl E.262 (X.2) 0, 1, or 2 O-C2-C6-alkenyl C2-C6-alkenyl E.263 (X.3) 0, 1, or 2 O-C2-C6-alkenyl C2-C6-alkenyl E.264 (X.4) 0, 1, or 2 O-C2-C6-alkenyl C2-C6-alkenyl E.265 (X.5) 0, 1, or 2 O-C2-C6-alkenyl C2-C6-alkenyl E.266 (X.1) 0, 1, or 2 O-C2-C6-alkynyl C2-C6-alkenyl E.267 (X.2) 0, 1, or 2 O-C2-C6-alkynyl C2-C6-alkenyl E.268 (X.3) 0, 1, or 2 O-C2-C6-alkynyl C2-C6-alkenyl E.269 (X.4) 0, 1, or 2 O-C2-C6-alkynyl C2-C6-alkenyl E.270 (X.5) 0, 1, or 2 O-C2-C6-alkynyl C2-C6-alkenyl E.271 (X.1) 0, 1, or 2 C3-C6-cycloalkyl C2-C6-alkenyl E.272 (X.2) 0, 1, or 2 C3-C6-cycloalkyl C2-C6-alkenyl E.273 (X.3) 0, 1, or 2 C3-C6-cycloalkyl C2-C6-alkenyl E.274 (X.4) 0, 1, or 2 C3-C6-cycloalkyl C2-C6-alkenyl E.275 (X.5) 0, 1, or 2 C3-C6-cycloalkyl C2-C6-alkenyl In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 is represented by embodiment 5.1 and R6 is represented by embodiment 6.1. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 is represented by embodiment 5.2 and R6 is represented by embodiment 6.1. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 is represented by embodiment 5.3 and R6 is represented by embodiment 6.1. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 is represented by embodiment 5.4 and R6 is represented by embodiment 6.1. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 is represented by embodiment 5.1 and R6 is represented by embodiment 6.2. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 is represented by embodiment 5.2 and R6 is represented by embodiment 6.2. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 is represented by embodiment 5.3 and R6 is represented by embodiment 6.2. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table 230124 29 E, wherein R5 is represented by embodiment 5.4 and R6 is represented by embodiment 6.2. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 is represented by embodiment 5.1 and R6 is represented by embodiment 6.3. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 is represented by embodiment 5.2 and R6 is represented by embodiment 6.3. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 is represented by embodiment 5.3 and R6 is represented by embodiment 6.3. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 is represented by embodiment 5.4 and R6 is represented by embodiment 6.3. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 and R6 arerepresented by embodiment 6.4. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R5 and R6 arerepresented by embodiment 6.5. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.1 and R8 is represented by embodiment 8.1. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.2 and R8 is represented by embodiment 8.1. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.3 and R8 is represented by embodiment 8.1. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.4 and R8 is represented by embodiment 8.1. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.1 and R8 is represented by embodiment 8.2. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.2 and R8 is represented by embodiment 8.2. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.3 and R8 is represented by embodiment 8.2. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.4 and R8 is represented by embodiment 8.2. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.1 and R8 is represented by embodiment 8.3. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.2 and R8 is represented by embodiment 8.3. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.3 and R8 is represented by embodiment 8.3. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 is represented by embodiment 7.4 and R8 is represented by embodiment 8.3. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 and R8 arerepresented by embodiment 8.4. In further aspects the present invention relates to the embodiments E.1 to E.275 listed in Table E, wherein R7 and R8 arerepresented by embodiment 8.7. In particular with a view to their use, according to one embodiment, preference is given to the compounds of the compounds I.A-1, I.A-2, I.A-3, I.A-4, I.A-5, I.A-6, I.A-7, I.A-8, I.A-9; I.B-1, I.B- 2, I.B-3, I.B-4, I.B-5, I.B-6; I.C-1, I.C-2, I.C-3, I.C-4, I.C-5, I.C-6; that are compiled in the Table 1a. Each of the groups mentioned for a substituent in the tables is furthermore per se, inde- pendently of the combination in which it is mentioned, a particularly preferred aspect of the sub- stituent in question.
31 5 230124 32 Table 1a Compounds of the formula I.A-1, I.A-2, I.A-3, I.A-4, I.A-5, I.A-6, I.B-1, I.B-2, I.B-3, I.B-4, I.B-5, I.B-6; I.C-1, I.C-2, I.C-3, I.C-4, I.C-5, I.C-6; in which the meaning for the combina- 230124 33 No. X1 X2 R5 R6 R7 R8 B-1 H H H H H H B-2 H H H CH3 H H B-3 H H CH3 CH3 H H B-4 H H =O H H B-5 H H -CH2-CH2- H H B-6 H H -CH2-CH2-CH2- H H B-7 H H -CH2-CH2-CH2-CH2- H H B-8 H H H H H CH3 B-9 H H H CH3 H CH3 B-10 H H CH3 CH3 H CH3 B-11 H H =O H CH3 B-12 H H -CH2-CH2- H CH3 B-13 H H -CH2-CH2-CH2- H CH3 B-14 H H -CH2-CH2-CH2-CH2- H CH3 B-15 H H H H CH3 CH3 B-16 H H H CH3 CH3 CH3 B-17 H H CH3 CH3 CH3 CH3 B-18 H H =O CH3 CH3 B-19 H H -CH2-CH2- CH3 CH3 B-20 H H -CH2-CH2-CH2- CH3 CH3 B-21 H H -CH2-CH2-CH2-CH2- CH3 CH3 B-22 H H H H -CH2-CH2- B-23 H H H CH3 -CH2-CH2- B-24 H H CH3 CH3 -CH2-CH2- B-25 H H =O -CH2-CH2- B-26 H H -CH2-CH2- -CH2-CH2- 230124 34 No. X1 X2 R5 R6 R7 R8 B-27 H H -CH2-CH2-CH2- -CH2-CH2- B-28 H H -CH2-CH2-CH2-CH2- -CH2-CH2- B-29 H H H H -CH2-CH2-CH2- B-30 H H H CH3 -CH2-CH2-CH2- B-31 H H CH3 CH3 -CH2-CH2-CH2- B-32 H H =O -CH2-CH2-CH2- B-33 H H -CH2-CH2- -CH2-CH2-CH2- B-34 H H -CH2-CH2-CH2- -CH2-CH2-CH2- B-35 H H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-36 H H H H -CH2-CH2-CH2-CH2- B-37 H H H CH3 -CH2-CH2-CH2-CH2- B-38 H H CH3 CH3 -CH2-CH2-CH2-CH2- B-39 H H =O -CH2-CH2-CH2-CH2- B-40 H H -CH2-CH2- -CH2-CH2-CH2-CH2- B-41 H H -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-42 H H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-43 H F H H H H B-44 H F H CH3 H H B-45 H F CH3 CH3 H H B-46 H F =O H H B-47 H F -CH2-CH2- H H B-48 H F -CH2-CH2-CH2- H H B-49 H F -CH2-CH2-CH2-CH2- H H B-50 H F H H H CH3 B-51 H F H CH3 H CH3 B-52 H F CH3 CH3 H CH3 230124 35 No. X1 X2 R5 R6 R7 R8 B-53 H F =O H CH3 B-54 H F -CH2-CH2- H CH3 B-55 H F -CH2-CH2-CH2- H CH3 B-56 H F -CH2-CH2-CH2-CH2- H CH3 B-57 H F H H CH3 CH3 B-58 H F H CH3 CH3 CH3 B-59 H F CH3 CH3 CH3 CH3 B-60 H F =O CH3 CH3 B-61 H F -CH2-CH2- CH3 CH3 B-62 H F -CH2-CH2-CH2- CH3 CH3 B-63 H F -CH2-CH2-CH2-CH2- CH3 CH3 B-64 H F H H -CH2-CH2- B-65 H F H CH3 -CH2-CH2- B-66 H F CH3 CH3 -CH2-CH2- B-67 H F =O -CH2-CH2- B-68 H F -CH2-CH2- -CH2-CH2- B-69 H F -CH2-CH2-CH2- -CH2-CH2- B-70 H F -CH2-CH2-CH2-CH2- -CH2-CH2- B-71 H F H H -CH2-CH2-CH2- B-72 H F H CH3 -CH2-CH2-CH2- B-73 H F CH3 CH3 -CH2-CH2-CH2- B-74 H F =O -CH2-CH2-CH2- B-75 H F -CH2-CH2- -CH2-CH2-CH2- B-76 H F -CH2-CH2-CH2- -CH2-CH2-CH2- B-77 H F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-78 H F H H -CH2-CH2-CH2-CH2- B-79 H F H CH3 -CH2-CH2-CH2-CH2- 230124 36 No. X1 X2 R5 R6 R7 R8 B-80 H F CH3 CH3 -CH2-CH2-CH2-CH2- B-81 H F =O -CH2-CH2-CH2-CH2- B-82 H F -CH2-CH2- -CH2-CH2-CH2-CH2- B-83 H F -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-84 H F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-85 H SCH3 H H H H B-86 H SCH3 H CH3 H H B-87 H SCH3 CH3 CH3 H H B-88 H SCH3 =O H H B-89 H SCH3 -CH2-CH2- H H B-90 H SCH3 -CH2-CH2-CH2- H H B-91 H SCH3 -CH2-CH2-CH2-CH2- H H B-92 H SCH3 H H H CH3 B-93 H SCH3 H CH3 H CH3 B-94 H SCH3 CH3 CH3 H CH3 B-95 H SCH3 =O H CH3 B-96 H SCH3 -CH2-CH2- H CH3 B-97 H SCH3 -CH2-CH2-CH2- H CH3 B-98 H SCH3 -CH2-CH2-CH2-CH2- H CH3 B-99 H SCH3 H H CH3 CH3 B-100 H SCH3 H CH3 CH3 CH3 B-101 H SCH3 CH3 CH3 CH3 CH3 B-102 H SCH3 =O CH3 CH3 B-103 H SCH3 -CH2-CH2- CH3 CH3 B-104 H SCH3 -CH2-CH2-CH2- CH3 CH3 B-105 H SCH3 -CH2-CH2-CH2-CH2- CH3 CH3 230124 37 No. X1 X2 R5 R6 R7 R8 B-106 H SCH3 H H -CH2-CH2- B-107 H SCH3 H CH3 -CH2-CH2- B-108 H SCH3 CH3 CH3 -CH2-CH2- B-109 H SCH3 =O -CH2-CH2- B-110 H SCH3 -CH2-CH2- -CH2-CH2- B-111 H SCH3 -CH2-CH2-CH2- -CH2-CH2- B-112 H SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-113 H SCH3 H H -CH2-CH2-CH2- B-114 H SCH3 H CH3 -CH2-CH2-CH2- B-115 H SCH3 CH3 CH3 -CH2-CH2-CH2- B-116 H SCH3 =O -CH2-CH2-CH2- B-117 H SCH3 -CH2-CH2- -CH2-CH2-CH2- B-118 H SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-119 H SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-120 H SCH3 H H -CH2-CH2-CH2-CH2- B-121 H SCH3 H CH3 -CH2-CH2-CH2-CH2- B-122 H SCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-123 H SCH3 =O -CH2-CH2-CH2-CH2- B-124 H SCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-125 H SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-126 H SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-127 H OCH3 H H H H B-128 H OCH3 H CH3 H H B-129 H OCH3 CH3 CH3 H H B-130 H OCH3 =O H H B-131 H OCH3 -CH2-CH2- H H 230124 38 No. X1 X2 R5 R6 R7 R8 B-132 H OCH3 -CH2-CH2-CH2- H H B-133 H OCH3 -CH2-CH2-CH2-CH2- H H B-134 H OCH3 H H H CH3 B-135 H OCH3 H CH3 H CH3 B-136 H OCH3 CH3 CH3 H CH3 B-137 H OCH3 =O H CH3 B-138 H OCH3 -CH2-CH2- H CH3 B-139 H OCH3 -CH2-CH2-CH2- H CH3 B-140 H OCH3 -CH2-CH2-CH2-CH2- H CH3 B-141 H OCH3 H H CH3 CH3 B-142 H OCH3 H CH3 CH3 CH3 B-143 H OCH3 CH3 CH3 CH3 CH3 B-144 H OCH3 =O CH3 CH3 B-145 H OCH3 -CH2-CH2- CH3 CH3 B-146 H OCH3 -CH2-CH2-CH2- CH3 CH3 B-147 H OCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-148 H OCH3 H H -CH2-CH2- B-149 H OCH3 H CH3 -CH2-CH2- B-150 H OCH3 CH3 CH3 -CH2-CH2- B-151 H OCH3 =O -CH2-CH2- B-152 H OCH3 -CH2-CH2- -CH2-CH2- B-153 H OCH3 -CH2-CH2-CH2- -CH2-CH2- B-154 H OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-155 H OCH3 H H -CH2-CH2-CH2- B-156 H OCH3 H CH3 -CH2-CH2-CH2- B-157 H OCH3 CH3 CH3 -CH2-CH2-CH2- B-158 H OCH3 =O -CH2-CH2-CH2- 230124 39 No. X1 X2 R5 R6 R7 R8 B-159 H OCH3 -CH2-CH2- -CH2-CH2-CH2- B-160 H OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-161 H OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-162 H OCH3 H H -CH2-CH2-CH2-CH2- B-163 H OCH3 H CH3 -CH2-CH2-CH2-CH2- B-164 H OCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-165 H OCH3 =O -CH2-CH2-CH2-CH2- B-166 H OCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-167 H OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-168 H OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-169 F H H H H H B-170 F H H CH3 H H B-171 F H CH3 CH3 H H B-172 F H =O H H B-173 F H -CH2-CH2- H H B-174 F H -CH2-CH2-CH2- H H B-175 F H -CH2-CH2-CH2-CH2- H H B-176 F H H H H CH3 B-177 F H H CH3 H CH3 B-178 F H CH3 CH3 H CH3 B-179 F H =O H CH3 B-180 F H -CH2-CH2- H CH3 B-181 F H -CH2-CH2-CH2- H CH3 B-182 F H -CH2-CH2-CH2-CH2- H CH3 B-183 F H H H CH3 CH3 B-184 F H H CH3 CH3 CH3 230124 40 No. X1 X2 R5 R6 R7 R8 B-185 F H CH3 CH3 CH3 CH3 B-186 F H =O CH3 CH3 B-187 F H -CH2-CH2- CH3 CH3 B-188 F H -CH2-CH2-CH2- CH3 CH3 B-189 F H -CH2-CH2-CH2-CH2- CH3 CH3 B-190 F H H H -CH2-CH2- B-191 F H H CH3 -CH2-CH2- B-192 F H CH3 CH3 -CH2-CH2- B-193 F H =O -CH2-CH2- B-194 F H -CH2-CH2- -CH2-CH2- B-195 F H -CH2-CH2-CH2- -CH2-CH2- B-196 F H -CH2-CH2-CH2-CH2- -CH2-CH2- B-197 F H H H -CH2-CH2-CH2- B-198 F H H CH3 -CH2-CH2-CH2- B-199 F H CH3 CH3 -CH2-CH2-CH2- B-200 F H =O -CH2-CH2-CH2- B-201 F H -CH2-CH2- -CH2-CH2-CH2- B-202 F H -CH2-CH2-CH2- -CH2-CH2-CH2- B-203 F H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-204 F H H H -CH2-CH2-CH2-CH2- B-205 F H H CH3 -CH2-CH2-CH2-CH2- B-206 F H CH3 CH3 -CH2-CH2-CH2-CH2- B-207 F H =O -CH2-CH2-CH2-CH2- B-208 F H -CH2-CH2- -CH2-CH2-CH2-CH2- B-209 F H -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-210 F H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-211 F F H H H H 230124 41 No. X1 X2 R5 R6 R7 R8 B-212 F F H CH3 H H B-213 F F CH3 CH3 H H B-214 F F =O H H B-215 F F -CH2-CH2- H H B-216 F F -CH2-CH2-CH2- H H B-217 F F -CH2-CH2-CH2-CH2- H H B-218 F F H H H CH3 B-219 F F H CH3 H CH3 B-220 F F CH3 CH3 H CH3 B-221 F F =O H CH3 B-222 F F -CH2-CH2- H CH3 B-223 F F -CH2-CH2-CH2- H CH3 B-224 F F -CH2-CH2-CH2-CH2- H CH3 B-225 F F H H CH3 CH3 B-226 F F H CH3 CH3 CH3 B-227 F F CH3 CH3 CH3 CH3 B-228 F F =O CH3 CH3 B-229 F F -CH2-CH2- CH3 CH3 B-230 F F -CH2-CH2-CH2- CH3 CH3 B-231 F F -CH2-CH2-CH2-CH2- CH3 CH3 B-232 F F H H -CH2-CH2- B-233 F F H CH3 -CH2-CH2- B-234 F F CH3 CH3 -CH2-CH2- B-235 F F =O -CH2-CH2- B-236 F F -CH2-CH2- -CH2-CH2- B-237 F F -CH2-CH2-CH2- -CH2-CH2- 230124 42 No. X1 X2 R5 R6 R7 R8 B-238 F F -CH2-CH2-CH2-CH2- -CH2-CH2- B-239 F F H H -CH2-CH2-CH2- B-240 F F H CH3 -CH2-CH2-CH2- B-241 F F CH3 CH3 -CH2-CH2-CH2- B-242 F F =O -CH2-CH2-CH2- B-243 F F -CH2-CH2- -CH2-CH2-CH2- B-244 F F -CH2-CH2-CH2- -CH2-CH2-CH2- B-245 F F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-246 F F H H -CH2-CH2-CH2-CH2- B-247 F F H CH3 -CH2-CH2-CH2-CH2- B-248 F F CH3 CH3 -CH2-CH2-CH2-CH2- B-249 F F =O -CH2-CH2-CH2-CH2- B-250 F F -CH2-CH2- -CH2-CH2-CH2-CH2- B-251 F F -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-252 F F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-253 F SCH3 H H H H B-254 F SCH3 H CH3 H H B-255 F SCH3 CH3 CH3 H H B-256 F SCH3 =O H H B-257 F SCH3 -CH2-CH2- H H B-258 F SCH3 -CH2-CH2-CH2- H H B-259 F SCH3 -CH2-CH2-CH2-CH2- H H B-260 F SCH3 H H H CH3 B-261 F SCH3 H CH3 H CH3 B-262 F SCH3 CH3 CH3 H CH3 B-263 F SCH3 =O H CH3 230124 43 No. X1 X2 R5 R6 R7 R8 B-264 F SCH3 -CH2-CH2- H CH3 B-265 F SCH3 -CH2-CH2-CH2- H CH3 B-266 F SCH3 -CH2-CH2-CH2-CH2- H CH3 B-267 F SCH3 H H CH3 CH3 B-268 F SCH3 H CH3 CH3 CH3 B-269 F SCH3 CH3 CH3 CH3 CH3 B-270 F SCH3 =O CH3 CH3 B-271 F SCH3 -CH2-CH2- CH3 CH3 B-272 F SCH3 -CH2-CH2-CH2- CH3 CH3 B-273 F SCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-274 F SCH3 H H -CH2-CH2- B-275 F SCH3 H CH3 -CH2-CH2- B-276 F SCH3 CH3 CH3 -CH2-CH2- B-277 F SCH3 =O -CH2-CH2- B-278 F SCH3 -CH2-CH2- -CH2-CH2- B-279 F SCH3 -CH2-CH2-CH2- -CH2-CH2- B-280 F SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-281 F SCH3 H H -CH2-CH2-CH2- B-282 F SCH3 H CH3 -CH2-CH2-CH2- B-283 F SCH3 CH3 CH3 -CH2-CH2-CH2- B-284 F SCH3 =O -CH2-CH2-CH2- B-285 F SCH3 -CH2-CH2- -CH2-CH2-CH2- B-286 F SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-287 F SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-288 F SCH3 H H -CH2-CH2-CH2-CH2- B-289 F SCH3 H CH3 -CH2-CH2-CH2-CH2- B-290 F SCH3 CH3 CH3 -CH2-CH2-CH2-CH2- 230124 44 No. X1 X2 R5 R6 R7 R8 B-291 F SCH3 =O -CH2-CH2-CH2-CH2- B-292 F SCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-293 F SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-294 F SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-295 F OCH3 H H H H B-296 F OCH3 H CH3 H H B-297 F OCH3 CH3 CH3 H H B-298 F OCH3 =O H H B-299 F OCH3 -CH2-CH2- H H B-300 F OCH3 -CH2-CH2-CH2- H H B-301 F OCH3 -CH2-CH2-CH2-CH2- H H B-302 F OCH3 H H H CH3 B-303 F OCH3 H CH3 H CH3 B-304 F OCH3 CH3 CH3 H CH3 B-305 F OCH3 =O H CH3 B-306 F OCH3 -CH2-CH2- H CH3 B-307 F OCH3 -CH2-CH2-CH2- H CH3 B-308 F OCH3 -CH2-CH2-CH2-CH2- H CH3 B-309 F OCH3 H H CH3 CH3 B-310 F OCH3 H CH3 CH3 CH3 B-311 F OCH3 CH3 CH3 CH3 CH3 B-312 F OCH3 =O CH3 CH3 B-313 F OCH3 -CH2-CH2- CH3 CH3 B-314 F OCH3 -CH2-CH2-CH2- CH3 CH3 B-315 F OCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-316 F OCH3 H H -CH2-CH2- 230124 45 No. X1 X2 R5 R6 R7 R8 B-317 F OCH3 H CH3 -CH2-CH2- B-318 F OCH3 CH3 CH3 -CH2-CH2- B-319 F OCH3 =O -CH2-CH2- B-320 F OCH3 -CH2-CH2- -CH2-CH2- B-321 F OCH3 -CH2-CH2-CH2- -CH2-CH2- B-322 F OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-323 F OCH3 H H -CH2-CH2-CH2- B-324 F OCH3 H CH3 -CH2-CH2-CH2- B-325 F OCH3 CH3 CH3 -CH2-CH2-CH2- B-326 F OCH3 =O -CH2-CH2-CH2- B-327 F OCH3 -CH2-CH2- -CH2-CH2-CH2- B-328 F OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-329 F OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-330 F OCH3 H H -CH2-CH2-CH2-CH2- B-331 F OCH3 H CH3 -CH2-CH2-CH2-CH2- B-332 F OCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-333 F OCH3 =O -CH2-CH2-CH2-CH2- B-334 F OCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-335 F OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-336 F OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-337 CCH H H H H H B-338 CCH H H CH3 H H B-339 CCH H CH3 CH3 H H B-340 CCH H =O H H B-341 CCH H -CH2-CH2- H H B-342 CCH H -CH2-CH2-CH2- H H 230124 46 No. X1 X2 R5 R6 R7 R8 B-343 CCH H -CH2-CH2-CH2-CH2- H H B-344 CCH H H H H CH3 B-345 CCH H H CH3 H CH3 B-346 CCH H CH3 CH3 H CH3 B-347 CCH H =O H CH3 B-348 CCH H -CH2-CH2- H CH3 B-349 CCH H -CH2-CH2-CH2- H CH3 B-350 CCH H -CH2-CH2-CH2-CH2- H CH3 B-351 CCH H H H CH3 CH3 B-352 CCH H H CH3 CH3 CH3 B-353 CCH H CH3 CH3 CH3 CH3 B-354 CCH H =O CH3 CH3 B-355 CCH H -CH2-CH2- CH3 CH3 B-356 CCH H -CH2-CH2-CH2- CH3 CH3 B-357 CCH H -CH2-CH2-CH2-CH2- CH3 CH3 B-358 CCH H H H -CH2-CH2- B-359 CCH H H CH3 -CH2-CH2- B-360 CCH H CH3 CH3 -CH2-CH2- B-361 CCH H =O -CH2-CH2- B-362 CCH H -CH2-CH2- -CH2-CH2- B-363 CCH H -CH2-CH2-CH2- -CH2-CH2- B-364 CCH H -CH2-CH2-CH2-CH2- -CH2-CH2- B-365 CCH H H H -CH2-CH2-CH2- B-366 CCH H H CH3 -CH2-CH2-CH2- B-367 CCH H CH3 CH3 -CH2-CH2-CH2- B-368 CCH H =O -CH2-CH2-CH2- B-369 CCH H -CH2-CH2- -CH2-CH2-CH2- 230124 47 No. X1 X2 R5 R6 R7 R8 B-370 CCH H -CH2-CH2-CH2- -CH2-CH2-CH2- B-371 CCH H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-372 CCH H H H -CH2-CH2-CH2-CH2- B-373 CCH H H CH3 -CH2-CH2-CH2-CH2- B-374 CCH H CH3 CH3 -CH2-CH2-CH2-CH2- B-375 CCH H =O -CH2-CH2-CH2-CH2- B-376 CCH H -CH2-CH2- -CH2-CH2-CH2-CH2- B-377 CCH H -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-378 CCH H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-379 CCH F H H H H B-380 CCH F H CH3 H H B-381 CCH F CH3 CH3 H H B-382 CCH F =O H H B-383 CCH F -CH2-CH2- H H B-384 CCH F -CH2-CH2-CH2- H H B-385 CCH F -CH2-CH2-CH2-CH2- H H B-386 CCH F H H H CH3 B-387 CCH F H CH3 H CH3 B-388 CCH F CH3 CH3 H CH3 B-389 CCH F =O H CH3 B-390 CCH F -CH2-CH2- H CH3 B-391 CCH F -CH2-CH2-CH2- H CH3 B-392 CCH F -CH2-CH2-CH2-CH2- H CH3 B-393 CCH F H H CH3 CH3 B-394 CCH F H CH3 CH3 CH3 B-395 CCH F CH3 CH3 CH3 CH3 230124 48 No. X1 X2 R5 R6 R7 R8 B-396 CCH F =O CH3 CH3 B-397 CCH F -CH2-CH2- CH3 CH3 B-398 CCH F -CH2-CH2-CH2- CH3 CH3 B-399 CCH F -CH2-CH2-CH2-CH2- CH3 CH3 B-400 CCH F H H -CH2-CH2- B-401 CCH F H CH3 -CH2-CH2- B-402 CCH F CH3 CH3 -CH2-CH2- B-403 CCH F =O -CH2-CH2- B-404 CCH F -CH2-CH2- -CH2-CH2- B-405 CCH F -CH2-CH2-CH2- -CH2-CH2- B-406 CCH F -CH2-CH2-CH2-CH2- -CH2-CH2- B-407 CCH F H H -CH2-CH2-CH2- B-408 CCH F H CH3 -CH2-CH2-CH2- B-409 CCH F CH3 CH3 -CH2-CH2-CH2- B-410 CCH F =O -CH2-CH2-CH2- B-411 CCH F -CH2-CH2- -CH2-CH2-CH2- B-412 CCH F -CH2-CH2-CH2- -CH2-CH2-CH2- B-413 CCH F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-414 CCH F H H -CH2-CH2-CH2-CH2- B-415 CCH F H CH3 -CH2-CH2-CH2-CH2- B-416 CCH F CH3 CH3 -CH2-CH2-CH2-CH2- B-417 CCH F =O -CH2-CH2-CH2-CH2- B-418 CCH F -CH2-CH2- -CH2-CH2-CH2-CH2- B-419 CCH F -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-420 CCH F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-421 CCH SCH3 H H H H B-422 CCH SCH3 H CH3 H H 230124 49 No. X1 X2 R5 R6 R7 R8 B-423 CCH SCH3 CH3 CH3 H H B-424 CCH SCH3 =O H H B-425 CCH SCH3 -CH2-CH2- H H B-426 CCH SCH3 -CH2-CH2-CH2- H H B-427 CCH SCH3 -CH2-CH2-CH2-CH2- H H B-428 CCH SCH3 H H H CH3 B-429 CCH SCH3 H CH3 H CH3 B-430 CCH SCH3 CH3 CH3 H CH3 B-431 CCH SCH3 =O H CH3 B-432 CCH SCH3 -CH2-CH2- H CH3 B-433 CCH SCH3 -CH2-CH2-CH2- H CH3 B-434 CCH SCH3 -CH2-CH2-CH2-CH2- H CH3 B-435 CCH SCH3 H H CH3 CH3 B-436 CCH SCH3 H CH3 CH3 CH3 B-437 CCH SCH3 CH3 CH3 CH3 CH3 B-438 CCH SCH3 =O CH3 CH3 B-439 CCH SCH3 -CH2-CH2- CH3 CH3 B-440 CCH SCH3 -CH2-CH2-CH2- CH3 CH3 B-441 CCH SCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-442 CCH SCH3 H H -CH2-CH2- B-443 CCH SCH3 H CH3 -CH2-CH2- B-444 CCH SCH3 CH3 CH3 -CH2-CH2- B-445 CCH SCH3 =O -CH2-CH2- B-446 CCH SCH3 -CH2-CH2- -CH2-CH2- B-447 CCH SCH3 -CH2-CH2-CH2- -CH2-CH2- B-448 CCH SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- 230124 50 No. X1 X2 R5 R6 R7 R8 B-449 CCH SCH3 H H -CH2-CH2-CH2- B-450 CCH SCH3 H CH3 -CH2-CH2-CH2- B-451 CCH SCH3 CH3 CH3 -CH2-CH2-CH2- B-452 CCH SCH3 =O -CH2-CH2-CH2- B-453 CCH SCH3 -CH2-CH2- -CH2-CH2-CH2- B-454 CCH SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-455 CCH SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-456 CCH SCH3 H H -CH2-CH2-CH2-CH2- B-457 CCH SCH3 H CH3 -CH2-CH2-CH2-CH2- B-458 CCH SCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-459 CCH SCH3 =O -CH2-CH2-CH2-CH2- B-460 CCH SCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-461 CCH SCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-462 CCH SCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-463 CCH OCH3 H H H H B-464 CCH OCH3 H CH3 H H B-465 CCH OCH3 CH3 CH3 H H B-466 CCH OCH3 =O H H B-467 CCH OCH3 -CH2-CH2- H H B-468 CCH OCH3 -CH2-CH2-CH2- H H B-469 CCH OCH3 -CH2-CH2-CH2-CH2- H H B-470 CCH OCH3 H H H CH3 B-471 CCH OCH3 H CH3 H CH3 B-472 CCH OCH3 CH3 CH3 H CH3 B-473 CCH OCH3 =O H CH3 B-474 CCH OCH3 -CH2-CH2- H CH3 230124 51 No. X1 X2 R5 R6 R7 R8 B-475 CCH OCH3 -CH2-CH2-CH2- H CH3 B-476 CCH OCH3 -CH2-CH2-CH2-CH2- H CH3 B-477 CCH OCH3 H H CH3 CH3 B-478 CCH OCH3 H CH3 CH3 CH3 B-479 CCH OCH3 CH3 CH3 CH3 CH3 B-480 CCH OCH3 =O CH3 CH3 B-481 CCH OCH3 -CH2-CH2- CH3 CH3 B-482 CCH OCH3 -CH2-CH2-CH2- CH3 CH3 B-483 CCH OCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-484 CCH OCH3 H H -CH2-CH2- B-485 CCH OCH3 H CH3 -CH2-CH2- B-486 CCH OCH3 CH3 CH3 -CH2-CH2- B-487 CCH OCH3 =O -CH2-CH2- B-488 CCH OCH3 -CH2-CH2- -CH2-CH2- B-489 CCH OCH3 -CH2-CH2-CH2- -CH2-CH2- B-490 CCH OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-491 CCH OCH3 H H -CH2-CH2-CH2- B-492 CCH OCH3 H CH3 -CH2-CH2-CH2- B-493 CCH OCH3 CH3 CH3 -CH2-CH2-CH2- B-494 CCH OCH3 =O -CH2-CH2-CH2- B-495 CCH OCH3 -CH2-CH2- -CH2-CH2-CH2- B-496 CCH OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-497 CCH OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-498 CCH OCH3 H H -CH2-CH2-CH2-CH2- B-499 CCH OCH3 H CH3 -CH2-CH2-CH2-CH2- B-500 CCH OCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-501 CCH OCH3 =O -CH2-CH2-CH2-CH2- 230124 52 No. X1 X2 R5 R6 R7 R8 B-502 CCH OCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-503 CCH OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-504 CCH OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-505 CH3 H H H H H B-506 CH3 H H CH3 H H B-507 CH3 H CH3 CH3 H H B-508 CH3 H =O H H B-509 CH3 H -CH2-CH2- H H B-510 CH3 H -CH2-CH2-CH2- H H B-511 CH3 H -CH2-CH2-CH2-CH2- H H B-512 CH3 H H H H CH3 B-513 CH3 H H CH3 H CH3 B-514 CH3 H CH3 CH3 H CH3 B-515 CH3 H =O H CH3 B-516 CH3 H -CH2-CH2- H CH3 B-517 CH3 H -CH2-CH2-CH2- H CH3 B-518 CH3 H -CH2-CH2-CH2-CH2- H CH3 B-519 CH3 H H H CH3 CH3 B-520 CH3 H H CH3 CH3 CH3 B-521 CH3 H CH3 CH3 CH3 CH3 B-522 CH3 H =O CH3 CH3 B-523 CH3 H -CH2-CH2- CH3 CH3 B-524 CH3 H -CH2-CH2-CH2- CH3 CH3 B-525 CH3 H -CH2-CH2-CH2-CH2- CH3 CH3 B-526 CH3 H H H -CH2-CH2- B-527 CH3 H H CH3 -CH2-CH2- 230124 53 No. X1 X2 R5 R6 R7 R8 B-528 CH3 H CH3 CH3 -CH2-CH2- B-529 CH3 H =O -CH2-CH2- B-530 CH3 H -CH2-CH2- -CH2-CH2- B-531 CH3 H -CH2-CH2-CH2- -CH2-CH2- B-532 CH3 H -CH2-CH2-CH2-CH2- -CH2-CH2- B-533 CH3 H H H -CH2-CH2-CH2- B-534 CH3 H H CH3 -CH2-CH2-CH2- B-535 CH3 H CH3 CH3 -CH2-CH2-CH2- B-536 CH3 H =O -CH2-CH2-CH2- B-537 CH3 H -CH2-CH2- -CH2-CH2-CH2- B-538 CH3 H -CH2-CH2-CH2- -CH2-CH2-CH2- B-539 CH3 H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-540 CH3 H H H -CH2-CH2-CH2-CH2- B-541 CH3 H H CH3 -CH2-CH2-CH2-CH2- B-542 CH3 H CH3 CH3 -CH2-CH2-CH2-CH2- B-543 CH3 H =O -CH2-CH2-CH2-CH2- B-544 CH3 H -CH2-CH2- -CH2-CH2-CH2-CH2- B-545 CH3 H -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-546 CH3 H -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-547 CH3 F H H H H B-548 CH3 F H CH3 H H B-549 CH3 F CH3 CH3 H H B-550 CH3 F =O H H B-551 CH3 F -CH2-CH2- H H B-552 CH3 F -CH2-CH2-CH2- H H B-553 CH3 F -CH2-CH2-CH2-CH2- H H 230124 54 No. X1 X2 R5 R6 R7 R8 B-554 CH3 F H H H CH3 B-555 CH3 F H CH3 H CH3 B-556 CH3 F CH3 CH3 H CH3 B-557 CH3 F =O H CH3 B-558 CH3 F -CH2-CH2- H CH3 B-559 CH3 F -CH2-CH2-CH2- H CH3 B-560 CH3 F -CH2-CH2-CH2-CH2- H CH3 B-561 CH3 F H H CH3 CH3 B-562 CH3 F H CH3 CH3 CH3 B-563 CH3 F CH3 CH3 CH3 CH3 B-564 CH3 F =O CH3 CH3 B-565 CH3 F -CH2-CH2- CH3 CH3 B-566 CH3 F -CH2-CH2-CH2- CH3 CH3 B-567 CH3 F -CH2-CH2-CH2-CH2- CH3 CH3 B-568 CH3 F H H -CH2-CH2- B-569 CH3 F H CH3 -CH2-CH2- B-570 CH3 F CH3 CH3 -CH2-CH2- B-571 CH3 F =O -CH2-CH2- B-572 CH3 F -CH2-CH2- -CH2-CH2- B-573 CH3 F -CH2-CH2-CH2- -CH2-CH2- B-574 CH3 F -CH2-CH2-CH2-CH2- -CH2-CH2- B-575 CH3 F H H -CH2-CH2-CH2- B-576 CH3 F H CH3 -CH2-CH2-CH2- B-577 CH3 F CH3 CH3 -CH2-CH2-CH2- B-578 CH3 F =O -CH2-CH2-CH2- B-579 CH3 F -CH2-CH2- -CH2-CH2-CH2- B-580 CH3 F -CH2-CH2-CH2- -CH2-CH2-CH2- 230124 55 No. X1 X2 R5 R6 R7 R8 B-581 CH3 F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-582 CH3 F H H -CH2-CH2-CH2-CH2- B-583 CH3 F H CH3 -CH2-CH2-CH2-CH2- B-584 CH3 F CH3 CH3 -CH2-CH2-CH2-CH2- B-585 CH3 F =O -CH2-CH2-CH2-CH2- B-586 CH3 F -CH2-CH2- -CH2-CH2-CH2-CH2- B-587 CH3 F -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-588 CH3 F -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-589 CH3 CH3 H H H H B-590 CH3 CH3 H CH3 H H B-591 CH3 CH3 CH3 CH3 H H B-592 CH3 CH3 =O H H B-593 CH3 CH3 -CH2-CH2- H H B-594 CH3 CH3 -CH2-CH2-CH2- H H B-595 CH3 CH3 -CH2-CH2-CH2-CH2- H H B-596 CH3 CH3 H H H CH3 B-597 CH3 CH3 H CH3 H CH3 B-598 CH3 CH3 CH3 CH3 H CH3 B-599 CH3 CH3 =O H CH3 B-600 CH3 CH3 -CH2-CH2- H CH3 B-601 CH3 CH3 -CH2-CH2-CH2- H CH3 B-602 CH3 CH3 -CH2-CH2-CH2-CH2- H CH3 B-603 CH3 CH3 H H CH3 CH3 B-604 CH3 CH3 H CH3 CH3 CH3 B-605 CH3 CH3 CH3 CH3 CH3 CH3 B-606 CH3 CH3 =O CH3 CH3 230124 56 No. X1 X2 R5 R6 R7 R8 B-607 CH3 CH3 -CH2-CH2- CH3 CH3 B-608 CH3 CH3 -CH2-CH2-CH2- CH3 CH3 B-609 CH3 CH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-610 CH3 CH3 H H -CH2-CH2- B-611 CH3 CH3 H CH3 -CH2-CH2- B-612 CH3 CH3 CH3 CH3 -CH2-CH2- B-613 CH3 CH3 =O -CH2-CH2- B-614 CH3 CH3 -CH2-CH2- -CH2-CH2- B-615 CH3 CH3 -CH2-CH2-CH2- -CH2-CH2- B-616 CH3 CH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-617 CH3 CH3 H H -CH2-CH2-CH2- B-618 CH3 CH3 H CH3 -CH2-CH2-CH2- B-619 CH3 CH3 CH3 CH3 -CH2-CH2-CH2- B-620 CH3 CH3 =O -CH2-CH2-CH2- B-621 CH3 CH3 -CH2-CH2- -CH2-CH2-CH2- B-622 CH3 CH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-623 CH3 CH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-624 CH3 CH3 H H -CH2-CH2-CH2-CH2- B-625 CH3 CH3 H CH3 -CH2-CH2-CH2-CH2- B-626 CH3 CH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-627 CH3 CH3 =O -CH2-CH2-CH2-CH2- B-628 CH3 CH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-629 CH3 CH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-630 CH3 CH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-631 CH3 OCH3 H H H H B-632 CH3 OCH3 H CH3 H H B-633 CH3 OCH3 CH3 CH3 H H 230124 57 No. X1 X2 R5 R6 R7 R8 B-634 CH3 OCH3 =O H H B-635 CH3 OCH3 -CH2-CH2- H H B-636 CH3 OCH3 -CH2-CH2-CH2- H H B-637 CH3 OCH3 -CH2-CH2-CH2-CH2- H H B-638 CH3 OCH3 H H H CH3 B-639 CH3 OCH3 H CH3 H CH3 B-640 CH3 OCH3 CH3 CH3 H CH3 B-641 CH3 OCH3 =O H CH3 B-642 CH3 OCH3 -CH2-CH2- H CH3 B-643 CH3 OCH3 -CH2-CH2-CH2- H CH3 B-644 CH3 OCH3 -CH2-CH2-CH2-CH2- H CH3 B-645 CH3 OCH3 H H CH3 CH3 B-646 CH3 OCH3 H CH3 CH3 CH3 B-647 CH3 OCH3 CH3 CH3 CH3 CH3 B-648 CH3 OCH3 =O CH3 CH3 B-649 CH3 OCH3 -CH2-CH2- CH3 CH3 B-650 CH3 OCH3 -CH2-CH2-CH2- CH3 CH3 B-651 CH3 OCH3 -CH2-CH2-CH2-CH2- CH3 CH3 B-652 CH3 OCH3 H H -CH2-CH2- B-653 CH3 OCH3 H CH3 -CH2-CH2- B-654 CH3 OCH3 CH3 CH3 -CH2-CH2- B-655 CH3 OCH3 =O -CH2-CH2- B-656 CH3 OCH3 -CH2-CH2- -CH2-CH2- B-657 CH3 OCH3 -CH2-CH2-CH2- -CH2-CH2- B-658 CH3 OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2- B-659 CH3 OCH3 H H -CH2-CH2-CH2- 230124 58 No. X1 X2 R5 R6 R7 R8 B-660 CH3 OCH3 H CH3 -CH2-CH2-CH2- B-661 CH3 OCH3 CH3 CH3 -CH2-CH2-CH2- B-662 CH3 OCH3 =O -CH2-CH2-CH2- B-663 CH3 OCH3 -CH2-CH2- -CH2-CH2-CH2- B-664 CH3 OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2- B-665 CH3 OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2- B-666 CH3 OCH3 H H -CH2-CH2-CH2-CH2- B-667 CH3 OCH3 H CH3 -CH2-CH2-CH2-CH2- B-668 CH3 OCH3 CH3 CH3 -CH2-CH2-CH2-CH2- B-669 CH3 OCH3 =O -CH2-CH2-CH2-CH2- B-670 CH3 OCH3 -CH2-CH2- -CH2-CH2-CH2-CH2- B-671 CH3 OCH3 -CH2-CH2-CH2- -CH2-CH2-CH2-CH2- B-672 CH3 OCH3 -CH2-CH2-CH2-CH2- -CH2-CH2-CH2-CH2- Compounds of the present invention can be made as shown in the following schemes, in which, unless otherwise stated, the definition of each variable is as defined above for a compound of formula I. The compounds of the formula I can be prepared according to methods or in analogy to methods that are described in the prior art. The synthesis takes advantage of starting materi- als that are commercially available or may be prepared according to conventional procedures starting from readily available compounds. For example, compounds I can be prepared in various oxidation states (Z=S, SO or SO2) and are herein distingishued with the representation Ia (sulfide), Ib (sulfoxide) and Ic (sulfone). Com- pounds Ia can be prepared via nucleophilic aromatic substitution and subsequent ring closure reactions of aryl ketones (3) and amino thiols, or their respective salts, represented by the gen- eral formula (4). These amino thiols are commercially available or can be prepared by numer- ous methods expected to be known by a person skilled in the art. The reaction would be carried out in the presence of a suitable base (1-4 equivalents), such as Cs2CO3 or K2CO3, at ambient or elevated temperatures (40-60 °C) in analogy to procedures described in WO2013/184734, 2013, A1, US5371064, 1994, A or Chem. Eur.J.2015, 21(38), 13344-13356. Compounds of the formula I, herein represented as Ic can be prepared via oxidation of dihydro- benzothiazepines represented by the general formula Ia using at least 2.0 eq. of an appropriate 230124 59 oxidant, for example hydrogen peroxide in combination with a metal catalyst, such as ammo- nium heptamolybdate, as described in Catal. Commun.2009, 10(14), 1948-1951. Other meth- ods include, but are not limited to, other oxidants such as peracids, hypervalent iodine reagents, halogenaters, perhalogenates, nitric oxides or metal oxides, as described in Phosphorus Sulfur Silicon Relat. Elem.2020, 195, 181-193. Compounds of the formula Ib can be prepared via oxidation of dihydrobenzothiazepines repre- sented by the general formula Ia using equimolar equivalents of a suitable oxidant, for example hydrogen peroxide in combination with a metal catalyst, such as ammonium heptamolybdate, as described in Dalton Trans.2018, 47, 11882-11887. Compounds Ic may alternatively be ob- tained from compounds Ib via an oxidation under these conditions described. Aryl ketones (3) are either commercially available, or can be prepared by scheme by oxidation of the aryl alcohol 5, using for example manganese dioxide, as described in Inorganica Chimica Acta (2012), 382, 72- 78, WO 2000/038618, CN107879989 A, or Chinese Science Bulletin 2010, 55(25), 2817-2819. Aryl alcohols (5) can be prepared by by isopropyl magnesium chloride-mediated bromine/io- dine-magnesium exchange of 7, and subsequent addition to commercially available aldehydes represented by the general formula (6). The reaction is preferentially carried out at 0 °C, with an equimolar ratio of iPrMgCl and aryl halides (7), the intermediate of which is employed in a ratio 230124 60 of 1.2-1.3:1 with respect to aldehydes (6), as described in WO2021/71821 A1, J. Med. Chem., (2013), 56, 10158-10170, WO2014/102233 A1, or US2016/83401 A1. The compounds I and the compositions thereof, respectively, are suitable as fungicides effec- tive against a broad spectrum of phytopathogenic fungi, including soil-borne fungi, in particular from the classes of Plasmodiophoromycetes, Peronosporomycetes (syn. Oomycetes), Chytridi- omycetes, Zygomycetes, Ascomycetes, Basidiomycetes, and Deuteromycetes (syn. Fungi im- perfecti). They can be used in crop protection as foliar fungicides, fungicides for seed dressing, and soil fungicides. The compounds I and the compositions thereof are preferably useful in the control of phytopath- ogenic fungi on various cultivated plants, such as cereals, e. g. wheat, rye, barley, triticale, oats, or rice; beet, e. g. sugar beet or fodder beet; fruits, e. g. pomes (apples, pears, etc.), stone fruits (e.g. plums, peaches, almonds, cherries), or soft fruits, also called berries (strawberries, rasp- berries, blackberries, gooseberries, etc.); leguminous plants, e. g. lentils, peas, alfalfa, or soy- beans; oil plants, e. g. oilseed rape, mustard, olives, sunflowers, coconut, cocoa beans, castor oil plants, oil palms, ground nuts, or soybeans; cucurbits, e. g. squashes, cucumber, or melons; fiber plants, e. g. cotton, flax, hemp, or jute; citrus fruits, e. g. oranges, lemons, grapefruits, or mandarins; vegetables, e. g. spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, cucurbits, or paprika; lauraceous plants, e. g. avocados, cinnamon, or camphor; en- ergy and raw material plants, e. g. corn, soybean, oilseed rape, sugar cane, or oil palm; corn; tobacco; nuts; coffee; tea; bananas; vines (table grapes and grape juice grape vines); hop; turf; sweet leaf (also called Stevia); natural rubber plants; or ornamental and forestry plants, e. g. flowers, shrubs, broad-leaved trees, or evergreens (conifers, eucalypts, etc.); on the plant prop- agation material, such as seeds; and on the crop material of these plants. More preferably, compounds I and compositions thereof, respectively are used for controlling fungi on field crops, such as potatoes, sugar beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, oilseed rape, legumes, sunflowers, coffee or sugar cane; fruits; vines; orna- mentals; or vegetables, such as cucumbers, tomatoes, beans or squashes. The term "plant propagation material" is to be understood to denote all the generative parts of the plant, such as seeds; and vegetative plant materials, such as cuttings and tubers (e. g. pota- toes), which can be used for the multiplication of the plant. This includes seeds, roots, fruits, tu- bers, bulbs, rhizomes, shoots, sprouts and other parts of plants; including seedlings and young 230124 61 plants to be transplanted after germination or after emergence from soil. Preferably, treatment of plant propagation materials with compounds I and compositions thereof, respectively, is used for controlling fungi on cereals, such as wheat, rye, barley and oats; rice, corn, cotton and soybeans. According to the invention all of the above cultivated plants are understood to comprise all spe- cies, subspecies, variants, varieties and/or hybrids which belong to the respective cultivated plants, including but not limited to winter and spring varieties, in particular in cereals such as wheat and barley, as well as oilseed rape, e.g. winter wheat, spring wheat, winter barley etc. Corn is also known as Indian corn or maize (Zea mays) which comprises all kinds of corn such as field corn and sweet corn. According to the invention all maize or corn subspecies and/or varieties are comprised, in particular flour corn (Zea mays var. amylacea), popcorn (Zea mays var. everta), dent corn (Zea mays var. indentata), flint corn (Zea mays var. indurata), sweet corn (Zea mays var. saccharata and var. rugosa), waxy corn (Zea mays var. ceratina), amylomaize (high amylose Zea mays varieties), pod corn or wild maize (Zea mays var. tunicata) and striped maize (Zea mays var. japonica). Most soybean cultivars are classifiable into indeterminate and determinate growth habit, whereas Glycine soja, the wild progenitor of soybean, is indeterminate (PNAS 2010, 107 (19) 8563-856). The indeterminate growth habit (Maturity Group, MG 00 to MG 4.9) is characterized by a continuation of vegetative growth after flowering begins whereas determinate soybean vari- eties (MG 5 to MG 8) characteristically have finished most of their vegetative growth when flow- ering begins. According to the invention all soybean cultivars or varieties are comprised, in par- ticular indeterminate and determinate cultivars or varieties. The term "cultivated plants" is to be understood as including plants which have been modi- fied by mutagenesis or genetic engineering to provide a new trait to a plant or to modify an al- ready present trait. Mutagenesis includes random mutagenesis using X-rays or mutagenic chemicals, but also targeted mutagenesis to create mutations at a specific locus of a plant ge- nome. Targeted mutagenesis frequently uses oligonucleotides or proteins like CRISPR/Cas, zinc-finger nucleases, TALENs or meganucleases. Genetic engineering usually uses recombi- nant DNA techniques to create modifications in a plant genome which under natural circum- stances cannot readily be obtained by cross breeding, mutagenesis or natural recombination. Typically, one or more genes are integrated into the genome of a plant to add a trait or improve or modify a trait. These integrated genes are also referred to as transgenes, while plant com- prising such transgenes are referred to as transgenic plants. The process of plant transforma- tion usually produces several transformation events, wich differ in the genomic locus in which a transgene has been integrated. Plants comprising a specific transgene on a specific genomic locus are usually described as comprising a specific “event”, which is referred to by a specific event name. Traits which have been introduced in plants or have been modified include herbici- de tolerance, insect resistance, increased yield and tolerance to abiotic conditions, like drought. 230124 62 Herbicide tolerance has been created by using mutagenesis and genetic engineering. Plants which have been rendered tolerant to acetolactate synthase (ALS) inhibitor herbicides by muta- genesis and breeding are e.g. available under the name Clearfield®. Herbicide tolerance to glyphosate, glufosinate, 2,4-D, dicamba, oxynil herbicides, like bromoxynil and ioxynil, sulfonyl- urea herbicides, ALS inhibitors and 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors, like isoxaflutole and mesotrione, has been created via the use of transgenes. Transgenes to provide herbicide tolerance traits comprise: for tolerance to glyphosate: cp4 epsps, epsps grg23ace5, mepsps, 2mepsps, gat4601, gat4621, goxv247; for tolerance to glufosinate: pat and bar, for tolerance to 2,4-D: aad-1, aad-12; for tolerance to dicamba: dmo; for tolerance to oxynil herbicies: bxn; for tolerance to sulfonylurea herbicides: zm-hra, csr1-2, gm-hra, S4-HrA; for tolerance to ALS inhibitors: csr1-2; and for tolerance to HPPD inhibitors: hppdPF, W336, avhppd-03. Transgenic corn events comprising herbicide tolerance genes include, but are not limited to, DAS40278, MON801, MON802, MON809, MON810, MON832, MON87411, MON87419, MON87427, MON88017, MON89034, NK603, GA21, MZHG0JG, HCEM485, VCO-Ø1981-5, 676, 678, 680, 33121, 4114, 59122, 98140, Bt10, Bt176, CBH-351, DBT418, DLL25, MS3, MS6, MZIR098, T25, TC1507 and TC6275. Transgenic soybean events comprising herbicide tolerance genes include, but are not limited to, GTS 40-3-2, MON87705, MON87708, MON87712, MON87769, MON89788, A2704-12, A2704-21, A5547-127, A5547-35, DP356043, DAS44406-6, DAS68416-4, DAS-81419-2, GU262, SYHTØH2, W62, W98, FG72 and CV127. Transgenic cotton events comprising herbicide tolerance genes include, but are not limited to, 19-51a, 31707, 42317, 81910, 281-24-236, 3006-210-23, BXN10211, BXN10215, BXN10222, BXN10224, MON1445, MON1698, MON88701, MON88913, GHB119, GHB614, LLCotton25, T303-3 and T304-40. Transgenic canola events comprising herbicide tolerance genes are for example, but not excluding others, MON88302, HCR-1, HCN10, HCN28, HCN92, MS1, MS8, PHY14, PHY23, PHY35, PHY36, RF1, RF2 and RF3. Transgenes to provide insect resistance preferably are toxin genes of Bacillus spp. and syn- thetic variants thereof, like cry1A, cry1Ab, cry1Ab-Ac, cry1Ac, cry1A.105, cry1F, cry1Fa2, cry2Ab2, cry2Ae, mcry3A, ecry3.1Ab, cry3Bb1, cry34Ab1, cry35Ab1, cry9C, vip3A(a), vip3Aa20. In addition, transgenes of plant origin, such as genes coding for protease inhibitors, like CpTI and pinII, can be used. A further approach uses transgenes such as dvsnf7 to produce double-stranded RNA in plants. Transgenic corn events comprising genes for insecticidal proteins or double stranded RNA include, but are not limited to, Bt10, Bt11, Bt176, MON801, MON802, MON809, MON810, MON863, MON87411, MON88017, MON89034, 33121, 4114, 5307, 59122, TC1507, TC6275, CBH-351, MIR162, DBT418 and MZIR098. Transgenic soybean events comprising genes for insecticidal proteins include, but are not limited to, MON87701, MON87751 and DAS-81419. Transgenic cotton events comprising genes for insecticidal proteins include, but are not limited 230124 63 to, SGK321, MON531, MON757, MON1076, MON15985, 31707, 31803, 31807, 31808, 42317, BNLA-601, Event1, COT67B, COT102, T303-3, T304-40, GFM Cry1A, GK12, MLS 9124, 281- 24-236, 3006-210-23, GHB119 and SGK321. Cultivated plants with increased yield have been created by using the transgene athb17 (e.g. corn event MON87403), or bbx32 (e.g. soybean event MON87712). Cultivated plants comprising a modified oil content have been created by using the transgenes: gm-fad2-1, Pj.D6D, Nc.Fad3, fad2-1A and fatb1-A (e.g. soybean events 260-05, MON87705 and MON87769). Tolerance to abiotic conditions, such as drought, has been created by using the transgene cspB (corn event MON87460) and Hahb-4 (soybean event IND-ØØ41Ø-5). Traits are frequently combined by combining genes in a transformation event or by combin- ing different events during the breeding process resulting in a cultivated plant with stacked traits. Preferred combinations of traits are combinations of herbicide tolerance traits to different groups of herbicides, combinations of insect tolerance to different kind of insects, in particular tolerance to lepidopteran and coleopteran insects, combinations of herbicide tolerance with one or several types of insect resistance, combinations of herbicide tolerance with increased yield as well as combinations of herbicide tolerance and tolerance to abiotic conditions. Plants comprising singular or stacked traits as well as the genes and events providing these traits are well known in the art. For example, detailed information as to the mutagenized or inte- grated genes and the respective events are available from websites of the organizations “Inter- national Service for the Acquisition of Agri-biotech Applications (ISAAA)” (http://www.isaaa.org/gmapprovaldatabase) and the “Center for Environmental Risk Assess- ment (CERA)” (http://cera-gmc.org/GMCropDatabase). Further information on specific events and methods to detect them can be found for canola events MS1, MS8, RF3, GT73, MON88302, KK179 in WO01/031042, WO01/041558, WO01/041558, WO02/036831, WO11/153186, WO13/003558; for cotton events MON1445, MON15985, MON531 (MON15985), LLCotton25, MON88913, COT102, 281-24-236, 3006-210-23, COT67B, GHB614, T304-40, GHB119, MON88701, 81910 in WO02/034946, WO02/100163, WO02/100163, WO03/013224, WO04/072235, WO04/039986, WO05/103266, WO05/103266, WO06/128573, WO07/017186, WO08/122406, WO08/151780, WO12/134808, WO13/112527; for corn events GA21, MON810, DLL25, TC1507, MON863, MIR604, LY038, MON88017, 3272, 59122, NK603, MIR162, MON89034, 98140, 32138, MON87460, 5307, 4114, MON87427, DAS40278, MON87411, 33121, MON87403, MON87419 in WO98/044140, US02/102582, US03/126634, WO04/099447, WO04/011601, WO05/103301, WO05/061720, WO05/059103, WO06/098952, WO06/039376, US2007/292854, WO07/142840, WO07/140256, WO08/112019, WO09/103049, WO09/111263, WO10/077816, WO11/084621, WO11/062904, WO11/022469, WO13/169923, WO14/116854, WO15/053998, WO15/142571; for potato events E12, F10, J3, J55, V11, X17, Y9 in WO14/178910, WO14/178913, WO14/178941, 230124 64 WO14/179276, WO16/183445, WO17/062831, WO17/062825; for rice events LLRICE06, LLRICE601, LLRICE62 in WO00/026345, WO00/026356, WO00/026345; and for soybean events H7-1, MON89788, A2704-12, A5547-127, DP305423, DP356043, MON87701, MON87769, CV127, MON87705, DAS68416-4, MON87708, MON87712, SYHT0H2, DAS81419, DAS81419 x DAS44406-6, MON87751 in WO04/074492, WO06/130436, WO06/108674, WO06/108675, WO08/054747, WO08/002872, WO09/064652, WO09/102873, WO10/080829, WO10/037016, WO11/066384, WO11/034704, WO12/051199, WO12/082548, WO13/016527, WO13/016516, WO14/201235. The use of compounds I and compositions thereof, respectively, on cultivated plants may re- sult in effects which are specific to a cultivated plant comprising a certain transgene or event. These effects might involve changes in growth behavior or changed resistance to biotic or abi- otic stress factors. Such effects may in particular comprise enhanced yield, enhanced re- sistance or tolerance to insects, nematodes, fungal, bacterial, mycoplasma, viral or viroid patho- gens as well as early vigour, early or delayed ripening, cold or heat tolerance as well as changed amino acid or fatty acid spectrum or content. The compounds I and compositions thereof, respectively, are particularly suitable for control- ling the following causal agents of plant diseases: Albugo spp. (white rust) on ornamentals, vegetables (e. g. A. candida) and sunflowers (e. g. A. tragopogonis); Alternaria spp. (Alternaria leaf spot) on vegetables (e.g. A. dauci or A. porri), oilseed rape (A. brassicicola or brassicae), sugar beets (A. tenuis), fruits (e.g. A. grandis), rice, soybeans, potatoes and tomatoes (e. g. A. solani, A. grandis or A. alternata), tomatoes (e. g. A. solani or A. alternata) and wheat (e.g. A. triticina); Aphanomyces spp. on sugar beets and vege- tables; Ascochyta spp. on cereals and vegetables, e. g. A. tritici (anthracnose) on wheat and A. hordei on barley; Aureobasidium zeae (syn. Kapatiella zeae) on corn; Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp.), e. g. Southern leaf blight (D. maydis) or Northern leaf blight (B. zeicola) on corn, e. g. spot blotch (B. sorokiniana) on cereals and e. g. B. oryzae on rice and turfs; Blumeria (formerly Erysiphe) graminis (powdery mildew) on cereals (e. g. on wheat or barley); Botrytis cinerea (teleomorph: Botryotinia fuckeliana: grey mold) on fruits and berries (e. g. strawberries), vegetables (e. g. lettuce, carrots, celery and cabbages); B. squa- mosa or B. allii on onion family), oilseed rape, ornamentals (e.g. B eliptica), vines, forestry plants and wheat; Bremia lactucae (downy mildew) on lettuce; Ceratocystis (syn. Ophiostoma) spp. (rot or wilt) on broad-leaved trees and evergreens, e. g. C. ulmi (Dutch elm disease) on elms; Cercospora spp. (Cercospora leaf spots) on corn (e. g. Gray leaf spot: C. zeae-maydis), rice, sugar beets (e. g. C. beticola), sugar cane, vegetables, coffee, soybeans (e. g. C. sojina or C. kikuchii) and rice; Cladobotryum (syn. Dactylium) spp. (e.g. C. mycophilum 230124 65 (formerly Dactylium dendroides, teleomorph: Nectria albertinii, Nectria rosella syn. Hypomyces rosellus) on mushrooms; Cladosporium spp. on tomatoes (e. g. C. fulvum: leaf mold) and cere- als, e. g. C. herbarum (black ear) on wheat; Claviceps purpurea (ergot) on cereals; Cochliobo- lus (anamorph: Helminthosporium of Bipolaris) spp. (leaf spots) on corn (C. carbonum), cereals (e. g. C. sativus, anamorph: B. sorokiniana) and rice (e. g. C. miyabeanus, anamorph: H. ory- zae); Colletotrichum (teleomorph: Glomerella) spp. (anthracnose) on cotton (e. g. C. gossypii), corn (e. g. C. graminicola: Anthracnose stalk rot), soft fruits, potatoes (e. g. C. coccodes: black dot), beans (e. g. C. lindemuthianum), soybeans (e. g. C. truncatum or C. gloeosporioides), veg- etables (e.g. C. lagenarium or C. capsici), fruits (e.g. C. acutatum), coffee (e.g. C. coffeanum or C. kahawae) and C. gloeosporioides on various crops; Corticium spp., e. g. C. sasakii (sheath blight) on rice; Corynespora cassiicola (leaf spots) on soybeans, cotton and ornamentals; Cy- cloconium spp., e. g. C. oleaginum on olive trees; Cylindrocarpon spp. (e. g. fruit tree canker or young vine decline, teleomorph: Nectria or Neonectria spp.) on fruit trees, vines (e. g. C. lirio- dendri, teleomorph: Neonectria liriodendri: Black Foot Disease) and ornamentals; Dematophora (teleomorph: Rosellinia) necatrix (root and stem rot) on soybeans; Diaporthe spp., e. g. D. phaseolorum (damping off) on soybeans; Drechslera (syn. Helminthosporium, teleomorph: Pyr- enophora) spp. on corn, cereals, such as barley (e. g. D. teres, net blotch) and wheat (e. g. D. tritici-repentis: tan spot), rice and turf; Esca (dieback, apoplexy) on vines, caused by Formiti- poria (syn. Phellinus) punctata, F. mediterranea, Phaeomoniella chlamydospora (formerly Phae- oacremonium chlamydosporum), Phaeoacremonium aleophilum and/or Botryosphaeria obtusa; Elsinoe spp. on pome fruits (E. pyri), soft fruits (E. veneta: anthracnose) and vines (E. ampelina: anthracnose); Entyloma oryzae (leaf smut) on rice; Epicoccum spp. (black mold) on wheat; Ery- siphe spp. (powdery mildew) on sugar beets (E. betae), vegetables (e. g. E. pisi), such as cu- curbits (e. g. E. cichoracearum), cabbages, oilseed rape (e. g. E. cruciferarum); Eutypa lata (Eu- typa canker or dieback, anamorph: Cytosporina lata, syn. Libertella blepharis) on fruit trees, vines and ornamental woods; Exserohilum (syn. Helminthosporium) spp. on corn (e. g. E. turci- cum); Fusarium (teleomorph: Gibberella) spp. (wilt, root or stem rot) on various plants, such as F. graminearum or F. culmorum (root rot, scab or head blight) on cereals (e. g. wheat or barley), F. oxysporum on tomatoes, F. solani (f. sp. glycines now syn. F. virguliforme ) and F. tucu- maniae and F. brasiliense each causing sudden death syndrome on soybeans, and F. verticil- lioides on corn; Gaeumannomyces graminis (take-all) on cereals (e. g. wheat or barley) and corn; Gibberella spp. on cereals (e. g. G. zeae) and rice (e. g. G. fujikuroi: Bakanae disease); Glomerella cingulata on vines, pome fruits and other plants and G. gossypii on cotton; Grain- staining complex on rice; Guignardia bidwellii (black rot) on vines; Gymnosporangium spp. on rosaceous plants and junipers, e. g. G. sabinae (rust) on pears; Helminthosporium spp. (syn. Drechslera, teleomorph: Cochliobolus) on corn, cereals, potatoes and rice; Hemileia spp., e. g. H. vastatrix (coffee leaf rust) on coffee; Isariopsis clavispora (syn. Cladosporium vitis) on vines; 230124 66 Macrophomina phaseolina (syn. phaseoli) (root and stem rot) on soybeans and cotton; Microdo- chium (syn. Fusarium) nivale (pink snow mold) on cereals (e. g. wheat or barley); Microsphaera diffusa (powdery mildew) on soybeans; Monilinia spp., e. g. M. laxa, M. fructicola and M. fructi- gena (syn. Monilia spp.: bloom and twig blight, brown rot) on stone fruits and other rosaceous plants; Mycosphaerella spp. on cereals, bananas, soft fruits and ground nuts, such as e. g. M. graminicola (anamorph: Zymoseptoria tritici formerly Septoria tritici: Septoria blotch) on wheat or M. fijiensis (syn. Pseudocercospora fijiensis: black Sigatoka disease) and M. musicola on bana- nas, M. arachidicola (syn. M. arachidis or Cercospora arachidis), M. berkeleyi on peanuts, M. pisi on peas and M. brassiciola on brassicas; Peronospora spp. (downy mildew) on cabbage (e. g. P. brassicae), oilseed rape (e. g. P. parasitica), onions (e. g. P. destructor), tobacco (P. tabacina) and soybeans (e. g. P. manshurica); Phakopsora pachyrhizi and P. meibomiae (soy- bean rust) on soybeans; Phialophora spp. e. g. on vines (e. g. P. tracheiphila and P. tetraspora) and soybeans (e. g. P. gregata: stem rot); Phoma lingam (syn. Leptosphaeria biglobosa and L. maculans: root and stem rot) on oilseed rape and cabbage, P. betae (root rot, leaf spot and damping-off) on sugar beets and P. zeae-maydis (syn. Phyllostica zeae) on corn; Phomopsis spp. on sunflowers, vines (e. g. P. viticola: can and leaf spot) and soybeans (e. g. stem rot: P. phaseoli, teleomorph: Diaporthe phaseolorum); Physoderma maydis (brown spots) on corn; Phytophthora spp. (wilt, root, leaf, fruit and stem root) on various plants, such as paprika and cucurbits (e. g. P. capsici), soybeans (e. g. P. megasperma, syn. P. sojae), potatoes and toma- toes (e. g. P. infestans: late blight) and broad-leaved trees (e. g. P. ramorum: sudden oak death); Plasmodiophora brassicae (club root) on cabbage,oilseed rape, radish and other plants; Plasmopara spp., e. g. P. viticola (grapevine downy mildew) on vines and P. halstedii on sun- flowers; Podosphaera spp. (powdery mildew) on rosaceous plants, hop, pome and soft fruits (e. g. P. leucotricha on apples) and curcurbits (P. xanthii); Polymyxa spp., e. g. on cereals, such as barley and wheat (P. graminis) and sugar beets (P. betae) and thereby transmitted viral dis- eases; Pseudocercosporella herpotrichoides (syn. Oculimacula yallundae, O. acuformis: eye- spot, teleomorph: Tapesia yallundae) on cereals, e. g. wheat or barley; Pseudoperonospora (downy mildew) on various plants, e. g. P. cubensis on cucurbits or P. humili on hop; Pseudo- pezicula tracheiphila (red fire disease or ‚rotbrenner’, anamorph: Phialophora) on vines; Puc- cinia spp. (rusts) on various plants, e. g. P. triticina (brown or leaf rust), P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, such as e. g. wheat, barley or rye, P. kuehnii (orange rust) on sugar cane and P. asparagi on asparagus; Pyrenopeziza spp., e.g. P. brassicae on oilseed rape; Pyrenophora (anamorph: Drechslera) tritici-repentis (tan spot) on wheat or P. teres (net blotch) on barley; Pyricularia spp., e. g. P. oryzae (teleomorph: Magnaporthe grisea: rice blast) on rice and P. grisea on turf and cereals; Pythium spp. (damping-off) on turf, rice, corn, wheat, cotton, oilseed rape, sunflowers, soybeans, sugar beets, vegetables and various other plants (e. g. P. ultimum or P. aphanidermatum) and P. oligandrum on mushrooms; Ramularia spp., e. g. R. collo-cygni 230124 67 (Ramularia leaf spots, Physiological leaf spots) on barley, R. areola (teleomorph: Myco- sphaerella areola) on cotton and R. beticola on sugar beets; Rhizoctonia spp. on cotton, rice, potatoes, turf, corn, oilseed rape, potatoes, sugar beets, vegetables and various other plants, e. g. R. solani (root and stem rot) on soybeans, R. solani (sheath blight) on rice or R. cerealis (Rhizoctonia spring blight) on wheat or barley; Rhizopus stolonifer (black mold, soft rot) on strawberries, carrots, cabbage, vines and tomatoes; Rhynchosporium secalis and R. commune (scald) on barley, rye and triticale; Sarocladium oryzae and S. attenuatum (sheath rot) on rice; Sclerotinia spp. (stem rot or white mold) on vegetables (S. minor and S. sclerotiorum) and field crops, such as oilseed rape, sunflowers (e. g. S. sclerotiorum) and soybeans, S. rolfsii (syn. Athelia rolfsii) on soybeans, peanut, vegetables, corn, cereals and ornamentals; Septoria spp. on various plants, e. g. S. glycines (brown spot) on soybeans, S. tritici (syn. Zymoseptoria tritici, Septoria blotch) on wheat and S. (syn. Stagonospora) nodorum (Stagonospora blotch) on cere- als; Uncinula (syn. Erysiphe) necator (powdery mildew, anamorph: Oidium tuckeri) on vines; Se- tosphaeria spp. (leaf blight) on corn (e. g. S. turcicum, syn. Helminthosporium turcicum) and turf; Sphacelotheca spp. (smut) on corn, (e. g. S. reiliana, syn. Ustilago reiliana: head smut), sorghum und sugar cane; Sphaerotheca fuliginea (syn. Podosphaera xanthii: powdery mildew) on cucurbits; Spongospora subterranea (powdery scab) on potatoes and thereby transmitted viral diseases; Stagonospora spp. on cereals, e. g. S. nodorum (Stagonospora blotch, teleo- morph: Leptosphaeria [syn. Phaeosphaeria] nodorum, syn. Septoria nodorum) on wheat; Synchytrium endobioticum on potatoes (potato wart disease); Taphrina spp., e. g. T. deformans (leaf curl disease) on peaches and T. pruni (plum pocket) on plums; Thielaviopsis spp. (black root rot) on tobacco, pome fruits, vegetables, soybeans and cotton, e. g. T. basicola (syn. Chalara elegans); Tilletia spp. (common bunt or stinking smut) on cereals, such as e. g. T. tritici (syn. T. caries, wheat bunt) and T. controversa (dwarf bunt) on wheat; Trichoderma harzianum on mushrooms; Typhula incarnata (grey snow mold) on barley or wheat; Urocystis spp., e. g. U. occulta (stem smut) on rye; Uromyces spp. (rust) on vegetables, such as beans (e. g. U. appen- diculatus, syn. U. phaseoli), sugar beets (e. g. U. betae or U. beticola) and on pulses (e.g. U. vignae, U. pisi, U. viciae-fabae and U. fabae); Ustilago spp. (loose smut) on cereals (e. g. U. nuda and U. avaenae), corn (e. g. U. maydis: corn smut) and sugar cane; Venturia spp. (scab) on apples (e. g. V. inaequalis) and pears; and Verticillium spp. (wilt) on various plants, such as fruits and ornamentals, vines, soft fruits, vegetables and field crops, e. g. V. longisporum on oilseed rape, V. dahliae on strawberries, oilseed rape, potatoes and tomatoes, and V. fungicola on mushrooms; Zymoseptoria tritici on cereals. The compounds I and compositions thereof, respectively, are particularly suitable for control- ling the following causal agents of plant diseases: rusts on soybean and cereals (e.g. Phakopsora pachyrhizi and P. meibomiae on soy; Puccinia tritici and P. striiformis on wheat); 230124 68 molds on specialty crops, soybean, oil seed rape and sunflowers (e.g. Botrytis cinerea on straw- berries and vines, Sclerotinia sclerotiorum, S. minor and S. rolfsii on oil seed rape, sunflowers and soybean); Fusarium diseases on cereals (e.g. Fusarium culmorum and F. graminearum on wheat); downy mildews on specialty crops (e.g. Plasmopara viticola on vines, Phytophthora in- festans on potatoes); powdery mildews on specialty crops and cereals (e.g. Uncinula necator on vines, Erysiphe spp. on various specialty crops, Blumeria graminis on cereals); and leaf spots on cereals, soybean and corn (e.g. Septoria tritici and S. nodorum on cereals, S. glycines on soybean, Cercospora spp. on corn and soybean). According to one embodiment compounds I.A-1.1a.B-1 to I.A-1.1a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-2.1a.B-1 to I.A-2.1a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-3.1a.B-1 to I.A-3.1a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-4.1a.B-1 to I.A-4.1a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-5.1a.B-1 to I.A-5.1a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-6.1a.B-1 to I.A-6.1a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-1.2a.B-1 to I.A-1.2a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-2.2a.B-1 to I.A-2.2a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-3.2a.B-1 to I.A-3.2a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-4.2a.B-1 to I.A-4.2a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-5.2a.B-1 to I.A-5.2a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-6.2a.B-1 to I.A-6.2a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. 230124 69 According to one embodiment compounds I.A-1.3a.B-1 to I.A-1.3a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-2.3a.B-1 to I.A-2.3a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-3.3a.B-1 to I.A-3.3a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-4.3a.B-1 to I.A-4.3a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-5.3a.B-1 to I.A-5.3a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-6.3a.B-1 to I.A-6.3a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-1.4a.B-1 to I.A-1.4a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-2.4a.B-1 to I.A-2.4a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-3.4a.B-1 to I.A-3.4a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-4.4a.B-1 to I.A-4.4a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-5.4a.B-1 to I.A-5.4a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-6.4a.B-1 to I.A-6.4a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-1.5a.B-1 to I.A-1.5a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-2.5a.B-1 to I.A-2.5a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-3.5a.B-1 to I.A-3.5a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-4.5a.B-1 to I.A-4.5a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. 230124 70 According to one embodiment compounds I.A-5.5a.B-1 to I.A-5.5a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-6.5a.B-1 to I.A-6.5a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-1.6a.B-1 to I.A-1.6a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-2.6a.B-1 to I.A-2.6a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-3.6a.B-1 to I.A-3.6a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-4.6a.B-1 to I.A-4.6a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-5.6a.B-1 to I.A-5.6a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-6.6a.B-1 to I.A-6.6a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-1.7a.B-1 to I.A-1.7a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-2.7a.B-1 to I.A-2.7a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-3.7a.B-1 to I.A-3.7a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-4.7a.B-1 to I.A-4.7a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-5.7a.B-1 to I.A-5.7a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds I.A-6.7a.B-1 to I.A-6.7a.B-180 are particularly suita- ble for controlling the causal agents of plant diseases according to the list Z. According to one embodiment compounds Ex-1 to Ex-92 are particularly suitable for controlling the causal agents of plant diseases according to the list Z. List Z: 230124 71 Albugo spp. (white rust) on ornamentals, vegetables (e. g. A. candida) and sunflowers (e. g. A. tragopogonis); Alternaria spp. (Alternaria leaf spot) on vegetables (e.g. A. dauci or A. porri), oilseed rape (A. brassicicola or brassicae), sugar beets (A. tenuis), fruits (e.g. A. grandis), rice, soybeans, potatoes and tomatoes (e. g. A. solani, A. grandis or A. alternata), tomatoes (e. g. A. solani or A. alternata) and wheat (e.g. A. triticina); Aphanomyces spp. on sugar beets and vege- tables; Ascochyta spp. on cereals and vegetables, e. g. A. tritici (anthracnose) on wheat and A. hordei on barley; Aureobasidium zeae (syn. Kapatiella zeae) on corn; Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp.), e. g. Southern leaf blight (D. maydis) or Northern leaf blight (B. zeicola) on corn, e. g. spot blotch (B. sorokiniana) on cereals and e. g. B. oryzae on rice and turfs; Blumeria (formerly Erysiphe) graminis (powdery mildew) on cereals (e. g. on wheat or barley); Botrytis cinerea (teleomorph: Botryotinia fuckeliana: grey mold) on fruits and berries (e. g. strawberries), vegetables (e. g. lettuce, carrots, celery and cabbages); B. squa- mosa or B. allii on onion family), oilseed rape, ornamentals (e.g. B eliptica), vines, forestry plants and wheat; Bremia lactucae (downy mildew) on lettuce; Ceratocystis (syn. Ophiostoma) spp. (rot or wilt) on broad-leaved trees and evergreens, e. g. C. ulmi (Dutch elm disease) on elms; Cercospora spp. (Cercospora leaf spots) on corn (e. g. Gray leaf spot: C. zeae-maydis), rice, sugar beets (e. g. C. beticola), sugar cane, vegetables, coffee, soybeans (e. g. C. sojina or C. kikuchii) and rice; Cladobotryum (syn. Dactylium) spp. (e.g. C. mycophilum (formerly Dactylium dendroides, teleomorph: Nectria albertinii, Nectria rosella syn. Hypomyces rosellus) on mushrooms; Cladosporium spp. on tomatoes (e. g. C. fulvum: leaf mold) and cere- als, e. g. C. herbarum (black ear) on wheat; Claviceps purpurea (ergot) on cereals; Cochliobo- lus (anamorph: Helminthosporium of Bipolaris) spp. (leaf spots) on corn (C. carbonum), cereals (e. g. C. sativus, anamorph: B. sorokiniana) and rice (e. g. C. miyabeanus, anamorph: H. ory- zae); Colletotrichum (teleomorph: Glomerella) spp. (anthracnose) on cotton (e. g. C. gossypii), corn (e. g. C. graminicola: Anthracnose stalk rot), soft fruits, potatoes (e. g. C. coccodes: black dot), beans (e. g. C. lindemuthianum), soybeans (e. g. C. truncatum or C. gloeosporioides), veg- etables (e.g. C. lagenarium or C. capsici), fruits (e.g. C. acutatum), coffee (e.g. C. coffeanum or C. kahawae) and C. gloeosporioides on various crops; Corticium spp., e. g. C. sasakii (sheath blight) on rice; Corynespora cassiicola (leaf spots) on soybeans, cotton and ornamentals; Cy- cloconium spp., e. g. C. oleaginum on olive trees; Cylindrocarpon spp. (e. g. fruit tree canker or young vine decline, teleomorph: Nectria or Neonectria spp.) on fruit trees, vines (e. g. C. lirio- dendri, teleomorph: Neonectria liriodendri: Black Foot Disease) and ornamentals; Dematophora (teleomorph: Rosellinia) necatrix (root and stem rot) on soybeans; Diaporthe spp., e. g. D. phaseolorum (damping off) on soybeans; Drechslera (syn. Helminthosporium, teleomorph: Pyr- enophora) spp. on corn, cereals, such as barley (e. g. D. teres, net blotch) and wheat (e. g. D. tritici-repentis: tan spot), rice and turf; Esca (dieback, apoplexy) on vines, caused by Formiti- 230124 72 poria (syn. Phellinus) punctata, F. mediterranea, Phaeomoniella chlamydospora (formerly Phae- oacremonium chlamydosporum), Phaeoacremonium aleophilum and/or Botryosphaeria obtusa; Elsinoe spp. on pome fruits (E. pyri), soft fruits (E. veneta: anthracnose) and vines (E. ampelina: anthracnose); Entyloma oryzae (leaf smut) on rice; Epicoccum spp. (black mold) on wheat; Ery- siphe spp. (powdery mildew) on sugar beets (E. betae), vegetables (e. g. E. pisi), such as cu- curbits (e. g. E. cichoracearum), cabbages, oilseed rape (e. g. E. cruciferarum); Eutypa lata (Eu- typa canker or dieback, anamorph: Cytosporina lata, syn. Libertella blepharis) on fruit trees, vines and ornamental woods; Exserohilum (syn. Helminthosporium) spp. on corn (e. g. E. turci- cum); Fusarium (teleomorph: Gibberella) spp. (wilt, root or stem rot) on various plants, such as F. graminearum or F. culmorum (root rot, scab or head blight) on cereals (e. g. wheat or barley), F. oxysporum on tomatoes, F. solani (f. sp. glycines now syn. F. virguliforme ) and F. tucu- maniae and F. brasiliense each causing sudden death syndrome on soybeans, and F. verticil- lioides on corn; Gaeumannomyces graminis (take-all) on cereals (e. g. wheat or barley) and corn; Gibberella spp. on cereals (e. g. G. zeae) and rice (e. g. G. fujikuroi: Bakanae disease); Glomerella cingulata on vines, pome fruits and other plants and G. gossypii on cotton; Grain- staining complex on rice; Guignardia bidwellii (black rot) on vines; Gymnosporangium spp. on rosaceous plants and junipers, e. g. G. sabinae (rust) on pears; Helminthosporium spp. (syn. Drechslera, teleomorph: Cochliobolus) on corn, cereals, potatoes and rice; Hemileia spp., e. g. H. vastatrix (coffee leaf rust) on coffee; Isariopsis clavispora (syn. Cladosporium vitis) on vines; Macrophomina phaseolina (syn. phaseoli) (root and stem rot) on soybeans and cotton; Microdo- chium (syn. Fusarium) nivale (pink snow mold) on cereals (e. g. wheat or barley); Microsphaera diffusa (powdery mildew) on soybeans; Monilinia spp., e. g. M. laxa, M. fructicola and M. fructi- gena (syn. Monilia spp.: bloom and twig blight, brown rot) on stone fruits and other rosaceous plants; Mycosphaerella spp. on cereals, bananas, soft fruits and ground nuts, such as e. g. M. graminicola (anamorph: Zymoseptoria tritici formerly Septoria tritici: Septoria blotch) on wheat or M. fijiensis (syn. Pseudocercospora fijiensis: black Sigatoka disease) and M. musicola on bana- nas, M. arachidicola (syn. M. arachidis or Cercospora arachidis), M. berkeleyi on peanuts, M. pisi on peas and M. brassiciola on brassicas; Peronospora spp. (downy mildew) on cabbage (e. g. P. brassicae), oilseed rape (e. g. P. parasitica), onions (e. g. P. destructor), tobacco (P. tabacina) and soybeans (e. g. P. manshurica); Phakopsora pachyrhizi and P. meibomiae (soy- bean rust) on soybeans; Phialophora spp. e. g. on vines (e. g. P. tracheiphila and P. tetraspora) and soybeans (e. g. P. gregata: stem rot); Phoma lingam (syn. Leptosphaeria biglobosa and L. maculans: root and stem rot) on oilseed rape and cabbage, P. betae (root rot, leaf spot and damping-off) on sugar beets and P. zeae-maydis (syn. Phyllostica zeae) on corn; Phomopsis spp. on sunflowers, vines (e. g. P. viticola: can and leaf spot) and soybeans (e. g. stem rot: P. phaseoli, teleomorph: Diaporthe phaseolorum); Physoderma maydis (brown spots) on corn; Phytophthora spp. (wilt, root, leaf, fruit and stem root) on various plants, such as paprika and 230124 73 cucurbits (e. g. P. capsici), soybeans (e. g. P. megasperma, syn. P. sojae), potatoes and toma- toes (e. g. P. infestans: late blight) and broad-leaved trees (e. g. P. ramorum: sudden oak death); Plasmodiophora brassicae (club root) on cabbage,oilseed rape, radish and other plants; Plasmopara spp., e. g. P. viticola (grapevine downy mildew) on vines and P. halstedii on sun- flowers; Podosphaera spp. (powdery mildew) on rosaceous plants, hop, pome and soft fruits (e. g. P. leucotricha on apples) and curcurbits (P. xanthii); Polymyxa spp., e. g. on cereals, such as barley and wheat (P. graminis) and sugar beets (P. betae) and thereby transmitted viral dis- eases; Pseudocercosporella herpotrichoides (syn. Oculimacula yallundae, O. acuformis: eye- spot, teleomorph: Tapesia yallundae) on cereals, e. g. wheat or barley; Pseudoperonospora (downy mildew) on various plants, e. g. P. cubensis on cucurbits or P. humili on hop; Pseudo- pezicula tracheiphila (red fire disease or ‚rotbrenner’, anamorph: Phialophora) on vines; Puc- cinia spp. (rusts) on various plants, e. g. P. triticina (brown or leaf rust), P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, such as e. g. wheat, barley or rye, P. kuehnii (orange rust) on sugar cane and P. asparagi on asparagus; Pyrenopeziza spp., e.g. P. brassicae on oilseed rape; Pyrenophora (anamorph: Drechslera) tritici-repentis (tan spot) on wheat or P. teres (net blotch) on barley; Pyricularia spp., e. g. P. oryzae (teleomorph: Magnaporthe grisea: rice blast) on rice and P. grisea on turf and cereals; Pythium spp. (damping-off) on turf, rice, corn, wheat, cotton, oilseed rape, sunflowers, soybeans, sugar beets, vegetables and various other plants (e. g. P. ultimum or P. aphanidermatum) and P. oligandrum on mushrooms; Ramularia spp., e. g. R. collo-cygni (Ramularia leaf spots, Physiological leaf spots) on barley, R. areola (teleomorph: Myco- sphaerella areola) on cotton and R. beticola on sugar beets; Rhizoctonia spp. on cotton, rice, potatoes, turf, corn, oilseed rape, potatoes, sugar beets, vegetables and various other plants, e. g. R. solani (root and stem rot) on soybeans, R. solani (sheath blight) on rice or R. cerealis (Rhizoctonia spring blight) on wheat or barley; Rhizopus stolonifer (black mold, soft rot) on strawberries, carrots, cabbage, vines and tomatoes; Rhynchosporium secalis and R. commune (scald) on barley, rye and triticale; Sarocladium oryzae and S. attenuatum (sheath rot) on rice; Sclerotinia spp. (stem rot or white mold) on vegetables (S. minor and S. sclerotiorum) and field crops, such as oilseed rape, sunflowers (e. g. S. sclerotiorum) and soybeans, S. rolfsii (syn. Athelia rolfsii) on soybeans, peanut, vegetables, corn, cereals and ornamentals; Septoria spp. on various plants, e. g. S. glycines (brown spot) on soybeans, S. tritici (syn. Zymoseptoria tritici, Septoria blotch) on wheat and S. (syn. Stagonospora) nodorum (Stagonospora blotch) on cere- als; Uncinula (syn. Erysiphe) necator (powdery mildew, anamorph: Oidium tuckeri) on vines; Se- tosphaeria spp. (leaf blight) on corn (e. g. S. turcicum, syn. Helminthosporium turcicum) and turf; Sphacelotheca spp. (smut) on corn, (e. g. S. reiliana, syn. Ustilago reiliana: head smut), sorghum und sugar cane; Sphaerotheca fuliginea (syn. Podosphaera xanthii: powdery mildew) on cucurbits; Spongospora subterranea (powdery scab) on potatoes and thereby transmitted 230124 74 viral diseases; Stagonospora spp. on cereals, e. g. S. nodorum (Stagonospora blotch, teleo- morph: Leptosphaeria [syn. Phaeosphaeria] nodorum, syn. Septoria nodorum) on wheat; Synchytrium endobioticum on potatoes (potato wart disease); Taphrina spp., e. g. T. deformans (leaf curl disease) on peaches and T. pruni (plum pocket) on plums; Thielaviopsis spp. (black root rot) on tobacco, pome fruits, vegetables, soybeans and cotton, e. g. T. basicola (syn. Chalara elegans); Tilletia spp. (common bunt or stinking smut) on cereals, such as e. g. T. tritici (syn. T. caries, wheat bunt) and T. controversa (dwarf bunt) on wheat; Trichoderma harzianum on mushrooms; Typhula incarnata (grey snow mold) on barley or wheat; Urocystis spp., e. g. U. occulta (stem smut) on rye; Uromyces spp. (rust) on vegetables, such as beans (e. g. U. appen- diculatus, syn. U. phaseoli), sugar beets (e. g. U. betae or U. beticola) and on pulses (e.g. U. vignae, U. pisi, U. viciae-fabae and U. fabae); Ustilago spp. (loose smut) on cereals (e. g. U. nuda and U. avaenae), corn (e. g. U. maydis: corn smut) and sugar cane; Venturia spp. (scab) on apples (e. g. V. inaequalis) and pears; and Verticillium spp. (wilt) on various plants, such as fruits and ornamentals, vines, soft fruits, vegetables and field crops, e. g. V. longisporum on oilseed rape, V. dahliae on strawberries, oilseed rape, potatoes and tomatoes, and V. fungicola on mushrooms; Zymoseptoria tritici on cereals. The compounds I and compositions thereof, respectively, are also suitable for controlling harmful microorganisms in the protection of stored products or harvest, and in the protection of materials. The term "stored products or harvest" is understood to denote natural substances of plant or animal origin and their processed forms for which long-term protection is desired. Stored prod- ucts of plant origin, for example stalks, leafs, tubers, seeds, fruits or grains, can be protected in the freshly harvested state or in processed form, such as pre-dried, moistened, comminuted, ground, pressed or roasted, which process is also known as post-harvest treatment. Also falling under the definition of stored products is timber, whether in the form of crude timber, such as construction timber, electricity pylons and barriers, or in the form of finished articles, such as fur- niture or objects made from wood. Stored products of animal origin are hides, leather, furs, hairs and alike. Preferably, "stored products" is understood to denote natural substances of plant origin and their processed forms, more preferably fruits and their processed forms, such as pomes, stone fruits, soft fruits and citrus fruits and their processed forms, where application of compounds I and compositions thereof can also prevent disadvantageous effects such as de- cay, discoloration or mold. The term "protection of materials" is to be understood to denote the protection of technical and non-living materials, such as adhesives, glues, wood, paper, paperboard, textiles, leather, 230124 75 paint dispersions, plastics, cooling lubricants, fiber, or fabrics against the infestation and de- struction by harmful microorganisms, such as fungi and bacteria. When used in the protection of materials or stored products, the amount of active substance applied depends on the kind of application area and on the desired effect. Amounts customarily applied in the protection of materials are 0.001 g to 2 kg, preferably 0.005 g to 1 kg, of active substance per cubic meter of treated material. The compounds I and compositions thereof, respectively, may be used for improving the health of a plant. The invention also relates to a method for improving plant health by treating a plant, its propagation material, and/or the locus where the plant is growing or is to grow with an effective amount of compounds I and compositions thereof, respectively. The term "plant health" is to be understood to denote a condition of the plant and/or its prod- ucts which is determined by several indicators alone or in combination with each other, such as yield (e. g. increased biomass and/or increased content of valuable ingredients), plant vigor (e. g. improved plant growth and/or greener leaves (“greening effect”)), quality (e. g. improved con- tent or composition of certain ingredients), and tolerance to abiotic and/or biotic stress. The above identified indicators for the health condition of a plant may be interdependent or may re- sult from each other. The compounds I are employed as such or in form of compositions by treating the fungi, the plants, plant propagation materials, such as seeds; soil, surfaces, materials, or rooms to be pro- tected from fungal attack with a fungicidally effective amount of the active substances. The ap- plication can be carried out both before and after the infection of the plants, plant propagation materials, such as seeds; soil, surfaces, materials or rooms by the fungi. An agrochemical composition comprises a fungicidally effective amount of a compound I. The term "fungicidally effective amount" denotes an amount of the composition or of the com- pounds I, which is sufficient for controlling harmful fungi on cultivated plants or in the protection of stored products or harvest or of materials and which does not result in a substantial damage to the treated plants, the treated stored products or harvest, or to the treated materials. Such an amount can vary in a broad range and is dependent on various factors, such as the fungal spe- cies to be controlled, the treated cultivated plant, stored product, harvest or material, the cli- matic conditions and the specific compound I used. Plant propagation materials may be treated with compounds I as such or a composition com- prising at least one compound I prophylactically either at or before planting or transplanting. When employed in plant protection, the amounts of active substances applied are, depend- ing on the kind of effect desired, from 0.001 to 2 kg per ha, preferably from 0.005 to 2 kg per ha, 230124 76 more preferably from 0.05 to 0.9 kg per ha, and in particular from 0.1 to 0.75 kg per ha. In treatment of plant propagation materials, such as seeds, e. g. by dusting, coating, or drenching, amounts of active substance of generally from 0.1 to 1000 g, preferably from 1 to 1000 g, more preferably from 1 to 100 g and most preferably from 5 to 100 g, per 100 kg of plant propagation material (preferably seeds) are required. The user applies the agrochemical composition usually from a predosage device, a knap- sack sprayer, a spray tank, a spray plane, or an irrigation system. Usually, the agrochemical composition is made up with water, buffer, and/or further auxiliaries to the desired application concentration and the ready-to-use spray liquor or the agrochemical composition according to the invention is thus obtained. Usually, 20 to 2000 liters, preferably 50 to 400 liters, of the ready- to-use spray liquor are applied per hectare of agricultural useful area. The compounds I, their N-oxides and salts can be converted into customary types of agro- chemical compositions, e. g. solutions, emulsions, suspensions, dusts, powders, pastes, gran- ules, pressings, capsules, and mixtures thereof. Examples for composition types (see also “Cat- alogue of pesticide formulation types and international coding system”, Technical Monograph No.2, 6th Ed. May 2008, CropLife International) are suspensions (e. g. SC, OD, FS), emulsifia- ble concentrates (e. g. EC), emulsions (e. g. EW, EO, ES, ME), capsules (e. g. CS, ZC), pastes, pastilles, wettable powders or dusts (e. g. WP, SP, WS, DP, DS), pressings (e. g. BR, TB, DT), granules (e. g. WG, SG, GR, FG, GG, MG), insecticidal articles (e. g. LN), as well as gel formu- lations for the treatment of plant propagation materials, such as seeds (e. g. GF). The composi- tions are prepared in a known manner, such as described by Mollet and Grubemann, Formula- tion technology, Wiley VCH, Weinheim, 2001; or by Knowles, New developments in crop protec- tion product formulation, Agrow Reports DS243, T&F Informa, London, 2005. The invention also relates to agrochemical compositions comprising an auxiliary and at least one compound I. Suitable auxiliaries are solvents, liquid carriers, solid carriers or fillers, surfactants, disper- sants, emulsifiers, wetters, adjuvants, solubilizers, penetration enhancers, protective colloids, adhesion agents, thickeners, humectants, repellents, attractants, feeding stimulants, compatibil- izers, bactericides, anti-freezing agents, anti-foaming agents, colorants, tackifiers, and binders. Suitable solvents and liquid carriers are water and organic solvents, such as mineral oil frac- tions of medium to high boiling point, e. g. kerosene, diesel oil; oils of vegetable or animal origin; aliphatic, cyclic and aromatic hydrocarbons, e. g. toluene, paraffin, tetrahydronaphthalene, and alkylated naphthalenes; alcohols, e. g. ethanol, propanol, butanol, benzyl alcohol, cyclohexanol, glycols; DMSO; ketones, e. g. cyclohexanone; esters, e. g. lactates, carbonates, fatty acid es- ters, gamma-butyrolactone; fatty acids; phosphonates; amines; amides, e. g. N-methyl pyrroli- done, fatty acid dimethyl amides; and mixtures thereof. 230124 77 Suitable solid carriers or fillers are mineral earths, e. g. silicates, silica gels, talc, kaolins, limestone, lime, chalk, clays, dolomite, diatomaceous earth, bentonite, calcium sulfate, magne- sium sulfate, magnesium oxide; polysaccharides, e. g. cellulose, starch; fertilizers, e. g. ammo- nium sulfate, ammonium phosphate, ammonium nitrate, ureas; products of vegetable origin, e. g. cereal meal, tree bark meal, wood meal, nutshell meal, and mixtures thereof. Suitable surfactants are surface-active compounds, such as anionic, cationic, nonionic and amphoteric surfactants, block polymers, polyelectrolytes, and mixtures thereof. Such surfactants can be used as emulsifier, dispersant, solubilizer, wetter, penetration enhancer, protective col- loid, or adjuvant. Examples of surfactants are listed in McCutcheon’s, Vol.1: Emulsifiers & De- tergents, McCutcheon’s Directories, Glen Rock, USA, 2008 (International Ed. or North American Ed.). Suitable anionic surfactants are alkali, alkaline earth or ammonium salts of sulfonates, sul- fates, phosphates, carboxylates, and mixtures thereof. Examples of sulfonates are alkylaryl sul- fonates, diphenyl sulfonates, alpha-olefin sulfonates, lignin sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of alkoxylated arylphenols, sul- fonates of condensed naphthalenes, sulfonates of dodecyl- and tridecylbenzenes, sulfonates of naphthalenes and of alkyl naphthalenes, sulfosuccinates, or sulfosuccinamates. Examples of sulfates are sulfates of fatty acids, of oils, of ethoxylated alkylphenols, of alcohols, of ethoxy- lated alcohols, or of fatty acid esters. Examples of phosphates are phosphate esters. Examples of carboxylates are alkyl carboxylates, and carboxylated alcohol or alkylphenol ethoxylates. Suitable nonionic surfactants are alkoxylates, N-substituted fatty acid amides, amine oxides, esters, sugar-based surfactants, polymeric surfactants, and mixtures thereof. Examples of alkoxylates are compounds such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids or fatty acid esters which have been alkoxylated with 1 to 50 equivalents. Ethylene oxide and/or propylene oxide may be employed for the alkoxylation, preferably ethylene oxide. Exam- ples of N-substituted fatty acid amides are fatty acid glucamides or fatty acid alkanolamides. Ex- amples of esters are fatty acid esters, glycerol esters, or monoglycerides. Examples of sugar- based surfactants are sorbitans, ethoxylated sorbitans, sucrose and glucose esters, or al- kylpolyglucosides. Examples of polymeric surfactants are home- or copolymers of vinyl pyrroli- done, vinyl alcohols, or vinyl acetate. Suitable cationic surfactants are quaternary surfactants, for example quaternary ammonium compounds with one or two hydrophobic groups, or salts of long-chain primary amines. Suitable amphoteric surfactants are alkylbetains and imidazolines. Suitable block polymers are block pol- ymers of the A-B or A-B-A type comprising blocks of polyethylene oxide and polypropylene ox- ide, or of the A-B-C type comprising alkanol, polyethylene oxide, and polypropylene oxide. Suit- 230124 78 able polyelectrolytes are polyacids or polybases. Examples of polyacids are alkali salts of poly- acrylic acid or polyacid comb polymers. Examples of polybases are polyvinyl amines or polyeth- ylene amines. Suitable adjuvants are compounds, which have a negligible or even no pesticidal activity themselves, and which improve the biological performance of the compound I on the target. Ex- amples are surfactants, mineral or vegetable oils, and other auxiliaries. Further examples are listed by Knowles, Adjuvants and additives, Agrow Reports DS256, T&F Informa UK, 2006, chapter 5. Suitable thickeners are polysaccharides (e. g. xanthan gum, carboxymethyl cellulose), inor- ganic clays (organically modified or unmodified), polycarboxylates, and silicates. Suitable bactericides are bronopol and isothiazolinone derivatives, such as alkylisothiazoli- nones and benzisothiazolinones. Suitable anti-freezing agents are ethylene glycol, propylene glycol, urea and glycerin. Suitable anti-foaming agents are silicones, long chain alcohols, and salts of fatty acids. Suitable colorants (e. g. in red, blue, or green) are pigments of low water solubility and wa- ter-soluble dyes. Examples are inorganic colorants (e. g. iron oxide, titan oxide, iron hexacy- anoferrate) and organic colorants (e. g. alizarin-, azo- and phthalocyanine colorants). Suitable tackifiers or binders are polyvinyl pyrrolidones, polyvinyl acetates, polyvinyl alco- hols, polyacrylates, biological or synthetic waxes, and cellulose ethers. The agrochemical compositions generally comprise between 0.01 and 95 %, preferably be- tween 0.1 and 90 %, more preferably between 1 and 70 %, and in particular between 10 and 60 %, by weight of active substances (e.g. at least one compound I). The agrochemical compo- sitions generally comprise between 5 and 99.9 %, preferably between 10 and 99.9 %, more preferably between 30 and 99 %, and in particular between 40 and 90 %, by weight of at least one auxiliary. The active substances (e.g. compounds I) are employed in a purity of from 90 % to 100 %, preferably from 95-% to 100 % (according to NMR spectrum). For the purposes of treatment of plant propagation materials, particularly seeds, solutions for seed treatment (LS), Suspoemulsions (SE), flowable concentrates (FS), powders for dry treat- ment (DS), water-dispersible powders for slurry treatment (WS), water-soluble powders (SS), emulsions (ES), emulsifiable concentrates (EC), and gels (GF) are usually employed. The com- positions in question give, after two-to-tenfold dilution, active substance concentrations of from 0.01 to 60 % by weight, preferably from 0.1 to 40 %, in the ready-to-use preparations. Applica- tion can be carried out before or during sowing. Methods for applying compound I and composi- tions thereof, respectively, onto plant propagation material, especially seeds, include dressing, 230124 79 coating, pelleting, dusting, soaking, as well as in-furrow application methods. Preferably, com- pound I or the compositions thereof, respectively, are applied on to the plant propagation mate- rial by a method such that germination is not induced, e. g. by seed dressing, pelleting, coating, and dusting. Various types of oils, wetters, adjuvants, fertilizers, or micronutrients, and further pesticides (e. g. fungicides, growth regulators, herbicides, insecticides, safeners) may be added to the compounds I or the compositions thereof as premix, or, not until immediately prior to use (tank mix). These agents can be admixed with the compositions according to the invention in a weight ratio of 1:100 to 100:1, preferably 1:10 to 10:1. A pesticide is generally a chemical or biological agent (such as pestidal active ingredient, compound, composition, virus, bacterium, antimicrobial, or disinfectant) that through its effect deters, incapacitates, kills or otherwise discourages pests. Target pests can include insects, plant pathogens, weeds, mollusks, birds, mammals, fish, nematodes (roundworms), and mi- crobes that destroy property, cause nuisance, spread disease or are vectors for disease. The term “pesticide” includes also plant growth regulators that alter the expected growth, flowering, or reproduction rate of plants; defoliants that cause leaves or other foliage to drop from a plant, usually to facilitate harvest; desiccants that promote drying of living tissues, such as unwanted plant tops; plant activators that activate plant physiology for defense of against certain pests; safeners that reduce unwanted herbicidal action of pesticides on crop plants; and plant growth promoters that affect plant physiology e.g. to increase plant growth, biomass, yield or any other quality parameter of the harvestable goods of a crop plant. Biopesticides have been defined as a form of pesticides based on microorganisms (bacteria, fungi, viruses, nematodes, etc.) or natural products (compounds, such as metabolites, proteins, or extracts from biological or other natural sources) (U.S. Environmental Protection Agency: http://www.epa.gov/pesticides/biopesticides/). Biopesticides fall into two major classes, micro- bial and biochemical pesticides: (1) Microbial pesticides consist of bacteria, fungi or viruses (and often include the metabo- lites that bacteria and fungi produce). Entomopathogenic nematodes are also classified as microbial pesticides, even though they are multi-cellular. (2) Biochemical pesticides are naturally occurring substances that control pests or provide other crop protection uses as defined below, but are relatively non-toxic to mammals. Mixing the compounds I or the compositions comprising them in the use form as fungicides with other fungicides results in many cases in an expansion of the fungicidal spectrum of activity or in a prevention of fungicide resistance development. Furthermore, in many cases, synergistic 230124 80 effects are obtained (synergistic mixtures). The following list of pesticides II, in conjunction with which the compounds I can be used, is intended to illustrate the possible combinations but does not limit them: A) A) Respiration inhibitors - Inhibitors of complex III at Qo site: azoxystrobin (A.1.1), coumethoxystrobin (A.1.2), coumoxystrobin (A.1.3), dimoxystrobin (A.1.4), enestroburin (A.1.5), fenaminstrobin (A.1.6), fenoxystrobin/flufenoxystrobin (A.1.7), fluoxastrobin (A.1.8), kresoxim-methyl (A.1.9), man- destrobin (A.1.10), metominostrobin (A.1.11), orysastrobin (A.1.12), picoxystrobin (A.1.13), pyraclostrobin (A.1.14), pyrametostrobin (A.1.15), pyraoxystrobin (A.1.16), trifloxystrobin (A.1.17), 2-(2-(3-(2,6-dichlorophenyl)-1-methyl-allylideneaminooxymethyl)-phenyl)-2-methox- yimino-N-methyl-acetamide (A.1.18), pyribencarb (A.1.19), triclopyricarb/chlorodincarb (A.1.20), famoxadone (A.1.21), fenamidone (A.1.21), methyl-N-[2-[(1,4-dimethyl-5-phenyl- pyrazol-3-yl)oxylmethyl]phenyl]-N-methoxy-carbamate (A.1.22), metyltetraprole (A.1.25), (Z,2E)-5-[1-(2,4-dichlorophenyl)pyrazol-3-yl]-oxy-2-methoxyimino-N,3-dimethyl-pent-3-en- amide (A.1.34), (Z,2E)-5-[1-(4-chlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl- pent-3-enamide (A.1.35), pyriminostrobin (A.1.36), bifujunzhi (A.1.37), 2-(ortho-((2,5-dimeth- ylphenyl-oxymethylen)phenyl)-3-methoxy-acrylic acid methylester (A.1.38); - inhibitors of complex III at Qi site: cyazofamid (A.2.1), amisulbrom (A.2.2), [(6S,7R,8R)-8-benzyl-3-[(3-hydroxy-4-methoxy-pyridine-2-carbonyl)amino]-6-methyl-4,9-di- oxo-1,5-dioxonan-7-yl] 2-methylpropanoate (A.2.3), fenpicoxamid (A.2.4), florylpicoxamid (A.2.5), metarylpicoxamid (A.2.6); - inhibitors of complex II: benodanil (A.3.1), benzovindiflupyr (A.3.2), bixafen (A.3.3), boscalid (A.3.4), carboxin (A.3.5), fenfuram (A.3.6), fluopyram (A.3.7), flutolanil (A.3.8), fluxapyroxad (A.3.9), furametpyr (A.3.10), isofetamid (A.3.11), isopyrazam (A.3.12), mepronil (A.3.13), ox- ycarboxin (A.3.14), penflufen (A.3.15), penthiopyrad (A.3.16), pydiflumetofen (A.3.17), pyra- ziflumid (A.3.18), sedaxane (A.3.19), tecloftalam (A.3.20), thifluzamide (A.3.21), inpyrfluxam (A.3.22), pyrapropoyne (A.3.23), fluindapyr (A.3.28), N-[2-[2-chloro-4-(trifluoromethyl)phe- noxy]phenyl]-3-(difluoromethyl)-5-fluoro-1-methyl-pyrazole-4-carboxamide (A.3.29), methyl (E)-2-[2-[(5-cyano-2-methyl-phenoxy)methyl]phenyl]-3-methoxy-prop-2-enoate (A.3.30), isoflucypram (A.3.31), 2-(difluoromethyl)-N-(1,1,3-trimethyl-indan-4-yl)pyridine-3-carbox- amide (A.3.32), 2-(difluoromethyl)-N-[(3R)-1,1,3-trimethylindan-4-yl]pyridine-3-carboxamide (A.3.33), 2-(difluoromethyl)-N-(3-ethyl-1,1-dimethyl-indan-4-yl)pyridine-3-carboxamide (A.3.34), 2-(difluoromethyl)-N-[(3R)-3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide (A.3.35), 2-(difluoromethyl)-N-(1,1-dimethyl-3-propyl-indan-4-yl)pyridine-3-carboxamide (A.3.36), 2-(difluoromethyl)-N-[(3R)-1,1-dimethyl-3-propyl-indan-4-yl]pyridine-3-carboxamide (A.3.37), 2-(difluoromethyl)-N-(3-isobutyl-1,1-dimethyl-indan-4-yl)pyridine-3-carboxamide 230124 81 (A.3.38), 2-(difluoromethyl)-N-[(3R)-3-isobutyl-1,1-dimethyl-indan-4-yl]pyridine-3-carbox- amide (A.3.39) cyclobutrifluram (A.3.24); - other respiration inhibitors: diflumetorim (A.4.1); nitrophenyl derivates: binapacryl (A.4.2), di- nobuton (A.4.3), dinocap (A.4.4), fluazinam (A.4.5), meptyldinocap (A.4.6), ferimzone (A.4.7); organometal compounds: fentin salts, e.g. fentin-acetate (A.4.8), fentin chloride (A.4.9) or fentin hydroxide (A.4.10); ametoctradin (A.4.11); silthiofam (A.4.12); B) Sterol biosynthesis inhibitors (SBI fungicides) - C14 demethylase inhibitors: triazoles: azaconazole (B.1.1), bitertanol (B.1.2), bromucona- zole (B.1.3), cyproconazole (B.1.4), difenoconazole (B.1.5), diniconazole (B.1.6), dinicona- zole-M (B.1.7), epoxiconazole (B.1.8), fenbuconazole (B.1.9), fluquinconazole (B.1.10), flusi- lazole (B.1.11), flutriafol (B.1.12), hexaconazole (B.1.13), imibenconazole (B.1.14), ipcona- zole (B.1.15), metconazole (B.1.17), myclobutanil (B.1.18), oxpoconazole (B.1.19), paclobu- trazole (B.1.20), penconazole (B.1.21), propiconazole (B.1.22), prothioconazole (B.1.23), simeconazole (B.1.24), tebuconazole (B.1.25), tetraconazole (B.1.26), triadimefon (B.1.27), triadimenol (B.1.28), triticonazole (B.1.29), uniconazole (B.1.30), 2-(2,4-difluorophenyl)-1,1- difluoro-3-(tetrazol-1-yl)-1-[5-[4-(2,2,2-trifluoroethoxy)phenyl]-2-pyridyl]propan-2-ol (B.1.31), 2-(2,4-difluorophenyl)-1,1-difluoro-3-(tetrazol-1-yl)-1-[5-[4-(trifluoromethoxy)phenyl]-2- pyridyl]propan-2-ol (B.1.32), fluoxytioconazole (B.1.33), ipfentrifluconazole (B.1.37), mefen- trifluconazole (B.1.38), (2R)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-tria- zol-1-yl)propan-2-ol, (2S)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-triazol-1- yl)propan-2-ol, 2-(chloromethyl)-2-methyl-5-(p-tolylmethyl)-1-(1,2,4-triazol-1-ylmethyl)cyclo- pentanol (B.1.43); imidazoles: imazalil (B.1.44), pefurazoate (B.1.45), prochloraz (B.1.46), triflumizol (B.1.47); pyrimidines, pyridines, piperazines: fenarimol (B.1.49), pyrifenox (B.1.50), triforine (B.1.51), [3-(4-chloro-2-fluoro-phenyl)-5-(2,4-difluorophenyl)isoxazol-4-yl]- (3-pyridyl)methanol (B.1.52), 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-tria- zol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile (B.1.53), 2-[6-(4-bromophenoxy)-2-(trifluoromethyl)- 3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol (B.1.54), 2-[6-(4-chlorophenoxy)-2-(trifluorome- thyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol (B.1.55), methyl 2-[2-chloro-4-(4-chlorophe- noxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate (B.1.56), methyl 2-[2-chloro-4-(4- chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid (B.1.57); - Delta14-reductase inhibitors: aldimorph (B.2.1), dodemorph (B.2.2), dodemorph-acetate (B.2.3), fenpropimorph (B.2.4), tridemorph (B.2.5), fenpropidin (B.2.6), piperalin (B.2.7), spi- roxamine (B.2.8); - Inhibitors of 3-keto reductase: fenhexamid (B.3.1); - Other Sterol biosynthesis inhibitors: chlorphenomizole (B.4.1); 230124 82 C) Nucleic acid synthesis inhibitors - phenylamides or acyl amino acid fungicides: benalaxyl (C.1.1), benalaxyl-M (C.1.2), kiralaxyl (C.1.3), metalaxyl (C.1.4), metalaxyl-M (C.1.5), ofurace (C.1.6), oxadixyl (C.1.7); - other nucleic acid synthesis inhibitors: hymexazole (C.2.1), octhilinone (C.2.2), oxolinic acid (C.2.3), bupirimate (C.2.4), 5-fluorocytosine (C.2.5), 5-fluoro-2-(p-tolylmethoxy)pyrimidin- 4-amine (C.2.6), 5-fluoro-2-(4-fluorophenylmethoxy)pyrimidin-4-amine (C.2.7), 5-fluoro- 2-(4-chlorophenylmethoxy)pyrimidin-4 amine (C.2.8); D) Inhibitors of cell division and cytoskeleton - tubulin inhibitors: benomyl (D.1.1), carbendazim (D.1.2), fuberidazole (D1.3), thiabendazole (D.1.4), thiophanate-methyl (D.1.5), pyridachlometyl (D.1.6), N-ethyl-2-[(3-ethynyl-8-methyl- 6-quinolyl)oxy]butanamide (D.1.8), N-ethyl-2-[(3-ethynyl-8-methyl-6-quinolyl)oxy]-2-methyl- sulfanyl-acetamide (D.1.9), 2-[(3-ethynyl-8-methyl-6-quinolyl)oxy]-N-(2-fluoroethyl)butan- amide (D.1.10), 2-[(3-ethynyl-8-methyl-6-quinolyl)oxy]-N-(2-fluoroethyl)-2-methoxy-acetam- ide (D.1.11), 2-[(3-ethynyl-8-methyl-6-quinolyl)oxy]-N-propyl-butanamide (D.1.12), 2-[(3-ethynyl-8-methyl-6-quinolyl)oxy]-2-methoxy-N-propyl-acetamide (D.1.13), 2-[(3-ethynyl- 8-methyl-6-quinolyl)oxy]-2-methylsulfanyl-N-propyl-acetamide (D.1.14), 2-[(3-ethynyl-8-meth- yl-6-quinolyl)oxy]-N-(2-fluoroethyl)-2-methylsulfanyl-acetamide (D.1.15), 4-(2-bromo-4-fluoro- phenyl)-N-(2-chloro-6-fluoro-phenyl)-2,5-dimethyl-pyrazol-3-amine (D.1.16); - other cell division inhibitors: diethofencarb (D.2.1), ethaboxam (D.2.2), pencycuron (D.2.3), fluopicolide (D.2.4), zoxamide (D.2.5), metrafenone (D.2.6), pyriofenone (D.2.7), phenamac- ril (D.2.8); E) Inhibitors of amino acid and protein synthesis - methionine synthesis inhibitors: cyprodinil (E.1.1), mepanipyrim (E.1.2), pyrimethanil (E.1.3); - protein synthesis inhibitors: blasticidin-S (E.2.1), kasugamycin (E.2.2), kasugamycin hydro- chloride-hydrate (E.2.3), mildiomycin (E.2.4), streptomycin (E.2.5), oxytetracyclin (E.2.6); F) Signal transduction inhibitors - MAP / histidine kinase inhibitors: fluoroimid (F.1.1), iprodione (F.1.2), procymidone (F.1.3), vinclozolin (F.1.4), fludioxonil (F.1.5); - G protein inhibitors: quinoxyfen (F.2.1); G) Lipid and membrane synthesis inhibitors - Phospholipid biosynthesis inhibitors: edifenphos (G.1.1), iprobenfos (G.1.2), pyrazophos (G.1.3), isoprothiolane (G.1.4); - lipid peroxidation: dicloran (G.2.1), quintozene (G.2.2), tecnazene (G.2.3), tolclofos-methyl 230124 83 (G.2.4), biphenyl (G.2.5), chloroneb (G.2.6), etridiazole (G.2.7), zinc thiazole (G.2.8); - phospholipid biosynthesis and cell wall deposition: dimethomorph (G.3.1), flumorph (G.3.2), mandipropamid (G.3.3), pyrimorph (G.3.4), benthiavalicarb (G.3.5), iprovalicarb (G.3.6), valifenalate (G.3.7); - compounds affecting cell membrane permeability and fatty acides: propamocarb (G.4.1); - inhibitors of oxysterol binding protein: oxathiapiprolin (G.5.1), fluoxapiprolin (G.5.3), 4-[1-[2-[3-(difluoromethyl)-5-methyl-pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine- 2-carboxamide (G.5.4), 4-[1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-te- tralin-1-yl-pyridine-2-carboxamide (G.5.5), 4-[1-[2-[3-(difluoromethyl)-5-(trifluoromethyl)pyra- zol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide (G.5.6), 4-[1-[2-[5-cyclo- propyl-3-(difluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carbox- amide (G.5.7), 4-[1-[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin- 1-yl-pyridine-2-carboxamide (G.5.8), 4-[1-[2-[5-(difluoromethyl)-3-(trifluoromethyl)pyrazol- 1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide (G.5.9), 4-[1-[2-[3,5-bis(trifluo- romethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide (G.5.10), (4-[1-[2-[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyri- dine-2-carboxamide (G.5.11); H) Inhibitors with Multi Site Action - inorganic active substances: Bordeaux mixture (H.1.1), copper (H.1.2), copper acetate (H.1.3), copper hydroxide (H.1.4), copper oxychloride (H.1.5), basic copper sulfate (H.1.6), sulfur (H.1.7); - thio- and dithiocarbamates: ferbam (H.2.1), mancozeb (H.2.2), maneb (H.2.3), metam (H.2.4), metiram (H.2.5), propineb (H.2.6), thiram (H.2.7), zineb (H.2.8), ziram (H.2.9); - organochlorine compounds: anilazine (H.3.1), chlorothalonil (H.3.2), captafol (H.3.3), captan (H.3.4), folpet (H.3.5), dichlofluanid (H.3.6), dichlorophen (H.3.7), hexachlorobenzene (H.3.8), pentachlorphenole (H.3.9) and its salts, phthalide (H.3.10), tolylfluanid (H.3.11); - guanidines and others: guanidine (H.4.1), dodine (H.4.2), dodine free base (H.4.3), guazatine (H.4.4), guazatine-acetate (H.4.5), iminoctadine (H.4.6), iminoctadine-triacetate (H.4.7), iminoctadine-tris(albesilate) (H.4.8), dithianon (H.4.9), 2,6-dimethyl-1H,5H-[1,4]di- thiino[2,3-c:5,6-c']dipyrrole-1,3,5,7(2H,6H)-tetraone (H.4.10); I) Cell wall synthesis inhibitors - inhibitors of glucan synthesis: validamycin (I.1.1), polyoxin B (I.1.2); - melanin synthesis inhibitors: pyroquilon (I.2.1), tricyclazole (I.2.2), carpropamid (I.2.3), dicy- clomet (I.2.4), fenoxanil (I.2.5); 230124 84 J) Plant defence inducers - acibenzolar-S-methyl (J.1.1), probenazole (J.1.2), isotianil (J.1.3), tiadinil (J.1.4), prohexadi- one-calcium (J.1.5); phosphonates: fosetyl (J.1.6), fosetyl-aluminum (J.1.7), phosphorous acid and its salts (J.1.8), calcium phosphonate (J.1.11), potassium phosphonate (J.1.12), potassium or sodium bicarbonate (J.1.9), 4-cyclopropyl-N-(2,4-dimethoxyphenyl)thiadiazole- 5-carboxamide (J.1.10); K) Unknown mode of action - bronopol (K.1.1), chinomethionat (K.1.2), cyflufenamid (K.1.3), cymoxanil (K.1.4), dazomet (K.1.5), debacarb (K.1.6), diclocymet (K.1.7), diclomezine (K.1.8), difenzoquat (K.1.9), difen- zoquat-methylsulfate (K.1.10), diphenylamin (K.1.11), fenitropan (K.1.12), fenpyrazamine (K.1.13), flumetover (K.1.14), flumetylsulforim (K.1.60), flusulfamide (K.1.15), flutianil (K.1.16), harpin (K.1.17), methasulfocarb (K.1.18), nitrapyrin (K.1.19), nitrothal-isopropyl (K.1.20), tolprocarb (K.1.21), oxin-copper (K.1.22), proquinazid (K.1.23), seboctylamine (K.1.61), tebufloquin (K.1.24), tecloftalam (K.1.25), triazoxide (K.1.26), N’-(4-(4-chloro-3-tri- fluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-methyl formamidine (K.1.27), N’-(4-(4- fluoro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-methyl formamidine (K.1.28), N’-[4-[[3-[(4-chlorophenyl)methyl]-1,2,4-thiadiazol-5-yl]oxy]-2,5-dimethyl-phenyl]-N- ethyl-N-methyl-formamidine (K.1.29), N’-(5-bromo-6-indan-2-yloxy-2-methyl-3-pyridyl)-N- ethyl-N-methyl-formamidine (K.1.30), N’-[5-bromo-6-[1-(3,5-difluorophenyl)ethoxy]-2-methyl- 3-pyridyl]-N-ethyl-N-methyl-formamidine (K.1.31), N’-[5-bromo-6-(4-isopropylcyclohexoxy)-2- methyl-3-pyridyl]-N-ethyl-N-methyl-formamidine (K.1.32), N’-[5-bromo-2-methyl-6-(1-phe- nylethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine (K.1.33), N’-(2-methyl-5-trifluoromethyl- 4-(3-trimethylsilanyl-propoxy)-phenyl)-N-ethyl-N-methyl formamidine (K.1.34), N’-(5-difluoro- methyl-2-methyl-4-(3-trimethylsilanyl-propoxy)-phenyl)-N-ethyl-N-methyl formamidine (K.1.35), 2-(4-chloro-phenyl)-N-[4-(3,4-dimethoxy-phenyl)-isoxazol-5-yl]-2-prop-2-ynyloxy- acetamide (K.1.36), 3-[5-(4-chloro-phenyl)-2,3-dimethyl-isoxazolidin-3-yl]-pyridine (pyrisoxa- zole) (K.1.37), 3-[5-(4-methylphenyl)-2,3-dimethyl-isoxazolidin-3-yl]-pyridine (K.1.38), 5- chloro-1-(4,6-dimethoxy-pyrimidin-2-yl)-2-methyl-1H-benzoimidazole (K.1.39), ethyl (Z)-3-amino-2-cyano-3-phenyl-prop-2-enoate (K.1.40), picarbutrazox (K.1.41), pentyl N-[6- [[(Z)-[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate (K.1.42), but-3-ynyl N-[6-[[(Z)-[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2- pyridyl]carbamate (K.1.43), ipflufenoquin (K.1.44), quinofumelin (K.1.47), benziothiazolinone (K.1.48), bromothalonil (K.1.49), 2-(6-benzyl-2-pyridyl)quinazoline (K.1.50), 2-[6-(3-fluoro- 4-methoxy-phenyl)-5-methyl-2-pyridyl]quinazoline (K.1.51), dichlobentiazox (K.1.52), N’-(2,5- dimethyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine (K.1.53), aminopyrifen (K.1.54), fluopimomide (K.1.55), N'-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N- 230124 85 ethyl-N-methyl-formamidine (K.1.56), N'-[4-(4,5-dichlorothiazol-2-yl)oxy-2,5-dimethyl-phe- nyl]-N-ethyl-N-methyl-formamidine (K.1.57), flufenoxadiazam (K.1.58), N-methyl-4-[5-(trifluo- romethyl)-1,2,4-oxadiazol-3-yl]benzenecarbothioamide (K.1.59), N-methoxy-N-[[4-[5-(trifluo- romethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide (K.1.60; WO2018/177894, WO 2020/212513), N-((4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phe- nyl)methyl)propanamide (K.1.62), 3,3,3-trifluoro-N-[[3-fluoro-4-[5-(trifluoromethyl)-1,2,4- oxadiazol-3-yl]phenyl]methyl]propanamide (K.1.63), 3,3,3-trifluoro-N-[[2-fluoro-4-[5-(trifluoro- methyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide (K.1.64), N-[2,3-difluoro-4-[5-(tri- fluoromethyl)-1,2,4-oxadiazol-3-yl]benzyl]butanamide (K.1.65), N-[[2,3-difluoro-4-[5-(trifluoro- methyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-3,3,3-trifluoro-propanamide (K.1.66), 1-methoxy- 1-methyl-3-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.67), 1,1-di- ethyl-3-[[4-[5-[trifluoromethyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.68), N,2-di- methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide (K.1.69), N-ethyl-2-methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide (K.1.70), 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]me- thyl]urea (K.1.71), 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2- one (K.1.72), 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]piperidin-2-one (K.1.73), 4-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]morpholin-3-one (K.1.74), 4,4-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazoli- din-3-one (K.1.75), 2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin- 3-one (K.1.76), 5,5-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]- isoxazolidin-3-one (K.1.77), 3,3-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phen- yl]methyl]piperidin-2-one (K.1.78), 2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]meth- yl]oxazinan-3-one (K.1.79), 1-[[3-fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]me- thyl]azepan-2-one (K.1.80), 4,4-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phe- nyl]methyl]pyrrolidin-2-one (K.1.81), 5-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol- 3-yl]phenyl]methyl]pyrrolidin-2-one (K.1.82), ethyl 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol- 3-yl]phenyl]methyl]pyrazole-4-carboxylate (K.1.83), N-methyl-1-[[4-[5-(trifluoromethyl)- 1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide (K.1.84), N,N-dimethyl- 1-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzyl]-1H-1,2,4-triazol-3-amine (K.1.85), N-methoxy-N-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole- 4-carboxamide (K.1.86), propyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]- pyrazole-4-carboxamide (K.1.87), N-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol- 3-yl]phenyl]methyl]pyrazole-4-carboxamide (K.1.88), N-allyl-N-[[4-[5-(trifluoromethyl)- 1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide (K.1.89), 3-ethyl-1-methoxy-1-[[4-[5-(trifluo- romethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.90), 1,3-dimethoxy-1-[[4-[5-(trifluoro- methyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.91), N-allyl-N-[[4-[5-(trifluoromethyl)- 230124 86 1,2,4-oxadiazol-3-yl]phenyl]methyl]acetamide (K.1.92), N-[4-[5-(trifluoromethyl)-1,2,4-oxadia- zol-3-yl]benzyl]cyclopropanecarboxamide (K.1.93), 1-methyl-3-[[4-[5-(trifluoromethyl)-1,2,4- oxadiazol-3-yl]phenyl]methyl]urea (K.1.94), N'-[2-chloro-4-(2-fluorophenoxy)-5-methyl-phe- nyl]-N-ethyl-N-methyl-formamidine (K.1.95), N'-[2-chloro-4-[(4-methoxy-phenyl)methyl]-5- methyl-phenyl]-N-ethyl-N-methyl-formamidine (K.1.96), N'-[2-chloro-4-[(4-cyano-phenyl)me- thyl]-5-methyl-phenyl]-N-ethyl-N-methyl-formamidine (K.1.97), N'-[2,5-dimethyl-4-(o-tolylme- thyl)phenyl]-N-ethyl-N-methyl-formamidine (K.1.98), 6-chloro-3-(3-cyclopropyl-2-fluoro-phe- noxy)-N-[2-(2,4-dimethylphenyl)-2,2-difluoro-ethyl]-5-methyl-pyridazine-4-carboxamide (K.1.99), 3-(3-bromo-2-fluoro-phenoxy)-6-chloro-N-[2-(2-chloro-4-methyl-phenyl)-2,2- difluoro-ethyl]-5-methyl-pyridazine-4-carboxamide (K.1.100), 6-chloro-N-[2-(2-chloro-4-me- thyl-phenyl)-2,2-difluoro-ethyl]-3-(3-cyclopropyl-2-fluoro-phenoxy)-5-methyl-pyridazine-4-car- boxamide (K.1.101), 6-chloro-3-(3-cyclopropyl-2-fluoro-phenoxy)-N-[2-(3,4-dimethylphenyl)- 2,2-difluoro-ethyl]-5-methyl-pyridazine-4-carboxamide (K.1.102), 6-chloro-3-(3-chloro-2- fluoro-phenoxy)-N-[2-(2,4-dimethylphenyl)-2,2-difluoro-ethyl]-5-methyl-pyridazine-4-carbox- amide (K.1.103), N-[2-(2-bromo-4-methyl-phenyl)-2,2-difluoro-ethyl]-6-chloro-3-(3-cyclopro- pyl-2-fluoro-phenoxy)-5-methyl-pyridazine-4-carboxamide (K.1.104); L) Biopesticides L1)Microbial pesticides with fungicidal, bactericidal, viricidal and/or plant defense activator activ- ity: Ampelomyces quisqualis, Aspergillus flavus, Aureobasidium pullulans, Bacillus altitudi- nis, B. amyloliquefaciens, B. amyloliquefaciens ssp. plantarum (also referred to as B. vele- zensis), B. megaterium, B. mojavensis, B. mycoides, B. pumilus, B. simplex, B. solisalsi, B. subtilis, B. subtilis var. amyloliquefaciens, B. velezensis, Candida oleophila, C. saitoana, Clavibacter michiganensis (bacteriophages), Coniothyrium minitans, Cryphonectria parasit- ica, Cryptococcus albidus, Dilophosphora alopecuri, Fusarium oxysporum, Clonostachys rosea f. catenulate (also named Gliocladium catenulatum), Gliocladium roseum, Lysobacter antibioticus, L. enzymogenes, Metschnikowia fructicola, Microdochium dimerum, Micro- sphaeropsis ochracea, Muscodor albus, Paenibacillus alvei, Paenibacillus epiphyticus, P. polymyxa, Pantoea vagans, Penicillium bilaiae, Phlebiopsis gigantea, Pseudomonas sp., Pseudomonas chloraphis, Pseudozyma flocculosa, Pichia anomala, Pythium oligandrum, Sphaerodes mycoparasitica, Streptomyces griseoviridis, S. lydicus, S. violaceusniger, Tala- romyces flavus, Trichoderma asperelloides, T. asperellum, T. atroviride, T. fertile, T. gamsii, T. harmatum, T. harzianum, T. polysporum, T. stromaticum, T. virens, T. viride, Typhula pha- corrhiza, Ulocladium oudemansii, Verticillium dahlia, zucchini yellow mosaic virus (avirulent strain); L2) Biochemical pesticides with fungicidal, bactericidal, viricidal and/or plant defense activator activity: harpin protein, Reynoutria sachalinensis extract; 230124 87 L3) Microbial pesticides with insecticidal, acaricidal, molluscidal and/or nematicidal activity: Ag- robacterium radiobacter, Bacillus cereus, B. firmus, B. thuringiensis, B. thuringiensis ssp. ai- zawai, B. t. ssp. israelensis, B. t. ssp. galleriae, B. t. ssp. kurstaki, B. t. ssp. tenebrionis, Beauveria bassiana, B. brongniartii, Burkholderia spp., Chromobacterium subtsugae, Cydia pomonella granulovirus (CpGV), Cryptophlebia leucotreta granulovirus (CrleGV), Flavobac- terium spp., Helicoverpa armigera nucleopolyhedrovirus (HearNPV), Helicoverpa zea nucle- opolyhedrovirus (HzNPV), Helicoverpa zea single capsid nucleopolyhedrovirus (HzSNPV), Heterorhabditis bacteriophora, Isaria fumosorosea, Lecanicillium longisporum, L. musca- rium, Metarhizium anisopliae, M. anisopliae var. anisopliae, M. anisopliae var. acridum, Nomuraea rileyi, Paecilomyces fumosoroseus, P. lilacinus, Paenibacillus popilliae, Pasteuria spp., P. nishizawae, P. penetrans, P. ramosa, P. thornea, P. usgae, Pseudomonas fluo- rescens, Spodoptera littoralis nucleopolyhedrovirus (SpliNPV), Steinernema carpocapsae, S. feltiae, S. kraussei, Streptomyces galbus, S. microflavus; L4) Biochemical pesticides with insecticidal, acaricidal, molluscidal, pheromone and/or nemati- cidal activity: L-carvone, citral, (E,Z)-7,9-dodecadien-1-yl acetate, ethyl formate, (E,Z)-2,4- ethyl decadienoate (pear ester), (Z,Z,E)-7,11,13-hexadecatrienal, heptyl butyrate, isopropyl myristate, lavanulyl senecioate, cis-jasmone, 2-methyl 1-butanol, methyl eugenol, methyl jasmonate, (E,Z)-2,13-octadecadien-1-ol, (E,Z)-2,13-octadecadien-1-ol acetate, (E,Z)-3,13- octadecadien-1-ol, (R)-1-octen-3-ol, pentatermanone, (E,Z,Z)-3,8,11-tetradecatrienyl ace- tate, (Z,E)-9,12-tetradecadien-1-yl acetate, (Z)-7-tetradecen-2-one, (Z)-9-tetradecen-1-yl ac- etate, (Z)-11-tetradecenal, (Z)-11-tetradecen-1-ol, extract of Chenopodium ambrosiodes, Neem oil, Quillay extract; L5) Microbial pesticides with plant stress reducing, plant growth regulator, plant growth promot- ing and/or yield enhancing activity: Azospirillum amazonense, A. brasilense, A. lipoferum, A. irakense, A. halopraeferens, Bradyrhizobium spp., B. elkanii, B. japonicum, B. liaoningense, B. lupini, Delftia acidovorans, Glomus intraradices, Mesorhizobium spp., Rhizobium legumi- nosarum bv. phaseoli, R. l. bv. trifolii, R. l. bv. viciae, R. tropici, Sinorhizobium meliloti; O) Insecticides from classes O.1 to O.29 O.1 Acetylcholine esterase (AChE) inhibitors: aldicarb, alanycarb, bendiocarb, benfuracarb, bu- tocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetanate, furathiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, propoxur, thiodicarb, thiofanox, trimethacarb, XMC, xylylcarb, triazamate; acephate, aza- methiphos, azinphos-ethyl, azinphosmethyl, cadusafos, chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos, chlorpyrifos-methyl, coumaphos, cyanophos, demeton-S-methyl, diazinon, dichlorvos/ DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, famphur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, 230124 88 imicyafos, isofenphos, isopropyl O-(methoxyaminothio-phosphoryl) salicylate, isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosa- lone, phosmet, phosphamidon, phoxim, pirimiphos- methyl, profenofos, propetamphos, pro- thiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, trichlorfon, vamidothion; O.2 GABA-gated chloride channel antagonists: endosulfan, chlordane; ethiprole, fipronil, flufiprole, pyrafluprole, pyriprole; O.3 Sodium channel modulators: acrinathrin, allethrin, d-cis-trans allethrin, d-trans allethrin, bifenthrin, kappa-bifenthrin, bioallethrin, bioallethrin S-cylclopentenyl, bioresmethrin, cyclo- prothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cy- permethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, empenthrin, esfenvalerate, etofenprox, fenpropathrin, fen- valerate, flucythrinate, flumethrin, tau-fluvalinate, halfenprox, heptafluthrin, imiprothrin, me- perfluthrin, metofluthrin, momfluorothrin, epsilon-momfluorothrin, permethrin, phenothrin, prallethrin, profluthrin, pyrethrin (pyrethrum), resmethrin, silafluofen, tefluthrin, kappa-tefluth- rin, tetramethylfluthrin, tetramethrin, tralomethrin, transfluthrin; DDT, methoxychlor; O.4 Nicotinic acetylcholine receptor (nAChR) agonists: acetamiprid, clothianidin, cycloxaprid, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam; 4,5-dihydro-N-nitro- 1-(2-oxiranylmethyl)-1H-imidazol-2-amine, (2E)-1-[(6-chloropyridin-3-yl)methyl]-N’-nitro- 2-pentylidenehydrazinecarboximidamide; 1-[(6-chloropyridin-3-yl)methyl]-7-methyl-8-nitro- 5-propoxy-1,2,3,5,6,7-hexahydroimidazo[1,2-a]pyridine; nicotine; sulfoxaflor, flupyradifurone, triflumezopyrim, fenmezoditiaz, flupyrimin; O.5 Nicotinic acetylcholine receptor allosteric activators: spinosad, spinetoram; O.6 Chloride channel activators: abamectin, emamectin benzoate, ivermectin, lepimectin, milbe- mectin; O.7 Juvenile hormone mimics: hydroprene, kinoprene, methoprene; fenoxycarb, pyriproxyfen; O.8 miscellaneous non-specific (multi-site) inhibitors: methyl bromide and other alkyl halides; chloropicrin, sulfuryl fluoride, borax, tartar emetic; O.9 Chordotonal organ TRPV channel modulators: afidopyropen, pymetrozine, pyrifluquinazon; O.10 Mite growth inhibitors: clofentezine, hexythiazox, diflovidazin; etoxazole; O.11 Microbial disruptors of insect midgut membranes: Bacillus thuringiensis, B. sphaericus and the insecticdal proteins they produce: Bacillus thuringiensis subsp. israelensis, B. sphaeri- cus, B. thuringiensis subsp. aizawai, B. thuringiensis subsp. kurstaki, B. thuringiensis subsp. 230124 89 tenebrionis, the Bt crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, Cry34/35Ab1; O.12 Inhibitors of mitochondrial ATP synthase: diafenthiuron; azocyclotin, cyhexatin, fenbutatin oxide, propargite, tetradifon; O.13 Uncouplers of oxidative phosphorylation via disruption of the proton gradient: chlorfenapyr, DNOC, sulfluramid; O.14 Nicotinic acetylcholine receptor (nAChR) channel blockers: bensultap, cartap hydrochlo- ride, thiocyclam, thiosultap sodium; O.15 Inhibitors of the chitin biosynthesis type 0: bistrifluron, chlorfluazuron, diflubenzuron, flu- cycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron; O.16 Inhibitors of the chitin biosynthesis type 1: buprofezin; O.17 Moulting disruptors: cyromazine; O.18 Ecdyson receptor agonists: methoxyfenozide, tebufenozide, halofenozide, fufenozide, chromafenozide; O.19 Octopamin receptor agonists: amitraz; O.20 Mitochondrial complex III electron transport inhibitors: hydramethylnon, acequinocyl, fluacrypyrim, bifenazate; O.21 Mitochondrial complex I electron transport inhibitors: fenazaquin, fenpyroximate, pyrim- idifen, pyridaben, tebufenpyrad, tolfenpyrad; rotenone; O.22 Voltage-dependent sodium channel blockers: indoxacarb, metaflumizone, 2-[2-(4-cyano- phenyl)-1-[3-(trifluoromethyl)phenyl]ethylidene]-N-[4-(difluoromethoxy)phenyl]-hydrazinecar- boxamide, N-(3-chloro-2-methylphenyl)-2-[(4-chlorophenyl)-[4-[methyl(methylsulfonyl)- amino]phenyl]methylene]-hydrazinecarboxamide, N-[4-chloro-2-[[(1,1-dimethylethyl)ami- no]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-3-(fluoromethoxy)-1H-pyrazole-5-car- boxamide, 2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylidene]-N-[4-(difluorometh- oxy)phenyl]-hydrazinecarboxamide; O.23 Inhibitors of the of acetyl CoA carboxylase: spirodiclofen, spiromesifen, spirotetramat, spi- ropidion, spirobudifen, 11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-aza- dispiro[4.2.4.2]tetradec-11-en-10-one, spidoxamat; O.24 Mitochondrial complex IV electron transport inhibitors: aluminium phosphide, calcium phosphide, phosphine, zinc phosphide, cyanide; 230124 90 O.25 Mitochondrial complex II electron transport inhibitors: cyenopyrafen, cyflumetofen, cy- etpyrafen, pyflubumide; O.28 Ryanodine receptor-modulators: chlorantraniliprole, cyantraniliprole, cyclaniliprole, fluben- diamide, fluchlodiniliprole, (R)-3-chloro-N1-{2-methyl-4-[1,2,2,2 –tetrafluoro-1-(trifluorometh- yl)ethyl]phenyl}-N2-(1-methyl-2-methylsulfonylethyl)phthalamide, (S)-3-chloro-N1-{2-methyl- 4-[1,2,2,2–tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}-N2-(1-methyl-2-methylsulfonylethyl)- phthalamide, methyl-2-[3,5-dibromo-2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]- carbonyl}amino)benzoyl]-1,2-dimethylhydrazinecarboxylate; N-[4,6-dichloro-2-[(diethyl- lambda-4-sulfanylidene)carbamoyl]-phenyl]-2-(3-chloro-2-pyridyl)-5-(trifluoromethyl)pyrazole- 3-carboxamide; N-[4-chloro-2-[(diethyl-lambda-4-sulfanylidene)carbamoyl]-6-methyl-phenyl]- 2-(3-chloro-2-pyridyl)-5-(trifluoromethyl)pyrazole-3-carboxamide; N-[2-(5-amino-1,3,4-thiadi- azol-2-yl)-4-chloro-6-methylphenyl]-3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carbox- amide; 3-chloro-1-(3-chloro-2-pyridinyl)-N-[2,4-dichloro-6-[[(1-cyano-1-meth- ylethyl)amino]carbonyl]phenyl]-1H-pyrazole-5-carboxamide; tetrachlorantraniliprole; tetraniliprole; tiorantraniliprole; N-[4-chloro-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-meth- ylphenyl]-1-(3-chloro-2-pyridinyl)-3-(fluoromethoxy)-1H-pyrazole-5-carboxamide; cyhalodi- amide; N-[2-(5-amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methylphenyl]-3-bromo-1-(3-chloro-2- pyridinyl)-1H-pyrazole-5-carboxamide; O.29 Chordotonal organ modulators: flonicamid; O.30 GABA-gated chloride channel allosteric modulators: broflanilide, fluxametamide, isocyclo- seram; O.33 Calcium-activated potassium channel modulators: acynonapyr; O.34 Mitochondrial complex III electron transport inhibitors at Qi site: flometoquin; O.UN Insecticidal compounds of unknown or uncertain mode of action: afoxolaner, azadirachtin, amidoflumet, ben-zoximate, bromopropylate, chino¬methionat, cryolite, cyproflanilid, dicloro- mezotiaz, dicofol, dimpropyridaz, flufenerim, flometoquin, fluensulfone, fluhexafon, fluopy- ram, fluralaner, metaldehyde, metoxadiazone, piperonyl butoxide, pyridalyl, tioxazafen, triflu- enfuronate, umifoxolaner, 11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-aza- dispiro[4.2.4.2]-tetradec-11-en-10-one, 3-(4’-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8- oxa-1-azaspiro[4.5]dec-3-en-2-one, 4-cyano-N-[2-cyano-5-[[[2,6-dibromo-4-[1,2,2,3,3,3-hex- afluoro-1-(trifluoromethyl)propyl]phenyl]amino]carbonyl]phenyl]-2-methyl-benzamide, 4-cy- ano-3-[(4-cyano-2-methyl-benzoyl)amino]-N-[2,6-dichloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluo- romethyl)propyl]phenyl]-2-fluoro-benzamide, N-[5-[[[2-chloro-6-cyano-4-[1,2,2,3,3,3-hex- afluoro-1-(trifluoromethyl)propyl]phenyl]amino]carbonyl]-2-cyano-phenyl]-4-cyano-2-methyl- benzamide, N-[5-[[[2-bromo-6-chloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phe- nyl]amino]carbonyl]-2-cyano-phenyl]-4-cyano-2-methyl-benzamide, N-[5-[[[2-bromo-6-chloro- 230124 91 4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl]phenyl]amino]carbonyl]-2-cyano-phenyl]- 4-cyano-2-methyl-benzamide, 4-cyano-N-[2-cyano-5-[[[2,6-dichloro-4-[1,2,2,3,3,3-hex- afluoro-1-(trifluoromethyl)propyl]phenyl]amino]carbonyl]phenyl]-2-methyl-benzamide, 1-[2- fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl]-3-(trifluoromethyl)-1H-1,2,4-triazole-5- amine, N-[5-[[[2-bromo-6-chloro-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phe- nyl]amino]carbonyl]-2-cyano-phenyl]-4-cyano-2-methyl-benzamide, 4-cyano-N-[2-cyano-5- [[[2,6-dichloro-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]phenyl]-2- methyl-benzamide, actives on basis of Bacillus firmus (Votivo, I-1582); fluazaindolizine; 5-[3-[2,6-dichloro-4-(3,3-dichloroallyloxy)phenoxy]propoxy]-1H-pyrazole; N-[5-[[2-bromo-6- chloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)-propyl]phenyl]carbamoyl]-2-cyano-phe- nyl]-4-cyano-2-methyl-benzamide; 4-cyano-N-[2-cyano-5-[[2,6-dichloro-4-[1,2,2,3,3,3-hex- afluoro-1-(trifluoromethyl)-propyl]phenyl]carbamoyl]phenyl]-2-methyl-benzamide; 4-cyano- N-[2-cyano-5-[[2,6-dichloro-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]carba- moyl]¬phenyl]-2-methyl-benzamide; N-[5-[[2-bromo-6-chloro-4-[1,2,2,2-tetrafluoro-1-(trifluo- romethyl)ethyl]phenyl]carba¬moyl]-2-cyano-phenyl]-4-cyano-2-methyl-benzamide; 2-(1,3- dioxan-2-yl)-6-[2-(3-pyridinyl)-5-thiazolyl]-pyridine; 2-[6-[2-(5-fluoro-3-pyridinyl)-5-thiazo¬lyl]- 2-pyridinyl]-pyrimidine; 2-[6-[2-(3-pyridinyl)-5-thiazolyl]-2-pyridinyl]-pyrimidine; N-methyl- sul¬fonyl-6-[2-(3-pyridyl)thiazol-5-yl]pyridine-2-carboxamide; N-methylsulfonyl-6-[2-(3- pyridyl)thiazol-5-yl]pyridine-2-carboxamide; 1-[(6-chloro-3-pyridinyl)methyl]-1,2,3,5,6,7-hexa- hydro-5-methoxy-7-methyl-8-nitro-imidazo[1,2-a]pyridine; 1-[(6-chloropyridin-3-yl)methyl]-7- methyl-8-nitro-1,2,3,5,6,7-hexahydroimidazo[1,2-a]pyridin-5-ol; N-(3-chloro-2-methylphenyl)- 2-[(4-chlorophenyl)[4-[methyl(methylsulfonyl)amino]phenyl]methylene]-hydrazinecarbox- amide; 1-[(6-chloro-3-pyridinyl)methyl]-1,2,3,5,6,7-hexahydro-5-methoxy-7-methyl-8-nitro- imidazo[1,2-a]pyridine; 2-(3-pyridinyl)-N-(2-pyrimidinylmethyl)-2H-indazole-5-carboxamide; tyclopyrazoflor; sarolaner, lotilaner; N-[4-chloro-3-[[(phenylmethyl)amino]carbonyl]phenyl]-1- methyl-3-(1,1,2,2,2-pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; N-[4- chloro-3-[[(phenylmethyl)amino]carbonyl]phenyl]-1-methyl-3-(1,1,2,2,2-pentafluoroethyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; 2-(3-ethylsulfonyl-2-pyridyl)-3-methyl-6-(tri-flu- oromethyl)imidazo[4,5-b]pyridine, 2-[3-ethylsulfonyl-5-(trifluoromethyl)-2-pyridyl]-3-methyl-6- (trifluoromethyl)imidazo[4,5-b]pyridine; N-[4-chloro-3-(cyclopropylcarbamoyl)phenyl]-2-me- thyl-5-(1,1,2,2,2-pentafluoroethyl)-4-(trifluoromethyl)pyrazole-3-carboxamide, N-[4-chloro-3- [(1-cyanocyclopropyl)carbamoyl]phenyl]-2-methyl-5-(1,1,2,2,2-pentafluoroethyl)-4-(trifluoro- methyl)pyrazole-3-carboxamide; benzpyrimoxan; tigolaner; oxazosulfyl; [(2S,3R,4R,5S,6S)- 3,5-dimethoxy-6-methyl-4-propoxy-tetrahydropyran-2-yl]-N-[4-[1-[4-(trifluoromethoxy)phenyl]- 1,2,4-triazol-3-yl]phenyl]carbamate; [(2S,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyl-tetrahy- dropyran-2-yl]-N-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]carbamate; [(2S,3R,4R,5S,6S)-3,5-dimethoxy-6-methyl-4-propoxy-tetrahydropyran-2-yl]-N-[4-[1-[4- (1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]carbamate; [(2S,3R,4R,5S,6S)- 230124 92 3,4,5-trimethoxy-6-methyl-tetrahydropyran-2-yl]-N-[4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phe- nyl]-1,2,4-triazol-3-yl]phenyl]carbamate; (2Z)-3-(2-isopropylphenyl)-2-[(E)-[4-[1-[4-(trifluoro- methoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]methylenehydrazono]thiazolidin-4-one, (2Z)-3-(2- isopropylphenyl)-2-[(E)-[4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazol-3-yl]phe- nyl]methylenehydrazono]thiazolidin-4-one, (2Z)-3-(2-isopro¬pyl¬phenyl)-2-[(E)-[4-[1-[4- (1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]methylenehydrazono]thiazoli- din-4-one; 2-(6-chloro-3-ethylsulfonyl-imidazo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluorome- thyl)imidazo[4,5-b]pyridine, 2-(6-bromo-3-ethylsulfonyl-imidazo[1,2-a]pyridin-2-yl)-3-methyl- 6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-(3-ethylsulfonyl-6-iodo-imidazo[1,2-a]pyridin-2- yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-(7-chloro-3-ethylsulfonyl-imid- azo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-(7-chloro-3-ethyl- sulfonyl-imidazo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-(3- ethylsulfonyl-7-iodo-imidazo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyri- dine, 3-ethylsulfonyl-6-iodo-2-[3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridin-2-yl]imid- azo[1,2-a]pyridine-8-carbonitrile, 2-[3-ethylsulfonyl-8-fluoro-6-(trifluoromethyl)imidazo[1,2- a]pyridin-2-yl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-[3-ethylsulfonyl-7-(trifluo- romethyl)imidazo[1,2-a]pyridin-2-yl]-3-methyl-6-(trifluoromethylsulfinyl)imidazo[4,5-b]pyri- dine, 2-[3-ethylsulfonyl-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-3-methyl-6-(trifluorome- thyl)imidazo[4,5-c]pyridine, 2-(6-bromo-3-ethylsulfonyl-imidazo[1,2-a]pyridin-2-yl)-6-(trifluoro- methyl)pyrazolo[4,3-c]pyridine; N-[[2-fluoro-4-[(2S,3S)-2-hydroxy-3-(3,4,5-trichlorophenyl)-3- (trifluoromethyl)pyrrolidin-1-yl]phenyl]methyl]cyclopropanecarboxamide; 2-[2-fluoro-4-methyl- 5-(2,2,2-trifluoroethylsulfinyl)phenyl]imino-3-(2,2,2-trifluoroethyl)thiazolidin-4-one; flupenti- ofenox, N-[3-chloro-1-(3-pyridyl)pyrazol-4-yl]-2-methylsulfonyl-propanamide, cyclobutriflu- ram; N-[4-chloro-3-[(1-cyanocyclopropyl)carbamoyl]phenyl]-2-methyl-4-methylsulfonyl-5- (1,1,2,2,2-pentafluoroethyl)pyrazole-3-carboxamide, cyproflanilide, nicofluprole; 1,4-dime- thyl-2-[2-(pyridin-3-yl)-2H-indazol-5-yl]-1,2,4-triazolidine-3,5-dione, 2-[2-fluoro-4-methyl-5- (2,2,2-trifluoroethylsulfanyl)phenyl]imino-3-(2,2,2-trifluoroethyl)thiazolidin-4-one, indazapy- roxamet, N-[4-chloro-2-(3-pyridyl)thiazol-5-yl]-N-ethyl-3-methylsulfonyl-propanamide, N-cy- clopropyl-5-[(5S)-5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]isoquin- oline-8-carboxamide, 5-[(5S)-5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H-isoxazol- 3-yl]-N-(pyrimidin-2-ylmethyl)isoquinoline-8-carboxamide, N-[1-(2,6-difluorophenyl)pyrazol-3- yl]-2-(trifluoromethyl)benzamide, 5-((1R,3R)-3-(3,5-bis(trifluoromethyl)phenyl)-2,2-dichlorocy- clopropane-1-carboxamido)-2-chloro-N-(3-(2,2-difluoroacetamido)-2,4-difluorophenyl)ben- zamide, 1-[6-(2,2-difluoro-7-methyl-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-5-ethylsulfonyl-3- pyridyl]cyclopropanecarbonitrile, 6-(5-cyclopropyl-3-ethylsulfonyl-2-pyridyl)-2,2-difluoro- 7-methyl-[1,3]dioxolo[4,5-f]benzimidazole. The active substances referred to as component 2, their preparation and their activity e. g. 230124 93 against harmful fungi is known (cf.: http://www.alanwood.net/pesticides/); these substances are commercially available. The compounds described by IUPAC nomenclature, their preparation and their pesticidal activity are also known (cf. Can. J. Plant Sci.48(6), 587-94, 1968; EP-A 141317; EP-A 152031; EP-A 226917; EP-A 243970; EP-A 256503; EP-A 428941; EP-A 532022; EP-A 1028125; EP-A 1035122; EP-A 1201648; EP-A 1122244, JP 2002316902; DE 19650197; DE 10021412; DE 102005009458; US 3,296,272; US 3,325,503; WO 98/46608; WO 99/14187; WO 99/24413; WO 99/27783; WO 00/29404; WO 00/46148; WO 00/65913; WO 01/54501; WO 01/56358; WO 02/22583; WO 02/40431; WO 03/10149; WO 03/11853; WO 03/14103; WO 03/16286; WO 03/53145; WO 03/61388; WO 03/66609; WO 03/74491; WO 04/49804; WO 04/83193; WO 05/120234; WO 05/123689; WO 05/123690; WO 05/63721; WO 05/87772; WO 05/87773; WO 06/15866; WO 06/87325; WO 06/87343; WO 07/82098; WO 07/90624, WO 10/139271, WO 11/028657, WO 12/168188, WO 07/006670, WO 11/77514; WO 13/047749, WO 10/069882, WO 13/047441, WO 03/16303, WO 09/90181, WO 13/007767, WO 13/010862, WO 13/127704, WO 13/024009, WO 13/24010, WO 13/047441, WO 13/162072, WO 13/092224, WO 11/135833, CN 1907024, CN 1456054, CN 103387541, CN 1309897, WO 12/84812, CN 1907024, WO 09094442, WO 14/60177, WO 13/116251, WO 08/013622, WO 15/65922, WO 94/01546, EP 2865265, WO 07/129454, WO 12/165511, WO 11/081174, WO 13/47441, WO 16/156241, WO 16/162265). Some com- pounds are identified by their CAS Registry Number which is separated by hyphens into three parts, the first consisting from two up to seven digits, the second consisting of two digits, and the third consisting of a single digit. According to the invention, the solid material (dry matter) of the biopesticides (with the ex- ception of oils such as Neem oil) are considered as active components (e. g. to be obtained af- ter drying or evaporation of the extraction or suspension medium in case of liquid formulations of the microbial pesticides). The weight ratios and percentages used for a biological extract such as Quillay extract are based on the total weight of the dry content (solid material) of the re- spective extract(s). The total weight ratios of compositions comprising at least one microbial pesticide in the form of viable microbial cells including dormant forms, can be determined using the amount of CFU of the respective microorganism to calculate the total weight of the respective active component with the following equation that 1 x 1010 CFU equals one gram of total weight of the respective active component. Colony forming unit is measure of viable microbial cells. In addition, CFU may also be understood as the number of (juvenile) individual nematodes in case of nematode biopesticides, such as Steinernema feltiae. In the binary mixtures the weight ratio of the component 1) and the component 2) generally 230124 94 depends from the properties of the components used, usually it is in the range of from 1:10,000 to 10,000:1, often from 1:100 to 100:1, regularly from 1:50 to 50:1, preferably from 1:20 to 20:1, more preferably from 1:10 to 10:1, even more preferably from 1:4 to 4:1 and in particular from 1:2 to 2:1. According to further embodiments, the weight ratio of the component 1) and the com- ponent 2) usually is in the range of from 1000:1 to 1:1, often from 100: 1 to 1:1, regularly from 50:1 to 1:1, preferably from 20:1 to 1:1, more preferably from 10:1 to 1:1, even more preferably from 4:1 to 1:1 and in particular from 2:1 to 1:1. According to further embodiments, the weight ratio of the component 1) and the component 2) usually is in the range of from 20,000:1 to 1:10, often from 10,000:1 to 1:1, regularly from 5,000:1 to 5:1, preferably from 5,000:1 to 10:1, more preferably from 2,000:1 to 30:1, even more preferably from 2,000:1 to 100:1 and in particular from 1,000:1 to 100:1. According to further embodiments, the weight ratio of the component 1) and the component 2) usually is in the range of from 1:1 to 1:1000, often from 1:1 to 1:100, reg- ularly from 1:1 to 1:50, preferably from 1:1 to 1:20, more preferably from 1:1 to 1:10, even more preferably from 1:1 to 1:4 and in particular from 1:1 to 1:2. According to further embodiments, the weight ratio of the component 1) and the component 2) usually is in the range of from 10:1 to 1:20,000, often from 1:1 to 1:10,000, regularly from 1:5 to 1:5,000, preferably from 1:10 to 1:5,000, more preferably from 1:30 to 1:2,000, even more preferably from 1:100 to 1:2,000 to and in particular from 1:100 to 1:1,000. In the ternary mixtures, i.e. compositions comprising the component 1) and component 2) and a compound III (component 3), the weight ratio of component 1) and component 2) de- pends from the properties of the active substances used, usually it is in the range of from 1:100 to 100:1, regularly from 1:50 to 50:1, preferably from 1:20 to 20:1, more preferably from 1:10 to 10:1 and in particular from 1:4 to 4:1, and the weight ratio of component 1) and component 3) usually it is in the range of from 1:100 to 100:1, regularly from 1:50 to 50:1, preferably from 1:20 to 20:1, more preferably from 1:10 to 10:1 and in particular from 1:4 to 4:1. Any further active components are, if desired, added in a ratio of from 20:1 to 1:20 to the component 1). These ra- tios are also suitable for mixtures applied by seed treatment. When mixtures comprising microbial pesticides are employed in crop protection, the applica- tion rates range from 1 x 106 to 5 x 1016 (or more) CFU/ha, preferably from 1 x 108 to 1 x 1013 CFU/ha, and even more preferably from 1 x 109 to 5 x 1015 CFU/ha and in particular from 1 x 1012 to 5 x 1014 CFU/ha. In the case of nematodes as microbial pesticides (e. g. Steinernema feltiae), the application rates regularly range from 1 x 105 to 1 x 1012 (or more), preferably from 1 x 108 to 1 x 1011, more preferably from 5 x 108 to 1 x 1010 individuals (e. g. in the form of eggs, juvenile or any other live stages, preferably in an infetive juvenile stage) per ha. 230124 95 When mixtures comprising microbial pesticides are employed in seed treatment, the applica- tion rates generally range from 1 x 106 to 1 x 1012 (or more) CFU/seed, preferably from 1 x 106 to 1 x 109 CFU/seed. Furthermore, the application rates with respect to seed treatment gener- ally range from 1 x 107 to 1 x 1014 (or more) CFU per 100 kg of seed, preferably from 1 x 109 to 1 x 1012 CFU per 100 kg of seed. Preference is given to mixtures comprising as component 2) at least one active substance selected from inhibitors of complex III at Qo site in group A), more preferably selected from com- pounds (A.1.1), (A.1.4), (A.1.8), (A.1.9), (A.1.10), (A.1.12), (A.1.13), (A.1.14), (A.1.17), (A.1.21), (A.1.25), (A.1.34) and (A.1.35); particularly selected from (A.1.1), (A.1.4), (A.1.8), (A.1.9), (A.1.13), (A.1.14), (A.1.17), (A.1.25), (A.1.34) and (A.1.35). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from inhibitors of complex III at Qi site in group A), more preferably selected from compounds (A.2.1), (A.2.3), (A.2.4) and (A.2.6); particularly selected from (A.2.3), (A.2.4) and (A.2.6). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from inhibitors of complex II in group A), more preferably selected from com- pounds (A.3.2), (A.3.3), (A.3.4), (A.3.7), (A.3.9), (A.3.11), (A.3.12), (A.3.15), (A.3.16), (A.3.17), (A.3.18), (A.3.19), (A.3.20), (A.3.21), (A.3.22), (A.3.23), (A.3.24), (A.3.28), (A.3.31), (A.3.32), (A.3.33), (A.3.34), (A.3.35), (A.3.36), (A.3.37), (A.3.38) and (A.3.39); particularly selected from (A.3.2), (A.3.3), (A.3.4), (A.3.7), (A.3.9), (A.3.12), (A.3.15), (A.3.17), (A.3.19), (A.3.22), (A.3.23), (A.3.24), (A.3.31), (A.3.32), (A.3.33), (A.3.34), (A.3.35), (A.3.36), (A.3.37), (A.3.38) and (A.3.39). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from other respiration inhibitors in group A), more preferably selected from compounds (A.4.5) and (A.4.11); in particular (A.4.11). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from C14 demethylase inhibitors in group B), more preferably selected from compounds (B.1.4), (B.1.5), (B.1.8), (B.1.10), (B.1.11), (B.1.12), (B.1.13), (B.1.17), (B.1.18), (B.1.21), (B.1.22), (B.1.23), (B.1.25), (B.1.26), (B.1.29), (B.1.34), (B.1.37), (B.1.38), (B.1.43), (B.1.46), (B.1.53), (B.1.54) and (B.1.55); particularly selected from (B.1.5), (B.1.8), (B.1.10), (B.1.17), (B.1.22), (B.1.23), (B.1.25), (B.1.33), (B.1.34), (B.1.37), (B.1.38), (B.1.43) and (B.1.46). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from Delta14-reductase inhibitors in group B), more preferably selected from 230124 96 compounds (B.2.4), (B.2.5), (B.2.6) and (B.2.8); in particular (B.2.4). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from phenylamides and acyl amino acid fungicides in group C), more preferably selected from compounds (C.1.1), (C.1.2), (C.1.4) and (C.1.5); particularly selected from (C.1.1) and (C.1.4). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from other nucleic acid synthesis inhibitors in group C), more preferably se- lected from compounds (C.2.6), (C.2.7) and (C.2.8). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from group D), more preferably selected from compounds (D.1.1), (D.1.2), (D.1.5), (D.2.4) and (D.2.6); particularly selected from (D.1.2), (D.1.5) and (D.2.6). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from group E), more preferably selected from compounds (E.1.1), (E.1.3), (E.2.2) and (E.2.3); in particular (E.1.3). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from group F), more preferably selected from compounds (F.1.2), (F.1.4) and (F.1.5). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from group G), more preferably selected from compounds (G.3.1), (G.3.3), (G.3.6), (G.5.1), (G.5.3), (G.5.4), (G.5.5), G.5.6), G.5.7), (G.5.8), (G.5.9), (G.5.10) and (G.5.11); particularly selected from (G.3.1), (G.5.1) and (G.5.3). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from group H), more preferably selected from compounds (H.2.2), (H.2.3), (H.2.5), (H.2.7), (H.2.8), (H.3.2), (H.3.4), (H.3.5), (H.4.9) and (H.4.10); particularly selected from (H.2.2), (H.2.5), (H.3.2), (H.4.9) and (H.4.10). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from group I), more preferably selected from compounds (I.2.2) and (I.2.5). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from group J), more preferably selected from compounds (J.1.2), (J.1.5), (J.1.8), (J.1.11) and (J.1.12); in particular (J.1.5). Preference is also given to mixtures comprising as component 2) at least one active sub- stance selected from group K), more preferably selected from compounds (K.1.41), (K.1.42), (K.1.44), (K.1.47), (K.1.57), (K.1.58) and (K.1.59); particularly selected from (K.1.41), (K.1.44), (K.1.47), (K.1.57), (K.1.58) and (K.1.59). 230124 97 The biopesticides from group L1) and/or L2) may also have insecticidal, acaricidal, mollus- cidal, pheromone, nematicidal, plant stress reducing, plant growth regulator, plant growth pro- moting and/or yield enhancing activity. The biopesticides from group L3) and/or L4) may also have fungicidal, bactericidal, viricidal, plant defense activator, plant stress reducing, plant growth regulator, plant growth promoting and/or yield enhancing activity. The biopesticides from group L5) may also have fungicidal, bactericidal, viricidal, plant defense activator, insecticidal, acaricidal, molluscidal, pheromone and/or nematicidal activity. The microbial pesticides, in particular those from groups L1), L3) and L5), embrace not only the isolated, pure cultures of the respective microorganism as defined herein, but also its cell- free extract, its suspension in a whole broth culture and a metabolite-containing culture medium or a purified metabolite obtained from a whole broth culture of the microorganism. Many of these biopesticides have been deposited under deposition numbers mentioned herein (the prefices such as ATCC or DSM refer to the acronym of the respective culture collec- tion, for details see e. g. here: http://www. wfcc.info/ccinfo/collection/by_acronym/), are referred to in literature, registered and/or are commercially available: mixtures of Aureobasidium pullu- lans DSM 14940 and DSM 14941 isolated in 1989 in Konstanz, Germany (e. g. blastospores in BlossomProtect® from bio-ferm GmbH, Austria), Azospirillum brasilense Sp245 originally iso- lated in wheat reagion of South Brazil (Passo Fundo) at least prior to 1980 (BR 11005; e. g. GELFIX® Gramíneas from BASF Agricultural Specialties Ltd., Brazil), A. brasilense strains Ab- V5 and Ab-V6 (e. g. in AzoMax from Novozymes BioAg Produtos papra Agricultura Ltda., Quat- tro Barras, Brazil or Simbiose-Maíz® from Simbiose-Agro, Brazil; Plant Soil 331, 413-425, 2010), Bacillus amyloliquefaciens strain AP-188 (NRRL B-50615 and B-50331; US 8,445,255); B. amyloliquefaciens ssp. plantarum strains formerly also sometimes referred to as B. subtilis, recently together with B. methylotrophicus, and B. velezensis classified as B. velezensis (Int. J. Syst. Evol. Microbiol.66, 1212–1217, 2016): B. a. ssp. plantarum or B. velezensis D747 iso- lated from air in Kikugawa-shi, Japan (US 20130236522 A1; FERM BP-8234; e. g. Double Nickel™ 55 WDG from Certis LLC, USA), B. a. ssp. plantarum or B. velezensis FZB24 isolated from soil in Brandenburg, Germany (also called SB3615; DSM 96-2; J. Plant Dis. Prot.105, 181–197, 1998; e. g. Taegro® from Novozyme Biologicals, Inc., USA), B. a. ssp. plantarum or B. velezensis FZB42 isolated from soil in Brandenburg, Germany (DSM 23117; J. Plant Dis. Prot.105, 181–197, 1998; e. g. RhizoVital® 42 from AbiTEP GmbH, Germany), B. a. ssp. plantarum or B. velezensis MBI600 isolated from faba bean in Sutton Bonington, Nottingham- shire, U.K. at least before 1988 (also called 1430; NRRL B-50595; US 2012/0149571 A1; e. g. Integral® from BASF Corp., USA), B. a. ssp. plantarum or B. velezensis QST-713 isolated from peach orchard in 1995 in California, U.S.A. (NRRL B-21661; e. g. Serenade® MAX from Bayer Crop Science LP, USA), B. a. ssp. plantarum or B. velezensis TJ1000 isolated in 1992 in South 230124 98 Dakoda, U.S.A. (also called 1BE; ATCC BAA-390; CA 2471555 A1; e. g. QuickRoots™ from TJ Technologies, Watertown, SD, USA); B. firmus CNCM I-1582, a variant of parental strain EIP- N1 (CNCM I-1556) isolated from soil of central plain area of Israel (WO 2009/126473, US 6,406,690; e. g. Votivo® from Bayer CropScience LP, USA), B. pumilus GHA 180 isolated from apple tree rhizosphere in Mexico (IDAC 260707-01; e. g. PRO-MIX® BX from Premier Horticul- ture, Quebec, Canada), B. pumilus INR-7 otherwise referred to as BU-F22 and BU-F33 isolated at least before 1993 from cucumber infested by Erwinia tracheiphila (NRRL B-50185, NRRL B- 50153; US 8,445,255), B. pumilus KFP9F isolated from the rhizosphere of grasses in South Af- rica at least before 2008 (NRRL B-50754; WO 2014/029697; e. g. BAC-UP or FUSION-P from BASF Agricultural Specialities (Pty) Ltd., South Africa), B. pumilus QST 2808 was isolated from soil collected in Pohnpei, Federated States of Micronesia, in 1998 (NRRL B-30087; e. g. So- nata® or Ballad® Plus from Bayer Crop Science LP, USA), B. simplex ABU 288 (NRRL B- 50304; US 8,445,255), B. subtilis FB17 also called UD 1022 or UD10-22 isolated from red beet roots in North America (ATCC PTA-11857; System. Appl. Microbiol.27, 372-379, 2004; US 2010/0260735; WO 2011/109395); B. thuringiensis ssp. aizawai ABTS-1857 isolated from soil taken from a lawn in Ephraim, Wisconsin, U.S.A., in 1987 (also called ABG-6346; ATCC SD- 1372; e. g. XenTari® from BioFa AG, Münsingen, Germany), B. t. ssp. kurstaki ABTS-351 iden- tical to HD-1 isolated in 1967 from diseased Pink Bollworm black larvae in Brownsville, Texas, U.S.A. (ATCC SD-1275; e. g. Dipel® DF from Valent BioSciences, IL, USA), B. t. ssp. kurstaki SB4 isolated from E. saccharina larval cadavers (NRRL B-50753; e. g. Beta Pro® from BASF Agricultural Specialities (Pty) Ltd., South Africa), B. t. ssp. tenebrionis NB-176-1, a mutant of strain NB-125, a wild type strain isolated in 1982 from a dead pupa of the beetle Tenebrio molitor (DSM 5480; EP 585215 B1; e. g. Novodor® from Valent BioSciences, Switzerland), Beauveria bassiana GHA (ATCC 74250; e. g. BotaniGard® 22WGP from Laverlam Int. Corp., USA), B. bassiana JW-1 (ATCC 74040; e. g. Naturalis® from CBC (Europe) S.r.l., Italy), B. bas- siana PPRI 5339 isolated from the larva of the tortoise beetle Conchyloctenia punctata (NRRL 50757; e. g. BroadBand® from BASF Agricultural Specialities (Pty) Ltd., South Africa), Bradyrhi- zobium elkanii strains SEMIA 5019 (also called 29W) isolated in Rio de Janeiro, Brazil and SEMIA 587 isolated in 1967 in the State of Rio Grande do Sul, from an area previously inocu- lated with a North American isolate, and used in commercial inoculants since 1968 (Appl. Environ. Microbiol.73(8), 2635, 2007; e. g. GELFIX 5 from BASF Agricultural Specialties Ltd., Brazil), B. japonicum 532c isolated from Wisconsin field in U.S.A. (Nitragin 61A152; Can. J. Plant. Sci.70, 661-666, 1990; e. g. in Rhizoflo®, Histick®, Hicoat® Super from BASF Agricultural Specialties Ltd., Canada), B. japonicum E-109 variant of strain USDA 138 (INTA E109, SEMIA 5085; Eur. J. Soil Biol.45, 28–35, 2009; Biol. Fertil. Soils 47, 81–89, 2011); B. ja- ponicum strains deposited at SEMIA known from Appl. Environ. Microbiol.73(8), 2635, 2007: SEMIA 5079 isolated from soil in Cerrados region, Brazil by Embrapa-Cerrados used in com- mercial inoculants since 1992 (CPAC 15; e. g. GELFIX 5 or ADHERE 60 from BASF Agricultural 230124 99 Specialties Ltd., Brazil), B. japonicum SEMIA 5080 obtained under lab condtions by Embrapa- Cerrados in Brazil and used in commercial inoculants since 1992, being a natural variant of SEMIA 586 (CB1809) originally isolated in U.S.A. (CPAC 7; e. g. GELFIX 5 or ADHERE 60 from BASF Agricultural Specialties Ltd., Brazil); Burkholderia sp. A396 isolated from soil in Nikko, Ja- pan, in 2008 (NRRL B-50319; WO 2013/032693; Marrone Bio Innovations, Inc., USA), Coni- othyrium minitans CON/M/91-08 isolated from oilseed rape (WO 1996/021358; DSM 9660; e. g. Contans® WG, Intercept® WG from Bayer CropScience AG, Germany), harpin (alpha-beta) protein (Science 257, 85-88, 1992; e. g. Messenger™ or HARP-N-Tek from Plant Health Care plc, U.K.), Helicoverpa armigera nucleopolyhedrovirus (HearNPV) (J. Invertebrate Pathol.107, 112–126, 2011; e. g. Helicovex® from Adermatt Biocontrol, Switzerland; Diplomata® from Kop- pert, Brazil; Vivus® Max from AgBiTech Pty Ltd., Queensland, Australia), Helicoverpa zea sin- gle capsid nucleopolyhedrovirus (HzSNPV) (e. g. Gemstar® from Certis LLC, USA), Heli- coverpa zea nucleopolyhedrovirus ABA-NPV-U (e. g. Heligen® from AgBiTech Pty Ltd., Queensland, Australia), Heterorhabditis bacteriophora (e. g. Nemasys® G from BASF Agricul- tural Specialities Limited, UK), Isaria fumosorosea Apopka-97 isolated from mealy bug on gynura in Apopka, Florida, U.S.A. (ATCC 20874; Biocontrol Science Technol.22(7), 747-761, 2012; e. g. PFR-97™ or PreFeRal® from Certis LLC, USA), Metarhizium anisopliae var. an- isopliae F52 also called 275 or V275 isolated from codling moth in Austria (DSM 3884, ATCC 90448; e. g. Met52® Novozymes Biologicals BioAg Group, Canada), Metschnikowia fructicola 277 isolated from grapes in the central part of Israel (US 6,994,849; NRRL Y-30752; e. g. for- merly Shemer® from Agrogreen, Israel), Paecilomyces ilacinus 251 isolated from infected nem- atode eggs in the Philippines (AGAL 89/030550; WO1991/02051; Crop Protection 27, 352-361, 2008; e. g. BioAct®from Bayer CropScience AG, Germany and MeloCon® from Certis, USA), Paenibacillus alvei NAS6G6 isolated from the rhizosphere of grasses in South Africa at least before 2008 (WO 2014/029697; NRRL B-50755; e.g. BAC-UP from BASF Agricultural Speciali- ties (Pty) Ltd., South Africa), Paenibacillus strains isolated from soil samples from a variety of European locations including Germany: P. epiphyticus Lu17015 (WO 2016/020371; DSM 26971), P. polymyxa ssp. plantarum Lu16774 (WO 2016/020371; DSM 26969), P. p. ssp. plantarum strain Lu17007 (WO 2016/020371; DSM 26970); Pasteuria nishizawae Pn1 isolated from a soybean field in the mid-2000s in Illinois, U.S.A. (ATCC SD-5833; Federal Register 76(22), 5808, February 2, 2011; e.g. Clariva™ PN from Syngenta Crop Protection, LLC, USA), Penicillium bilaiae (also called P. bilaii) strains ATCC 18309 (= ATCC 74319), ATCC 20851 and/or ATCC 22348 (= ATCC 74318) originally isolated from soil in Alberta, Canada (Fertilizer Res.39, 97-103, 1994; Can. J. Plant Sci.78(1), 91-102, 1998; US 5,026,417, WO 1995/017806; e. g. Jump Start®, Provide® from Novozymes Biologicals BioAg Group, Can- ada), Reynoutria sachalinensis extract (EP 0307510 B1; e. g. Regalia® SC from Marrone BioIn- novations, Davis, CA, USA or Milsana® from BioFa AG, Germany), Steinernema carpocapsae (e. g. Millenium® from BASF Agricultural Specialities Limited, UK), S. feltiae (e. g. Nemashield® 230124 100 from BioWorks, Inc., USA; Nemasys® from BASF Agricultural Specialities Limited, UK), Strepto- myces microflavus NRRL B-50550 (WO 2014/124369; Bayer CropScience, Germany), Tricho- derma asperelloides JM41R isolated in South Africa (NRRL 50759; also referred to as T. fertile; e. g. Trichoplus® from BASF Agricultural Specialities (Pty) Ltd., South Africa), T. harzianum T- 22 also called KRL-AG2 (ATCC 20847; BioControl 57, 687-696, 2012; e. g. Plantshield® from BioWorks Inc., USA or SabrEx™ from Advanced Biological Marketing Inc., Van Wert, OH, USA). According to another embodiment of the mixtures, the at least one pesticide II is selected from the groups L1) to L5): L1) Microbial pesticides with fungicidal, bactericidal, viricidal and/or plant defense activator ac- tivity: Aureobasidium pullulans DSM 14940 and DSM 14941 (L1.1), Bacillus amyloliquefa- ciens AP-188 (L.1.2), B. amyloliquefaciens ssp. plantarum D747 (L.1.3), B. amyloliquefa- ciens ssp. plantarum FZB24 (L.1.4), B. amyloliquefaciens ssp. plantarum FZB42 (L.1.5), B. amyloliquefaciens ssp. plantarum MBI600 (L.1.6), B. amyloliquefaciens ssp. plantarum QST-713 (L.1.7), B. amyloliquefaciens ssp. plantarum TJ1000 (L.1.8), B. pumilus GB34 (L.1.9), B. pumilus GHA 180 (L.1.10), B. pumilus INR-7 (L.1.11), B. pumilus KFP9F (L.1.12), B. pumilus QST 2808 (L.1.13), B. simplex ABU 288 (L.1.14), B. subtilis FB17 (L.1.15), Coniothyrium minitans CON/M/91-08 (L.1.16), Metschnikowia fructicola NRRL Y-30752 (L.1.17), Paenibacillus alvei NAS6G6 (L.1.18), P. epiphyticus Lu17015 (L.1.25), P. polymyxa ssp. plantarum Lu16774 (L.1.26), P. p. ssp. plantarum strain Lu17007 (L.1.27), Penicillium bilaiae ATCC 22348 (L.1.19), P. bilaiae ATCC 20851 (L.1.20), Penicillium bilaiae ATCC 18309 (L.1.21), Streptomyces microflavus NRRL B-50550 (L.1.22), Tricho- derma asperelloides JM41R (L.1.23), T. harzianum T-22 (L.1.24); L2) Biochemical pesticides with fungicidal, bactericidal, viricidal and/or plant defense activator activity: harpin protein (L.2.1), Reynoutria sachalinensis extract (L.2.2); L3) Microbial pesticides with insecticidal, acaricidal, molluscidal and/or nematicidal activity: Ba- cillus firmus I-1582 (L.3.1); B. thuringiensis ssp. aizawai ABTS-1857 (L.3.2), B. t. ssp. kurstaki ABTS-351 (L.3.3), B. t. ssp. kurstaki SB4 (L.3.4), B. t. ssp. tenebrionis NB-176-1 (L.3.5), Beauveria bassiana GHA (L.3.6), B. bassiana JW-1 (L.3.7), B. bassiana PPRI 5339 (L.3.8), Burkholderia sp. A396 (L.3.9), Helicoverpa armigera nucleopolyhedrovirus (HearNPV) (L.3.10), Helicoverpa zea nucleopolyhedrovirus (HzNPV) ABA-NPV-U (L.3.11), Helicoverpa zea single capsid nucleopolyhedrovirus (HzSNPV) (L.3.12), Heterohabditis bacteriophora (L.3.13), Isaria fumosorosea Apopka-97 (L.3.14), Metarhizium anisopliae var. anisopliae F52 (L.3.15), Paecilomyces lilacinus 251 (L.3.16), Pasteuria nishizawae Pn1 (L.3.17), Steinernema carpocapsae (L.3.18), S. feltiae (L.3.19); 230124 101 L4) Biochemical pesticides with insecticidal, acaricidal, molluscidal, pheromone and/or nemati- cidal activity: cis-jasmone (L.4.1), methyl jasmonate (L.4.2), Quillay extract (L.4.3); L5) Microbial pesticides with plant stress reducing, plant growth regulator, plant growth promot- ing and/or yield enhancing activity: Azospirillum brasilense Ab-V5 and Ab-V6 (L.5.1), A. bra- silense Sp245 (L.5.2), Bradyrhizobium elkanii SEMIA 587 (L.5.3), B. elkanii SEMIA 5019 (L.5.4), B. japonicum 532c (L.5.5), B. japonicum E-109 (L.5.6), B. japonicum SEMIA 5079 (L.5.7), B. japonicum SEMIA 5080 (L.5.8). The present invention furthermore relates to agrochemical compositions comprising a mixture of at least one compound I (component 1) and at least one biopesticide selected from the group L) (component 2), in particular at least one biopesticide selected from the groups L1) and L2), as described above, and if desired at least one suitable auxiliary. The present invention furthermore relates to agrochemical compositions comprising a mixture of of at least one compound I (component 1) and at least one biopesticide selected from the group L) (component 2), in particular at least one biopesticide selected from the groups L3) and L4), as described above, and if desired at least one suitable auxiliary. Preference is also given to mixtures comprising as pesticide II (component 2) a biopesticide selected from the groups L1), L3) and L5), preferably selected from strains denoted above as (L.1.2), (L.1.3), (L.1.4), (L.1.5), (L.1.6), (L.1.7), (L.1.8), (L.1.10), (L.1.11), (L.1.12), (L.1.13), (L.1.14), (L.1.15), (L.1.17), (L.1.18), (L.1.19), (L.1.20), (L.1.21), (L.1.25), (L.1.26), (L.1.27), (L.3.1); (L.3.9), (L.3.16), (L.3.17), (L.5.1), (L.5.2), (L.5.3), (L.5.4), (L.5.5), (L.5.6), (L.5.7), (L.5.8); (L.4.2), and (L.4.1); even more preferably selected from (L.1.2), (L.1.6), (L.1.7), (L.1.8), (L.1.11), (L.1.12), (L.1.13), (L.1.14), (L.1.15), (L.1.18), (L.1.19), (L.1.20), (L.1.21), (L.3.1); (L.3.9), (L.3.16), (L.3.17), (L.5.1), (L.5.2), (L.5.5), (L.5.6); (L.4.2), and (L.4.1). These mixtures are particularly suitable for treatment of propagation materials, i. e. seed treatment purposes and likewise for soil treatment. These seed treatment mixtures are particularly suitable for crops such as cereals, corn and leguminous plants such as soybean. Preference is also given to mixtures comprising as pesticide II (component 2) a biopesticide selected from the groups L1), L3) and L5), preferably selected from strains denoted above as (L1.1), (L.1.2), (L.1.3), (L.1.6), (L.1.7), (L.1.9), (L.1.11), (L.1.12), (L.1.13), (L.1.14), (L.1.15), (L.1.17), (L.1.18), (L.1.22), (L.1.23), (L.1.24), (L.1.25), (L.1.26), (L.1.27), (L.2.2); (L.3.2), (L.3.3), (L.3.4), (L.3.5), (L.3.6), (L.3.7), (L.3.8), (L.3.10), (L.3.11), (L.3.12), (L.3.13), (L.3.14), (L.3.15), (L.3.18), (L.3.19); (L.4.2), even more preferably selected from (L.1.2), (L.1.7), (L.1.11), (L.1.13), (L.1.14), (L.1.15), (L.1.18), (L.1.23), (L.3.3), (L.3.4), (L.3.6), (L.3.7), (L.3.8), (L.3.10), (L.3.11), (L.3.12), (L.3.15), and (L.4.2). These mixtures are particularly suitable for foliar treatment of cultivated plants, preferably of vegetables, fruits, vines, cereals, corn, and leguminous crops 230124 102 such as soybeans. The compositions comprising mixtures of active ingredients can be prepared by usual means, e. g. by the means given for the compositions of compounds I. When living microorganisms, such as pesticides II from groups L1), L3) and L5), form part of the compositions, such compositions can be prepared by usual means (e. g. H.D. Burges: Formula- tion of Microbial Biopesticides, Springer, 1998; WO 2008/002371, US 6,955,912, US 5,422,107). I. Synthesis examples 3-yl)-9-fluoro-2,2- 1,1-dioxide Step 1: Preparation of (6-(difluoromethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanol The solution of 1,2-difluoro-3-iodobenzene (16.8 g, 0.07 mol) in THF (150 mL) was added i- PrMgCl (2M) (36 mL, 0.073 mol) at 0 °C under N2 and the mixture was stirred at 0 °C for 30 min. Then 6-(difluoromethyl)-5-methylnicotinaldehyde (10 g, 0.058 mol) in THF was added at 0 °C and the mixture was stirred for 4 h at 0~20 °C under N2. TLC (PE:EtOAc=3:1) showed the reaction complete. The reaction mixture was quenched with NH4Cl aq. (200 mL), extracted with EtOAc (150 mL) and washed with brine (200 mL). The organic layer was dried over Na2SO4 and con- centrated to give (6-(difluoromethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanol (16.7 g, crude) as yellow solid. The title compound was used directly without further purification. 1H NMR (400 MHz, CDCl3) δ [ppm] = 8.38 (s, 1 H) 7.54 (s, 1 H) 7.20 - 7.25 (m, 1 H) 7.02 - 7.09 (m, 2 H) 6.45 - 6.75 (m, 1 H) 6.14 (s, 1 H) 2.40 - 2.44 (m, 3 H). Step 2: Preparation of (6-(difluoromethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanone The solution of (6-(difluoromethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanol (16.7 g, 0.059 mol) in THF (200 mL) was added MnO2 (51 g, 0.59 mol) and the mixture was stirred at 80 °C for 16 h. TLC (PE: EtOAc=3:1) showed the reaction complete. The reaction mixture was filtered and the filtrate was concentrated, purified by column (PE: EtOAc=7: 1) to give (6-(difluo- romethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanone (12.5 g, 75%) as yellow oil. The ti- tle compound was used directly without further purification. 230124 103 1H NMR (400 MHz, CDCl3) δ [ppm] = 8.69 (s, 1 H) 7.95 (s, 1 H) 7.27 - 7.41 (m, 2 H) 7.19 - 7.24 (m, 1 H) 6.49 - 6.84 (m, 1 H) 2.53 (s, 3 H). Step 3: 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydro- benzo[f][1,4]thiazepine To a solution of (6-(difluoromethyl)-5-methylpyridin-3-yl)(2,3-difluorophenyl)methanone (1 g, 3.53 mmol) and 1-amino-2-methylpropane-2-thiol hydrochloride (751 mg, 5.30 mmol) in DMF (20 mL) was added Cs2CO3 (3.45 g, 10.60 mmol) at 25 °C under N2. Then the mixture was stirred at 40oC for 2 hrs. TLC (PE: EtOAc= 3: 1) showed the reaction was completely. The reaction mixture was quenched into H2O (15 mL), extracted with EtOAc (10 mL x 3). The organic phase was washed with brine (10 mL x 2), dried over Na2SO4 and concentrated. The residue was purified by column (PE: EtOAc= 7: 1) to give 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-di- hydrobenzo[f][1,4]thiazepine (1.1 g, yield: 88.9%) as a yellow solid. 1H NMR (400 MHz, MeOD) δ [ppm] = 8.45 (s, 1 H), 7.80 (s, 1 H), 7.43 (td, J=7.91, 5.19 Hz, 1 H), 7.26 (t, J=8.32 Hz, 1 H), 6.93 (d, J=7.63 Hz, 1 H), 6.62 - 6.90 (m, 1 H), 3.21 (s, 2 H), 2.41 (s, 3 H), 1.39 (s, 6 H) Step 4: 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydro- benzo[f][1,4]thiazepine 1-oxide To a solution of 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydro- benzo[f][1,4]thiazepine (300 mg, 0.86 mmol) in EtOH (3 mL) was added (NH4)6Mo7O24 ^4H2O (498 mg, 0.43 mmol) and H2O2 (30%, 300 mg, 0.86 mmol) at 25°C under N2 and the mixture was stirred at 25 °C for 16 hrs. LCMS showed the reaction was completely. The reaction was quenched into H2O (5 mL), adjusted pH to 7~8 with ~10% NaHCO3 aq. Then the resulting solution was added Na2SO3 aq. (20 mL), extracted with EtOAc (3 mL x 3), washed with brine (3 mL x 2), dried over Na2SO4 and concentrated. The residue was purified by column (PE: EtOAc= 3:1 to 1:1) to give 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydrobenzo[f][1,4]thiaze- pine 1-oxide (230 mg, yield: 74%) as yellow solid. 1H NMR (400 MHz, MeOD) δ [ppm] = 8.58 (d, J=1.00 Hz, 1 H), 7.89 (s, 1 H), 7.76 - 7.82 (m, 1 H), 7.49 - 7.54 (m, 1 H), 7.21 (dd, J=7.63, 0.63 Hz, 1 H), 6.72 - 6.99 (m, 1 H), 4.02 (d, J=11.13 Hz, 1 H), 3.36 (d, J=11.13 Hz, 1 H), 2.51 (s, 3 H), 1.66 (s, 3 H), 1.27 (s, 3 H). Step 5: 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydro- benzo[f][1,4]thiazepine 1,1-dioxide 230124 104 To a solution of 5-(6-(difluoromethyl)-5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydro- benzo[f][1,4]thiazepine (420 mg, 1.20 mmol) in EtOH (5 mL) was added (NH4)6Mo7O24 ^4H2O (698 mg, 0.60 mmol) and H2O2 (30%, 1.36 g, 11.99 mmol) at 25°C under N2. The mixture was stirred at 25°C for 16 hrs. LCMS showed the reaction was completely. The reaction was quenched into H2O (5 mL), adjusted pH to 7~8 with ~10% NaHCO3 aq. Then the resulting solution was added Na2SO3 aq. (20 mL), extracted with EtOAc (5 mL x 3), washed with brine (5 mL x 2), dried over Na2SO4 and concentrated. The residue was purified by Prep-HPLC to give 5-(6-(difluoromethyl)- 5-methylpyridin-3-yl)-9-fluoro-2,2-dimethyl-2,3-dihydrobenzo[f][1,4]thiazepine 1,1-dioxide (200 mg, yield: 43.5%) as yellow solid. The compounds listed in Table I were prepared in an analogous manner. Table I: Compounds Ex-1 to Ex-92 of formula I, wherein the meaning of R2, R3 , R5, R6, R7, R8, R9 and Xn are as defined in each line. LCMS: Liquid chromatography–mass spectrometry; Shimadzu Nexera LC-30 LCMS-2020 (ESI+) using HPLC-column Kinetex XB C181,7µ (50 x 2,1 mm); eluent: acetonitrile / water + 0.1% trifluoroacetic acid (gradient from 5:95 to 100:0 in 1.5 min at 60°C, flow gradient from 0.8 to 1.0 mL/min in 1.5 min); **LCMS: Liquid chromatography–mass spectrometry; Shimadzu Nexera LC-30 LCMS-2020 (ESI+) using HPLC-column LUX Cellulose-15 µm (150 x 4.6 mm); eluent: acetonitrile / water + 0.1% formic acid (gradient from 50:50 to 100 : 0 in 10 min at 40°C, flow fate 0.6 mL/min in); *** LCMS: Liquid chromatography–mass spectrometry; Shimadzu LCMS DELIVER-220 (ESI+) using HPLC-column Luna-C18 (30 mm × 2.0 mm × 3 µm particles); eluent: acetonitrile (+0,02% TFA) / water (+0,04%) (gradient from 5:95 to 95:5 in 1.5 min at 40°C, flow gradient from 0.8 to 0,8 mL/min in 3 min); Rt: retention time in minutes. 230124 105
230124 106 T R _ S 3 5 1 7 2 1 2 M 1 9 9 7 4 4 3 8 2 _ , 1 , 1 9 9 9 0 , 2 7 0 7 C 1 1 , 1 , 0 , 0 , 0 1 , 0 , 0 L Z M _ S 9 , 9 9 9 0 9 9 9 0 , 0 , , . , 3 , , M _ 5 C 3 5 0 3 5 6 7 6 8 0 0 3 6 3 6 3 6 3 3 3 3 3 3 L F- F- F- F- F- F F F F 9 9 9 9 9 - 9 - 9 - 9 - 9 X ) 2 S S S O = O O O O S = S = O S = ( = = S S S Z 3 3 3 3 3 3 3 3 3 H H H H H H H H H C C C C C C C C C 8 R 3 3 3 7 H H C H H H C H H C H H R 3 3 3 3 3 3 H H H H H H H H C C C C H C C 6 R 5 H H H H H H H H H R F 2 F 2 F 2 F 2 F 2 F 2 F 2 3 3 H H H H H H 3 H H H C C C C C C C C C R 3 3 3 3 3 3 3 3 3 H H H H H H H H H 2 C C C C C C C C C R - e - re d e r d - d d t n e n o , ) - o n - a o , ) - o n a s a t a s i ai ) s f R d 3 , n s ) i f ,) S ) R s i f R d 3 , n s ) i f ,) S ) R S ) a i ) R) o , ) R S a ) S o 3, 3 R , S ) o , ) S a ) S o 3, 3 R , S ) 1- d 3 R d 3 S e x e l , 3 , e l , 3 , r u 2 , 3 , R3 , S S 3 , S 5- e x r 2 u , 2 S , S 3, 7 e R 2 3 1 R , R3 , e 2, 2, S 3, 1 R -x r u , S S 3 , S r u S 1 R R E g R n i 2 ( S g R 2 S t x 1 2 : 2 ( n i ( : 2 ( i ( , R2 , : S 2 E t x : ( , 2, E t x 1 2 , R i s r ) R , R2 , t x : 1 ( , 2, R 1 ( i ( : S 2 i , R s r ) R R 1 ( o S r N e S r e M - 2 4 s 1 1 - r ( R ( M 6 e 3, M s 1 1 M e 3, - mS 8- r ( R ( 9 mS x -x m 3 o - x m o x e 1 m ( x 2, S x e 1 m ( - x 2, S E E E E E 1 ( E E 1 ( 230124 107 8 8 7 6 6 3 2 4 8 2 9 9 7 4 , 8 , 0 , 0 , 7 , 7 , 4 . 8 , 2 , 2 , 9 0 1 0 0 1 1 0 0 6 0 1 1 , 0 , 1 , 1 9 , 9 , 9 , 9 , 9 , 9 4 9 9 8 8 8 8 4 4 2 2 , , , , , , , , 1 3 1 3 8 3 8 6 3 4 6 3 4 1 3 5 4 3 1 8 3 6 6 3 6 4 3 8 0 3 0 8 4 4 3 F - F F F - 9 , - -- F- F- F- F- F- F- F- 9 , H 9 , 9 , F 9 9 9 9 9 9 9 9 F F - - O F- F 9 8 -8 8 - 8 ) 2 ) 2 ) 2 ) 2 ) 2 S S O = O O O ( = ( = ( = ( S S S S O = O = S S S S S S ( S 3 3 3 3 3 3 3 3 3 3 3 3H H H H H H H H H H H H - C C C C C C C C C C C C 2 H C2 H 3 3 3 3 3 C - H H H H H H H H H H H H C C C C C 3 3 3 3 3 3 3H H H H H H H C C C C C C C H H H H H H H H H H H H H H H H H H H 3 3 2 2 3 3 2 3 2 2 2 2 2H H F F H F F F F F F C C H H H H H H H H H H C C C C C C C C C C C 3 3 3 3 3 3 3 3 3 3 3 3 3H H H H H H H H H H H H H C C C C C C C C C C C C C ) ) ) ) ) -- ) a - -i S 3 a i R a i S 3 -a - i R3 a i S 3 - o a i i R 3 t n * d , ) d 3 , ) d , ) d , ) d , ) d , ) a * ) e l R R e R S e SR3 e S S 3 e SR e S S 3 n S g 2 ( 3 : , l g 2 ( 3 : , l 2 l 2 l 2 3 l 2 e S g ( , g ( , g ( , g ( , e 3 , 9 0 2 3 4 5 n i r S 2 n i r 2 n i : r R n i : r R2 n i : r R n i : r R l g S 1- 2- 2- 2- 2- 2-S e ( S e ( S e 2 e ( e 2 e 2 ( 2 x x x x x x 0 m 1 d md m( S m S m( S m n i ( : E E E E E E- o x e n 1 a 1- o e n 2 a 1- o d 3 e n 1- o d e n 4 1- o d 5 e n 1- o d e n S r e E r e t x r e x r a s E t s E e x r a x r a t e x r a 6 1 m s E e t s E t s E e t - s x E 230124 108 1 9 2 7 3 7 9 1 3 9 0 2 3 0 8 9 2 0 3 9 8 9 0 1 3 9 4 1 6 9 3 , , , , , , , , , , , , , 0 , 1 , 8 7 8 0 0 0 1 0 1 1 0 1 0 0 1 0 1 1 , 0 , 0 , 3 8 , 8 , 8 8 8 8 9 8 8 7 9 9 9 9 9 9 1 4 0 , 6 , 5 , , , , , , , , 1 , , , , , 6 3 4 2 1 4 0 8 2 8 4 6 6 2 3 4 0 0 6 7 3 3 3 3 3 3 3 3 4 3 6 3 9 3 6 3 8 3 3 2 3 5 3 4 3 4 3 6 3 F F - F- F- F- F- - - - F F F F F F F F F- 9 9 9 9 9 - 9 - 9 - 9 - 9 - 9 - 9 - 9 - 9 - 9 9 ) 2 ) 2 ) 2 O = O O S = S = ( S O = S S S O = O O O O S = ( = = S = ( S S S O = O = O = S S S S S S S 3 3 3 3 3 3 3 3 3 3 3 3 3 3-2 H H H H H H H H H H H H H H H H HH C C C C C C C C C C C C C C C2 H C - 3 3 3 3 3 3 3 3 3 3 3 3 3 H H H H H H H H H H H H H C C C C C C C C C H H C C H C C H 3 3 3 3 H H H H H H H H H H H H H H C C H H C H H C 3 3 3 H H H H H H H H H H H H H C C H H C H H H F2 3 3 3 F 2 F 2 2 3 2 2 3 2 3 3 2 H N N F F F H F H FH H H H H H H H 3 H C C C C C H C H C H C C C C C C C O H C C O C C 3 3 3 3 3 r 3 3 3 3 3 3 H 3 H 3 3H H H H H H H H r H H H H H H C C C C C B C C C B C C C C C C C C C C -o i t n a * * n ) e S 6 7 3 2- 2 8 2 9 2 0 1 3 4 5 6 7 8 9 0 1 2 3 e , x -x -x - 3 x - 3 x - 3 3 3 3 3 3 3 4 4 4 4 x -x - - - - - - - - - - l g S E E E E E E E x E x E x E x E x E x E x E x E x E x E n i 2 S ( : 4 r 4 e - m x E 230124 109 4 2 2 7 5 2 9 8 5 0 7 7 6 7 8 , 2 , 0 , 5 , 2 , 4 , 1 , 8 , 0 , 7 , 6 0 4 1 1 1 6 2 6 2 1 0 5 5 , 5 , 9 , 8 , 6 6 2 6 4 , 5 4 5 1 3 2 3 7 , 3 1 , 7 , 9 1 , 4 6 1 , 5 3 9 9 , 4 , 3 3 0 3 3 3 0 3 3 0 3 3 5 6 3 3 6 3 1 6 3 3 3 5 3 3 F- F- F- F F F F F F F F - - F 9 9 9 - 9 - 9 - 9 - 9 - 9 - 9 - 9 - 9 - 9 ) 2 ) 2 S S S S S S S S O = O O O S = ( = S ( S S = S S 3 3 H H C C H H H H H H H H H H H H H H H H H H H H H H H H H H )2 3 H 3 3 3 3 3 3 3 3 3 3 3 H H H C 3H H H H H H H H H ( H C2 H C C C C C C C C C C C2 H C H C C 3 H H H H H H H C H H H H H H H F 2 3 F 2 3 F 2 3 F 2 2 2 2 2 2N N F F F F F C C H H C H H H C H C H H H H H H C C C C C C C C C 3 3 3 3 3 3 3 3 3 3 3 3 3 3H H H H H H H H H H H H H H C C C C C C C C C C C C C C ) ) -o -o -o -o -o -o -o -o - --a -i S S i t i t i t i t i t i t i t i t o i t o i d 3 , ) a i 3 e R d , ) n l S 3 e R a n n * a n n n n n n n t n * a * a * a * a * a * a * a * a * g 2 n ( l R 3 e * ) n e * ) n e * ) n e * ) n e * ) n e * ) n e * ) n e * ) n e * ) n e * ) i : , g 2 ( : , e l R e l R e l S ( e l S ( 1 5 2 5 e l S ( e l S e l R e l S e l S e l RS r R n e 2 ( i S r S e 2 ( g ( ni : r g ( ni : r g n i : r g n : r -x - ( x g n : ( ( ( ( r g n : r g n : r g n : r g n : r g n : r 5 md md e e e i e E E i e i e i e i e i e i e 4- o 6 o S m S m S m S m S m S m S m S m S m S mx e n 4 r a - x e n r a 7 8 9 0 7 8 9 0 1 2 E e t s E e t 4- 4- 4- 5- 5- 5- 5- 6- 6- 6- s x E x E x E x E x E x E x E x E x E x E 230124 110 0 6 9 1 , 9 0 1 1 1 1 3 1 2 9 8 8 0 2 0 4 0 9 0 2 , , , , , , 4 8 3 4 0 1 9 0 1 9 8 8 9 8 , 8 , 1 , 8 , 8 , 7 , 7 , 1 , 1 3 1 1 , 9 , 2 2 9 , 4 , 4 , 2 5 , 5 2 , 2 , 9 , 4 5 6 4 7 9 1 9 9 8 7 93 6 1 1 3 3 3 6 3 4 3 7 1 3 3 5 6 3 3 1 3 3 1 3 1 3 3 F- - F- F- F F - F F F F 9 9 9 9 - - - F 9 9 9 - 9 - 9 - - - - - 9 S S S S S S S S S S S S S S S 3 3 3 3 H H H H H H H H H H H H H H H C C C C H H H H H H H H H H H H H H H 2 2 ) ) 3 3 2 h h 3 H )3 P2 P 3 3 3 3 2 H H H H H C ( 3 H H C HH H C C C C C ( H 2 C ( H H H H C C H C C H H C 2 H C C C H H H H H H H H H H H H H H H F 2 F 2 3 3 F 2 F 2 F 2 F 2 2 2 2 2 N N F F F FH H H H H N C C C H C H H H H H H C C C C C C C C C C C 3 3 3 3 3 3 3 3 3 3 3 3 3H H r B H H r B H H H H H H H H H C C C C C C C C C C C C C -o -t o - t o - t o - - - - - - - -i i i i o i o i o i o i o i o i o i o i n t t t t t t t t a n n * a n a n a n a n a n a n a n a n a n a * t * n * * ) n * n * n * n * n * n * n * n * n * ) a ) e * e * e * e * e * e * e * e * e * e * n S n S e l S ) e g ( : l S e ) ) ) g ( : l R e R e S ) e S ) e S ) e S 1 ) ) e g ( : l g ( : l g ( : l g ( : l g ( : l g ( : 7- e S e S e r e o e r o 9 7 0 8 x l g ( : l g ( : l g l R g R - - n i r S e n i r e n i r n i r n i r e n i r e n i r e n i r e E n i r n i r n i ( n i ( x E x E 3 m S m S e S e S e e m S S S S S S : r S : r 6 4 5 m 6 m 7 8 m 9 m 0 m 2 m 3 m 7 e e- 6 m 8 mx - 6- 6- 6- 6- 6- 7- 7- 7- 7- 7- E x E x E x E x E x E x E x E x E x E x E x E 230124 111 9 5 4 7 8 7 5 3 5 8 0 4 0 9 5 3 , 7 , 0 7 , 0 1 , 0 8 , 1 8 , 9 1 , 4 8 , 9 9 , 0 8 , 2 9 , 1 1 , 2 1 , 2 1 , 1 2 , 4 , 5 , 9 4 4 4 9 9 7 7 3 3 , , 7 , , , 7 , 5 3 3 3 3 4 7 9 7 7 6 9 4 6 3 3 3 3 3 3 3 4 3 9 3 3 9 3 9 3 9 3 3 6 3 3 ,3 ,3 ,3 ,3 ,3 ,3 , F F H F H F H F H F H F H F F 3 - - - - - - S - - - - - H F 9 9 C - 9 C S C C C C- - - 9 S- 9 S- 9 S- 9 S 9 9 C- - 9 8 8 8 8 8 - 8 8 S S S S S S S S S S S S S S 2 3 3 3 H3 3 H H H C C C C H 3 3 3 3 3 3 3 3H H 2 2 2 H H H H H H H H C C H H H C2 C C C C C C C C C C C H C 3 H H H H H H H H H H H H H C H 3 3 3 3 3 3 3 3 H H H H H H H H H H H H H H C C C C C C C C H H H H H H H H H H H H H H F 2 F 2 F 2 F 2 F 2 F 2 F 2 F 2 F 2 F 2 F 2 F 2 F 2 F 2H H H H H H H H H H H H H H C C C C C C C C C C C C C C 3 3 3 3 3 3 3 3 3 3 3 3 3 3H H H H H H H H H H H H H H C C C C C C C C C C C C C C -o - -i t o i o - i o - i o - - - i o i o i o i n * t n * t n * t * t * t * t * t * - ) a S - ) ) a R -a S a * a * a * n * n * n * ) n * n * ) i 3 ) i 3 i 3 ) n ) e S n ) e S n ) a e S n ) a e S n ) a e S n a ) a d , e R n e S n R e SR d , 3 e S S 3 d , e SR 3 e r r l o e l o 3 8 e r r l o e o 6 3 3 3 8 e , e , e , e e 3 , l g 2 ( : , l g 2 ( , R 3 l 9 g 2 ( : , g n i R ( g n i R - ( x g l n i R ( g n i R - ( x l g n S l i 2 ( g n R l i 2 ( g n R l 2 ( g n S n 2 i ( S r R n e 2 ( i : S r e 2 ( - x n i S r R e 2 ( S : S : E S : S : E : : i : i : 1 md 2 md E 4 md 1 r 8 e 2 r e 4 r e 5 r e S 7 r e S 8 r e S 9 r e S 0 r e 9- o n 9 o n 9 o n- m 8 x e r a - x e r a - x e r a x - m 8 x - m 8 x - m 8 x - m 8 x - m 8 x - m 9- m E e t E e t E e t E E E E E E x E x E s s s 230124 112 2 2 3 0 3 0 1 5 8 8 1 6 7 6 6 5 , , , 5 1 2 2 3 1 3 2 5 5 1 1 1 , 7 , 8 , 7 , 7 , 1 , 1 , 8 , 8 , 1 , 1 5 9 6 , 4 3 9 0 , 4 , 1 , 4 , 9 , 9 , 9 9 , 8 1 3 8 1 3 8 2 3 8 1 3 8 0 3 5 5 6 6 , 3 2 4 4 2 , 3 3 3 6 2 6 0 3 3 83 , , 3 3 ,3 ,3 ,3 ,3 ,3 H F H F H F H F H F H F H F F F C- 9 C- 9 C- 9 C- C- C- C- - -- 9 9 9 9 9 9 - - - - 8 O- O 8 - O 8 - O 8 - O 8 - O 8 - 8 S S S S S S S S S S S S S 2 2 H H 3 3 3 3 3 3 3 3 C C H H 3 3H H H H H H H H H H C C C C C C C H C C2 C2 C C H H C C 3 H H H H H H H H H C H H H H 33 3 3 3 3 3 3 H C 3 3H H H H H H H 2 H H C C C C C C C H H H H C C C H H H H H H H H H H H H H F 2 F 2 F 2 F 2 F 2 F 2 F 2 F 2 3 2 2H H H H H H H H H F F r r C C C C C C C C C H H C C B B 3 3 3 3 3 3 3 3 3 3 3 3H H H H H H H H N H H H H C C C C C C C C C C C C C - - - -- ) a i R - ) a S - ) o a R i t o i it it -it -it - ) - ) d 3 , ) i 3 n * t n * n * * n * * n n a i S * a i S e S d , ) i 3 R d , ) * S a * l S n ) a n ) a n e ) a S n ) a a R n * n * d 3 , * ) d 3 , * * ) g 2 3 e l S 2 3 e l S 2 3 e S 3 e R 3 e 3 e e * , e 3 2 3 e ) e e * ) e l g S 2 R 3 e l g R 2 Rn ( i : , 3 R g n ( : , R g n ( : , R e l , e l , l g R l g , S 0 S r e 2 ( i S r e 2 ( i S r e 2 ( g S 2 g R 2 n i 2 1 0 l g S ( l g R ( n i ( : , n i ( : , ( n i 2 ( - 1- n i : r n i : r S r e R S r e S 5 m 9- o d n 6 m n i ( n i ( S 9- o d 7 md S : e n 9- o n r e S : r : e 0 r S : x e 1 r e E x E S e 4 m S e o 5 m 6 o 0 m2 1 o ( e d 7 2 ( 0 m 1 o d x e r a x r a x e r a 8 9 0 m 0 m 0 0 - r n - e r n E e t e e 9- m 9- m 1 - o 1 - o 1- 1- x e a x e a s E t s E t s x E x E x E x E x E x E E t s E t s 230124 113 1 2 9 6 6 6 3 2 1 6 4 1 , 5 9 , 3 9 , 4 9 , 7 9 , 3 1 , 3 8 , 4 8 , 5 8 , 9 8 , 4 8 , 8 9 , 9 , 9 4 4 4 2 4 2 2 , 1 , , , 6 6 , , 6 6 2 6 1 1 1 2 2 6 6 3 3 6 3 3 5 3 5 3 5 3 3 3 2 3 2 3 - - - - F- F- F- F- F F F 9 9 9 9 - 9 - 9 - 9 S S S S S S S S S S S 3 3 3 3 3 3 3 H H H C 3 2 C 3 3 3H H H H 2 C H H H H C C C C 2 H H H C C C C C C C H H H H H H H H H H H 3 3 3 3 3 3 3 3H H H H H H H H H C C C C H H C C C C H H H H H H H H H H H r F 2 F 2 F 2 B r B r B r B H H H N N N N C C C C C C C 3 3 3 3 3 3 3 3 3 3 3H H H H H H H H H H H C C C C C C C C C C C -it , -it , -it , -i , -i -i -i , -i , -i , -i , n R n R n R t n R t n t n t n R t R t R t R a 2 n ( 2 e r a ( 2 e o n r a ( 2 r a ( * * 2 r a * ) a * ) a ( n 2 r a ( n 2 r a ( n 2 r a ( rl ) e o n ) e o n ) e o * n ) * * e R n e n e r S r o n n n ) e o ) e o ) e o ) g S * * e l S * * e l R* e l R) e l o e l o e l R* * e l R* * e l S * * e l S * n 3 ) g n 3 ) g * n 3 ) S g 2 n 3 S 1 g n S g n R g n 3 ) g n 3 ) g n 3 ) g * n 3 ) i S , S R 3 i S , S R 3 i S , 3 i , 3 1 - i ( i ( i , S 3 i , S 3 i , S R 3 i , S R 3 8 0 2 ( 9 2 S ( 0 2 S S ( 1 2 ( x S E 3 r e S 4 r e S 5 S 2 S S S ( 6 2 ( 7 2 S ( 8 2 ( 1- r x e 0 1- r e 1 1- r e 1 1 r e 1 1 m o 1 1 m o 1 1 r e 1 1 r e 1 1 r e 1 1 r e E m o x E m o x - E m o x - E m o x - E x - E x - E m o x - E m o x E m - o x E m o 230124 114 1 8 6 5 3 6 0 8 4 9 9 1 9 6 3 , , 2 , 9 5 1 1 5 6 6 4 8 8 , 1 0 1 , 9 , 1 , 1 , 1 , 8 , 8 , 8 , 8 1 , 5 , 8 , 9 , 9 , 9 5 5 5 4 5 5 4 4 5 , 8 9 , , , , 6 6 9 9 9 5 5 9 5 5 6 5 5 3 3 3 3 3 9 , 3 3 3 6 6 4 3 3 3 63 ,3 ,3 ,3 F- F 9 - F 9 - F 9 - F 9 - F 9 - 9 - - - H CF- H F- H F- - 9 C 9 C 9 8 - 8 - 8 S S S S S S S S S S S S 3 H 2 2 2 3 3 3 3 3 C 2 H 2 H 2 H 3 3 3 H H H H H 2 H C H C H C H H H C C C C C H CH CH CH C C C C C C C 3 3 3 3 3 H H H H H C C C C C H H H H H H H 3 3 3 3 3 3 3 3 3 3 3 3 H H H H H H H H H H H H C C C C C C C C C C C C H H H H H H H H H H H H F 2 F 2 3 3 3 F 2 F 2 F 2 F 2 F 2 F 2 2 H H H F H H C C C H H H H H H H C C C C C C C C C 3 3 r r r 3 3 3 3 3 3 3 H H H H H H H H H C C B B B C C C C C C C -it -it -it -it ) ) ) -it , -it , -i , -i , n n n - - - S R t R t S an a a n a a i R a i S a i R n 2 ( n 2 ( n 2 n 2 ( e * n e * n e * n e * d 3 * * d 3 ) d 3 ) a e , ) , R , S n e r a o n e r a ( a o n e r n e r o e * l ) e * g R n ( l ) 1 e * ) e * ) l g S ( 2 l g R ( l g S ( g S n 2 S i r n i ( : 3 e l , g S n 2 i ( 3 e : , l g S 2 3 , e ) * e ) * e o ) * e ) * R n i ( : R l g S 3 * ) l g S * ) l g S * ) l g S * ) S e i r S e 1-x n i r n i r S r e R S r e 2 E S e S e 4 2 ( 5 ( S r 6 e 2 ( n i S , RR 3 n i 3 S , S R 3 n i 3 S , S R 3 n i 3 S , RR 3 9 m 1 o 0 m 2 o 2 m 2 o 3 m 2 o 2 m 1 o e d n 2 m 1 o d e n 2 m 1 o d e n 7 2 ( 8 2 ( 9 2 2 r 0 ( 1- 1 1 1 - r a - r a - r a 2 1 r 2 1 r 2 1 e 3 1 r x - - - x E e t x E e t x E e t - e - e - m - e E x E x E x E s s s x E m o x E m o x E o x E m o 230124 115 9 5 3 4 8 9 0 2 0 5 7 6 3 8 1 , 2 2 9 0 3 0 8 6 5 5 3 8 , 9 , 9 , 1 , 3 , 4 , 1 , 9 , 8 , 8 , 8 , 8 , 1 4 , 9 9 5 4 5 2 2 5 5 5 9 5 , 6 6 , 6 , 9 , 9 , 9 0 , 0 , 0 , 9 , 9 , 9 , 6 3 6 3 6 3 2 3 2 3 2 4 3 3 4 3 4 3 5 3 5 3 5 3 7 3 ,3 H C F- F 9 - F 9 - F 9 - F 9 - F 9 - F 9 - F F 9 - 9 - - - - F-- 9 9 8 S S S S S S S S S S S S S 2 2 2 2 3 3 3 3 3 3 3 2 H 2 H 2 H 2 HH H H H H H H H H H C H C H C H C C C C C C C C CH CH CH CH C C C C 3 3 3 3 3 3 H H H H H H H H H C C C C C C H H H H 3 3 3 3 3 3 3 3 3 3 3 3 3H H H H H H H H H H H H H C C C C C C C C C C C C C H H H H H H H H H H H H H F 2 r 3 3 3 F 2 2 2 2 B r B N F F FH H H H N N H H H H C C C C C C C C C C C 3 3 3 3 3 3 3 3 3 3 3 3 3H H H H H H H H H H H H H C C C C C C C C C C C C C -it , -it -it -it -it -it -it -i , -i , -i , n S a 2 n n n n n n t n R t 2 n S 2 t n S 2 -a ) S n ( e r a o n a a * e * n * * n * ) a n * * ) a n * * ) a n * * ) a n ( r a n ( r a n ( r i d 3, ) R e l ) g S * * e * ) e e * ) * e * e R e r e R e r 7 e R e r e R e r e o ) e o e o e ) e ) e l S ) l g S ( l g R ( 4 l g o l g o 3 l g o l g o l g S * * ) l g R* * ) l g S * * g ) n i 2 ( 3 , n i 3 , R n i r n i r 3 1 n i S ( n i S ( 1- n i S n i S n i 3, R n i 3 , S n i 3 , R S r e R2 SR3 S e S e - S S x S ( S ( S S 3 SR 3 R 3 ( 1 2 2 m m x E r e r e E r e r e 2 2 S 2 3 4 m o d 3 ( 3 o 3 3 o 5 3 6 3 8 3 9 3 0 ( 1 ( 2 ( 1 e n 1 r e 1 1 1 m 1 m 1 m 1 m 4 1 r 4 1 r 4 1 r - r a-x -x -x -x o - o - o - o - e - e - e x E e t E m o E E E x E x E x E x E m o x E m o x E m o s 230124 116 6 8 6 8 1 4 0 2 4 5 9 8 4 1 , , 7 6 6 3 2 2 1 1 6 7 1 8 , 8 , 8 , 8 , 9 , 9 , 1 , 1 , 1 , 9 , 1 4 , 4 , 4 4 4 8 8 9 9 9 9 7 7 , , , , , , , , , 3 7 7 7 7 7 5 7 2 5 5 8 3 3 3 7 3 7 3 7 3 7 3 7 3 6 3 2 3 2 3 7 3 3 F- F- F F F F F F F F F F 9 9 - 9 - 9 - 9 - 9 - 9 - 9 - 9 - 9 - 9 - 9 S S S S S S S S S S S S 2 2 2 2 2 2 2 H 2 H 2 H 2 H 2 H 2 H 3 3H C H C H C H C H C CH CH CH CH CH H H H C H H CH C C H H C C C C C C H H H H H H H H H H H H 33 3 3 3 3 3 3 3 3 HH H H H H H H C C C C C C H H H C C C 2 - C H 2 C H C-2 H C - H H H H H H H H H H H F 2 F 2 F 2 F 2 F 2 2H H H H H N N F 3 3 3 3 H C C C C C C C H H H H C C C C C 3 3 3 3 3H H H H H r r 3 N N r l C C C C C B B H C C C B C -a ) -i , -i , -i , -i , -i -i ) ) -ii S t * n R t a 2 ( n S t a 2 ( n S t a 2 ( n S t a 2 ( n t a * n - - a * a i S a i S t n d 3 e , * * l ) n e r o n e r o n e r o n e r * o n e ) * g R 2 S n e ) S d 3 , ) R d 3 , ) a R n e * * ( R e l ) * e l ) * e l ) * e l ) * e r e r 1 e l g S 2 ( 3 e , l g R 2 3 e ) S * * n i : 3, g S 3 * ) g R 3 * ) g S 3 * ) g S 3 * ) l g o l g o 5 1 n i : r R n i ( : , S l g ( 5 S r 4 e S 2 n i , R n i , S n i , R n i , R n i R ( n i R ( - x S e 2 ( S r e 2 ( n i r e 5 1-4 mo ( S 5 S 2 3 SR 3 SR 3 SR 3 S 6 2 7 2 8 2 9 r e S 0 r e E 2 5 m o d 3 5 m S o d 4 m x 1-x e r d n 4 ( E e t a 1- r x e 4 ( 1- r e 4 ( 1- r e 4 ( 1- r e 4 1- m o 5 1- m o 1-x e n r a 1 - e n r a 5 o E E e t x E e t 1- s E m o x E m o x E m o x E m o x E x E s s x E 230124 117 0 1 , 9 4 5 7 4 2 1 1 1 4 8 6 7 1 5 0 , 5 6 8 6 3 3 5 7 8 4 0 5 4 0 7 6 8 2 4 3 8 , 8 , 9 , 8 , 8 , 8 , 8 , 8 , 8 , 7 , 1 , 1 4 , 5 , 5 5 5 9 8 5 , 1 , , 6 6 6 2 2 , , 3 5 3 6 5 3 6 3 3 4 3 6 3 3 6 2 3 3 2 3 2 3 1 3 1 3 7 3 9 3 8 3 F F- F- F - - 9 F F F F F F F F F - - - - - - - F 9 9 9 , - 9 9 9 9 9 9 9 - 9 - 9 8 S S S S S S S S S S S S S 3 3 H 2 2 3 H 2 H 2 H 3 3 3 3 3H C C H C H C H H H H H C 2 2 H CH CH C H H H H C C C C C C C C 3 3 3H H H H H H H H H H C H H H C C 3 h P 3 3 3 3 3 H H 2 H H H H H H H C H C C H H 3 C C C C H C H H H H H H H H H H H H H 3 F 2 F 2 F 2 F 2 2 3 3 3 3 3H F H H H H H H H H N N C H H C C C C C C C C C C C C 2l 3 3 3 3 3 C H H H H H N N N N N H r C C C C C C C C C C C H B C -it , -it , -i -i -i -i , -i , -i , -i -i n R a 2 n R t n t n t n t n R t n R t n R t n t n * n ( * r a 2 n ( r a n a n * * ) a n * * ) a 2 n ( r a 2 n ( r a 2 n ( r a n * * * ) a n * ) * e e o ) e e o ) e * e * ) e e R e r e R e r e o ) e o e o e * e ) e ) e R e r e R r 7 8 6 l g R* * ) l g R* * ) l g S ( l g o l g o l g S * ) l g S * * ) l g R* * l g o l g o 6 6 5 1- n i 3 S , S S 3 n i 3 S , S S 3 n i r n S e i S n S ( i S n S ( i 3, S R 3 n i 3, S R 3 n i 3, ) S 3 n i S ( n i S ( 1- 1 x -x x 7 2 2 m r e r e S 2 S 2 S S 2 S r e S r e E E E 5 ( 8 5 ( 9 5 o 0 6 1 6 2 6 ( 3 6 ( 4 ( 5 6 1- r 1 r 1 1 m 1 m 1 r x e - x e - x -x o - x o - x e 1- r e 6 1- r e 6 1- m o 6 1- m o E m o E m o E E E E m o x E m o x E m o x E x E 230124 118 4 3 2 1 9 7 9 1 1 9 , , 2 0 2 2 0 2 , 9 1 , 1 , 1 3 3 2 3 1 0 , 8 9 , 2 7 3 9 2 2 9 0 1 5 3 , 1 , 1 , 4 8 , 1 2 8 1 , 4 , 5 , 6 1 3 3 2 3 F- F F F F F F F 9 - 9 - 9 - 9 - 9 - 9 - 9 - 9 S S S S S S S S 3 3 H H H H H H C H H C 3 3 3 3 2 3 H H H H H H H C H C C C C C H 3 3 -2 H H C H H H H HH C C-2 H C - 3 H H C H H H H H 3 N 3 3 3 3 3 3H H H H H H H C C C C C C C C N H C l l l l l N C C C C C C C C -it -i -i , n t n t R an * * * n 2 e ) a * a ( R n e ) R n e r o9 6 0 7 1 7 e l r e l r 4 7 5 7 e l ) R* 1- 1- 1 - g o n S g o n 1- 1 - g * n 3 ) x x x i ( i S ( i , S E E E S 2 r S r x x S S 3 7 e 3 e E E 6 2 ( 1- m x o 7 1- m x o 7 1- r e E E x E m o 230124 119 Microtest The active compounds were formulated separately as a stock solution having a concentration of 10000 ppm in dimethyl sulfoxide. Example 1 - Activity against the grey mold Botrytis cinerea in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Botrci cinerea in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the sample which had been treated with 31 ppm of the active substance from exam- ple Ex-1 showed 0 % growth of the pathogen. Further, in this test, the samples which had been treated with 31 ppm of the active substance from examples Ex-57, Ex-58, Ex-60, Ex-61, Ex-63, Ex-64, Ex-65, Ex-66, Ex-67, Ex-68, Ex-69, Ex-70, Ex-71, Ex-72, Ex-73, Ex-74, Ex-75, Ex-76, Ex-77, Ex-78, Ex-79, Ex-80, Ex-81, Ex-82, Ex-83, Ex-84, Ex-85 showed up to 24 % growth of the pathogen. Example 2 - Activity against the leaf blotch on wheat caused by Septoria tritici in the mi- crotiterplate test The active compounds were formulated separately as a stock solution having a concentration of 10000 ppm in dimethyl sulfoxide. The stock solutions were mixed according to the ratio, pipet- ted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Septorion tritici in an aqueous biomalt or yeast-bactopeptone-glycerine or DOB solution was then added. In this test, the sample which had been treated with 31 ppm of the active substance from exam- ple Ex-1 showed 9 % growth of the pathogen. Further, in this test, the samples which had been treated with 31 ppm of the active substance from examples Ex-61, Ex-68, Ex-72, Ex-73, Ex-78 showed up to 21 % growth of the pathogen. Example 3 - Activity against Fusarium culmorum in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Fusarium culmorum 230124 120 in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an ab- sorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-57, Ex-60, Ex-63, Ex-64, Ex-68, Ex-70, Ex-71, Ex-72, Ex-74, Ex-75, Ex-80showed up to 22 % growth of the pathogen. Example 4 - Activity against Alternaria alternata in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Alternaria alternata in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-25, Ex-26, Ex-29, Ex-31, Ex- 33, Ex-39, Ex-40, Ex-41, Ex-45, Ex-46, Ex-48, Ex-49, Ex-50, Ex-51, Ex-52 showed up to 13 % growth of the pathogen. Example 5 - Activity against Alternaria solani in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Alternaria solani in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-25, Ex-26, Ex-29, Ex-31, Ex- 33, Ex-39, Ex-40, Ex-41, Ex-45, Ex-48, Ex-49, Ex-50, Ex-51, Ex-52 showed up to 12 % growth of the pathogen. Example 6 - Activity against Cochliobolus sativus in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Cochliobolus sativus in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an ab- sorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-23, Ex-24, Ex-25, Ex-26, Ex- 230124 121 29, Ex-31, Ex-33, Ex-39, Ex-40, Ex-41, Ex-45, Ex-46, Ex-48, Ex-49, Ex-50, Ex-51, Ex-52 showed up to 19 % growth of the pathogen. Example 7 - Activity against Cercospora beticula in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Cercospora beticula in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an ab- sorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-25, Ex-41, Ex-48, Ex-49, Ex-50, Ex-51, Ex-52 showed up to 13 % growth of the pathogen. Example 8 - Activity against Cercospora sojina in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Cercospora sojina in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-23, Ex-24, Ex-25, Ex-31, Ex-41, Ex- 47, Ex-48, Ex-49, Ex-50, Ex-51, Ex-52 showed up to 18 % growth of the pathogen. Example 9 - Activity against Cercospora zea maydis in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Cercospora zea maydis in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-10, Ex-11, Ex-16, Ex-20, Ex-25, Ex-31, Ex-38, Ex-40, Ex-45, Ex-52 showed up to 18 % growth of the pathogen. Example 10 - Activity against Colletotrichum orbiculare in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Colletotrichum orbic- ulare in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. 230124 122 The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-4, Ex-5, Ex-7, Ex-8. Ex-9, Ex-10, Ex-11, Ex-13, Ex-14, Ex-15, Ex- 16, Ex-19, Ex-20, Ex-23, Ex-25, Ex-26, Ex-27, Ex-28, Ex-29, Ex-30, Ex-31, Ex-33, Ex-34, Ex- 35, Ex-36, Ex-38, Ex-39, Ex-40, Ex-41, Ex-42, Ex-43, Ex-44, Ex-45, Ex-46, Ex-48, Ex-49, Ex- 50, Ex-51, Ex-52 showed up to 18 % growth of the pathogen. Example 11 - Activity against Corynespora cassiicola resistant isolate (G143A) in the mi- crotiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Corynespora cassiicola resistant isolate (G143A) in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-25, Ex-41, Ex-45, Ex-46, Ex-48, Ex- 49, Ex-50, Ex-51, Ex-52 showed up to 17 % growth of the pathogen. Example 12 - Activity against Fusarium graminearum in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Fusarium gramine- arum in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-31, Ex-48, Ex-49, Ex-50, Ex-51, Ex-52 showed up to 14 % growth of the pathogen. Example 13 - Activity against Leptosphaerium nodorum in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Leptosphaerium no- dorum in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-5, Ex-7, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-22, Ex-23, Ex-25, 230124 123 Ex-26, Ex-29, Ex-31, Ex-33, Ex-39, Ex-40, Ex-41, Ex-45, Ex-46, Ex-47, Ex-48, Ex-49, Ex-50, Ex-51, Ex-52 showed up to 18 % growth of the pathogen. Example 14 - Activity against Microdochium nivale in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Microdochium nivale in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an ab- sorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-23, Ex-24, Ex-25, Ex-26, Ex- 29, Ex-31, Ex-33, Ex-34, Ex-35, Ex-39, Ex-40, Ex-41, Ex-42, Ex-43, Ex-45, Ex-46, Ex-47, Ex- 48, Ex-49, Ex-50, Ex-51, Ex-52 showed up to 14 % growth of the pathogen. Example 15 - Activity against Monilinia laxa in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Monilinia laxa in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-4, Ex-5, Ex-6, Ex-7, Ex-8. Ex-9, Ex-10, Ex-11, Ex-12, Ex-13, Ex- 14, Ex-15, Ex-16, Ex-19, Ex-20, Ex-23, Ex-24, Ex-25, Ex-26, Ex-27, Ex-28, Ex-29, Ex-31, Ex- 33, Ex-37, Ex-38, Ex-39, Ex-40, Ex-41, Ex-42, Ex-44, Ex-45, Ex-46, Ex-37, Ex-48, Ex-49, Ex- 50, Ex-51, Ex-52 showed up to 15 % growth of the pathogen. Example 16 - Activity against Leptosphaeria maculans in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Leptosphaeria macu- lans in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an ab- sorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-12, Ex-13, Ex-16, Ex-19, Ex-20, Ex-25, Ex-26, Ex- 29, Ex-31, Ex-33, Ex-36, Ex-40, Ex-41, Ex-42, Ex-45, Ex-46, Ex-47, Ex-48, Ex-49, Ex-50, Ex- 51, Ex-52 showed up to 13 % growth of the pathogen. Example 17 - Activity against Pyrenophora teres resistant isolate (F129L) in the micro- titerplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Pyrenophora teres resistant isolate (F129L) in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-5, Ex-7, Ex-10, Ex-11, Ex-12, Ex-14, Ex-16, Ex-19, Ex-20, Ex-24, Ex-25, Ex-26, Ex-29, Ex-31, Ex-33, Ex-34, Ex-35, Ex-36, Ex-39, Ex-42, Ex-43, Ex-44 showed up to 20 % growth of the pathogen. Example 18 - Activity against Rhizoctonia solani in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Rhizoctonia solani resistant isolate (F129L) in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- ample Ex-41 showed up to 18 % growth of the pathogen. Example 19 - Activity against Pyricularia oryzae in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Pyricularia oryzae in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-4, Ex-5, Ex-6, Ex-7, Ex-8, Ex-9, Ex-10, Ex-11, Ex-12, Ex-13, Ex- 14, Ex-15, Ex-16, Ex-19, Ex-20, Ex-23, Ex-24, Ex-25, Ex-26, Ex-27, Ex-28, Ex-29, Ex-30, Ex- 31, Ex-33, Ex-34, Ex-35, Ex-36, Ex-37, Ex-38, Ex-39, Ex-40, Ex-41, Ex-43, Ex-44, Ex-45, Ex- 46, Ex-47, Ex-48, Ex-49, Ex-50, Ex-51, Ex-52 showed up to 17 % growth of the pathogen. Example 20 - Activity against Stemphylium sp. in the microtiterplate test 125 The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Stemphylium sp. in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-10, Ex-11, Ex-16, Ex-19, Ex-20, Ex-25, Ex-26, Ex-29, Ex-31, Ex- 33, Ex-36, Ex-37, Ex-40, Ex-41, Ex-42, Ex-46, Ex-47, Ex-49, Ex-50, Ex-51, Ex-52 showed up to 14 % growth of the pathogen. Example 21 - Activity against Ustilago maydis in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Ustilago maydis in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-47, Ex-48 showed up to 6 % growth of the pathogen. Example 22 - Activity against Phytophthora infestans in the microtiterplate test The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Phytophthora in- festans in an aqueous biomalt or yeast-bactopeptone-sodiumacetate solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18°C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation. In this test, the samples which had been treated with 31 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-10, Ex-19, Ex-20, Ex-23, Ex-25, Ex-29, Ex-31, Ex-33, Ex-42, Ex-47, Ex- 48, Ex-52 showed up to 18 % growth of the pathogen. The measured parameters were compared to the growth of the active compound-free control variant (100%) and the fungus-free blank value to determine the relative growth in % of the path- ogens in the respective active compounds. Green House The compound was dissolved in a mixture of acetone and/or dimethylsulfoxide and the wetting agent/emulsifier Wettol, which is based on ethoxylated alkylphenoles, in a ratio (volume) solvent- 230124 126 eulsifier of 99 to 1 to give a total volume of 5 ml. Subsequently, water was added to total volume of 100 ml. This stock solution was then diluted with the described solvent-emulsifier-water mixture to the final concentration given in the table below. Example 1 - Preventative fungicidal control of Botrytis cinerea on leaves of green pepper Young seedlings of green pepper were grown in pots to the 4 to 5 leaf stage. These plants were sprayed to run-off with previously described spray solution, containing the concentration of active ingredient or mixture mentioned in the table below. The next day the plants were inoculated with an aqueous biomalt or DOB solution containing the spore suspension of Botrytis cinerea. Then the plants were immediately transferred to a humid chamber. After 5 days at 22 to 24°C and a saturated relative humidity, the extent of fungal attack on the leaves was visually assessed as % diseased leaf area. In this test, the samples which had been treated with 125 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-5, Ex-6, Ex-7, Ex-8, Ex-9, Ex-11, Ex-12, Ex-16, Ex-19, Ex-20, Ex- 24, Ex-25, Ex-31, Ex-33, Ex-39, Ex-40, Ex-41, Ex-45, Ex-46, Ex-49,Ex-50, Ex-51, Ex-52, Ex-53, Ex-56, Ex-60, Ex-61, Ex-63, Ex-64, Ex-67, Ex-68, Ex-69, Ex-70, Ex-72, Ex-73, Ex-80, Ex-81, Ex-82, Ex-83, Ex-85, Ex-86, Ex-87, Ex-89, Ex-91, Ex-92 respectively, showed less than 26 % growth of the pathogen compared to untreated sample which showed 90% growth of the patho- gen. Example 2 - Preventative fungicidal control of Botrytis cinerea on leaves of green pepper Young seedlings of green pepper were grown in pots to the 4 to 5 leaf stage. These plants were sprayed to run-off with previously described spray solution, containing the concentration of active ingredient or mixture mentioned in the table below. Seven days later the plants were inoculated with an aqueous biomalt or DOB solution containing the spore suspension of Botrytis cinerea. Then the plants were immediately transferred to a humid chamber. After 5 days at 22 to 24^C and a saturated relative humidity, the extent of fungal attack on the leaves was visually assessed as % diseased leaf area. In this test, the samples which had been treated with 125 ppm of the active substance from ex- amples Ex-1, Ex-7, Ex-11, Ex-16, Ex-19, Ex-20, Ex-25, Ex-31, Ex-33, Ex-39, Ex-40 respectively, showed less than 20 % growth of the pathogen compared to untreated sample which showed 90% growth of the pathogen. 230124 127 Example 3 - Preventative fungicidal control of target spot on soybeans caused by Corynespora cassiicola Young seedlings of soybeans were grown in pots. These plants were sprayed to run-off with previously described spray solution, containing the concentration of active ingredient or mixture mentioned in the table below. The next day the treated plants were inoculated with an aqueous biomalt or DOB solution of Corynespora cassiicola. Then the trial plants were cultivated for 8 days in a greenhouse chamber at 22oC and a relative humidity of 90%. The extent of fungal attack on the leaves was visually assessed as % diseased leaf area. In this test, the samples which had been treated with 125 ppm of the active substance from ex- ample Ex-1 showed less than 11 % growth of the pathogen compared to untreated sample which showed 90% growth of the pathogen. Example 4 - Preventative fungicidal control of white mold on soybeans caused by Sclerotinia sclerotiorum Young seedlings of soybeans were grown in pots. These plants were sprayed to run-off with previously described spray solution, containing the concentration of active ingredient or mixture mentioned in the table below. The next day the treated plants were inoculated with a suspension, containing the mycelium of Sclerotinia sclerotiorum. Then the trial plants were cultivated for 6 days in a greenhouse chamber at 23oC and a relative humidity between 80 and 85%. The extent of fungal attack on the leaves was visually assessed as % diseased leaf area. In this test, the samples which had been treated with 125 ppm of the active substance from ex- amples Ex-1, Ex-2, Ex-3, Ex-16, Ex-19, Ex-20, Ex-25, Ex-40, Ex-41, Ex-45, Ex-46, Ex-49, Ex- 51, Ex-53, Ex-61, Ex-64, Ex-67, Ex-68, Ex-72, Ex-73, Ex-81, Ex-86, Ex, Ex-87, Ex-89, Ex-91 re- spectively, showed less than 23 % growth of the pathogen compared to untreated sample which showed 90% growth of the pathogen. Example 5 - Preventative fungicidal control of white mold on cabbage caused by (Sclerotinia sclerotiorum Cabagges were grown in pots to the 13 to 14 leaf stage. These plants were sprayed to run-off with previously described spray solution, containing the concentration of active ingredient or their mixture mentioned in the table below. 230124 128 The plants could air-dry. The next day the cabbage leaves were inoculated with 50 µl of a mixture of ground petals, methylcellulose, water and yeast-bacto-peptone media (inkludes spores of Scle- rotinia sclerotiorum). After 8 days at 21oC and a relative humidity of 60 % the extent of fungal attack on the leaves were visually assessed as % diseased leaf area. In this test, the samples which had been treated with 125 ppm of the active substance from ex- amples Ex-20, Ex-25, Ex-46, Ex-49, Ex-56, Ex-68, Ex-72, Ex-80, Ex-81, Ex-82, Ex, Ex-83 re- spectively, showed less than 23 % growth of the pathogen compared to untreated sample which showed 90% growth of the pathogen.

Claims

230124 129 Claims 1. Compounds of formula I Y is N, CR1; Z is S, SO or SO2 R1 is in each case independently selected from H, halogen, CN, C1-C4-alkyl, C1-C4-halogen- alkyl; R2 is in each case independently selected from halogen, CN, C1-C6-alkyl, C1-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, O-C1-C6-alkyl, O-C2-C6-alkenyl, O-C2-C6-alkynyl, C3-C6-cycloalkyl, S-C1-C6-alkyl, S-C2-C6-alkenyl, S-C2- C6-alkynyl; R3 is in each case independently selected from halogen, CN, C1-C6-alkyl, C1-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, O-C1-C6-alkyl, O-C2-C6-alkenyl, O-C2-C6-alkynyl, C3-C6-cycloalkyl, S-C1-C6-alkyl, S-C2-C6-alkenyl, S-C2- C6-alkynyl; R4 is in each case independently selected from H, halogen, CN, C1-C4-alkyl, C1-C4-halogen- alkyl; R5 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6- haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, benzyl, five- or six-membered heteroaryl or five- or six-membered CH2 -heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substit- uents R5a; where 230124 130 each R5a is independently halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl or O-C1-C6-alkyl; R6 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6- haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, ben- zyl, five- or six-membered heteroaryl or five- or six-membered CH2- heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substituents R6a; where each R6a is independently halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl or O-C1-C6-alkyl; or R5 and R6 form together an oxo group (=O); or a thioxo group (=S); or R5 and R6 together with the carbon atom to which they are bound, form a 3-, 4-, 5- or 6-mem- bered saturated carbocyclic ring or a 3-, 4-, 5- or 6-membered saturated heterocyclic ring containing 1, 2 or 3 heteroatoms selected from O and S as ring members; where the car- bocyclic or heterocyclic ring is unsubstituted or carries 1, 2 or 3 substituents R56; where each R56 is independently halogen, C1-C6-alkyl or C1-C6-haloalkyl; R7 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6- haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, ben- zyl, five- or six-membered heteroaryl or five- or six-membered CH2heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substituents R7a; where each R7a is independently halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl or O-C1-C6-alkyl; R8 is in each case independently selected from hydrogen, halogen, CN, C1-C6-alkyl, C1-C6- haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, phenyl, ben- zyl, five- or six-membered heteroaryl or five- or six-membered CH2heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the aliphatic or aromatic radicals are unsubstituted or carry 1, 2 or 3 substituents R8a; where 230124 131 each R8a is independently halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl or O-C1-C6-alkyl; or R7 and R8 together with the carbon atom to which they are bound, form a 3-, 4-, 5- or 6-mem- bered saturated carbocyclic ring or a 3-, 4-, 5- or 6-membered saturated heterocyclic ring containing 1, 2 or 3 heteroatoms selected from O and S as ring members; X is in each case independently selected from halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C6-alkoxy or C1-C6-haloalkoxy, phenyl, benzyl, phenoxy, benzoxy, C1-C6-thioalkyl; wherein phenyl, benzyl, phenoxy, benzoxy can be unsubstituted or substituted by halogen, CN, C1-C6-alkyl or C1-C6-haloalkyl; n is 0, 1, 2 or 3; with the proviso that if Y is CR1, R5, R6, R7 and R8 cannot all be H; or the N-oxides, tautomers, stereoisomers or agriculturally acceptable salts thereof. 2. Compound of claim 1, wherein Y is CR1 and R1 is H. 3. Compound of any one of claims 1 to 2, wherein R2 is C1-C6-alkyl. 4. Compound of any one of claims 1 to 3, wherein R2 is CH3. 5. Compound of any one of claims 1 to 4, wherein R3 is selected from C1-C6-alkyl, C1-C6- halogenalkyl. 6. Compound of any one of claims 1 to 5, wherein R3 is CH3 or CHF2. 7. Compound of any one of claims 1 to 6, wherein R4 is H. 8. Compound of any one of claims 1 to 7, wherein R5 and R6 are H or C1-C6-alkyl. 9. Compound of any one of claims 1 to 8, wherein R5 and R6 form together with the C at- oms to which they are bound a C3-C6-cycloalkyl or a (=O) group. 10. Compound of any one of claims 1 to 9, wherein R7 and R8 are H or C1-C6-alkyl. 11. Compound of any one of claims 1 to 10, wherein X is selected from halogen, C1-C6- alkyl, O-C1-C6-alkyl, O-C1-C6-halogenalkyl. 12. A composition, comprising one compound of formula I, as defined in any of the claims 1 to 11, an N-oxide or an agriculturally acceptable salt thereof. 230124 132 13. A method for combating phytopathogenic fungi, comprising treating the fungi or the materials, plants, the soil or seeds to be protected against fungal attack with an effec- tive amount of at least one compound of formula I, as defined in any of the claims 1 to 11 or with a composition, as defined in any of the claim 12. 14. Seed, coated with at least one compound of the formula I, as defined in any of the claims 1 to 11 or an agriculturally acceptable salt thereof or with a composition, as de- fined in any of the claim 12, in an amount of from 0.1 to 10 kg per 100 kg of seed.
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