[go: up one dir, main page]

ATE529102T1 - Verbindung zur vorbeugung und behandlung von glaukoma - Google Patents

Verbindung zur vorbeugung und behandlung von glaukoma

Info

Publication number
ATE529102T1
ATE529102T1 AT04014078T AT04014078T ATE529102T1 AT E529102 T1 ATE529102 T1 AT E529102T1 AT 04014078 T AT04014078 T AT 04014078T AT 04014078 T AT04014078 T AT 04014078T AT E529102 T1 ATE529102 T1 AT E529102T1
Authority
AT
Austria
Prior art keywords
compound
glaucoma
prophylaxis
treatment
agent
Prior art date
Application number
AT04014078T
Other languages
English (en)
Inventor
Mitsuyoshi Azuma
Yukuo Yoshida
Mitsunori Waki
Masayoshi Uehata
Original Assignee
Senju Pharma Co
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharma Co, Mitsubishi Tanabe Pharma Corp filed Critical Senju Pharma Co
Application granted granted Critical
Publication of ATE529102T1 publication Critical patent/ATE529102T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT04014078T 1998-08-17 1999-08-13 Verbindung zur vorbeugung und behandlung von glaukoma ATE529102T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24776298 1998-08-17
JP12296099 1999-04-28

Publications (1)

Publication Number Publication Date
ATE529102T1 true ATE529102T1 (de) 2011-11-15

Family

ID=26459997

Family Applications (3)

Application Number Title Priority Date Filing Date
AT04014077T ATE527993T1 (de) 1998-08-17 1999-08-13 Verbindung zur vorbeugung und behandlung von augen-asthenopie und pseudomyopie
AT04014078T ATE529102T1 (de) 1998-08-17 1999-08-13 Verbindung zur vorbeugung und behandlung von glaukoma
AT99937073T ATE307609T1 (de) 1998-08-17 1999-08-13 Präventiva/mittel zur glaukombehandlung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT04014077T ATE527993T1 (de) 1998-08-17 1999-08-13 Verbindung zur vorbeugung und behandlung von augen-asthenopie und pseudomyopie

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99937073T ATE307609T1 (de) 1998-08-17 1999-08-13 Präventiva/mittel zur glaukombehandlung

Country Status (12)

Country Link
US (2) US6673812B1 (de)
EP (3) EP1034793B1 (de)
JP (2) JP3720264B2 (de)
KR (1) KR100616466B1 (de)
CN (2) CN1195547C (de)
AT (3) ATE527993T1 (de)
AU (1) AU5198199A (de)
CA (2) CA2635412C (de)
DE (1) DE69927936T2 (de)
ES (3) ES2247822T3 (de)
HK (3) HK1069121A1 (de)
WO (1) WO2000009162A1 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4260370B2 (ja) * 1998-08-10 2009-04-30 旭化成ファーマ株式会社 塩酸ファスジルの経口徐放性製剤
WO2000057913A1 (fr) * 1999-03-25 2000-10-05 Welfide Corporation Prophylaxies/remedes pour la pneumonie interstitielle et la fibrose pulmonaire
WO2000057914A1 (fr) * 1999-03-25 2000-10-05 Santen Pharmaceutical Co., Ltd. Agents permettant d'abaisser la tension oculaire
US9603741B2 (en) 2000-05-19 2017-03-28 Michael S. Berlin Delivery system and method of use for the eye
BR0114020A (pt) 2000-09-20 2003-07-22 Merck Patent Gmbh 4-amino-quinazolinas
CA2707827A1 (en) * 2001-04-11 2002-10-24 Senju Pharmaceutical Co., Ltd. Visual function disorder improving agents containing rho kinase inhibitors
JP2003010158A (ja) * 2001-04-26 2003-01-14 Biochemical & Pharmacological Laboratories Inc 眼精疲労モデル、その作製方法、そのモデルを用いた評価方法およびその評価法を用いて選択された薬剤
US7829566B2 (en) 2001-09-17 2010-11-09 Werner Mederski 4-amino-quinazolines
ES2305435T3 (es) 2002-01-10 2008-11-01 Bayer Healthcare Ag Inhibidores de la rho-quinasa.
DE60318177T2 (de) 2002-01-23 2008-10-09 Bayer Pharmaceuticals Corp., West Haven Rho-kinase inhibitoren
US6924290B2 (en) 2002-01-23 2005-08-02 Bayer Pharmaceuticals Corporation Rho-kinase inhibitors
US7645878B2 (en) 2002-03-22 2010-01-12 Bayer Healthcare Llc Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
GB0206860D0 (en) 2002-03-22 2002-05-01 Glaxo Group Ltd Compounds
CA2496797C (en) 2002-08-29 2012-01-10 Santen Pharmaceutical Co., Ltd. Therapeutic agent for glaucoma comprising rho kinase inhibitor and prostaglandin
AU2003269413A1 (en) * 2002-11-01 2004-05-25 Pharmacia & Upjohn Company Llc Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
EP1568382B1 (de) * 2002-11-18 2013-11-06 Santen Pharmaceutical Co., Ltd. HEILMITTEL FÜR GRÜNEN STAR, UMFASSEND Rho-KINASE UND beta-BLOCKER
US7160894B2 (en) * 2003-06-06 2007-01-09 Asahi Kasei Pharma Corporation Tricyclic compound
CN100390173C (zh) * 2003-06-06 2008-05-28 旭化成制药株式会社 3环系化合物
EP2468729B1 (de) 2003-10-15 2013-12-25 Ube Industries, Ltd. Neues Indazolderivat
WO2005053683A1 (en) 2003-11-26 2005-06-16 Duke University A method of preventing or treating glaucoma
SI1696920T1 (sl) 2003-12-19 2015-02-27 Plexxikon Inc. Spojine in postopki za razvoj modulatorjev ret
US7083783B2 (en) * 2004-02-18 2006-08-01 Wisconsin Alumni Research Foundation Method for treating glaucoma
WO2005102345A1 (en) * 2004-03-30 2005-11-03 Alcon, Inc. Use of rho kinase inhibitors in the treatment of hearing loss, tinnitus and improving body balance
FR2868310A1 (fr) * 2004-04-02 2005-10-07 Oreal Utilisation cosmetique d'au moins un inhibiteur de la production et/ou de l'activation des rhoa kinases comme agent destine a detendre les traits et/ou decontracter la peau
JP4932480B2 (ja) 2004-06-03 2012-05-16 千寿製薬株式会社 アミド化合物を含有する角膜知覚回復剤
TWI367098B (en) 2004-12-23 2012-07-01 Kowa Co Treating agent for glaucoma
WO2006071548A2 (en) * 2004-12-27 2006-07-06 Alcon, Inc. Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases
EP1854484A4 (de) * 2005-02-16 2010-02-10 Astellas Pharma Inc Einen rock-hemmer enthaltendes schmerzmittel
EP1902731B1 (de) * 2005-06-21 2013-04-10 Kowa Company, Ltd. Mittel zur prävention oder heilmittel für glaukom
JP4972552B2 (ja) * 2005-07-12 2012-07-11 興和株式会社 緑内障を予防又は治療する薬剤
KR20080040027A (ko) 2005-09-02 2008-05-07 아스테라스 세이야쿠 가부시키가이샤 Ｒｏｃｋ 억제제로서 아미드 유도체
US7867999B1 (en) 2005-12-22 2011-01-11 Alcon Research, Ltd. Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions
US7655662B2 (en) 2005-12-22 2010-02-02 Alcon Research, Ltd. (Indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines for treating glaucoma and controlling intraocular pressure
RU2008152065A (ru) 2006-06-08 2010-07-20 Убе Индастриз, Лтд (Jp) Новое производное имидазола со спироциклической структурой в боковой цепи
KR20090057223A (ko) * 2006-07-31 2009-06-04 센주 세이야꾸 가부시키가이샤 아미드 화합물을 함유하는 수성 액제
US20100022517A1 (en) * 2006-12-18 2010-01-28 Richards Lori A Ophthalmic formulation of rho kinase inhibitor compound
AR064420A1 (es) * 2006-12-21 2009-04-01 Alcon Mfg Ltd Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop).
EP2107052B1 (de) 2006-12-26 2011-10-12 Santen Pharmaceutical Co., Ltd Neue n-(2-aminophenyl)benzamidderivate mit harnstoffstruktur
CA2680517A1 (en) 2007-03-28 2008-10-02 Santen Pharmaceutical Co., Ltd. Novel pyridinecarboxylic acid (2-aminophenyl)amide derivative having urea structure
WO2008123395A1 (ja) 2007-03-28 2008-10-16 Santen Pharmaceutical Co., Ltd. ヒストン脱アセチル化酵素阻害作用を有する化合物を有効成分として含有する眼圧下降剤
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
EP2193806B1 (de) 2007-08-29 2017-12-06 Senju Pharmaceutical Co., Ltd. Mittel zur förderung der endothelialzelladhäsion der hornhaut
US8372811B2 (en) * 2007-09-21 2013-02-12 Eyegene, Inc. Composition for treating retinopathy or glaucoma comprising thrombin derived peptides
US20170360609A9 (en) 2007-09-24 2017-12-21 Ivantis, Inc. Methods and devices for increasing aqueous humor outflow
CA2717441A1 (en) 2008-03-05 2009-09-11 Ivantis, Inc. Methods and apparatus for treating glaucoma
EP2292611B1 (de) 2008-05-23 2012-07-25 Santen Pharmaceutical Co., Ltd Neues thiophendiaminderivat mit harnstoffstruktur
EP2319539A4 (de) * 2008-07-24 2012-03-28 Univ Osaka Prophylaktischer oder therapeutischer wirkstoff gegen axiale myopie
EP2319514A4 (de) * 2008-07-25 2011-11-02 Asahi Kasei Pharma Corp Stabile wässrige lösungszusammensetzung mit einer sulfonamidverbindung
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
BRPI0918045A2 (pt) * 2008-09-18 2015-12-01 Astellas Pharma Inc compostos de carboxamida heterocíclicos
US10842669B2 (en) 2008-11-13 2020-11-24 Gholam A. Peyman Ophthalmic drug delivery method
US20110125090A1 (en) * 2008-11-13 2011-05-26 Peyman Gholam A Ophthalmic drug delivery system and method
US10272035B2 (en) * 2008-11-13 2019-04-30 Gholam A. Peyman Ophthalmic drug delivery method
NZ594398A (en) 2009-04-03 2014-03-28 Plexxikon Inc Propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1h-pyrrol [2, 3-b] pyridine-3-carbonyl]-2,4-difluoro-phenyl} -amide compositions and uses thereof
US20100298335A1 (en) * 2009-05-22 2010-11-25 Kaufman Herbert E Preparations and Methods for Ameliorating or Reducing Presbyopia
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
US9693899B2 (en) 2009-07-09 2017-07-04 Ivantis, Inc. Single operator device for delivering an ocular implant
CA2766192C (en) 2009-07-09 2017-10-24 Ivantis, Inc. Ocular implants for residing partially in schlemm's canal
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
WO2011021221A2 (en) 2009-08-17 2011-02-24 Reliance Life Sciences Pvt. Ltd. Compositions for spinal cord injury
NZ629615A (en) 2009-11-06 2016-01-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
KR20130095263A (ko) * 2010-07-27 2013-08-27 인스파이어 파마슈티컬스 인코퍼레이티드 전구약물 형태의 키나아제 저해제 화합물을 사용하여 안질환을 치료하는 방법
TW201729813A (zh) 2011-02-04 2017-09-01 Kowa Co Ltd 青光眼預防或治療之藥物療法
BR112013020041B1 (pt) 2011-02-07 2021-11-23 Plexxikon, Inc Compostos e composições para a modulação de quinases e uso dos mesmos
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US8657776B2 (en) 2011-06-14 2014-02-25 Ivantis, Inc. Ocular implants for delivery into the eye
US8663150B2 (en) 2011-12-19 2014-03-04 Ivantis, Inc. Delivering ocular implants into the eye
US9358156B2 (en) 2012-04-18 2016-06-07 Invantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
CA2878370C (en) * 2012-07-13 2021-01-19 Santen Pharmaceutical Co., Ltd. Combinations comprising a sulfonamide compound for the treatment of glaucoma or ocular hypertension
US10617558B2 (en) 2012-11-28 2020-04-14 Ivantis, Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
EP3785668A1 (de) 2013-03-15 2021-03-03 Alcon Inc. Aufbewahrungs- und ladevorrichtung für intraokularlinsen und verfahren zur verwendung
EP2990040B1 (de) 2013-04-24 2019-12-04 Kyushu University, National University Corporation Therapeutikum für erkrankungen des augenhintergrunds
US10709547B2 (en) 2014-07-14 2020-07-14 Ivantis, Inc. Ocular implant delivery system and method
US9844556B2 (en) 2015-03-25 2017-12-19 Megumi Honjo Preventive/therapeutic method and preventive/therapeutic agent for complications after cataract surgery
EP4265231A3 (de) 2015-08-14 2023-12-20 Alcon Inc. Augenimplantat mit drucksensor
US12048761B2 (en) 2015-10-13 2024-07-30 Inserm (Institut National De La Santé Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion
EP4088719A1 (de) 2015-10-13 2022-11-16 Institut National de la Santé et de la Recherche Médicale (INSERM) Verfahren und pharmazeutische zusammensetzungen zur behandlung von kapillarer nichtperfusion der netzhaut
US11938058B2 (en) 2015-12-15 2024-03-26 Alcon Inc. Ocular implant and delivery system
ES2972934T3 (es) 2017-12-21 2024-06-17 Santen Pharmaceutical Co Ltd Combinación de sepetaprost y ripasudil para su uso en la profilaxis o tratamiento del glaucoma o hipertensión ocular
US12029683B2 (en) 2018-02-22 2024-07-09 Alcon Inc. Ocular implant and delivery system
US20230069076A1 (en) 2020-02-05 2023-03-02 Nicox S.A. Compositions for the treatment of glaucoma and ocular hypertension
WO2022150684A1 (en) 2021-01-11 2022-07-14 Ivantis, Inc. Systems and methods for viscoelastic delivery
MX2023008141A (es) 2021-01-11 2023-10-20 Incyte Corp Terapia combinada que comprende el inhibidor de la vía de proteínas tirosina cinasas de janus cinasas (jak) y el inhibidor de la proteína cinasa asociada a rho (rock).
US12245930B2 (en) 2023-06-30 2025-03-11 Alcon Inc. System and methods for compensating for intraocular lens tilt

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4838677A (en) 1987-04-06 1989-06-13 Ayetech Inc. Eye exercising devices
US5250547A (en) 1991-08-29 1993-10-05 Syntex (U.S.A.) Inc. Benzopyran derivatives
DE69231297T2 (de) * 1991-09-06 2000-11-23 Yoshitomi Pharmaceutical Industries, Ltd. 4-amino(alkyl)cyclohexan-1-carboxamidverbindungen und ihre verwendung
ZA931063B (en) 1992-02-17 1993-09-23 Ciba Geigy Treatment of glaucoma.
US5618955A (en) 1992-11-30 1997-04-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Fatty acid derivatives and pharmaceutical compositions containing same
IL103932A (en) 1992-11-30 1997-02-18 Yissum Res & Dev Fatty acid and pharmaceutical compositions containing them
JP3066561B2 (ja) * 1993-10-07 2000-07-17 武田薬品工業株式会社 近視予防・治療剤
JPH07133225A (ja) * 1993-11-09 1995-05-23 Santen Pharmaceut Co Ltd 毛様体筋緊張緩和剤
EP1195372A1 (de) 1994-04-18 2002-04-10 Mitsubishi Pharma Corporation N-Heterozyklisch substitutierte Benzamid Deriviate mit antihypertensiver Wirkung
JPH08198876A (ja) 1995-01-30 1996-08-06 Yoshitomi Pharmaceut Ind Ltd トランス−Ｎ−（１Ｈ−ピラゾロ〔３，４−ｂ〕ピリジン−４−イル）−４−グアニジノメチルシクロヘキサンカルボキサミド・１メタンスルホン酸塩・１水和物
US5888173A (en) 1995-08-10 1999-03-30 Singhal; Tara Chand Health saver computer break
US5906819A (en) 1995-11-20 1999-05-25 Kirin Beer Kabushiki Kaisha Rho target protein Rho-kinase
JP3421217B2 (ja) * 1995-11-20 2003-06-30 麒麟麦酒株式会社 Ｒｈｏ標的タンパク質Ｒｈｏキナーゼ
JPH09143099A (ja) * 1995-11-27 1997-06-03 Santen Pharmaceut Co Ltd 毛様体筋緊張緩和剤
JP3719609B2 (ja) 1995-12-21 2005-11-24 アルコン ラボラトリーズ，インコーポレイテッド 緑内障および眼虚血の治療のための特定のイソキノリンスルホニル化合物の使用
US5798380A (en) * 1996-02-21 1998-08-25 Wisconsin Alumni Research Foundation Cytoskeletal active agents for glaucoma therapy
JPH10203982A (ja) * 1996-07-05 1998-08-04 Takeda Chem Ind Ltd 視機能障害の予防・治療剤
ES2286834T5 (es) * 1996-08-12 2011-01-31 Mitsubishi Tanabe Pharma Corporation Medicamentos que comprenden un inhibidor de la rho quinasa.

Also Published As

Publication number Publication date
ES2247822T3 (es) 2006-03-01
DE69927936T2 (de) 2006-06-29
EP1459743A8 (de) 2005-02-02
EP1459742A3 (de) 2007-12-26
DE69927936D1 (de) 2005-12-01
ATE307609T1 (de) 2005-11-15
EP1459742A2 (de) 2004-09-22
WO2000009162A1 (fr) 2000-02-24
EP1459742B9 (de) 2012-05-02
ES2372572T3 (es) 2012-01-23
CA2635412A1 (en) 2000-02-24
JP3720264B2 (ja) 2005-11-24
CN1195547C (zh) 2005-04-06
CN1494903A (zh) 2004-05-12
EP1459743B1 (de) 2011-10-19
KR100616466B1 (ko) 2006-08-29
ES2374518T3 (es) 2012-02-17
HK1069121A1 (en) 2005-05-13
EP1034793A1 (de) 2000-09-13
CN1287494A (zh) 2001-03-14
EP1459743B9 (de) 2012-08-01
EP1034793A4 (de) 2003-07-09
EP1034793B1 (de) 2005-10-26
EP1459742B1 (de) 2011-10-12
JP4490748B2 (ja) 2010-06-30
CA2307285C (en) 2009-03-31
US20030125351A1 (en) 2003-07-03
US6673812B1 (en) 2004-01-06
HK1069120A1 (en) 2005-05-13
CA2635412C (en) 2011-06-21
KR20010015761A (ko) 2001-02-26
CA2307285A1 (en) 2000-02-24
EP1459743A3 (de) 2007-12-26
EP1459743A2 (de) 2004-09-22
JP2004277432A (ja) 2004-10-07
CN1293878C (zh) 2007-01-10
US6649625B2 (en) 2003-11-18
HK1030883A1 (en) 2001-05-25
AU5198199A (en) 2000-03-06
ATE527993T1 (de) 2011-10-15

Similar Documents

Publication Publication Date Title
ATE529102T1 (de) Verbindung zur vorbeugung und behandlung von glaukoma
DE69634414D1 (de) Verwendung von substituierten isochinolinsulfonyl-verbindungen zur herstellung eines medikaments für die behandlung von glaukom und okularer ischämie
CY1108651T1 (el) Προληπτικος ή θεραπευτικος παραγων για γλαυκωμα
DE60036540D1 (de) Rho-kinase-inhibitoren für die vorbeugung oder behandlung von interstitieller pneumonie und pulmonaler fibrose
HK1083624A1 (en) Hydroxyethylamine derivatives for the treatment ofalzheimer's disease
ES2139195T3 (es) Derivados de sulfonamidas como inhibidores de la aspartil-proteasa.
TNSN04082A1 (en) N,n'-substituted-1,3-diamino-2-hydroxypropane derivatives
DE69521620D1 (de) Verwendung von 9-deoxyprostaglandinderivaten zur behandlung von glaukom
DE69019774D1 (de) Isochinolin-Derivate zur Behandlung des Glaukoms oder der okulären Hypertonie.
BR0210241A (pt) Piranoindazóis e seu uso no tratamento de glaucoma
PT1263504E (pt) Compostos com actividade 5-ht1a uteis para o tratamento de perturbacoes da retina externa
ATE238792T1 (de) Verwendung von makroliden zur behandlung von glaukom
DE3872701D1 (de) Prostaglandin-derivate zur behandlung von glaucoma oder augenueberdruck.
BR0017157A (pt) Derivados de 6-hidroxi-indazol para o tratamento de glaucoma
BR0210238A (pt) Novos análogos de aril-amino-propano e seu uso para o tratamento de glaucoma
DE69430521D1 (de) Anwendung von Prostagrandin-Analogen für die Behandlung von Glaukome und okuläre Hypertension
DE60135972D1 (de) Orhthalmologische zusammenstellungen zur behandlung von ocularer hypertension
BR0316775A (pt) Novos análogos de benzopirano e seu uso para o tratamento de glaucoma
ATE428470T1 (de) Heilmittel zur behandlung von erkrankungen des sehnervs
MXPA03012039A (es) Derivados de benzo [g]quinolina para tratar glaucoma y miopia.
MXPA04001255A (es) Uso de compuesto para el tratamiento de condiciones que resultan de lesion al nervio corneo despues de lasik y otras cirugias oculares o trauma.
DE69905489D1 (de) Protein c zur behandlung von sichelzellanämie und thalassämie
ATE428436T1 (de) Mittel zur behandlung oder prävention allergischer erkrankungen mit bearbeitetem erdnusssamen-überzug
ATE311901T1 (de) Verwendung von tgf-beta inhibitoren zur behandlung von cerebralen krankheiten
ATE314854T1 (de) Mittel zur prävention und/oder behandlung einer gewebeveränderung mesenchymalen ursprungs

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties