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ATE512994T1 - Hocheffizientes verfahren zur herstellung von polyalkylenoxidcarbonsäuren - Google Patents

Hocheffizientes verfahren zur herstellung von polyalkylenoxidcarbonsäuren

Info

Publication number
ATE512994T1
ATE512994T1 AT06849274T AT06849274T ATE512994T1 AT E512994 T1 ATE512994 T1 AT E512994T1 AT 06849274 T AT06849274 T AT 06849274T AT 06849274 T AT06849274 T AT 06849274T AT E512994 T1 ATE512994 T1 AT E512994T1
Authority
AT
Austria
Prior art keywords
oxidecarbonic
acids
highly efficient
efficient process
polyalkylene oxide
Prior art date
Application number
AT06849274T
Other languages
English (en)
Inventor
Hong Zhao
Anthony Martinez
Original Assignee
Enzon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Pharmaceuticals Inc filed Critical Enzon Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE512994T1 publication Critical patent/ATE512994T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/337—Polymers modified by chemical after-treatment with organic compounds containing other elements
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06849274T 2006-01-10 2006-12-28 Hocheffizientes verfahren zur herstellung von polyalkylenoxidcarbonsäuren ATE512994T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/328,662 US7989554B2 (en) 2006-01-10 2006-01-10 Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
PCT/US2006/049706 WO2007081596A2 (en) 2006-01-10 2006-12-28 High efficiency method of preparing polyalkylene oxide carboxylic acids

Publications (1)

Publication Number Publication Date
ATE512994T1 true ATE512994T1 (de) 2011-07-15

Family

ID=38256821

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06849274T ATE512994T1 (de) 2006-01-10 2006-12-28 Hocheffizientes verfahren zur herstellung von polyalkylenoxidcarbonsäuren

Country Status (11)

Country Link
US (1) US7989554B2 (de)
EP (1) EP1976896B1 (de)
JP (1) JP5199125B2 (de)
KR (1) KR20080083064A (de)
CN (1) CN101356203A (de)
AT (1) ATE512994T1 (de)
AU (1) AU2006335041A1 (de)
CA (1) CA2636280A1 (de)
IL (1) IL192409A0 (de)
TW (1) TW200732374A (de)
WO (1) WO2007081596A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
WO2007146835A2 (en) * 2006-06-09 2007-12-21 Enzon Pharmaceuticals, Inc. Indenoisoquinoline-releasable polymer conjugates
CN101605539B (zh) * 2007-02-09 2013-01-02 安佐制药股份有限公司 用7-乙基-10-羟基喜树碱的多臂聚合缀合物治疗抵抗性或顽固性癌症
CN101680039B (zh) * 2007-04-20 2016-08-24 希格马托罕见疾病有限公司 酶的抗癌治疗
CA2684750C (en) * 2007-04-20 2014-08-05 Enzon Pharmaceuticals, Inc. Stable recombinant adenosine deaminase
TW200922624A (en) * 2007-07-11 2009-06-01 Enzon Pharmaceuticals Inc Polymeric drug delivery system containing a multi-substituted aromatic moiety
WO2010025337A1 (en) * 2008-08-29 2010-03-04 Enzon Pharmaceuticals, Inc. Method of treating ras associated cancer
AU2009307922A1 (en) * 2008-10-21 2010-04-29 Enzon Pharmaceuticals, Inc. Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
NZ746680A (en) 2014-10-14 2020-07-31 Halozyme Inc Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
EP4416256A1 (de) * 2021-10-13 2024-08-21 Basf Se Zusammensetzungen mit polymeren, polymere und deren verwendung

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US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4315074A (en) 1978-05-19 1982-02-09 Pierce Chemical Company Molecular transformation procedure
JPS57206622A (en) 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
JPS59204172A (ja) 1983-04-28 1984-11-19 Kowa Co アセメタシンの製造法
JPS60156395A (ja) 1984-01-17 1985-08-16 Mihama Hisaharu 修飾リパーゼ
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4760176A (en) 1985-12-20 1988-07-26 Borg-Warner Chemicals, Inc. Aminocarboxylic acid-terminated polyoxy-alkylenes and process for the preparation thereof
US4814098A (en) 1986-09-06 1989-03-21 Bellex Corporation Magnetic material-physiologically active substance conjugate
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US5006333A (en) 1987-08-03 1991-04-09 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US4925968A (en) 1987-12-23 1990-05-15 American Home Products Corporation N-acyl-N-naphthoylglycines as aldose reductase inhibitors
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5453517A (en) 1992-02-25 1995-09-26 Molecular Probes, Inc. Reactive derivatives of bapta used to make ion-selective chelators
US5122514A (en) 1990-04-23 1992-06-16 Abbott Laboratories Psoriasis treatment
US5244910A (en) 1990-08-15 1993-09-14 Abbott Laboratories Renin inhibitors
JP3051145B2 (ja) 1990-08-28 2000-06-12 住友製薬株式会社 新規なポリエチレングリコール誘導体修飾ペプチド
US5545698A (en) 1990-08-31 1996-08-13 University Of Minnesota Polyethylene glycol derivatives for solid-phase applications
US5145992A (en) 1991-05-06 1992-09-08 G. D. Searle & Co. Process and preparation of α-alkoxy acetic acids and their salts
AU4406793A (en) 1992-06-04 1993-12-30 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5278303A (en) 1992-06-12 1994-01-11 University Of Toronto Innovations Foundation Polymer-supported solution synthesis of oligosaccharides
CA2106141A1 (en) 1992-09-28 1994-03-29 Michael J. Betts Antibiotic compounds
US5298643A (en) 1992-12-22 1994-03-29 Enzon, Inc. Aryl imidate activated polyalkylene oxides
US5349001A (en) 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5321095A (en) 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
US5298410A (en) 1993-02-25 1994-03-29 Sterling Winthrop Inc. Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
US5436369A (en) 1993-06-16 1995-07-25 Bristol-Myers Squibb Company Alicyclic phospholipase A2 inhibitors
US5430043A (en) 1993-08-24 1995-07-04 G. D. Searle & Co. Platelet aggregation inhibitors
US5880131A (en) 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
JP3407397B2 (ja) * 1994-05-06 2003-05-19 日本油脂株式会社 ポリオキシアルキレン誘導体および製造方法
US5756593A (en) * 1995-05-15 1998-05-26 Enzon, Inc. Method of preparing polyalkyene oxide carboxylic acids
US5847003A (en) 1996-06-04 1998-12-08 Avon Products, Inc. Oxa acids and related compounds for treating skin conditions
JPH1087815A (ja) * 1996-08-22 1998-04-07 Enzon Inc ポリアルキレンオキシドカルボン酸の改良製造方法
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6756037B2 (en) 2000-03-31 2004-06-29 Enzon, Inc. Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups
ATE344289T1 (de) * 2002-07-24 2006-11-15 Hoffmann La Roche Polyethylenglykol-aldehydderivate
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US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers

Also Published As

Publication number Publication date
TW200732374A (en) 2007-09-01
AU2006335041A1 (en) 2007-07-19
CA2636280A1 (en) 2007-07-19
WO2007081596A2 (en) 2007-07-19
CN101356203A (zh) 2009-01-28
JP2009523191A (ja) 2009-06-18
WO2007081596A3 (en) 2007-12-13
JP5199125B2 (ja) 2013-05-15
KR20080083064A (ko) 2008-09-12
IL192409A0 (en) 2008-12-29
EP1976896B1 (de) 2011-06-15
EP1976896A4 (de) 2009-09-02
EP1976896A2 (de) 2008-10-08
US20070173615A1 (en) 2007-07-26
US7989554B2 (en) 2011-08-02

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