ATE462693T1 - Verfahren zur herstellung von remifentanil, zwischenprodukte davon, verwendung dieser zwischenprodukte und verfahren zu ihrer herstellung - Google Patents
Verfahren zur herstellung von remifentanil, zwischenprodukte davon, verwendung dieser zwischenprodukte und verfahren zu ihrer herstellungInfo
- Publication number
- ATE462693T1 ATE462693T1 AT07730143T AT07730143T ATE462693T1 AT E462693 T1 ATE462693 T1 AT E462693T1 AT 07730143 T AT07730143 T AT 07730143T AT 07730143 T AT07730143 T AT 07730143T AT E462693 T1 ATE462693 T1 AT E462693T1
- Authority
- AT
- Austria
- Prior art keywords
- intermediate products
- remifentanil
- producing
- production
- preparing
- Prior art date
Links
- ZTVQQQVZCWLTDF-UHFFFAOYSA-N Remifentanil Chemical compound C1CN(CCC(=O)OC)CCC1(C(=O)OC)N(C(=O)CC)C1=CC=CC=C1 ZTVQQQVZCWLTDF-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229960003394 remifentanil Drugs 0.000 title abstract 3
- 239000013067 intermediate product Substances 0.000 title 2
- YGKBIZCNRPCONR-UHFFFAOYSA-N (2-cyanopiperidin-1-yl) propanoate Chemical class CCC(=O)ON1CCCCC1C#N YGKBIZCNRPCONR-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000002560 nitrile group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80490606P | 2006-06-15 | 2006-06-15 | |
| EP06115527A EP1867635A1 (de) | 2006-06-15 | 2006-06-15 | Verfahren zur Herstellung von Remifentanil, seine Zwischenprodukte, die Verwendung von diesen Zwischenprodukten und das Verfahren zur deren Herstellung |
| PCT/EP2007/055859 WO2007144391A1 (en) | 2006-06-15 | 2007-06-13 | Process for preparing remifentanil, intermediates thereof, use of said intermediates and processes for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE462693T1 true ATE462693T1 (de) | 2010-04-15 |
Family
ID=37311927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07730143T ATE462693T1 (de) | 2006-06-15 | 2007-06-13 | Verfahren zur herstellung von remifentanil, zwischenprodukte davon, verwendung dieser zwischenprodukte und verfahren zu ihrer herstellung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100016601A1 (de) |
| EP (2) | EP1867635A1 (de) |
| AT (1) | ATE462693T1 (de) |
| DE (1) | DE602007005650D1 (de) |
| ES (1) | ES2343212T3 (de) |
| PT (1) | PT2044021E (de) |
| WO (1) | WO2007144391A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011526257A (ja) * | 2008-07-03 | 2011-10-06 | シラグ アーゲー | Ｎ−フェニル−ｎ−（４−ピペリジニル）アミド塩の製造方法 |
| JP5811602B2 (ja) * | 2010-12-16 | 2015-11-11 | ソニー株式会社 | 画像生成装置、プログラム、画像表示システム、および画像表示装置 |
| CN102060753B (zh) * | 2010-12-29 | 2013-01-09 | 宜昌人福药业有限责任公司 | 一种4-苯胺基哌啶类镇痛药的精制方法 |
| SE540413C2 (en) * | 2016-05-25 | 2018-09-11 | Wallenius Water Innovation Ab | A UV light liquid treatment system |
| PT3643704T (pt) * | 2018-10-26 | 2021-03-08 | Hameln Pharma Gmbh | Novos intermediários para a preparação de hidrocloreto de remifentanil |
| US10875563B2 (en) * | 2019-04-03 | 2020-12-29 | Jenny Heckler | Convertible stroller assembly |
| GB202010168D0 (en) * | 2020-07-02 | 2020-08-19 | Johnson Matthey Plc | Process for preparing remifentanil hydrochloride |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998834A (en) * | 1975-03-14 | 1976-12-21 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-n-phenylamides and -carbamates |
| US5019583A (en) * | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| US5106983A (en) * | 1990-04-30 | 1992-04-21 | The United States Of America As Represented By The Secretary Of The Army | Process of making carfentanil and related analgesics |
| AU2427201A (en) * | 1999-12-06 | 2001-06-12 | Mallinckrodt, Inc. | New methods for the syntheses of alfentanil, sufentanil and remifentanil |
| WO2007061555A1 (en) * | 2005-11-17 | 2007-05-31 | Mallinckrodt Inc. | Process for synthesizing remifentanil |
-
2006
- 2006-06-15 EP EP06115527A patent/EP1867635A1/de not_active Withdrawn
-
2007
- 2007-06-13 PT PT07730143T patent/PT2044021E/pt unknown
- 2007-06-13 US US12/304,977 patent/US20100016601A1/en not_active Abandoned
- 2007-06-13 ES ES07730143T patent/ES2343212T3/es active Active
- 2007-06-13 WO PCT/EP2007/055859 patent/WO2007144391A1/en active Application Filing
- 2007-06-13 EP EP07730143A patent/EP2044021B1/de not_active Not-in-force
- 2007-06-13 AT AT07730143T patent/ATE462693T1/de not_active IP Right Cessation
- 2007-06-13 DE DE602007005650T patent/DE602007005650D1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1867635A1 (de) | 2007-12-19 |
| EP2044021A1 (de) | 2009-04-08 |
| WO2007144391A1 (en) | 2007-12-21 |
| DE602007005650D1 (de) | 2010-05-12 |
| ES2343212T3 (es) | 2010-07-26 |
| PT2044021E (pt) | 2010-06-25 |
| EP2044021B1 (de) | 2010-03-31 |
| US20100016601A1 (en) | 2010-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |