ATE500264T1 - Makrozyklische peptide mit wirkung gegen das hepatitis-c-virus - Google Patents
Makrozyklische peptide mit wirkung gegen das hepatitis-c-virusInfo
- Publication number
- ATE500264T1 ATE500264T1 AT04761821T AT04761821T ATE500264T1 AT E500264 T1 ATE500264 T1 AT E500264T1 AT 04761821 T AT04761821 T AT 04761821T AT 04761821 T AT04761821 T AT 04761821T AT E500264 T1 ATE500264 T1 AT E500264T1
- Authority
- AT
- Austria
- Prior art keywords
- virus
- active against
- against hepatitis
- macrocyclic peptides
- peptides active
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50483903P | 2003-09-22 | 2003-09-22 | |
PCT/CA2004/001658 WO2005028501A1 (en) | 2003-09-22 | 2004-09-20 | Macrocyclic peptides active against the hepatitis c virus |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE500264T1 true ATE500264T1 (de) | 2011-03-15 |
Family
ID=34375541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04761821T ATE500264T1 (de) | 2003-09-22 | 2004-09-20 | Makrozyklische peptide mit wirkung gegen das hepatitis-c-virus |
Country Status (22)
Country | Link |
---|---|
US (2) | US7642235B2 (de) |
EP (1) | EP1673385B1 (de) |
JP (2) | JP4704342B2 (de) |
KR (1) | KR20060094083A (de) |
CN (1) | CN1856502A (de) |
AR (1) | AR045938A1 (de) |
AT (1) | ATE500264T1 (de) |
AU (1) | AU2004274051A1 (de) |
BR (1) | BRPI0414571A (de) |
CA (1) | CA2536182C (de) |
DE (1) | DE602004031645D1 (de) |
EA (1) | EA200600498A1 (de) |
EC (1) | ECSP066448A (de) |
ES (1) | ES2361997T3 (de) |
IL (1) | IL174403A0 (de) |
MX (1) | MXPA06003141A (de) |
NO (1) | NO20061767L (de) |
PE (1) | PE20050431A1 (de) |
RS (1) | RS20060197A (de) |
TW (1) | TW200521144A (de) |
UY (1) | UY28525A1 (de) |
WO (1) | WO2005028501A1 (de) |
Families Citing this family (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE04023B1 (et) | 1996-10-18 | 2003-04-15 | Vertex Pharmaceuticals Incorporated | Seriinproteaaside, eriti C-hepatiidi viiruse NS3-proteaasi inhibiitorid |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
US7119072B2 (en) * | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
EA010013B1 (ru) * | 2003-04-02 | 2008-06-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические композиции ингибиторов вирусной протеазы гепатита с |
EP1615947A2 (de) * | 2003-04-10 | 2006-01-18 | Boehringer Ingelheim International GmbH | Verfahren zur herstellung macrocyclischer verbindungen |
US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
DK1654261T3 (da) | 2003-05-21 | 2008-01-14 | Boehringer Ingelheim Int | Hepatitis C-inhibitorforbindelser |
AR045596A1 (es) | 2003-09-05 | 2005-11-02 | Vertex Pharma | Inhibidores de proteasas de serina en particular proteasa ns3-ns4a del vhc |
MXPA06003141A (es) * | 2003-09-22 | 2006-06-05 | Boehringer Ingelheim Int | Peptidos macrociclicos activos contra el virus de la hepatitis c. |
US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
US7132504B2 (en) * | 2003-11-12 | 2006-11-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
ES2320776T3 (es) * | 2003-12-08 | 2009-05-28 | Boehringer Ingelheim International Gmbh | Eliminacion de subproductos de rutenio por tratamiento con fluidos supercriticos. |
WO2005070955A1 (en) * | 2004-01-21 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis c virus |
AU2005224092A1 (en) * | 2004-03-15 | 2005-09-29 | Boehringer Ingelheim International, Gmbh | Process for preparing macrocyclic dipeptides which are suitable for the treatment of hepatitis C viral infections |
JP5156374B2 (ja) | 2004-05-25 | 2013-03-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非環式hcvプロテアーゼインヒビターの調製方法 |
WO2006007708A1 (en) | 2004-07-20 | 2006-01-26 | Boehringer Engelheim International Gmbh | Hepatitis c inhibitor peptide analogs |
UY29016A1 (es) | 2004-07-20 | 2006-02-24 | Boehringer Ingelheim Int | Analogos de dipeptidos inhibidores de la hepatitis c |
US7189844B2 (en) | 2004-09-17 | 2007-03-13 | Boehringer Ingelheim International Gmbh | Ring-closing metathesis process in supercritical fluid |
CA2577831A1 (en) * | 2004-09-17 | 2006-03-30 | Boehringer Ingelheim International Gmbh | Process for preparing macrocyclic hcv protease inhibitors |
CA2583472A1 (en) * | 2004-10-01 | 2006-04-13 | Chao Lin | Hcv ns3-ns4a protease inhibition |
TW201424733A (zh) | 2004-10-29 | 2014-07-01 | Vertex Pharma | 劑量型式 |
DE102005002336A1 (de) * | 2005-01-17 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Durchführung von kontinuierlichen Olefin-Ringschluss-Metathesen in komprimiertem Kohlendioxid |
US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP1863833B1 (de) | 2005-03-08 | 2013-09-18 | Boehringer Ingelheim International GmbH | Verfahren zur herstellung makrocyclischer verbindungen |
US7592336B2 (en) | 2005-05-10 | 2009-09-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7608592B2 (en) | 2005-06-30 | 2009-10-27 | Virobay, Inc. | HCV inhibitors |
US7601686B2 (en) | 2005-07-11 | 2009-10-13 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
CA2615666C (en) * | 2005-07-25 | 2014-08-26 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
CN101233131B (zh) * | 2005-07-29 | 2011-06-08 | 泰博特克药品有限公司 | 丙型肝炎病毒的大环抑制剂 |
SI1919899T1 (sl) | 2005-07-29 | 2011-05-31 | Tibotec Pharm Ltd | Makrociklični inhibitorji virusa hepatitisa C |
CN101273052B (zh) * | 2005-07-29 | 2016-01-13 | 爱尔兰詹森科学公司 | 丙型肝炎病毒的大环抑制剂 |
EA014293B1 (ru) * | 2005-07-29 | 2010-10-29 | Тиботек Фармасьютикалз Лтд. | Макроциклические ингибиторы вируса гепатита с |
DK1912997T3 (da) * | 2005-07-29 | 2012-01-02 | Tibotec Pharm Ltd | Makrocycliske inhibitorer af hepatitis C virus |
PE20070211A1 (es) * | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
JP2009502845A (ja) * | 2005-07-29 | 2009-01-29 | メディヴィル・アクチボラグ | C型肝炎ウイルスの大環状インヒビター |
PE20070210A1 (es) * | 2005-07-29 | 2007-04-16 | Tibotec Pharm Ltd | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
PE20070343A1 (es) * | 2005-07-29 | 2007-05-12 | Medivir Ab | Inhibidores macrociclicos del virus de la hepatitis c |
JP2009505966A (ja) * | 2005-08-02 | 2009-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼのインヒビター |
EP1915378A4 (de) | 2005-08-12 | 2009-07-22 | Boehringer Ingelheim Int | Viren-polymerasehemmer |
US7964624B1 (en) * | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
PL1934243T3 (pl) | 2005-09-09 | 2011-10-31 | Boehringer Ingelheim Int | Proces metatezy z zamknięciem pierścienia w zastosowaniu do wytwarzania peptydów makrocyklicznych |
DE602006019323D1 (de) | 2005-10-11 | 2011-02-10 | Intermune Inc | Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus |
US7772183B2 (en) | 2005-10-12 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2007053755A1 (en) * | 2005-11-03 | 2007-05-10 | Boehringer Ingelheim International Gmbh | Process for preparing substituted anisidines |
US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7642381B2 (en) * | 2006-01-25 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Two step process for preparing substituted anisidines |
US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
WO2007109080A2 (en) | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
UY30437A1 (es) * | 2006-06-26 | 2008-01-31 | Enanta Pharm Inc | Quinoxalinil macroceclicos inhibidores de serina proteasa del virus de la hepatitis c |
RU2008152171A (ru) * | 2006-07-05 | 2010-08-10 | Интермьюн, Инк. (Us) | Новые ингибиторы вирусной репликации гепатита с |
US7935670B2 (en) | 2006-07-11 | 2011-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EA017448B1 (ru) | 2006-07-13 | 2012-12-28 | Ачиллион Фармасьютикалз, Инк. | 4-амино-4-оксобутаноиловые пептиды как ингибиторы вирусной репликации |
US7718612B2 (en) * | 2007-08-02 | 2010-05-18 | Enanta Pharmaceuticals, Inc. | Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors |
BRPI0716060A2 (pt) | 2006-08-17 | 2013-09-17 | Boehringer Ingelheim Int | inibidores de polimerase viral. |
MX2009003452A (es) | 2006-10-10 | 2009-04-14 | Medivir Ab | Inhibidores nucleosidicos del vhc. |
US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
US7772180B2 (en) | 2006-11-09 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7888464B2 (en) | 2006-11-16 | 2011-02-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7763584B2 (en) | 2006-11-16 | 2010-07-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8003604B2 (en) | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
CA2679377A1 (en) | 2007-02-26 | 2008-09-04 | Achillion Pharmaceuticals, Inc. | Tertiary amine substituted peptides useful as inhibitors of hcv replication |
EP2134717A2 (de) * | 2007-02-27 | 2009-12-23 | Vertex Pharmceuticals Incorporated | Serinprotease-hemmer |
WO2008141227A1 (en) | 2007-05-10 | 2008-11-20 | Intermune, Inc. | Novel peptide inhibitors of hepatitis c virus replication |
CA2693997C (en) | 2007-08-03 | 2013-01-15 | Pierre L. Beaulieu | Viral polymerase inhibitors |
US8419332B2 (en) * | 2007-10-19 | 2013-04-16 | Atlas Bolt & Screw Company Llc | Non-dimpling fastener |
CN101977621A (zh) | 2007-12-05 | 2011-02-16 | 益安药业 | 氟化三肽hcv丝氨酸蛋白酶抑制剂 |
CN101932242A (zh) * | 2007-12-05 | 2010-12-29 | 益安药业 | 喹喔啉基衍生物 |
EP2234977A4 (de) | 2007-12-19 | 2011-04-13 | Boehringer Ingelheim Int | Viren-polymerasehemmer |
US8202996B2 (en) | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
MX2010008523A (es) * | 2008-02-04 | 2010-08-31 | Idenix Pharmaceuticals Inc | Inhibidores macrociclicos de serina proteasa. |
EA201001262A1 (ru) | 2008-02-07 | 2011-04-29 | Вайробей, Инк. | Ингибиторы катепсина в |
US8163921B2 (en) | 2008-04-16 | 2012-04-24 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US20090285773A1 (en) * | 2008-05-15 | 2009-11-19 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
CN101580535B (zh) * | 2008-05-16 | 2012-10-03 | 太景生物科技股份有限公司 | 丙型肝炎病毒蛋白酶抑制剂 |
JP5529120B2 (ja) * | 2008-05-29 | 2014-06-25 | ブリストル−マイヤーズ スクイブ カンパニー | C型肝炎ウイルス阻害剤 |
US7964560B2 (en) | 2008-05-29 | 2011-06-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
UY32099A (es) * | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
UA103496C2 (uk) * | 2008-09-17 | 2013-10-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Комбінація інгібітора протеази ns3 hcv з інтерфероном і рибавірином |
US8563505B2 (en) | 2008-09-29 | 2013-10-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8044087B2 (en) | 2008-09-29 | 2011-10-25 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
JP5723783B2 (ja) | 2008-12-10 | 2015-05-27 | アキリオン ファーマシューティカルズ,インコーポレーテッド | ウイルス複製の阻害剤としての新しい4−アミノ−4−オキソブタノイルペプチド |
US8283310B2 (en) | 2008-12-15 | 2012-10-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
MX2011007195A (es) | 2009-01-07 | 2013-07-12 | Scynexis Inc | Derivado de ciclosporina para el uso en el tratamiento de infección de virus de hepatitis c (vhc) y virus de inmunodeficiencia humana (vih). |
EP2396028A2 (de) | 2009-02-12 | 2011-12-21 | Vertex Pharmceuticals Incorporated | Hcv-kombinationstherapien mit pegyliertem interferon, ribavirin und telaprevir |
JP2012520891A (ja) | 2009-03-19 | 2012-09-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | スルホニルキノリンの製造方法 |
EP2417134B1 (de) | 2009-04-08 | 2017-05-17 | Idenix Pharmaceuticals LLC. | Macrocyclische serinproteaseinhibitoren |
JP5639155B2 (ja) | 2009-05-13 | 2014-12-10 | エナンタ ファーマシューティカルズ インコーポレイテッド | C型肝炎ウイルスインヒビターとしての大環状化合物 |
US8232246B2 (en) | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
AU2010270783B2 (en) * | 2009-07-07 | 2013-06-27 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition for a hepatitis C viral protease inhibitor |
AR077712A1 (es) | 2009-08-05 | 2011-09-14 | Idenix Pharmaceuticals Inc | Inhibidores de serina proteasa macrociclica |
EA022118B1 (ru) | 2009-09-15 | 2015-11-30 | Тайджен Байотекнолоджи Ко., Лтд. | Ингибиторы протеазы hcv |
CN102020698B (zh) * | 2009-09-15 | 2012-08-29 | 太景生物科技股份有限公司 | 丙型肝炎病毒蛋白酶抑制剂 |
WO2011049908A2 (en) * | 2009-10-19 | 2011-04-28 | Enanta Pharmaceuticals, Inc. | Bismacrokyclic compounds as hepatitis c virus inhibitors |
CA2779244A1 (en) | 2009-10-30 | 2011-05-05 | Boehringer Ingelheim International Gmbh | Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin |
WO2011063501A1 (en) * | 2009-11-24 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
KR20120139699A (ko) | 2010-01-29 | 2012-12-27 | 버텍스 파마슈티칼스 인코포레이티드 | C형 간염 바이러스 감염의 치료 요법 |
WO2011146336A1 (en) * | 2010-05-20 | 2011-11-24 | Array Biopharma Inc. | Macrocyclic compounds as trk kinase inhibitors |
WO2011156545A1 (en) | 2010-06-09 | 2011-12-15 | Vertex Pharmaceuticals Incorporated | Viral dynamic model for hcv combination therapy |
AR082215A1 (es) | 2010-07-14 | 2012-11-21 | Vertex Pharma | Composicion farmaceutica agradable al paladar |
NZ608720A (en) | 2010-09-21 | 2015-03-27 | Enanta Pharm Inc | Macrocyclic proline derived hcv serine protease inhibitors |
US8937041B2 (en) | 2010-12-30 | 2015-01-20 | Abbvie, Inc. | Macrocyclic hepatitis C serine protease inhibitors |
MX2013007698A (es) | 2010-12-30 | 2013-08-15 | Abbvie Inc | Inhibidores de serina proteasa de hepatitis c macrociclicos de fenantridina. |
US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
WO2012109646A1 (en) | 2011-02-11 | 2012-08-16 | Vertex Pharmaceuticals Incorporated | Treatment of hcv in hiv infection patients |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
CA2863002A1 (en) | 2012-01-11 | 2013-07-18 | Abbvie Inc. | Processes for making hcv protease inhibitors |
US20130195797A1 (en) | 2012-01-31 | 2013-08-01 | Vertex Pharmaceuticals Incorporated | High potency formulations of vx-950 |
CA2887621A1 (en) | 2012-10-08 | 2014-04-17 | Abbvie Inc. | Compounds useful for making hcv protease inhibitors |
WO2014062196A1 (en) * | 2012-10-19 | 2014-04-24 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
EP2914598B1 (de) | 2012-11-02 | 2017-10-18 | Bristol-Myers Squibb Company | Inhibitoren des hepatitis-c-virus |
WO2014070964A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2914614B1 (de) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Inhibitoren des hepatitis-c-virus |
US9580463B2 (en) | 2013-03-07 | 2017-02-28 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EA201591722A1 (ru) | 2013-03-14 | 2016-02-29 | Ачиллион Фармасьютикалз, Инк. | Новые способы получения совапревира |
WO2014145507A1 (en) | 2013-03-15 | 2014-09-18 | Achillion Pharmaceuticals, Inc. | A process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof |
WO2014145600A1 (en) | 2013-03-15 | 2014-09-18 | Achillion Pharmaceuticals, Inc. | Ach-0142684 sodium salt polymorphs, composition including the same, and method of manufacture thereof |
EP2970192A1 (de) | 2013-03-15 | 2016-01-20 | Achillion Pharmaceuticals, Inc. | Sovaprevir-polymorphe und verfahren zur herstellung davon |
EP3089757A1 (de) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Feste antivirale darreichungsformen |
US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
Family Cites Families (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3139421A (en) * | 1960-03-14 | 1964-06-30 | Parke Davis & Co | Azo compounds and methods for producing same |
CA2032559C (en) * | 1989-12-28 | 2001-11-06 | Kiyofumi Ishikawa | Endothelin antagonistic cyclic pentapeptides |
US5192746A (en) | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
US5721210A (en) * | 1990-07-09 | 1998-02-24 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
US5610054A (en) * | 1992-05-14 | 1997-03-11 | Ribozyme Pharmaceuticals, Inc. | Enzymatic RNA molecule targeted against Hepatitis C virus |
SG52262A1 (en) | 1993-01-08 | 1998-09-28 | Tanabe Seiyaku Co | Peptide inhibitors of cell adhesion |
US5830888A (en) * | 1993-04-16 | 1998-11-03 | Monsanto Company | Macrocyclic retroviral protease inhibitors |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US6159938A (en) * | 1994-11-21 | 2000-12-12 | Cortech, Inc. | Serine protease inhibitors comprising α-keto heterocycles |
MY147327A (en) | 1995-06-29 | 2012-11-30 | Novartis Ag | Somatostatin peptides |
GB9517022D0 (en) | 1995-08-19 | 1995-10-25 | Glaxo Group Ltd | Medicaments |
US5633388A (en) * | 1996-03-29 | 1997-05-27 | Viropharma Incorporated | Compounds, compositions and methods for treatment of hepatitis C |
EP0907659A1 (de) | 1996-05-10 | 1999-04-14 | Schering Corporation | Hepatitis c virus ns3 protease synthetische inhibitoren |
EE04023B1 (et) | 1996-10-18 | 2003-04-15 | Vertex Pharmaceuticals Incorporated | Seriinproteaaside, eriti C-hepatiidi viiruse NS3-proteaasi inhibiitorid |
GB9623908D0 (en) * | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
AU7127298A (en) | 1997-04-14 | 1998-11-11 | Emory University | Serine protease inhibitors |
GB9707659D0 (en) | 1997-04-16 | 1997-06-04 | Peptide Therapeutics Ltd | Hepatitis C NS3 Protease inhibitors |
JPH10298151A (ja) | 1997-04-30 | 1998-11-10 | Japan Energy Corp | C型肝炎ウイルスプロテアーゼ阻害剤 |
CA2291778A1 (en) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
JPH1135478A (ja) | 1997-07-17 | 1999-02-09 | Soyaku Gijutsu Kenkyusho:Kk | キク科植物の有機抽出物を含有する抗c型肝炎ウイルス剤及びプロテアーゼns3の特異的阻害剤 |
US6767991B1 (en) * | 1997-08-11 | 2004-07-27 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C inhibitor peptides |
AU757072B2 (en) | 1997-08-11 | 2003-01-30 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C inhibitor peptide analogues |
PT1003775E (pt) | 1997-08-11 | 2005-07-29 | Boehringer Ingelheim Ca Ltd | Peptidos inibidores da hepatite c |
JPH11127861A (ja) | 1997-10-29 | 1999-05-18 | Japan Energy Corp | C型肝炎ウイルス由来のセリンプロテアーゼに対する中和抗体部分ペプチド |
JP3612551B2 (ja) | 1997-11-07 | 2005-01-19 | 独立行政法人産業技術総合研究所 | C型肝炎ウイルスのns3プロテアーゼを阻害するrna分子 |
CA2260499A1 (en) | 1998-01-29 | 1999-07-29 | Sumitomo Pharmaceuticals Company Limited | Pharmaceutical compositions for the treatment of ischemic brain damage |
IT1299134B1 (it) | 1998-02-02 | 2000-02-29 | Angeletti P Ist Richerche Bio | Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi |
GB9806815D0 (en) | 1998-03-30 | 1998-05-27 | Hoffmann La Roche | Amino acid derivatives |
EP1066247B1 (de) | 1998-03-31 | 2006-11-22 | Vertex Pharmaceuticals Incorporated | Inhibitoren von serin proteasen, insbesondere von hepatitis c virus ns3 protease |
JPH11292840A (ja) | 1998-04-06 | 1999-10-26 | Soyaku Gijutsu Kenkyusho:Kk | ノルスタチン誘導体又はその塩 |
GB9809664D0 (en) * | 1998-05-06 | 1998-07-01 | Hoffmann La Roche | a-Ketoamide derivatives |
GB9812523D0 (en) | 1998-06-10 | 1998-08-05 | Angeletti P Ist Richerche Bio | Peptide inhibitors of hepatitis c virus ns3 protease |
EP1100763B8 (de) | 1998-07-27 | 2005-08-17 | Instituto di Ricerche di Biologia Molecolare p Angeletti S.P.A. | Diketosäure-derivate als hemmstoffe von polymerasen |
AR022061A1 (es) | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
WO2000020400A1 (en) | 1998-10-05 | 2000-04-13 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions for treating hepatitis c infections |
GB9825946D0 (en) | 1998-11-26 | 1999-01-20 | Angeletti P Ist Richerche Bio | Pharmaceutical compounds for the inhibition of hepatitis C virus NS3 protease |
UA74546C2 (en) * | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
CA2376965A1 (en) | 1999-07-07 | 2001-01-11 | Timothy Patrick Forsyth | Peptide boronic acid inhibitors of hepatitis c virus protease |
CA2376961A1 (en) | 1999-07-26 | 2001-02-01 | Bristol-Myers Squibb Pharma Company | Lactam inhibitors of hepatitis c virus ns3 protease |
AU7511800A (en) | 1999-08-30 | 2001-03-26 | K.U. Leuven Research And Development | Novel target for antiparasitic agents and inhibitors thereof |
JP2001103993A (ja) | 1999-10-05 | 2001-04-17 | Japan Energy Corp | 環状ペプチド及びセリンプロテアーゼ阻害剤 |
GB9925955D0 (en) | 1999-11-02 | 1999-12-29 | Angeletti P Ist Richerche Bio | Hcv n33 protease inhibitors |
CA2390349A1 (en) | 1999-12-03 | 2001-06-07 | Bristol-Myers Squibb Pharma Company | Alpha-ketoamide inhibitors of hepatitis c virus ns3 protease |
EP1162196A4 (de) | 1999-12-27 | 2003-04-16 | Japan Tobacco Inc | Verbindungen mit kondensierten ringen und ihre verwendung als medikamente |
WO2001058929A1 (en) | 2000-02-08 | 2001-08-16 | Schering Corporation | Azapeptides useful in the treatment of hepatitis c |
EP1261611A2 (de) | 2000-02-29 | 2002-12-04 | Bristol-Myers Squibb Pharma Company | Inhibitoren der hepatitis-c-virus-ns3-protease |
PT1268519E (pt) | 2000-04-03 | 2005-08-31 | Vertex Pharma | Inibidores de serina protease, particularmente protease ns3 do virus da hepatite c |
DE60137207D1 (de) | 2000-04-05 | 2009-02-12 | Schering Corp | Makrozyklische inhibitoren der ns3-serinprotease des hepatitis c-virus mit stickstoffhaltigen zyklischen p2-gruppen |
RU2002131163A (ru) | 2000-04-19 | 2004-06-27 | Шеринг Корпорейшн (US) | Макроциклические ингибиторы ns3-серинпротезы вируса гепатита с, содержащие алкил- и арилаланиновые p2 фрагменты |
WO2001085172A1 (en) | 2000-05-10 | 2001-11-15 | Smithkline Beecham Corporation | Novel anti-infectives |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
US20020068702A1 (en) | 2000-07-21 | 2002-06-06 | Marguerita Lim-Wilby | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus |
AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
AR034127A1 (es) | 2000-07-21 | 2004-02-04 | Schering Corp | Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento |
ES2341534T3 (es) | 2000-07-21 | 2010-06-22 | Schering Corporation | Peptidos como inhibidores de la serina proteasa ns3 del virus de la hepatitis c. |
EP1303487A4 (de) | 2000-07-21 | 2005-11-23 | Schering Corp | Neue peptide als ns3-serin protease inhibitoren des hepatitis c virus |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
JP3889708B2 (ja) | 2000-11-20 | 2007-03-07 | ブリストル−マイヤーズ スクイブ カンパニー | C型肝炎トリペプチド阻害剤 |
NZ526703A (en) | 2001-01-22 | 2004-12-24 | Merck & Co Inc | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
AU2002252183A1 (en) | 2001-03-06 | 2002-09-19 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
GB0107924D0 (en) | 2001-03-29 | 2001-05-23 | Angeletti P Ist Richerche Bio | Inhibitor of hepatitis C virus NS3 protease |
EP1256628A3 (de) | 2001-05-10 | 2003-03-19 | Agouron Pharmaceuticals, Inc. | Hepatitis C Virus (HCV) NS5B RNA Polymerase und davon abgeleitete Mutanten |
AR036081A1 (es) | 2001-06-07 | 2004-08-11 | Smithkline Beecham Corp | Compuesto de 1,2-dihidroquinolina, su uso para preparar una composicion farmaceutica, metodos para prepararlo y compuestos del acido 2-aminobenzoico n-alquilado de utilidad como intermediarios en dichos metodos |
SI1401825T1 (sl) | 2001-06-11 | 2010-01-29 | Virochem Pharma Inc | Tiofenski derivati kot protivirusna sredstva za flavirusno infekcijo |
EP1395571A1 (de) | 2001-06-11 | 2004-03-10 | Shire Biochem Inc. | Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen |
AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
WO2003007945A1 (en) | 2001-07-20 | 2003-01-30 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
EP2335700A1 (de) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur |
EP1429759A4 (de) | 2001-09-26 | 2004-12-15 | Bristol Myers Squibb Co | Verbindungen zur behandlung des hepatitus c virus |
US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
CA2369711A1 (en) | 2002-01-30 | 2003-07-30 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis c virus |
US7119072B2 (en) * | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
CA2370396A1 (en) | 2002-02-01 | 2003-08-01 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor tri-peptides |
CA2369970A1 (en) | 2002-02-01 | 2003-08-01 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor tri-peptides |
US6828301B2 (en) * | 2002-02-07 | 2004-12-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
WO2004043339A2 (en) * | 2002-05-20 | 2004-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkyl p1' hepatitis c virus inhibitors |
ES2361011T3 (es) | 2002-05-20 | 2011-06-13 | Bristol-Myers Squibb Company | Inhibidores del virus de la hepatitis c. |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
ES2350201T3 (es) * | 2002-05-20 | 2011-01-20 | Bristol-Myers Squibb Company | Sulfamidas heterocíclicas como inhibidores del virus de la hepatitis c. |
US20040138109A1 (en) * | 2002-09-30 | 2004-07-15 | Boehringer Ingelheim Pharmaceuticals, Inc. | Potent inhibitor of HCV serine protease |
US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
US20050159345A1 (en) | 2002-10-29 | 2005-07-21 | Boehringer Ingelheim International Gmbh | Composition for the treatment of infection by Flaviviridae viruses |
EA010013B1 (ru) * | 2003-04-02 | 2008-06-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические композиции ингибиторов вирусной протеазы гепатита с |
EP1615947A2 (de) * | 2003-04-10 | 2006-01-18 | Boehringer Ingelheim International GmbH | Verfahren zur herstellung macrocyclischer verbindungen |
JP2007523833A (ja) * | 2003-04-10 | 2007-08-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ルテニウム錯体触媒メタセシス反応による大環状化合物の製造方法 |
WO2004094452A2 (en) * | 2003-04-16 | 2004-11-04 | Bristol-Myers Squibb Company | Macrocyclic isoquinoline peptide inhibitors of hepatitis c virus |
DK1654261T3 (da) * | 2003-05-21 | 2008-01-14 | Boehringer Ingelheim Int | Hepatitis C-inhibitorforbindelser |
MXPA06003141A (es) * | 2003-09-22 | 2006-06-05 | Boehringer Ingelheim Int | Peptidos macrociclicos activos contra el virus de la hepatitis c. |
US7132504B2 (en) | 2003-11-12 | 2006-11-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2005053735A1 (en) * | 2003-11-20 | 2005-06-16 | Boehringer Ingelheim International Gmbh | Method of removing transition metals, especially from metathesis reaction products |
ES2320776T3 (es) * | 2003-12-08 | 2009-05-28 | Boehringer Ingelheim International Gmbh | Eliminacion de subproductos de rutenio por tratamiento con fluidos supercriticos. |
WO2005070955A1 (en) * | 2004-01-21 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis c virus |
ES2315839T3 (es) * | 2004-01-28 | 2009-04-01 | Boehringer Ingelheim International Gmbh | Metodo para separar los metales de transicion de soluciones reaccionantes que contienen productos secundarios de metales de transicion. |
AU2005224092A1 (en) * | 2004-03-15 | 2005-09-29 | Boehringer Ingelheim International, Gmbh | Process for preparing macrocyclic dipeptides which are suitable for the treatment of hepatitis C viral infections |
US7189844B2 (en) * | 2004-09-17 | 2007-03-13 | Boehringer Ingelheim International Gmbh | Ring-closing metathesis process in supercritical fluid |
CA2577831A1 (en) * | 2004-09-17 | 2006-03-30 | Boehringer Ingelheim International Gmbh | Process for preparing macrocyclic hcv protease inhibitors |
-
2004
- 2004-09-20 MX MXPA06003141A patent/MXPA06003141A/es not_active Application Discontinuation
- 2004-09-20 BR BRPI0414571-2A patent/BRPI0414571A/pt not_active IP Right Cessation
- 2004-09-20 RS YUP-2006/0197A patent/RS20060197A/sr unknown
- 2004-09-20 AT AT04761821T patent/ATE500264T1/de active
- 2004-09-20 ES ES04761821T patent/ES2361997T3/es not_active Expired - Lifetime
- 2004-09-20 DE DE602004031645T patent/DE602004031645D1/de not_active Expired - Lifetime
- 2004-09-20 CA CA2536182A patent/CA2536182C/en not_active Expired - Fee Related
- 2004-09-20 PE PE2004000913A patent/PE20050431A1/es not_active Application Discontinuation
- 2004-09-20 JP JP2006526494A patent/JP4704342B2/ja not_active Expired - Fee Related
- 2004-09-20 KR KR1020067007658A patent/KR20060094083A/ko not_active Application Discontinuation
- 2004-09-20 AU AU2004274051A patent/AU2004274051A1/en not_active Abandoned
- 2004-09-20 WO PCT/CA2004/001658 patent/WO2005028501A1/en active Application Filing
- 2004-09-20 US US10/945,518 patent/US7642235B2/en active Active
- 2004-09-20 CN CNA2004800274171A patent/CN1856502A/zh active Pending
- 2004-09-20 EP EP04761821A patent/EP1673385B1/de not_active Expired - Lifetime
- 2004-09-20 EA EA200600498A patent/EA200600498A1/ru unknown
- 2004-09-20 UY UY28525A patent/UY28525A1/es not_active Application Discontinuation
- 2004-09-21 TW TW093128495A patent/TW200521144A/zh unknown
- 2004-09-22 AR ARP040103399A patent/AR045938A1/es unknown
-
2006
- 2006-03-20 IL IL174403A patent/IL174403A0/en unknown
- 2006-03-22 EC EC2006006448A patent/ECSP066448A/es unknown
- 2006-04-21 NO NO20061767A patent/NO20061767L/no not_active Application Discontinuation
-
2009
- 2009-09-28 US US12/567,861 patent/US20100028300A1/en not_active Abandoned
-
2010
- 2010-07-08 JP JP2010156015A patent/JP2011006420A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1673385A1 (de) | 2006-06-28 |
PE20050431A1 (es) | 2005-07-19 |
EP1673385B1 (de) | 2011-03-02 |
NO20061767L (no) | 2006-06-16 |
US20100028300A1 (en) | 2010-02-04 |
DE602004031645D1 (de) | 2011-04-14 |
ECSP066448A (es) | 2006-09-18 |
EP1673385A4 (de) | 2006-10-04 |
CA2536182A1 (en) | 2005-03-31 |
AR045938A1 (es) | 2005-11-16 |
EA200600498A1 (ru) | 2006-10-27 |
MXPA06003141A (es) | 2006-06-05 |
JP4704342B2 (ja) | 2011-06-15 |
KR20060094083A (ko) | 2006-08-28 |
WO2005028501A1 (en) | 2005-03-31 |
CN1856502A (zh) | 2006-11-01 |
ES2361997T3 (es) | 2011-06-27 |
JP2007529411A (ja) | 2007-10-25 |
US20050080005A1 (en) | 2005-04-14 |
CA2536182C (en) | 2012-07-24 |
UY28525A1 (es) | 2005-04-29 |
US7642235B2 (en) | 2010-01-05 |
RS20060197A (en) | 2008-09-29 |
AU2004274051A1 (en) | 2005-03-31 |
BRPI0414571A (pt) | 2006-11-07 |
TW200521144A (en) | 2005-07-01 |
JP2011006420A (ja) | 2011-01-13 |
IL174403A0 (en) | 2006-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE500264T1 (de) | Makrozyklische peptide mit wirkung gegen das hepatitis-c-virus | |
ATE495185T1 (de) | Makrocyclische peptide mit wirkung gegen das hepatitis-c-virus | |
ATE414098T1 (de) | Makrozyklische peptide mit anti-hepatitis c virus wirkung | |
ID30459A (id) | Peptida-peptida makrosiklik yang aktif melawan virus hepatitis c | |
DK1478328T3 (da) | Bioaktive keratinpeptider | |
DK1501921T3 (da) | Forbedrede virusrensningsmetoder | |
EP1732581A4 (de) | Polypeptidtransduktion und fusogene peptide | |
IS8476A (is) | Lifrarbólgu C-veirutálmar | |
IS8475A (is) | Lifrarbólgu C-veirutálmar | |
ATE327696T1 (de) | Kippschirm | |
EP1307130A4 (de) | Impfstoff gegen menschlichen immunschwächevirus | |
DE60327407D1 (de) | Immunmodulierende peptide | |
IS7830A (is) | Bóluefni gegn lifrarbólgu C veiru (HCV) | |
DE60122873D1 (de) | Therapeutische porenbildende peptide | |
EP1735335A4 (de) | Zellabtötende peptide | |
NO20033829L (no) | Virusdrepende preparater | |
DE602004023624D1 (de) | Antimikrobielle peptide | |
EP1730180A4 (de) | Gegen pilze wirkende peptide | |
ATE419271T1 (de) | Antimikrobielle peptide | |
ATE394424T1 (de) | Herstellung von somatostatinpeptiden | |
DE60322070D1 (de) | Rekombinante bcg-vakzine | |
HK1209050A1 (zh) | 由存活蛋白衍生的肽以及其用途 | |
DK1625148T3 (da) | Peptidkompleks | |
EP1359930A4 (de) | Novispirine: antimikrobielle peptide | |
EP1487852A4 (de) | Impfstoff mit wirkung gegen protozoen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1673385 Country of ref document: EP |