ATE497961T1 - Als proteinkinaseinhibitoren geeignete verbindungen - Google Patents

Als proteinkinaseinhibitoren geeignete verbindungen

Info

Publication number: ATE497961T1
Authority: AT; Austria
Prior art keywords: protein kinase; kinase inhibitors; compounds suitable; compounds; compositions
Prior art date: 2006-12-14

Application number

AT07862967T

Other languages

English (en)

Inventor

Jean Damien Charrier

David Kay

Ronald Knegtel

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-14

Filing date

2007-12-14

Publication date

2011-02-15

2007-12-14 Application filed by Vertex Pharma filed Critical Vertex Pharma

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE497961T1 publication Critical patent/ATE497961T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Transplantation (AREA)
Virology (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT07862967T 2006-12-14 2007-12-14 Als proteinkinaseinhibitoren geeignete verbindungen ATE497961T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US87487806P	2006-12-14	2006-12-14
PCT/US2007/025688 WO2008076392A2 (en)	2006-12-14	2007-12-14	Compounds useful as protein kinase inhibitors

Publications (1)

Publication Number	Publication Date
ATE497961T1 true ATE497961T1 (de)	2011-02-15

Family

ID=39323721

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07862967T ATE497961T1 (de)	2006-12-14	2007-12-14	Als proteinkinaseinhibitoren geeignete verbindungen

Country Status (12)

Country	Link
US (2)	US8129387B2 (de)
EP (1)	EP2102210B1 (de)
JP (1)	JP5406725B2 (de)
CN (1)	CN101646671A (de)
AT (1)	ATE497961T1 (de)
AU (1)	AU2007334379B2 (de)
CA (1)	CA2672612A1 (de)
DE (1)	DE602007012473D1 (de)
ES (1)	ES2359467T3 (de)
MX (1)	MX2009006345A (de)
NZ (1)	NZ577638A (de)
WO (1)	WO2008076392A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0706537A2 (pt)	2006-01-17	2011-03-29	Vertex Pharma	azaindóis úteis como inibidores de janus cinases
WO2009103010A2 (en) *	2008-02-13	2009-08-20	Elan Pharmaceuticals, Inc.	Alpha-synuclein kinase
NZ590297A (en)	2008-06-23	2012-11-30	Vertex Pharma	2-Alkylamino-7,8-dihydropteridin-6(5H)-one and 2-alkylamino-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one derivatives
WO2010008454A1 (en)	2008-06-23	2010-01-21	Vertex Pharmaceuticals Incorporated	Protein kinase inhibitors
WO2010025073A1 (en) *	2008-08-28	2010-03-04	Takeda Pharmaceutical Company Limited	Dihydroimidazo [ 1, 5-f] pteridines as polo-like kinase inhibitors
SI2442809T1 (sl)	2009-06-17	2017-01-31	Vertex Pharmaceuticals Incorporated	Inhibitorji replikacije virusov gripe
PH12012501122A1 (en) *	2009-12-23	2012-10-29	Elan Pharm Inc	Pteridinones as inhibitors of polo-like kinase
CA2814084A1 (en) *	2010-10-08	2012-04-12	Elan Pharmaceuticals Inc.	Inhibitors of polo-like kinase
WO2012083117A1 (en)	2010-12-16	2012-06-21	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication
CN103702998A (zh)	2011-07-05	2014-04-02	沃泰克斯药物股份有限公司	生产氮杂吲哚类的方法和中间体
UA118010C2 (uk)	2011-08-01	2018-11-12	Вертекс Фармасьютікалз Інкорпорейтед	Інгібітори реплікації вірусів грипу
CA2912918C (en) *	2013-06-24	2021-07-27	Merck Patent Gmbh	Imidazole compounds as modulators of fshr and uses thereof
MX382171B (es)	2013-11-13	2025-03-13	Vertex Pharmaceuticals Incorporated	Inhibidores de replicacion del virus de influenza.
AU2014348752C1 (en)	2013-11-13	2019-11-21	Vertex Pharmaceuticals Incorporated	Methods of preparing inhibitors of influenza viruses replication
US9840503B2 (en)	2015-05-11	2017-12-12	Incyte Corporation	Heterocyclic compounds and uses thereof
MA42422A (fr)	2015-05-13	2018-05-23	Vertex Pharma	Inhibiteurs de la réplication des virus de la grippe
WO2016183116A1 (en)	2015-05-13	2016-11-17	Vertex Pharmaceuticals Incorporated	Methods of preparing inhibitors of influenza viruses replication
US9708333B2 (en)	2015-08-12	2017-07-18	Incyte Corporation	Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors
WO2017035366A1 (en)	2015-08-26	2017-03-02	Incyte Corporation	Pyrrolopyrimidine derivatives as tam inhibitors
MD3436461T2 (ro)	2016-03-28	2024-05-31	Incyte Corp	Compuși pirolotriazină ca inhibitori TAM
MX2020003375A (es)	2017-09-27	2020-08-03	Incyte Corp	Sales de inhibidores de macrofagos asociados a tumores (tam).
MX2021000127A (es)	2018-06-29	2021-03-29	Incyte Corp	Formulaciones de un inhibidor de axl/mer.
CN111217815B (zh) *	2018-11-27	2021-06-18	沈阳药科大学	含有喋啶酮骨架的化合物及其制备方法和应用
JP2023516441A (ja)	2020-03-06	2023-04-19	インサイト・コーポレイション	Ａｘｌ／ｍｅｒ阻害剤及びｐｄ－１／ｐｄ－ｌ１阻害剤を含む併用療法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999045009A1 (en)	1998-03-04	1999-09-10	Bristol-Myers Squibb Company	Heterocyclo-substituted imidazopyrazine protein tyrosine kinase inhibitors
CN101200457A (zh) *	2003-02-26	2008-06-18	贝林格尔英格海姆法玛两合公司	二氢蝶啶酮、其制法及作为药物制剂的用途
US20060074088A1 (en)	2004-08-14	2006-04-06	Boehringer Ingelheim International Gmbh	Dihydropteridinones for the treatment of cancer diseases
US7728134B2 (en)	2004-08-14	2010-06-01	Boehringer Ingelheim International Gmbh	Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060058311A1 (en)	2004-08-14	2006-03-16	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation
GB0621203D0 (en)	2006-10-25	2006-12-06	Chroma Therapeutics Ltd	PLK inhibitors
CA2665736A1 (en)	2006-10-25	2008-05-02	Chroma Therapeutics Ltd.	Pteridine derivatives as polo-like kinase inhibitors useful in the treatment of cancer
RU2339637C1 (ru)	2007-04-05	2008-11-27	Андрей Александрович Иващенко	Блокаторы гистаминного рецептора для фармацевтических композиций, обладающих противоаллергическим и аутоиммунным действием
WO2008123796A2 (ru)	2007-04-05	2008-10-16	Alla Chem, Llc	Замещенные 2,3,4,5-tetpaгидpo-1h-пиpидo[4,3-b]иhдoлы, способ их получения и применения

2007
- 2007-12-14 CA CA002672612A patent/CA2672612A1/en not_active Abandoned
- 2007-12-14 JP JP2009541404A patent/JP5406725B2/ja not_active Expired - Fee Related
- 2007-12-14 AT AT07862967T patent/ATE497961T1/de not_active IP Right Cessation
- 2007-12-14 NZ NZ577638A patent/NZ577638A/en not_active IP Right Cessation
- 2007-12-14 CN CN200780050825A patent/CN101646671A/zh active Pending
- 2007-12-14 DE DE602007012473T patent/DE602007012473D1/de active Active
- 2007-12-14 WO PCT/US2007/025688 patent/WO2008076392A2/en active Application Filing
- 2007-12-14 EP EP07862967A patent/EP2102210B1/de not_active Not-in-force
- 2007-12-14 MX MX2009006345A patent/MX2009006345A/es active IP Right Grant
- 2007-12-14 ES ES07862967T patent/ES2359467T3/es active Active
- 2007-12-14 AU AU2007334379A patent/AU2007334379B2/en not_active Ceased
- 2007-12-14 US US12/448,258 patent/US8129387B2/en not_active Expired - Fee Related
2012
- 2012-01-24 US US13/356,924 patent/US8557818B2/en active Active

Also Published As

Publication number	Publication date
JP2010513285A (ja)	2010-04-30
CN101646671A (zh)	2010-02-10
AU2007334379B2 (en)	2013-04-18
JP5406725B2 (ja)	2014-02-05
EP2102210B1 (de)	2011-02-09
US20100099686A1 (en)	2010-04-22
ES2359467T3 (es)	2011-05-23
US20120122879A1 (en)	2012-05-17
US8129387B2 (en)	2012-03-06
AU2007334379A1 (en)	2008-06-26
WO2008076392A2 (en)	2008-06-26
MX2009006345A (es)	2009-06-23
NZ577638A (en)	2012-03-30
WO2008076392A3 (en)	2008-08-07
EP2102210A2 (de)	2009-09-23
CA2672612A1 (en)	2008-06-26
DE602007012473D1 (de)	2011-03-24
US8557818B2 (en)	2013-10-15

Publication	Publication Date	Title
ATE497961T1 (de)	2011-02-15	Als proteinkinaseinhibitoren geeignete verbindungen
DE602007007985D1 (de)	2010-09-02	Als inhibitoren von proteinkinasen geeignete aminopyrimidine
DE602006021776D1 (de)	2011-06-16	Als kinaseinhibitoren geeignete aminopyrimidine
MX2009008253A (es)	2009-10-12	Derivados de 2-aminopiridina utiles como inhibidores de cinasa.
ATE482213T1 (de)	2010-10-15	Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine
ATE526328T1 (de)	2011-10-15	Als inhibitoren von proteinkinasen geeignete aminopyrimidine
DE602006004844D1 (de)	2009-03-05	Pyrrolopyrimidine verwendbar als protein kinase inhibitoren
ATE542814T1 (de)	2012-02-15	Pyrazinkinaseinhibitoren
TW200736250A (en)	2007-10-01	Aminopyrimidines useful as kinase inhibitors
MX2009009592A (es)	2009-11-10	Aminopiridinas utiles como inhibidores de proteinas cinasas.
NO20084747L (no)	2008-11-25	Tetrahydropteridiner anvendbare som inhibitorer av protein kinaser
TW200633980A (en)	2006-10-01	Pyridones useful as inhibitors of kinases
WO2007095188A3 (en)	2007-10-25	Dihydrodiazepines useful as inhibitors of protein kinases
NO20084435L (no)	2008-11-28	C-MET proteinkinaseinhibitorer
MX2009009590A (es)	2009-11-10	Aminopirimidinas utiles como inhibidores de proteinas cinasas.
MX2009010037A (es)	2009-11-05	Aminopirimidinas utiles como inhibidores de cinasas.
MX2009011810A (es)	2010-01-14	Tiazoles y pirazoles utiles como inhibidores de cinasa.
MX2009012719A (es)	2010-02-04	Tiazoles y pirazoles utiles como inhibidores de cinasa.
MX2009011811A (es)	2010-01-14	Aminopirimidinas utiles como inhibidores de cinasa.
ATE493401T1 (de)	2011-01-15	Als proteinkinaseinhibitoren geeignete diaminotriazolverbindungen
WO2007087283A3 (en)	2007-09-13	Thiophene-carboxamides useful as inhibitors of protein kinases
WO2007139816A3 (en)	2008-01-17	Thiophene-carboxamides useful as inhibitors of protein kinases
TW200745088A (en)	2007-12-16	Benzimidazoles useful as inhibitors of protein kinases
MX2009010127A (es)	2009-11-05	Compuestos utiles como inhibidores de janus cinasas.
ATE528309T1 (de)	2011-10-15	Als proteinkinaseinhibitoren geeignete verbindungen

Legal Events

Date	Code	Title	Description
2011-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties