ATE472604T1 - Verfahren zur herstellung von proteinen - Google Patents
Verfahren zur herstellung von proteinenInfo
- Publication number
- ATE472604T1 ATE472604T1 AT03750495T AT03750495T ATE472604T1 AT E472604 T1 ATE472604 T1 AT E472604T1 AT 03750495 T AT03750495 T AT 03750495T AT 03750495 T AT03750495 T AT 03750495T AT E472604 T1 ATE472604 T1 AT E472604T1
- Authority
- AT
- Austria
- Prior art keywords
- producing proteins
- proteins
- producing
- transient expression
- secreted protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000001938 protoplast Anatomy 0.000 abstract 1
- 230000010474 transient expression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020020382 EP1398383A1 (de) | 2002-09-12 | 2002-09-12 | Verfahren zur Herstellung von Proteinen |
| EP03015881 | 2003-07-11 | ||
| PCT/EP2003/009959 WO2004024927A1 (en) | 2002-09-12 | 2003-09-08 | Protein production method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE472604T1 true ATE472604T1 (de) | 2010-07-15 |
Family
ID=31995519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03750495T ATE472604T1 (de) | 2002-09-12 | 2003-09-08 | Verfahren zur herstellung von proteinen |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1539966B1 (de) |
| AT (1) | ATE472604T1 (de) |
| AU (1) | AU2003270152A1 (de) |
| DE (1) | DE60333201D1 (de) |
| DK (1) | DK1539966T3 (de) |
| ES (1) | ES2347325T3 (de) |
| PT (1) | PT1539966E (de) |
| SI (1) | SI1539966T1 (de) |
| WO (1) | WO2004024927A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2380910T3 (en) | 2003-11-05 | 2015-10-19 | Roche Glycart Ag | Antigen binding molecules with increased Fc receptor binding affinity and effector function |
| RU2488597C2 (ru) | 2005-02-07 | 2013-07-27 | Гликарт Биотехнологи Аг | Антигенсвязывающие молекулы, которые связывают egfr, кодирующие их векторы и их применение |
| AR055137A1 (es) | 2005-08-26 | 2007-08-08 | Glycart Biotechnology Ag | Moleculas de union al antigeno modificadas con actividad de senalizacion celular alterada |
| SE529610C2 (sv) | 2006-02-13 | 2007-10-02 | Alfa Laval Corp Ab | Centrifugalseparator |
| AR062223A1 (es) | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
| CA2770174A1 (en) | 2009-08-31 | 2011-03-03 | Roche Glycart Ag | Affinity-matured humanized anti cea monoclonal antibodies |
| WO2011101328A2 (en) | 2010-02-18 | 2011-08-25 | Roche Glycart Ag | Treatment with a humanized igg class anti egfr antibody and an antibody against insulin like growth factor 1 receptor |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| KR101780131B1 (ko) | 2010-08-13 | 2017-09-19 | 로슈 글리카트 아게 | 항-fap 항체 및 이의 사용 방법 |
| CN103168049B (zh) | 2010-08-13 | 2015-10-07 | 罗切格利卡特公司 | 抗生腱蛋白-c a2抗体及使用方法 |
| CN103476433A (zh) | 2011-02-10 | 2013-12-25 | 罗切格利卡特公司 | 改良的免疫疗法 |
| US20140088019A1 (en) | 2011-02-11 | 2014-03-27 | Zyngenia, Inc. | Monovalent and Multivalent Multispecific Complexes and Uses Thereof |
| PT2681244T (pt) | 2011-03-02 | 2018-01-24 | Roche Glycart Ag | Anticorpos do cea |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| EP2714738B1 (de) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalente und monovalente multispezifische komplexe und ihre verwendungen |
| EP2748202B1 (de) | 2011-08-23 | 2018-07-04 | Roche Glycart AG | Bispezifische antigenbindende moleküle |
| CN103890006A (zh) | 2011-08-23 | 2014-06-25 | 罗切格利卡特公司 | 抗mcsp抗体 |
| PL3434695T3 (pl) | 2012-08-07 | 2021-05-17 | Roche Glycart Ag | Ulepszona immunoterapia |
| EP2961772A1 (de) | 2013-02-26 | 2016-01-06 | Roche Glycart AG | Anti-mcsp-antikörper |
| CN107921090A (zh) | 2015-04-06 | 2018-04-17 | 苏伯多曼有限责任公司 | 含有从头结合结构域的多肽及其用途 |
| US11142565B2 (en) | 2015-09-24 | 2021-10-12 | Abvitro Llc | Broadly neutralizing anti-HIV-1 antibodies that bind to an N-glycan epitope on the envelope |
| EP3178848A1 (de) | 2015-12-09 | 2017-06-14 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antikörper zur verringerung der bildung von antikörpern gegen medikamente |
| IL313608A (en) | 2015-12-09 | 2024-08-01 | Hoffmann La Roche | Antibody against CD20 type II to reduce the formation of antibodies against drugs |
| JP2019515874A (ja) | 2016-03-01 | 2019-06-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 改変された細胞死誘導を有するオビヌツズマブ変異体 |
| JP7089483B2 (ja) | 2016-05-11 | 2022-06-22 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 修飾された抗テネイシン抗体及び使用方法 |
| EP3252078A1 (de) | 2016-06-02 | 2017-12-06 | F. Hoffmann-La Roche AG | Typ ii anti-cd20 antikörper und anti-cd20/cd3 bispecific antikörper zur behandlung von krebs |
| MX2019012793A (es) | 2017-04-27 | 2020-02-13 | Tesaro Inc | Agentes anticuerpos dirigidos contra el gen de activación de linfocitos-3 (lag-3) y usos de los mismos. |
| EP3630829A1 (de) | 2017-06-02 | 2020-04-08 | H. Hoffnabb-La Roche Ag | Typ-ii-anti-cd20-antikörper und anti-cd20/cd3-bispezifischer antikörper zur krebsbehandlung |
| MX2020004935A (es) | 2017-11-14 | 2020-09-25 | Arcellx Inc | Terapias con celulas inmunitarias multifuncionales. |
| AU2018369639C1 (en) | 2017-11-14 | 2025-04-03 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
| EP3737692A4 (de) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | Calreticulin-bindende konstrukte und gentechnisch veränderte t-zellen zur behandlung von krankheiten |
| WO2019178362A1 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| JP7403479B2 (ja) | 2018-06-03 | 2023-12-22 | ランカプ バイオ ベータ リミテッド | Ｃｅａｃａｍ５およびｃｄ４７に対する二重特異性抗体 |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| CN109295068B (zh) * | 2018-09-14 | 2021-04-09 | 昆明理工大学 | 一种三七类甜蛋白基因PnTLP2及应用 |
| CN109234284B (zh) * | 2018-09-14 | 2021-04-09 | 昆明理工大学 | 一种三七类甜蛋白基因PnTLP5及应用 |
| WO2020172605A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Antibody molecules that bind to nkp30 and uses thereof |
| CN114026122B (zh) | 2019-02-21 | 2024-12-31 | 马伦戈治疗公司 | 结合t细胞相关癌细胞的多功能分子及其用途 |
| EP3831849A1 (de) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispezifische antikörper gegen ceacam5 und cd47 |
| EP4084823A4 (de) | 2020-01-03 | 2024-05-15 | Marengo Therapeutics, Inc. | Anti-tcr-antikörpermoleküle und ihre verwendungen |
| EP4229068A1 (de) | 2020-10-13 | 2023-08-23 | Avitide LLC | Affinitätsligandbibliotheken von drei helixbündelproteinen und verwendungen davon |
| WO2022081775A1 (en) | 2020-10-13 | 2022-04-21 | Avitide LLC | Aav8 affinity agents |
| CN117241866A (zh) | 2021-02-19 | 2023-12-15 | 艾维泰有限责任公司 | Aav2亲和剂 |
| MX2023011110A (es) | 2021-03-26 | 2023-11-23 | Arcellx Inc | Terapias de celulas inmunitarias multifuncionales. |
| CN117222412A (zh) | 2021-04-23 | 2023-12-12 | 豪夫迈·罗氏有限公司 | Nk细胞接合剂相关的不良反应的预防或减轻 |
| CN118984834A (zh) | 2021-12-24 | 2024-11-19 | 阿维泰德有限责任公司 | Ch1结构域亲和配体和试剂 |
| EP4562022A1 (de) | 2022-07-29 | 2025-06-04 | Repligen Corporation | Affinitätsagent mit einem ligand zur bindung von vce und mit seq id no: 1 |
| CA3266644A1 (en) | 2022-09-09 | 2024-03-14 | Repligen Corporation | AFFINITY AGENTS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19947290A1 (de) * | 1999-10-01 | 2001-04-19 | Greenovation Pflanzenbiotechno | Verfahren zur Herstellung proteinöser Substanzen |
-
2003
- 2003-09-08 AT AT03750495T patent/ATE472604T1/de active
- 2003-09-08 EP EP03750495A patent/EP1539966B1/de not_active Expired - Lifetime
- 2003-09-08 DK DK03750495.8T patent/DK1539966T3/da active
- 2003-09-08 ES ES03750495T patent/ES2347325T3/es not_active Expired - Lifetime
- 2003-09-08 DE DE60333201T patent/DE60333201D1/de not_active Expired - Lifetime
- 2003-09-08 SI SI200331863T patent/SI1539966T1/sl unknown
- 2003-09-08 PT PT03750495T patent/PT1539966E/pt unknown
- 2003-09-08 AU AU2003270152A patent/AU2003270152A1/en not_active Abandoned
- 2003-09-08 WO PCT/EP2003/009959 patent/WO2004024927A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| SI1539966T1 (sl) | 2010-10-29 |
| EP1539966A1 (de) | 2005-06-15 |
| AU2003270152A1 (en) | 2004-04-30 |
| DK1539966T3 (da) | 2010-10-04 |
| PT1539966E (pt) | 2010-09-14 |
| DE60333201D1 (de) | 2010-08-12 |
| WO2004024927A1 (en) | 2004-03-25 |
| ES2347325T3 (es) | 2010-10-28 |
| EP1539966B1 (de) | 2010-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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