ATE447564T1 - Zwischenprodukte für die herstellung von trans-5- chlor-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenzä , 3:6,7üoxepinoä4,5-cüpyrrol - Google Patents

Zwischenprodukte für die herstellung von trans-5- chlor-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenzä , 3:6,7üoxepinoä4,5-cüpyrrol

Info

Publication number: ATE447564T1
Authority: AT; Austria
Prior art keywords: dibenzä; cupyrrol; tetrahydro; trans; chlorine
Prior art date: 2005-04-07

Application number

AT06112333T

Other languages

English (en)

Inventor

Gerardus Johannes Kemperman

Der Linden Jacobus Johanne Van

Michael Reeder

Original Assignee

Organon Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-04-07

Filing date

2006-04-06

Publication date

2009-11-15

2006-04-06 Application filed by Organon Nv filed Critical Organon Nv

2009-11-15 Application granted granted Critical

2009-11-15 Publication of ATE447564T1 publication Critical patent/ATE447564T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Pyrane Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT06112333T 2005-04-07 2006-04-06 Zwischenprodukte für die herstellung von trans-5- chlor-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenzä , 3:6,7üoxepinoä4,5-cüpyrrol ATE447564T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05102742		2005-04-07

Publications (1)

Publication Number	Publication Date
ATE447564T1 true ATE447564T1 (de)	2009-11-15

Family

ID=35511130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06112333T ATE447564T1 (de)	2005-04-07	2006-04-06	Zwischenprodukte für die herstellung von trans-5- chlor-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenzä , 3:6,7üoxepinoä4,5-cüpyrrol

Country Status (27)

Country	Link
EP (2)	EP1710241B1 (de)
JP (1)	JP2008534657A (de)
KR (1)	KR20070116973A (de)
CN (2)	CN101175741B (de)
AR (1)	AR063188A1 (de)
AT (1)	ATE447564T1 (de)
AU (1)	AU2006231281B2 (de)
BR (1)	BRPI0610677A2 (de)
CA (1)	CA2603181A1 (de)
CY (1)	CY1109722T1 (de)
DE (1)	DE602006010132D1 (de)
DK (1)	DK1710241T3 (de)
ES (1)	ES2333980T3 (de)
HR (1)	HRP20100031T1 (de)
IL (1)	IL186354A0 (de)
MX (1)	MX2007012446A (de)
NO (1)	NO20075152L (de)
NZ (1)	NZ562125A (de)
PL (1)	PL1710241T3 (de)
PT (1)	PT1710241E (de)
RS (1)	RS51341B (de)
RU (1)	RU2397164C2 (de)
SI (1)	SI1710241T1 (de)
TW (1)	TW200716589A (de)
UA (2)	UA93044C2 (de)
WO (1)	WO2006106136A1 (de)
ZA (2)	ZA200708493B (de)

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JP5027477B2 (ja) *	2005-10-21	2012-09-19	住友化学株式会社	ジベンゾオキセピノピロール化合物およびその中間体の製造方法ならびに新規中間体
TW200817414A (en) *	2006-07-05	2008-04-16	Organon Nv	Process for the preparation of asenapine and intermediate products used in said process
WO2008078482A1 (ja) *	2006-12-22	2008-07-03	Sumitomo Chemical Company, Limited	アセナピン合成中間体の製造方法
US7875729B2 (en)	2007-01-05	2011-01-25	Synthon Bv	Process for making asenapine
JP5245428B2 (ja) *	2007-07-06	2013-07-24	住友化学株式会社	トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体
JP2011508751A (ja)	2008-01-04	2011-03-17	ナームローゼ・フエンノートチヤツプ・オルガノン	アセナピンの調製方法および前記方法において使用される中間生成物
KR101435296B1 (ko)	2009-06-24	2014-08-27	머크 샤프 앤 도메 비.브이.	아세나핀을 함유하는 주사가능한 제제 및 그를 사용한 치료 방법
CN101851242B (zh) *	2010-05-25	2013-07-24	上海皓元生物医药科技有限公司	阿塞那平中间体的制备方法
CA2805542C (en) *	2010-07-29	2017-12-12	Laboratorios Lesvi, S.L.	Novel process for the preparation of asenapine
WO2012038975A2 (en) *	2010-09-22	2012-03-29	Msn Laboratories Limited	Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof
EP2468751B1 (de) *	2010-12-24	2016-03-16	Medichem, S.A.	Verfahren zur Herstellung von 5-Chlor-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol
ITMI20110734A1 (it) *	2011-05-02	2012-11-03	Olon Spa	Sali cristallini di asenapina
WO2013024492A2 (en) *	2011-07-01	2013-02-21	Megafine Pharma (P) Ltd.	A process for the preparation of asenapine and novel salts thereof
CN102952144A (zh) *	2011-08-29	2013-03-06	上海华拓医药科技发展股份有限公司	阿森纳平马来酸盐的晶型、制备方法及其药物组合物
AU2012346880A1 (en) *	2011-11-28	2014-06-19	Sun Pharmaceutical Industries Limited	Process for the preparation of asenapine intermediate
CN102746209A (zh) *	2012-06-20	2012-10-24	盛世泰科生物医药技术(苏州)有限公司	一种3-（2-（4-氯苯氧基）苯基）-1-甲基-2,4-二酮的合成方法
CN103965206A (zh) *	2013-01-29	2014-08-06	北京京卫燕康药物研究所有限公司	一种阿色纳品马来酸盐的新晶型及制备方法
CN103113379A (zh) *	2013-03-12	2013-05-22	盛世泰科生物医药技术(苏州)有限公司	阿塞那平马来酸盐的合成工艺
CN103254202A (zh) *	2013-05-19	2013-08-21	甘肃皓天化学科技有限公司	阿塞纳平的制备方法
CN103342707B (zh) *	2013-06-28	2015-09-02	甘肃皓天化学科技有限公司	用于制备阿塞纳平中间体的制备方法
CN104447771A (zh) *	2013-09-12	2015-03-25	天津市汉康医药生物技术有限公司	一种稳定的马来酸阿塞那平化合物
CN103864802B (zh) *	2014-03-31	2016-08-17	四川科伦药业股份有限公司	马来酸阿塞那平的制备方法
CN105693735A (zh) *	2016-01-15	2016-06-22	万特制药(海南)有限公司	马来酸阿塞那平一种制备方法
EP3558276B1 (de)	2016-12-20	2024-11-06	LTS Lohmann Therapie-Systeme AG	Transdermales therapeutisches system mit asenapin und polysiloxan oder polyisobutylen
RU2762896C2 (ru)	2016-12-20	2021-12-23	Лтс Ломанн Терапи-Систем Аг	Трансдермальная терапевтическая система, содержащая азенапин
CN110799180A (zh)	2017-06-26	2020-02-14	罗曼治疗系统股份公司	含阿塞那平和硅氧烷丙烯酸杂化聚合物的经皮治疗系统
CN109200025A (zh) *	2017-06-29	2019-01-15	哈尔滨莱博通药业有限公司	一种阿森纳平马来酸盐舌下片
BR112020026099A2 (pt)	2018-06-20	2021-03-23	Lts Lohmann Therapie-Systeme Ag	sistema terapêutico transdérmico que contém asenapina
US12329862B2 (en)	2018-06-20	2025-06-17	Lts Lohmann Therapie-Systeme Ag	Transdermal therapeutic system containing asenapine
CN110183457A (zh) *	2019-06-27	2019-08-30	浙江天顺药业有限公司	一种阿塞那平及其制备方法
CN112194665A (zh) *	2020-10-20	2021-01-08	连云港杰瑞药业有限公司	一种合成阿塞那平中间体的方法

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CZ284633B6 (cs)	1994-03-02	1999-01-13	Akzo Nobel N. V.	Farmaceutický prostředek a použití trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrolu pro výrobu farmaceutického prostředku
DK0726265T3 (da) *	1995-02-08	2001-10-22	Novartis Ag	10-Aminoaliphatyl-dibenz[b,f]oxepiner med antineurodegenerativ virkning
WO1999032108A1 (en)	1997-12-19	1999-07-01	Akzo Nobel N.V.	Org-5222 in the treatment of depression
US6002632A (en) *	1998-09-17	1999-12-14	Texas Instruments Incorporated	Circuits, systems, and methods with a memory interface for augmenting precharge control
ES2248080T3 (es) *	1999-06-03	2006-03-16	Nippon Suisan Kaisha, Ltd.	Compuestos heterociclicos condensados de tres ciclos, procedimiento de preparacion correspondiente y utilizacion de tales compuestos.

2006
- 2006-04-06 RU RU2007141161/04A patent/RU2397164C2/ru not_active IP Right Cessation
- 2006-04-06 AU AU2006231281A patent/AU2006231281B2/en not_active Ceased
- 2006-04-06 MX MX2007012446A patent/MX2007012446A/es active IP Right Grant
- 2006-04-06 SI SI200630526T patent/SI1710241T1/sl unknown
- 2006-04-06 BR BRPI0610677-3A patent/BRPI0610677A2/pt not_active IP Right Cessation
- 2006-04-06 CN CN2006800167535A patent/CN101175741B/zh not_active Expired - Fee Related
- 2006-04-06 AR ARP060101357A patent/AR063188A1/es unknown
- 2006-04-06 CA CA002603181A patent/CA2603181A1/en not_active Abandoned
- 2006-04-06 RS RSP-2010/0014A patent/RS51341B/en unknown
- 2006-04-06 DE DE602006010132T patent/DE602006010132D1/de active Active
- 2006-04-06 EP EP06112333A patent/EP1710241B1/de active Active
- 2006-04-06 AT AT06112333T patent/ATE447564T1/de not_active IP Right Cessation
- 2006-04-06 DK DK06112333.7T patent/DK1710241T3/da active
- 2006-04-06 EP EP09174540A patent/EP2154134B1/de active Active
- 2006-04-06 ES ES06112333T patent/ES2333980T3/es active Active
- 2006-04-06 WO PCT/EP2006/061409 patent/WO2006106136A1/en not_active Application Discontinuation
- 2006-04-06 UA UAA200711020A patent/UA93044C2/ru unknown
- 2006-04-06 JP JP2008504777A patent/JP2008534657A/ja not_active Withdrawn
- 2006-04-06 UA UAA200711019A patent/UA93043C2/ru unknown
- 2006-04-06 PL PL06112333T patent/PL1710241T3/pl unknown
- 2006-04-06 KR KR1020077025399A patent/KR20070116973A/ko not_active Ceased
- 2006-04-06 NZ NZ562125A patent/NZ562125A/en not_active IP Right Cessation
- 2006-04-06 CN CN2006100916992A patent/CN1861604B/zh active Active
- 2006-04-06 TW TW095112190A patent/TW200716589A/zh unknown
- 2006-04-06 PT PT06112333T patent/PT1710241E/pt unknown
2007
- 2007-10-04 ZA ZA200708493A patent/ZA200708493B/xx unknown
- 2007-10-04 ZA ZA200708490A patent/ZA200708490B/xx unknown
- 2007-10-07 IL IL186354A patent/IL186354A0/en not_active IP Right Cessation
- 2007-10-10 NO NO20075152A patent/NO20075152L/no not_active Application Discontinuation
2010
- 2010-01-08 CY CY20101100023T patent/CY1109722T1/el unknown
- 2010-01-18 HR HR20100031T patent/HRP20100031T1/hr unknown

Also Published As

Publication number	Publication date
CN1861604A (zh)	2006-11-15
NO20075152L (no)	2007-11-01
CY1109722T1 (el)	2014-04-09
RU2397164C2 (ru)	2010-08-20
EP1710241A1 (de)	2006-10-11
CA2603181A1 (en)	2006-10-12
ZA200708493B (en)	2009-09-30
RU2007141161A (ru)	2009-05-20
RS51341B (en)	2011-02-28
EP2154134B1 (de)	2012-10-24
CN101175741B (zh)	2011-06-22
PT1710241E (pt)	2009-12-10
HK1094800A1 (en)	2007-04-13
DE602006010132D1 (de)	2009-12-17
KR20070116973A (ko)	2007-12-11
UA93043C2 (ru)	2011-01-10
AU2006231281B2 (en)	2011-04-28
TW200716589A (en)	2007-05-01
NZ562125A (en)	2010-08-27
JP2008534657A (ja)	2008-08-28
UA93044C2 (en)	2011-01-10
PL1710241T3 (pl)	2010-04-30
EP2154134A1 (de)	2010-02-17
CN1861604B (zh)	2011-08-31
ZA200708490B (en)	2008-10-29
MX2007012446A (es)	2007-11-07
WO2006106136A1 (en)	2006-10-12
BRPI0610677A2 (pt)	2012-10-30
DK1710241T3 (da)	2010-03-01
HRP20100031T1 (hr)	2010-02-28
CN101175741A (zh)	2008-05-07
ES2333980T3 (es)	2010-03-03
AR063188A1 (es)	2009-01-14
EP1710241B1 (de)	2009-11-04
IL186354A0 (en)	2008-01-20
AU2006231281A1 (en)	2006-10-12
SI1710241T1 (sl)	2010-02-26

Publication	Publication Date	Title
ATE447564T1 (de)	2009-11-15	Zwischenprodukte für die herstellung von trans-5- chlor-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenzä , 3:6,7üoxepinoä4,5-cüpyrrol
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EP1908749A4 (de)	2010-05-26	Verfahren zur herstellung von isocyanat, danach hergestelltes isocyanat und verwendung von isocyanat
ZA200710360B (en)	2008-11-26	Novel 1,4-benzothiazepine-1, 1-dioxide derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof
MA28635B1 (fr)	2007-06-01	Methode de production de derives de 1, 4-diphenylazetidinone
IL176420A0 (en)	2006-10-05	Process for the manufacture of 2,3-dichloropyridine
IT1392456B1 (it)	2012-03-09	Processo per la sintesi di di- o oligosaccaridi l-fucosilati e loro nuovi intermedi 2,3,4-tribenzil-fucosil-derivati.
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ATE501114T1 (de)	2011-03-15	Herstellung von 3-pentennitril aus 1,3-butadien
EP1992613A4 (de)	2010-11-24	Verfahren zur herstellung von 3,4-disubstituiertem pyrrolidinderivat und zwischenprodukt für die herstellung
ITRM20040136A1 (it)	2004-06-17	Procedimento per la produzione di meringa per estrusione e relativi prodotti.
FR2895406B1 (fr)	2010-08-13	Procede pour la fabrication de 2,3-dimethylbut-1-ene
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EP1939184A4 (de)	2010-07-21	1,3-diiodhydantoinverbindung und verfahren zu deren herstellung
ATE384046T1 (de)	2008-02-15	Verfahren zur asymmetrischen hydrierung, das sich für die herstellung von cycloalkanindolderivaten eignet
EG25292A (en)	2011-12-07	Process for the production of anilines.
DE60238030D1 (de)	2010-12-02	Katalysatorzusammensetzung für die Herstellung von Polyolefinen
ATE377588T1 (de)	2007-11-15	Zwischenprodukt für die herstellung von pioglitazon
DE602004008092D1 (de)	2007-09-20	Pressblasmaschine für die herstellung von hohlen glaswaren
DE602005017357D1 (de)	2009-12-10	Überwachungseinrichtung für die herstellung von zusammensetzungen
ZA200800044B (en)	2008-12-31	Process for the production of linear alpha-olefins
RU2005120950A (ru)	2007-01-20	Природный материал для изготовления керамических изделий
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Legal Events

Date	Code	Title	Description
2010-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties