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ATE443151T1 - Verfahren zur herstellung von cladribin - Google Patents

Verfahren zur herstellung von cladribin

Info

Publication number
ATE443151T1
ATE443151T1 AT06026046T AT06026046T ATE443151T1 AT E443151 T1 ATE443151 T1 AT E443151T1 AT 06026046 T AT06026046 T AT 06026046T AT 06026046 T AT06026046 T AT 06026046T AT E443151 T1 ATE443151 T1 AT E443151T1
Authority
AT
Austria
Prior art keywords
cladribine
producing
reaction medium
reaction
phosphorylase
Prior art date
Application number
AT06026046T
Other languages
English (en)
Inventor
Gabriele Zuffi
Simone Monciardini
Original Assignee
Explora Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Explora Lab Sa filed Critical Explora Lab Sa
Application granted granted Critical
Publication of ATE443151T1 publication Critical patent/ATE443151T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT06026046T 2006-12-15 2006-12-15 Verfahren zur herstellung von cladribin ATE443151T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06026046A EP1932918B1 (de) 2006-12-15 2006-12-15 Verfahren zur Herstellung von Cladribin

Publications (1)

Publication Number Publication Date
ATE443151T1 true ATE443151T1 (de) 2009-10-15

Family

ID=38038673

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06026046T ATE443151T1 (de) 2006-12-15 2006-12-15 Verfahren zur herstellung von cladribin

Country Status (9)

Country Link
US (1) US8012717B2 (de)
EP (1) EP1932918B1 (de)
AT (1) ATE443151T1 (de)
CA (1) CA2610862A1 (de)
DE (1) DE602006009282D1 (de)
ES (1) ES2335796T3 (de)
PL (1) PL1932918T3 (de)
PT (1) PT1932918E (de)
SI (1) SI1932918T1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232387B2 (en) * 2009-08-18 2012-07-31 Scinopharm Taiwan, Ltd. Process for the preparation of cladribine
EP2993177A1 (de) 2014-09-05 2016-03-09 Technische Universität Berlin Chemoenzymatisches Herstellungsverfahren für Purinnucleosiden und deren Deaza- und Aza-Analoga
CN106929553B (zh) * 2015-12-31 2021-02-19 上海鑫欣生物科技有限公司 一种酶法合成阿糖腺苷的方法
CA3068611A1 (en) * 2017-06-30 2019-01-03 Dow Global Technologies Llc Coating for aldehyde remediation and method of making
DE102023123718A1 (de) 2023-09-04 2025-03-06 CHIRACON Pharma GmbH Verfahren zur Herstellung von Nukleosiden

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1269659A (en) 1984-08-06 1990-05-29 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US5208327A (en) * 1991-12-18 1993-05-04 Ortho Pharmaceutical Corporation Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine
US6252061B1 (en) * 1998-03-23 2001-06-26 Reliable Biopharmaceutical, Inc. Process for the production of 2-halo-6-aminopurine derivatives
US20020052491A1 (en) * 1999-04-28 2002-05-02 Szepsel Gerszberg Method for the production of 2-chloro-2' -deoxyadenosine (cladribine) and its 3,5-di-O-p-toluoyl derivative
US7038039B2 (en) * 2000-02-10 2006-05-02 Mitsui Chemicals, Inc. Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
EP1556400B1 (de) 2002-09-25 2013-05-01 Brigham Young University Verfahren zur herstellung von 2-halogen-2-desoxyadenosinverbindungen aus 2-desoxyguanosin
ES2292927T3 (es) * 2003-01-16 2008-03-16 Adorkem Technology Spa Biocatalizadores inmovilizados utilizables para la produccion de nucleosidos naturales y de analogos modificados a traves de reacciones enzimaticas de transglicosilacion.

Also Published As

Publication number Publication date
PL1932918T3 (pl) 2010-03-31
EP1932918B1 (de) 2009-09-16
DE602006009282D1 (de) 2009-10-29
US20100291632A1 (en) 2010-11-18
US8012717B2 (en) 2011-09-06
SI1932918T1 (sl) 2010-02-26
PT1932918E (pt) 2010-01-05
CA2610862A1 (en) 2008-06-15
EP1932918A1 (de) 2008-06-18
ES2335796T3 (es) 2010-04-05

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Legal Events

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