ATE401419T1 - Immobilisierung unmodifizierter nukleinsäuren an mit acylfluorid aktivierten substraten - Google Patents

Immobilisierung unmodifizierter nukleinsäuren an mit acylfluorid aktivierten substraten

Info

Publication number: ATE401419T1
Authority: AT; Austria
Prior art keywords: solid support; unmodified; biopolymers; acyl fluoride; nucleic acids
Prior art date: 1999-05-12

Application number

AT00928944T

Other languages

English (en)

Inventor

Robert Matson

Raymond Milton

Original Assignee

Beckman Coulter Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-12

Filing date

2000-05-10

Publication date

2008-08-15

2000-05-10 Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE401419T1 publication Critical patent/ATE401419T1/de

Links

150000001265 acyl fluorides Chemical class 0.000 title abstract 3
108020004707 nucleic acids Proteins 0.000 title abstract 2
102000039446 nucleic acids Human genes 0.000 title abstract 2
150000007523 nucleic acids Chemical class 0.000 title abstract 2
239000000758 substrate Substances 0.000 title 1
239000007787 solid Substances 0.000 abstract 7
229920001222 biopolymer Polymers 0.000 abstract 6
238000000034 method Methods 0.000 abstract 3
108091033319 polynucleotide Proteins 0.000 abstract 2
102000040430 polynucleotide Human genes 0.000 abstract 2
239000002157 polynucleotide Substances 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
235000014633 carbohydrates Nutrition 0.000 abstract 1
238000009396 hybridization Methods 0.000 abstract 1
238000003018 immunoassay Methods 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Food Science & Technology (AREA)
Cell Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Saccharide Compounds (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)

AT00928944T 1999-05-12 2000-05-10 Immobilisierung unmodifizierter nukleinsäuren an mit acylfluorid aktivierten substraten ATE401419T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/312,095 US6268141B1 (en)	1999-05-12	1999-05-12	Immobilization of unmodified biopolymers to acyl fluoride activated substrates

Publications (1)

Publication Number	Publication Date
ATE401419T1 true ATE401419T1 (de)	2008-08-15

Family

ID=23209859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00928944T ATE401419T1 (de)	1999-05-12	2000-05-10	Immobilisierung unmodifizierter nukleinsäuren an mit acylfluorid aktivierten substraten

Country Status (7)

Country	Link
US (2)	US6268141B1 (de)
EP (1)	EP1208226B1 (de)
JP (1)	JP4608107B2 (de)
AT (1)	ATE401419T1 (de)
DE (1)	DE60039519D1 (de)
ES (1)	ES2310167T3 (de)
WO (1)	WO2000070088A2 (de)

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US6989175B2 (en) *	2002-03-08	2006-01-24	Beckman Coulter, Inc.	Acyl fluoride activation of carboxysilyl-coated glass substrates
EP1495326A1 (de) *	2002-04-12	2005-01-12	Micronas GmbH	Verfahren zum immobilisieren von molekülen auf oberflächen
US6984485B2 (en) *	2002-04-23	2006-01-10	Beckman Coulter, Inc.	Polymer-coated substrates for immobilization of biomolecules and cells
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US9790538B2 (en) *	2013-03-07	2017-10-17	Apdn (B.V.I.) Inc.	Alkaline activation for immobilization of DNA taggants
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EP2566496B1 (de)	2010-05-03	2018-02-28	aTyr Pharma, Inc.	Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von methionyl-trna-synthetasen
JP5976638B2 (ja)	2010-05-03	2016-08-23	エータイアーファーマ，インコーポレイテッド	アルギニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
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1999
- 1999-05-12 US US09/312,095 patent/US6268141B1/en not_active Expired - Fee Related
2000
- 2000-05-10 AT AT00928944T patent/ATE401419T1/de not_active IP Right Cessation
- 2000-05-10 DE DE60039519T patent/DE60039519D1/de not_active Expired - Lifetime
- 2000-05-10 JP JP2000618493A patent/JP4608107B2/ja not_active Expired - Lifetime
- 2000-05-10 ES ES00928944T patent/ES2310167T3/es not_active Expired - Lifetime
- 2000-05-10 EP EP00928944A patent/EP1208226B1/de not_active Expired - Lifetime
- 2000-05-10 WO PCT/US2000/012729 patent/WO2000070088A2/en active Application Filing
2001
- 2001-05-31 US US09/872,052 patent/US20010039018A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2000070088A3 (en)	2002-03-28
JP2002544508A (ja)	2002-12-24
EP1208226B1 (de)	2008-07-16
DE60039519D1 (de)	2008-08-28
US6268141B1 (en)	2001-07-31
US20010039018A1 (en)	2001-11-08
EP1208226A2 (de)	2002-05-29
WO2000070088A2 (en)	2000-11-23
JP4608107B2 (ja)	2011-01-05
ES2310167T3 (es)	2009-01-01

Publication	Publication Date	Title
ATE401419T1 (de)	2008-08-15	Immobilisierung unmodifizierter nukleinsäuren an mit acylfluorid aktivierten substraten
EP1134294A3 (de)	2004-06-30	Verfahren zur Synthese eines immobilisierten Nukleinsäurestranges
AU3427693A (en)	1993-07-28	Process for immobilizing nucleic acid probes on polystyrene surfaces
CA2367698A1 (en)	2000-09-21	Individually addressable micro-electromagnetic unit array chips
WO1998031839A3 (en)	1998-09-17	Electronic-property probing of biological molecules at surfaces
FI953445A0 (fi)	1995-07-14	Menetelmä nukleiinihappojen herkkään osoitukseen
EA200100402A1 (ru)	2001-10-22	Способы амплификации и секвенирования нуклеиновых кислот
FR2737502B1 (fr)	1997-10-24	Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
WO2002061127A3 (en)	2003-07-24	Arrayed polynucleotides and their use in genome analysis
WO2001042508A3 (en)	2002-03-14	Methods and compositions relating to electrical detection of nucleic acid reactions
EP1562045A3 (de)	2005-11-02	Bioarraychip-Reaktionsapparatur und ihre Herstellung
DE69029726D1 (de)	1997-02-27	Festphasendiagnose von medizinischen konditionen
EP1598432A3 (de)	2006-06-07	Array-basierende Methoden zur Synthese von Nukleinsäuregemischen
WO1996013612A3 (en)	1996-07-11	Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences
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