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ATE325611T1 - Borsäuresalze und deren verwendung in der bereitstellung von medikamente für die thrombosebehandlung - Google Patents

Borsäuresalze und deren verwendung in der bereitstellung von medikamente für die thrombosebehandlung

Info

Publication number
ATE325611T1
ATE325611T1 AT03255629T AT03255629T ATE325611T1 AT E325611 T1 ATE325611 T1 AT E325611T1 AT 03255629 T AT03255629 T AT 03255629T AT 03255629 T AT03255629 T AT 03255629T AT E325611 T1 ATE325611 T1 AT E325611T1
Authority
AT
Austria
Prior art keywords
medications
provision
boric acid
acid salts
formula
Prior art date
Application number
AT03255629T
Other languages
English (en)
Inventor
David Jonathan Madge
Mark Dolman
Sophie Marie Combe-Marzelle
John Joseph Deadman
Anthony James Kennedy
Sanjay Kumar Kakkar
Original Assignee
Trigen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0220822A external-priority patent/GB0220822D0/en
Priority claimed from GB0220764A external-priority patent/GB0220764D0/en
Priority claimed from GB0307817A external-priority patent/GB0307817D0/en
Priority claimed from GB0311237A external-priority patent/GB0311237D0/en
Priority claimed from GB0315691A external-priority patent/GB0315691D0/en
Application filed by Trigen Ltd filed Critical Trigen Ltd
Application granted granted Critical
Publication of ATE325611T1 publication Critical patent/ATE325611T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03255629T 2002-09-09 2003-09-09 Borsäuresalze und deren verwendung in der bereitstellung von medikamente für die thrombosebehandlung ATE325611T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0220822A GB0220822D0 (en) 2002-09-09 2002-09-09 Boropeptides
GB0220764A GB0220764D0 (en) 2002-09-09 2002-09-09 Boropeptides
GB0307817A GB0307817D0 (en) 2003-04-04 2003-04-04 Boronic acid compounds
GB0311237A GB0311237D0 (en) 2003-05-16 2003-05-16 Boronic acid compounds
GB0315691A GB0315691D0 (en) 2003-07-04 2003-07-04 Boropeptides
US48578603P 2003-07-08 2003-07-08

Publications (1)

Publication Number Publication Date
ATE325611T1 true ATE325611T1 (de) 2006-06-15

Family

ID=31721886

Family Applications (3)

Application Number Title Priority Date Filing Date
AT04076510T ATE376551T1 (de) 2002-09-09 2003-09-09 Peptidborsäuren und deren verwendung in der herstellung von salzen derselben
AT03255590T ATE324899T1 (de) 2002-09-09 2003-09-09 In parenteralen formulierungen für die selektive thrombininhibierung verwendbare borsäuresalze
AT03255629T ATE325611T1 (de) 2002-09-09 2003-09-09 Borsäuresalze und deren verwendung in der bereitstellung von medikamente für die thrombosebehandlung

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT04076510T ATE376551T1 (de) 2002-09-09 2003-09-09 Peptidborsäuren und deren verwendung in der herstellung von salzen derselben
AT03255590T ATE324899T1 (de) 2002-09-09 2003-09-09 In parenteralen formulierungen für die selektive thrombininhibierung verwendbare borsäuresalze

Country Status (20)

Country Link
EP (8) EP1396269A1 (de)
JP (3) JP2006511593A (de)
KR (2) KR20050057295A (de)
CN (2) CN100553639C (de)
AT (3) ATE376551T1 (de)
AU (3) AU2003263343A1 (de)
BR (1) BR0314450A (de)
CA (3) CA2535792A1 (de)
CY (1) CY1105381T1 (de)
DE (3) DE60305113T2 (de)
DK (2) DK1400245T3 (de)
ES (2) ES2263924T3 (de)
HK (1) HK1063154A1 (de)
IL (1) IL167294A (de)
MX (2) MXPA05002662A (de)
NZ (2) NZ539333A (de)
PL (2) PL376439A1 (de)
PT (1) PT1396270E (de)
SI (2) SI1400245T1 (de)
WO (3) WO2004022072A1 (de)

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GB0405267D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
GB0405272D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
GB0405280D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
WO2006059082A1 (en) * 2004-11-30 2006-06-08 Trigen Limited Oxidised lipids as reversal agents for boronic acid drugs
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
GB0515003D0 (en) * 2005-07-21 2005-08-31 Univ Aston Medical devices and coatings therefor
US7261742B2 (en) 2005-10-13 2007-08-28 S.C. Johnson & Son, Inc. Method of deodorizing a textile
US20090092661A1 (en) * 2007-08-21 2009-04-09 Anthony Huang Liposome compositions for in vivo administration of boronic acid compounds
MX2010002101A (es) * 2007-08-21 2010-03-26 Alza Corp Formulaciones de liposomas de compuestos de acido boronico.
US8389232B2 (en) * 2008-05-13 2013-03-05 The Regents Of The University Of California Fluorescence detection of poison oak oil
EP2318419B2 (de) 2008-06-17 2024-10-30 Takeda Pharmaceutical Company Limited Boronatesterverbindungen und pharmazeutische zusammensetzungen davon
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WO2010096574A1 (en) 2009-02-20 2010-08-26 Lisanti Michael P A method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm
CN101928329B (zh) * 2009-06-19 2013-07-17 北京大学 三肽硼酸(酯)类化合物、其制备方法和应用
US10085987B2 (en) 2012-01-27 2018-10-02 Thomas Jefferson University MCT protein inhibitor-related prognostic and therapeutic methods
US10022372B2 (en) 2013-04-19 2018-07-17 Thomas Jefferson University Caveolin-1 related methods for treating glioblastoma with temozolomide
KR102457840B1 (ko) * 2014-10-01 2022-10-21 메르크 파텐트 게엠베하 보론산 유도체
WO2017222914A1 (en) 2016-06-21 2017-12-28 Inception 4, Inc. Carbocyclic prolinamide derivatives
PT3472149T (pt) 2016-06-21 2023-11-23 Orion Opthalmology Llc Derivados de prolinamida heterocíclicos
CN109187155B (zh) * 2018-07-27 2021-08-13 临沂大学 一种水样中有效硼的提取纯化方法和一种硼同位素组成的测试方法
KR102104507B1 (ko) * 2019-08-23 2020-04-24 브릿지바이오테라퓨틱스(주) 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법
CN113121666B (zh) * 2021-03-10 2023-09-12 厦门大学 抗菌肽Scybaumancin105-127及其应用
CN114106346B (zh) * 2021-10-29 2023-04-18 重庆第二师范学院 一种稀土双金属电致化学发光材料及其制备方法和应用

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DE10133786A1 (de) 2001-07-16 2003-02-06 Boehringer Ingelheim Pharma Verwendung von Thrombin-Inhibitoren zur Behandlung von Arthritis

Also Published As

Publication number Publication date
DE60305113D1 (de) 2006-06-14
JP2006503903A (ja) 2006-02-02
IL167294A (en) 2008-11-03
HK1063154A1 (en) 2004-12-17
WO2004022071A1 (en) 2004-03-18
KR20050057295A (ko) 2005-06-16
DE60317039T2 (de) 2008-07-31
EP1400245A1 (de) 2004-03-24
EP1466916B1 (de) 2007-10-24
EP1396270B1 (de) 2006-05-10
MXPA05002662A (es) 2005-09-20
EP1396269A1 (de) 2004-03-10
NZ539334A (en) 2007-11-30
EP1695711A3 (de) 2008-01-02
ES2264515T3 (es) 2007-01-01
CN100553639C (zh) 2009-10-28
DE60304956T2 (de) 2007-01-25
CA2535788A1 (en) 2004-03-18
CN100447151C (zh) 2008-12-31
EP1466916A1 (de) 2004-10-13
EP1400245B1 (de) 2006-05-03
CA2536010A1 (en) 2004-03-18
CN1684693A (zh) 2005-10-19
PT1396270E (pt) 2006-08-31
CA2535792A1 (en) 2004-03-18
EP1466917A1 (de) 2004-10-13
EP1561466A2 (de) 2005-08-10
DK1400245T3 (da) 2006-08-28
SI1396270T1 (sl) 2006-10-31
KR20050057294A (ko) 2005-06-16
EP1396270A1 (de) 2004-03-10
NZ539333A (en) 2007-02-23
EP1695711A2 (de) 2006-08-30
EP1695712A2 (de) 2006-08-30
ATE376551T1 (de) 2007-11-15
DK1396270T3 (da) 2006-08-28
DE60317039D1 (de) 2007-12-06
ATE324899T1 (de) 2006-06-15
AU2003263328A1 (en) 2004-03-29
PL376439A1 (en) 2005-12-27
CN1681517A (zh) 2005-10-12
EP1561466A3 (de) 2006-08-23
PL376535A1 (pl) 2006-01-09
CY1105381T1 (el) 2010-07-28
WO2004022070A1 (en) 2004-03-18
SI1400245T1 (sl) 2006-10-31
DE60304956D1 (de) 2006-06-08
WO2004022072A1 (en) 2004-03-18
JP2006509034A (ja) 2006-03-16
MXPA05002661A (es) 2005-08-19
JP2006511593A (ja) 2006-04-06
ES2263924T3 (es) 2006-12-16
AU2003263333A1 (en) 2004-03-29
EP1695712A3 (de) 2008-01-09
AU2003263343A1 (en) 2004-03-29
DE60305113T2 (de) 2006-12-07
BR0314450A (pt) 2005-07-26

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