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ATE310740T1 - Imidazotriazin-derivate als liganden für gaba- rezeptoren - Google Patents

Imidazotriazin-derivate als liganden für gaba- rezeptoren

Info

Publication number
ATE310740T1
ATE310740T1 AT01980742T AT01980742T ATE310740T1 AT E310740 T1 ATE310740 T1 AT E310740T1 AT 01980742 T AT01980742 T AT 01980742T AT 01980742 T AT01980742 T AT 01980742T AT E310740 T1 ATE310740 T1 AT E310740T1
Authority
AT
Austria
Prior art keywords
ligands
sub
gaba receptors
gaba
receptors
Prior art date
Application number
AT01980742T
Other languages
English (en)
Inventor
Michela Bettati
Peter Blurton
William Robert Carling
Mark Stuart Chambers
David James Hallett
Andrew Jennings
Richard Thomas Lewis
Michael Geoffrey Neil Russell
Leslie Joseph Street
Helen Jane Szekeres
Niel Monique Bodil Van
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0027562A external-priority patent/GB0027562D0/en
Priority claimed from GBGB0117277.4A external-priority patent/GB0117277D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE310740T1 publication Critical patent/ATE310740T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT01980742T 2000-11-10 2001-11-08 Imidazotriazin-derivate als liganden für gaba- rezeptoren ATE310740T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0027562A GB0027562D0 (en) 2000-11-10 2000-11-10 Therapeutic agents
GBGB0117277.4A GB0117277D0 (en) 2001-07-16 2001-07-16 Therapeutic agents
PCT/GB2001/004948 WO2002038568A1 (en) 2000-11-10 2001-11-08 Imidazo-triazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number Publication Date
ATE310740T1 true ATE310740T1 (de) 2005-12-15

Family

ID=26245271

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01980742T ATE310740T1 (de) 2000-11-10 2001-11-08 Imidazotriazin-derivate als liganden für gaba- rezeptoren

Country Status (9)

Country Link
US (1) US6936608B2 (de)
EP (1) EP1343788B1 (de)
JP (1) JP4302980B2 (de)
AT (1) ATE310740T1 (de)
AU (2) AU1253002A (de)
CA (1) CA2427779A1 (de)
DE (1) DE60115282T2 (de)
ES (1) ES2251518T3 (de)
WO (1) WO2002038568A1 (de)

Families Citing this family (44)

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GB0117277D0 (en) 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
GB0210127D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
GB0212048D0 (en) * 2002-05-24 2002-07-03 Merck Sharp & Dohme Therapeutic agents
AU2003246979B8 (en) * 2002-08-13 2009-08-06 Merck Sharp & Dohme Limited Phenylpyridazine derivatives as ligands for GABA receptors
US7485640B2 (en) 2002-11-06 2009-02-03 Merck Sharp & Dohme Limited Imidazopyrazinones as GABA-A receptor anxiolytics
JPWO2005019238A1 (ja) 2003-08-22 2006-10-19 明治製菓株式会社 新規アザライド及びアザラクタム誘導体とその製造法
EP2275096A3 (de) 2005-08-26 2011-07-13 Braincells, Inc. Neurogenese durch modulation des Muscarinrezeptors
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
EP1940389A2 (de) 2005-10-21 2008-07-09 Braincells, Inc. Modulation von neurogenese durch pde-hemmung
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
KR20080080206A (ko) 2005-12-20 2008-09-02 아스트라제네카 아베 Ｇａｂａａ-수용체 조절제로서의 치환된 신놀린 유도체 및그의 합성 방법
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2382975A3 (de) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenese mittels Angiotensin-Modulation
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
SI3034075T1 (sl) 2006-11-22 2018-12-31 Incyte Holdings Corporation Imidazotriazini in imidazopirimidini kot inhibitorji kinaze
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20110082147A1 (en) * 2009-07-24 2011-04-07 Concert Pharmaceuticals, Inc. Substituted imidazotriazines
CN102030770B (zh) * 2009-09-25 2012-10-31 北京大学 一种芳香硼酸酯化合物的制备方法
EP2468726B1 (de) * 2010-12-06 2013-08-28 Siena Biotech S.p.A. Verbindung zur Behandlung von Tumoren und Tumormetastasen
CN102898315B (zh) * 2012-11-05 2015-01-28 上海毕得医药科技有限公司 3-乙炔基-4-氟苯胺的制备方法
UA112028C2 (uk) 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора
CN104177304A (zh) * 2013-05-28 2014-12-03 海洋王照明科技股份有限公司 双极性蓝光磷光主体材料及其制备方法和有机电致发光器件
GB201321732D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2015123437A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
RS59559B1 (sr) 2014-02-13 2019-12-31 Incyte Corp Ciklopropilamini kao lsd1 inhibitori
PE20161384A1 (es) 2014-02-13 2016-12-28 Incyte Corp Ciclopropilaminas como inhibidores de lsd 1
EP3154979B1 (de) 2014-06-12 2018-03-07 Pfizer Limited Imidazopyridazinderivate als modulatoren der gabaa-rezeptoraktivität
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
TWI714567B (zh) 2015-04-03 2021-01-01 美商英塞特公司 作為lsd1抑制劑之雜環化合物
HUE070538T2 (hu) 2015-08-12 2025-06-28 Incyte Holdings Corp Egy LSD1 inhibitor sói
EP3407886A1 (de) 2016-01-27 2018-12-05 Universität Zürich Verwendung von gabaa-rezeptormodulatoren zur behandlung von juckreiz
EP3600656B1 (de) 2017-03-21 2025-01-15 Mississippi State University Unsymmetrische salze, ccc-nhc-zangenmetallkomplexe und verfahren zu ihrer herstellung
KR20250057112A (ko) * 2018-04-18 2025-04-28 뉴로사이클 테라퓨틱스, 인크. Gabaa 양성 알로스테릭 조절제 화합물, 이의 제조 방법 및 용도
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
BR112022007522A2 (pt) * 2019-10-22 2022-07-12 Neurocycle Therapeutics Inc Compostos moduladores alostéricos positivos de gabaa, métodos de produção e de usos dos mesmos
MX2022004945A (es) * 2019-10-23 2022-08-04 Neurocycle Therapeutics Inc Tratamiento de afecciones epilépticas con moduladores del receptor gabaa.
KR102537615B1 (ko) * 2020-02-25 2023-05-30 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
CN120865250A (zh) * 2022-02-25 2025-10-31 上海赛默罗生物科技有限公司 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途
CN117069725A (zh) 2022-05-10 2023-11-17 上海赛默罗生物科技有限公司 咪唑并哒嗪取代苯环类衍生物、制备方法、药物组合物及用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1581125B1 (de) * 1966-03-26 1970-08-27 Maierform Trust Reg Bug fuer Verdraengungsschiffe
US3422194A (en) * 1967-08-15 1969-01-14 Smithkline Corp The treatment of depression with imidazo(1,2-b)-as-triazines and compositions thereof
CN1167686C (zh) 1999-06-22 2004-09-22 神经研究公司 苯并咪唑衍生物和包括这些化合物的药物组合物
GB0117277D0 (en) * 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
EP1343788B1 (de) 2005-11-23
DE60115282D1 (de) 2005-12-29
DE60115282T2 (de) 2006-08-10
US6936608B2 (en) 2005-08-30
EP1343788A1 (de) 2003-09-17
JP2004513171A (ja) 2004-04-30
US20040023964A1 (en) 2004-02-05
WO2002038568A1 (en) 2002-05-16
CA2427779A1 (en) 2002-05-16
JP4302980B2 (ja) 2009-07-29
AU2002212530B2 (en) 2006-08-17
ES2251518T3 (es) 2006-05-01
AU1253002A (en) 2002-05-21

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Legal Events

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