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ATE298325T1 - Verfahren zur herstellung von n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperaz ne - Google Patents

Verfahren zur herstellung von n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperaz ne

Info

Publication number
ATE298325T1
ATE298325T1 AT00976949T AT00976949T ATE298325T1 AT E298325 T1 ATE298325 T1 AT E298325T1 AT 00976949 T AT00976949 T AT 00976949T AT 00976949 T AT00976949 T AT 00976949T AT E298325 T1 ATE298325 T1 AT E298325T1
Authority
AT
Austria
Prior art keywords
compound
formula
producing
piperaz
aminophenyl
Prior art date
Application number
AT00976949T
Other languages
English (en)
Inventor
Brigitte Giesinger
Ingrid Mergelsberg
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE298325T1 publication Critical patent/ATE298325T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
AT00976949T 1999-11-08 2000-11-06 Verfahren zur herstellung von n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperaz ne ATE298325T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43504999A 1999-11-08 1999-11-08
PCT/US2000/030457 WO2001034587A2 (en) 1999-11-08 2000-11-06 Process for preparing n-(4-hydroxy-phenyl)-n'-(4'-aminophenyl)-piperazine

Publications (1)

Publication Number Publication Date
ATE298325T1 true ATE298325T1 (de) 2005-07-15

Family

ID=23726755

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00976949T ATE298325T1 (de) 1999-11-08 2000-11-06 Verfahren zur herstellung von n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperaz ne

Country Status (11)

Country Link
EP (1) EP1230231B1 (de)
JP (1) JP4903963B2 (de)
CN (1) CN1177840C (de)
AT (1) ATE298325T1 (de)
AU (1) AU1465301A (de)
CA (1) CA2390296C (de)
DE (1) DE60020988T2 (de)
ES (1) ES2240202T3 (de)
HK (1) HK1046142A1 (de)
MX (1) MXPA02004545A (de)
WO (1) WO2001034587A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX343042B (es) 2005-12-23 2016-10-21 Ariad Pharma Inc Compuestos heteroarilicos biciclicos.
JP6013326B2 (ja) 2010-05-19 2016-10-25 サンド・アクチエンゲゼルシヤフト キラルトリアゾロンの調製のための方法
JP5956980B2 (ja) 2010-05-19 2016-07-27 サンド・アクチエンゲゼルシヤフト キラル化合物の調製の方法
CA2798010C (en) 2010-05-19 2018-09-25 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
WO2011144656A1 (en) 2010-05-19 2011-11-24 Sandoz Ag Preparation of posaconazole intermediates
CN101824009A (zh) * 2010-05-27 2010-09-08 北京德众万全药物技术开发有限公司 一种泊沙康唑及其哌嗪中间体的简单制备方法
US9493428B2 (en) 2011-06-16 2016-11-15 Sandoz Ag Process for the preparation of a chiral compound
CA3022250A1 (en) 2012-12-12 2014-06-12 Ariad Pharmaceuticals, Inc. Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
EP2789610A1 (de) 2013-04-10 2014-10-15 Sandoz Ag Reinigung von Posaconazol-Zwischenprodukten
CN108003118A (zh) * 2017-12-27 2018-05-08 张家口市格瑞高新技术有限公司 一种泊沙康唑中间体1-（4-羟基苯基）-4-（4-氨基苯基）-哌嗪的制备工艺
CN114516849A (zh) * 2020-11-18 2022-05-20 江苏恒盛药业有限公司 一种1-(4-氨基苯基)-4-(4-羟基苯基)哌嗪的合成方法
CN114276315A (zh) * 2021-12-16 2022-04-05 苏州汉德创宏生化科技有限公司 一种4-[4-[4-(4-羟基苯基)哌嗪-1-基]苯基]氨基甲酸苯酯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753715B2 (ja) * 1986-02-25 1995-06-07 大塚製薬株式会社 ベンゾヘテロ環化合物
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
JPH04247074A (ja) * 1991-02-01 1992-09-03 Yoshitomi Pharmaceut Ind Ltd ４−モルホリノ安息香酸誘導体の製造法
DE4234295A1 (de) * 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JPH0971564A (ja) * 1995-07-06 1997-03-18 Japan Tobacco Inc ベンズアミドオキシム誘導体及びその医薬用途

Also Published As

Publication number Publication date
DE60020988D1 (de) 2005-07-28
CN1177840C (zh) 2004-12-01
CA2390296C (en) 2009-12-29
AU1465301A (en) 2001-06-06
JP2003513966A (ja) 2003-04-15
CN1387520A (zh) 2002-12-25
HK1046142A1 (en) 2002-12-27
DE60020988T2 (de) 2006-04-27
CA2390296A1 (en) 2001-05-17
WO2001034587A3 (en) 2002-03-21
EP1230231B1 (de) 2005-06-22
MXPA02004545A (es) 2002-09-02
ES2240202T3 (es) 2005-10-16
EP1230231A2 (de) 2002-08-14
JP4903963B2 (ja) 2012-03-28
WO2001034587A2 (en) 2001-05-17

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