ATE297461T1 - Reguliertes autokrines wachstum von säugerzellen - Google Patents

Reguliertes autokrines wachstum von säugerzellen

Info

Publication number: ATE297461T1
Authority: AT; Austria
Prior art keywords: growth; host cells; regulated; autocrine growth; mammal cells
Prior art date: 1995-07-26

Application number

AT96924714T

Other languages

English (en)

Inventor

Sybille Marie Hunt

Peter Philip Gray

Merilyn Joy Sleigh

Original Assignee

Unisearch Ltd

Commw Scient Ind Res Org

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-26

Filing date

1996-07-26

Publication date

2005-06-15

1996-07-26 Application filed by Unisearch Ltd, Commw Scient Ind Res Org filed Critical Unisearch Ltd

2005-06-15 Application granted granted Critical

2005-06-15 Publication of ATE297461T1 publication Critical patent/ATE297461T1/de

Links

230000001105 regulatory effect Effects 0.000 title abstract 2
241000124008 Mammalia Species 0.000 title 1
230000003305 autocrine Effects 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
102000004196 processed proteins & peptides Human genes 0.000 abstract 3
102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 2
108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 2
YKYOUMDCQGMQQO-UHFFFAOYSA-L cadmium dichloride Chemical compound Cl[Cd]Cl YKYOUMDCQGMQQO-UHFFFAOYSA-L 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
229920001184 polypeptide Polymers 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
102000013275 Somatomedins Human genes 0.000 abstract 1
102000004338 Transferrin Human genes 0.000 abstract 1
108090000901 Transferrin Proteins 0.000 abstract 1
239000000411 inducer Substances 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
239000004017 serum-free culture medium Substances 0.000 abstract 1
239000012581 transferrin Substances 0.000 abstract 1
239000011592 zinc chloride Substances 0.000 abstract 1
235000005074 zinc chloride Nutrition 0.000 abstract 1
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT96924714T 1995-07-26 1996-07-26 Reguliertes autokrines wachstum von säugerzellen ATE297461T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPN4422A AUPN442295A0 (en)	1995-07-26	1995-07-26	Regulated autocrine growth of mammalian cells
PCT/AU1996/000472 WO1997005240A1 (en)	1995-07-26	1996-07-26	Regulated autocrine growth of mammalian cells

Publications (1)

Publication Number	Publication Date
ATE297461T1 true ATE297461T1 (de)	2005-06-15

Family

ID=3788757

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96924714T ATE297461T1 (de)	1995-07-26	1996-07-26	Reguliertes autokrines wachstum von säugerzellen

Country Status (7)

Country	Link
US (2)	US6340574B1 (de)
EP (1)	EP0843722B1 (de)
JP (1)	JP3961567B2 (de)
AT (1)	ATE297461T1 (de)
AU (1)	AUPN442295A0 (de)
DE (1)	DE69634819T2 (de)
WO (1)	WO1997005240A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT407255B (de) *	1997-06-20	2001-02-26	Immuno Ag	Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US6475725B1 (en)	1997-06-20	2002-11-05	Baxter Aktiengesellschaft	Recombinant cell clones having increased stability and methods of making and using the same
AT409379B (de)	1999-06-02	2002-07-25	Baxter Ag	Medium zur protein- und serumfreien kultivierung von zellen
DE59913565D1 (de) *	1999-08-05	2006-07-27	Baxter Ag	Rekombinanter stabiler zellklon, seine herstellung und verwendung
ES2272318T3 (es)	1999-08-25	2007-05-01	Immunex Corporation	Composiciones y metodos para el cultivo celular mejorado.
EP1754784A3 (de) *	1999-09-03	2007-02-28	Applied Research Systems ARS Holding N.V.	Verfahren zur Produktion eines heterologen sezernierten Proteins aus auf Mikroträgern gewachsenen Cho-Zellen
UA74557C2 (en) *	1999-09-03	2006-01-16	Applied Research Systems	A method for producing a heterologous secreted protein from chinese hamster ovaries cells grown on microcarriers
NZ538094A (en)	2002-07-09	2007-01-26	Baxter Int	Serum free and animal protein free culture medium for cultivation of cells
CU23097A1 (es)	2002-10-23	2005-11-18	Centro Inmunologia Molecular	Método para la obtención de líneas celulares en medio libre de proteína y líneas celulares obtenidas por este método
US8058156B2 (en) *	2004-07-20	2011-11-15	Applied Materials, Inc.	Plasma immersion ion implantation reactor having multiple ion shower grids
US20060094104A1 (en)	2004-10-29	2006-05-04	Leopold Grillberger	Animal protein-free media for cultivation of cells
TWI406870B (zh) *	2005-02-21	2013-09-01	Chugai Pharmaceutical Co Ltd	A method of making a protein using hamster IGF-1
PT2522717E (pt)	2006-01-04	2014-05-15	Baxter Healthcare Sa	Meios de cultura celulares livres de oligopeptídeos
EP1970441A1 (de) *	2007-03-06	2008-09-17	BioAlliance Pharma	Plasmid mit einer Sequenz, die eine Disintegrin-Domäne von Metargidin (RDD) kodiert
WO2008118959A1 (en) *	2007-03-26	2008-10-02	The University Of Chicago	Immunoassays and characterization of biomolecular interactions using self- assembled monolayers
WO2009115495A1 (de) *	2008-03-19	2009-09-24	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Methode zur steigerung der reklonierungseffizienz
US20110016548A1 (en) *	2009-07-16	2011-01-20	University Of Southern California	Control of endogenous dnmt1 gene expression by exogenous binary regulatory systems
EP2606119A1 (de)	2010-08-20	2013-06-26	Wyeth LLC	Zellkultur aus wachstumsfaktorfreien adaptierten zellen
CN103768611B (zh) *	2012-10-19	2016-12-28	河南师范大学	植物源性醇溶蛋白共轭ZnO/Cd(OH)C1纳米抗癌药物及其制备方法
EP2964749A4 (de) *	2013-03-08	2016-08-17	Neuclone Biolog Pty Ltd	Zellkulturmedienzusammensetzung und verfahren zur herstellung davon
AU2014225272B2 (en)	2013-03-08	2015-10-22	Neuclone Biologics Pty Ltd	A cell expression system
TWI656839B (zh)	2013-03-15	2019-04-21	健臻公司	高密度細胞儲存方法
ES2890454T3 (es)	2014-09-18	2022-01-19	Genzyme Corp	Métodos de establecimiento de bancos de células de densidad ultraalta
JP6245299B2 (ja) *	2016-04-27	2017-12-13	バクスアルタゲーエムベーハー	組換え安定細胞クローン、その産生およびその使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0136907A3 (de) *	1983-10-03	1986-12-30	Genentech, Inc.	Xenogeneisches Expressionskontrollsystem, Verfahren zu dessen Verwendung, dieses enthaltende Expressionsvektoren, mit denselben transformierte Zellen und daraus hergestellte heterolose Proteine
EP0217822B1 (de) *	1985-02-13	1993-05-12	Scios Nova Inc.	Menschlicher metallothionein ii-promotor in säugetierexpressionssystemen
IL87737A (en) *	1987-09-11	1993-08-18	Genentech Inc	Method for culturing polypeptide factor dependent vertebrate recombinant cells
AU612404B2 (en) *	1987-09-11	1991-07-11	Genentech Inc.	Method for increasing the expression of polypeptides in recombinant cell culture
WO1991003554A1 (en)	1989-09-01	1991-03-21	Genentech, Inc.	Cells transfected with nucleic acid encoding gtp
PT616645E (pt)	1991-12-06	2002-02-28	Genentech Inc	Celulas transformadas para prohormona convertase
US5262308A (en)	1992-01-28	1993-11-16	Thomas Jefferson University	Cell lines which constitutively express IGF-1 and IGF-1 R
GB9216151D0 (en) *	1992-07-29	1992-09-09	Ici Plc	Containment of plant germplasm
US5856179A (en) *	1994-03-10	1999-01-05	Genentech, Inc.	Polypeptide production in animal cell culture
US5723333A (en) *	1995-02-10	1998-03-03	Regents Of The University Of California	Human pancreatic cell lines: developments and uses

1995
- 1995-07-26 AU AUPN4422A patent/AUPN442295A0/en not_active Abandoned
1996
- 1996-07-26 EP EP96924714A patent/EP0843722B1/de not_active Expired - Lifetime
- 1996-07-26 AT AT96924714T patent/ATE297461T1/de not_active IP Right Cessation
- 1996-07-26 WO PCT/AU1996/000472 patent/WO1997005240A1/en active IP Right Grant
- 1996-07-26 US US09/000,442 patent/US6340574B1/en not_active Expired - Lifetime
- 1996-07-26 DE DE69634819T patent/DE69634819T2/de not_active Expired - Lifetime
- 1996-07-26 JP JP50701097A patent/JP3961567B2/ja not_active Expired - Fee Related
2001
- 2001-09-28 US US09/964,338 patent/US6797515B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0843722A4 (de)	2002-05-02
WO1997005240A1 (en)	1997-02-13
EP0843722A1 (de)	1998-05-27
EP0843722B1 (de)	2005-06-08
US20020102650A1 (en)	2002-08-01
US6340574B1 (en)	2002-01-22
DE69634819D1 (de)	2005-07-14
JPH11509734A (ja)	1999-08-31
DE69634819T2 (de)	2006-03-23
JP3961567B2 (ja)	2007-08-22
AUPN442295A0 (en)	1995-08-17
US6797515B2 (en)	2004-09-28

Publication	Publication Date	Title
ATE297461T1 (de)	2005-06-15	Reguliertes autokrines wachstum von säugerzellen
ATE160587T1 (de)	1997-12-15	Expression rekombinanter polypeptide mit verbesserter möglichkeit zur reinigung
ATE335078T1 (de)	2006-08-15	Überexpression von säugetier- und virusproteinen
DK0929564T3 (da)	2008-07-14	Höjniveau-ekspression af proteiner
DE69233008D1 (de)	2003-05-22	Fusionierung von Peptiden und Proteinen mit Thioredoxin und thioredoxin-ähnlichen Molekülen
ATE168719T1 (de)	1998-08-15	Osteogene peptide
DE60142446D1 (de)	2010-08-05	Verbesserung der homogenität und sekretion von rekombinanten proteinen in säugetiersystemen
ATE527364T1 (de)	2011-10-15	Polypeptide erhaltend eine modifizierte menschliche serum-albumin sekretions-pre-sequenz mit erhöhtem ausscheidungsertrag
DE69726868D1 (de)	2004-01-29	DEFORMYLIERUNG VON f-MET PEPTIDEN IN BAKTERIEN EXPRESSIONSSYSTEMEN
AU2001275267A1 (en)	2001-12-17	Leader peptides for enhancing secretion of recombinant protein from a host cell
AU4134989A (en)	1990-04-05	Recombinant systems for expression of cholera B-subunit with the aid of foreign promoters and/or leader peptides
CA2227789A1 (en)	1997-02-13	Regulated autocrine growth of mammalian cells
DK0467839T3 (da)	1996-09-16	In-vitro-behandling af fusionsproteiner
WO1999002708A8 (en)	1999-04-01	Fusion proteins comprising sequences derived from bovine if1 atpase inhibitor protein
DE59108261D1 (de)	1996-11-14	Peptide des HIV-gag Proteins, ihre Herstellung und Verwendung
WO2004089973A3 (en)	2006-01-26	Peptides, polypeptides, and proteins of reduced immunogenicity and methods for their production
SE0003573D0 (sv)	2000-10-04	Method and means for producing novel von Willebrand factor binding proteins and their use in biotechnology
AU6839900A (en)	2001-03-19	Nucleic acid molecule comprising a nucleic acid sequence which codes for a haemocyanin, and comprising at least one intron sequence
ES2120409T3 (es)	1998-11-01	Nuevos vectores de expresion y metodos para la produccion de proteinas intracelulares.
ATE93893T1 (de)	1993-09-15	Expressionssysteme zur ueberproduktion gewuenschter proteine.

Legal Events

Date	Code	Title	Description
2005-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties