ATE297190T1 - Mikroemulsionen mit adsorbierten makromolekülen und mikropartikeln - Google Patents
Mikroemulsionen mit adsorbierten makromolekülen und mikropartikelnInfo
- Publication number
- ATE297190T1 ATE297190T1 AT00907228T AT00907228T ATE297190T1 AT E297190 T1 ATE297190 T1 AT E297190T1 AT 00907228 T AT00907228 T AT 00907228T AT 00907228 T AT00907228 T AT 00907228T AT E297190 T1 ATE297190 T1 AT E297190T1
- Authority
- AT
- Austria
- Prior art keywords
- microparticles
- emulsifying agent
- oil
- microemulsions
- emulsion
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title abstract 5
- 229920002521 macromolecule Polymers 0.000 title abstract 2
- 239000004530 micro-emulsion Substances 0.000 title 1
- 239000003599 detergent Substances 0.000 abstract 3
- 239000003995 emulsifying agent Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000002671 adjuvant Substances 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- 230000003308 immunostimulating effect Effects 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- AIDS & HIV (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Colloid Chemistry (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12185899P | 1999-02-26 | 1999-02-26 | |
| US14639199P | 1999-07-29 | 1999-07-29 | |
| US16199799P | 1999-10-28 | 1999-10-28 | |
| PCT/US2000/003331 WO2000050006A2 (en) | 1999-02-26 | 2000-02-09 | Microemulsions with adsorbed macromoelecules and microparticles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE297190T1 true ATE297190T1 (de) | 2005-06-15 |
Family
ID=27382688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00907228T ATE297190T1 (de) | 1999-02-26 | 2000-02-09 | Mikroemulsionen mit adsorbierten makromolekülen und mikropartikeln |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US8206749B1 (de) |
| EP (3) | EP1574210B1 (de) |
| JP (4) | JP2002537102A (de) |
| AT (1) | ATE297190T1 (de) |
| AU (1) | AU2875700A (de) |
| CA (2) | CA2689696C (de) |
| DE (1) | DE60020677T2 (de) |
| ES (2) | ES2242604T3 (de) |
| WO (1) | WO2000050006A2 (de) |
Families Citing this family (154)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6589940B1 (en) | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
| CA2689696C (en) | 1999-02-26 | 2013-08-06 | Novartis Vaccines And Diagnostics, Inc. | Microemulsions with adsorbed macromolecules and microparticles |
| DK1322287T3 (da) * | 2000-09-28 | 2006-07-24 | Chiron Corp | Mikropartikler til administration af heterologe nukleinsyrer |
| AU9489801A (en) * | 2000-09-28 | 2002-04-08 | Chiron Corp | Microparticle compositions and methods for the manufacture thereof |
| FR2814958B1 (fr) * | 2000-10-06 | 2003-03-07 | Aventis Pasteur | Composition vaccinale |
| US6552004B1 (en) * | 2000-10-30 | 2003-04-22 | Universite De Montreal | Delivery system for entrapping charged macromolecules and a method for preparing same |
| EP1364010B1 (de) * | 2000-12-27 | 2010-06-16 | Dynavax Technologies Corporation | Immunomodulatorische polynukleotide und verfahren zur deren verwendung |
| US20030133988A1 (en) | 2001-08-07 | 2003-07-17 | Fearon Karen L. | Immunomodulatory compositions, formulations, and methods for use thereof |
| DE60234375D1 (de) * | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| WO2003028661A2 (en) * | 2001-10-03 | 2003-04-10 | Chiron Corporation | Adjuvanted meningococcus compositions |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| JP2005508945A (ja) * | 2001-10-06 | 2005-04-07 | メリアル リミテッド | Cpg配合物及び関連方法 |
| US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| US7501134B2 (en) | 2002-02-20 | 2009-03-10 | Novartis Vaccines And Diagnostics, Inc. | Microparticles with adsorbed polypeptide-containing molecules |
| WO2004012751A1 (ja) * | 2002-08-02 | 2004-02-12 | Sumitomo Pharmaceuticals Company, Limited | 細菌細胞壁骨格成分製剤 |
| NZ538628A (en) * | 2002-08-12 | 2008-06-30 | Dynavax Tech Corp | Immunomodulatory compositions, methods of making, and methods of use thereof |
| US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| JP2006520746A (ja) * | 2002-12-27 | 2006-09-14 | カイロン コーポレイション | リン脂質を含む免疫原性組成物 |
| WO2004096136A2 (en) * | 2003-04-25 | 2004-11-11 | Chiron Corporation | Compositions comprising cationic microparticles and hcv e1e2 dna and methods of use thereof |
| US9107831B2 (en) | 2003-06-02 | 2015-08-18 | Novartis Vaccines And Diagonstics, Inc. | Immunogenic compositions containing microparticles comprising adsorbed toxoid and polysaccharide-containing antigens |
| US20050208083A1 (en) | 2003-06-04 | 2005-09-22 | Nanobio Corporation | Compositions for inactivating pathogenic microorganisms, methods of making the compositons, and methods of use thereof |
| BRPI0507031B1 (pt) | 2004-01-23 | 2021-01-19 | Eden Research Plc. | método para exterminar nematódeos compreendendo a aplicação de uma composição nematocida compreendendo uma partícula oca de glicano que encapsula um componente de terpeno e uso da referida composição nematocida |
| SI1753529T1 (sl) | 2004-05-20 | 2013-12-31 | Eden Research Plc | Sestavki, ki vsebujejo votli delec glukana ali votli delec stene celice, ki enkapsulira komponento terpena, postopki njihove izdelave in uporabe |
| NZ561822A (en) | 2005-03-23 | 2010-04-30 | Glaxosmithkline Biolog Sa | Multivalent influenza virus vaccine |
| CA2604392A1 (en) * | 2005-04-11 | 2006-10-19 | Nanobio Corporation | Quaternary ammonium halides for treatment of infectious conditions |
| BRPI0612655B1 (pt) | 2005-06-27 | 2021-06-15 | Pfizer Ireland Pharmaceuticals | Composição imunogênica |
| CA2618974C (en) * | 2005-08-09 | 2014-01-28 | Nanobio Corporation | Nanoemulsion compositions having anti-inflammatory activity |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| CA2628158C (en) * | 2005-11-04 | 2015-12-15 | Novartis Vaccines And Diagnostics S.R.L. | Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines |
| AU2006310336B2 (en) * | 2005-11-04 | 2011-02-03 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| CA2628397C (en) * | 2005-11-04 | 2013-08-20 | Novartis Vaccines And Diagnostics S.R.L. | Changing th1/th2 balance in split influenza vaccines with adjuvants |
| WO2007070660A2 (en) | 2005-12-13 | 2007-06-21 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
| JP5484732B2 (ja) | 2005-12-14 | 2014-05-07 | サイトス バイオテクノロジー アーゲー | 過敏症の治療のための免疫賦活性核酸パッケージ粒子 |
| US9839685B2 (en) | 2006-04-13 | 2017-12-12 | The Regents Of The University Of Michigan | Methods of inducing human immunodeficiency virus-specific immune responses in a host comprising nasally administering compositions comprising a naonemulsion and recombinant GP120 immunogen |
| US10138279B2 (en) | 2006-04-13 | 2018-11-27 | Regents Of The University Of Michigan | Compositions and methods for Bacillus anthracis vaccination |
| RU2476595C2 (ru) | 2006-06-12 | 2013-02-27 | Цитос Биотехнологи Аг | Способы упаковки олигонуклеотидов в вирусоподобные частицы рнк-содержащих бактериофагов |
| HRP20140488T1 (hr) | 2006-07-17 | 2014-07-04 | Glaxosmithkline Biologicals S.A. | Cjepivo protiv influence |
| CA2671873C (en) | 2006-12-12 | 2018-10-09 | Brian Stephen Sproat | Oligonucleotides containing high concentrations of guanine monomers |
| US8877206B2 (en) * | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| KR20100016647A (ko) * | 2007-04-18 | 2010-02-12 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 단백질-변형된 나노-액적, 조성물 및 제조 방법 |
| US9452209B2 (en) | 2007-04-20 | 2016-09-27 | Glaxosmithkline Biologicals Sa | Influenza vaccine |
| US8815253B2 (en) | 2007-12-07 | 2014-08-26 | Novartis Ag | Compositions for inducing immune responses |
| WO2009102465A2 (en) | 2008-02-13 | 2009-08-20 | President And Fellows Of Harvard College | Continuous cell programming devices |
| US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
| CA2719252C (en) * | 2008-04-01 | 2016-01-19 | Innate Therapeutics Limited | Anti-infective agents comprising muramyl dipeptide microparticles and uses thereof |
| CN102137675A (zh) | 2008-04-17 | 2011-07-27 | Pds生物科技公司 | 通过阳离子脂质的对映体刺激免疫应答 |
| EP2280690A2 (de) * | 2008-04-18 | 2011-02-09 | Nanobio Corporation | Verfahren zur behandlung von infektionen mit dem herpesvirus |
| US9144606B2 (en) | 2008-04-21 | 2015-09-29 | Nanobio Corporation | Nanoemulsion influenza vaccine |
| US20090269394A1 (en) * | 2008-04-25 | 2009-10-29 | Nanobio Corporation | Methods and compositions for treating onchomycosis |
| US8226965B2 (en) | 2008-04-25 | 2012-07-24 | Nanobio Corporation | Methods of treating fungal, yeast and mold infections |
| CA2826508C (en) | 2008-05-23 | 2016-07-19 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
| ES2728949T3 (es) | 2008-06-27 | 2019-10-29 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
| US8962026B2 (en) | 2008-09-26 | 2015-02-24 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
| WO2010092479A2 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccines with reduced amounts of squalene |
| JP6110140B2 (ja) * | 2009-06-16 | 2017-04-05 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | ナノエマルションワクチン |
| EP2461828B1 (de) | 2009-07-31 | 2017-06-21 | President and Fellows of Harvard College | Programmierung von zellen für tolerogene therapien |
| GB0913442D0 (en) * | 2009-07-31 | 2009-09-16 | Univ Ramot | Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof |
| GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
| DE102009056883B4 (de) | 2009-12-03 | 2012-08-16 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| PT2343052E (pt) | 2009-12-03 | 2013-08-28 | Novartis Ag | Filtração hidrofílica durante o fabrico de adjuvantes de vacinas |
| AU2013202706B2 (en) * | 2009-12-03 | 2016-02-11 | Seqirus UK Limited | Circulation of components during microfluidization and/or homogenization emulsions |
| DE102009056871A1 (de) | 2009-12-03 | 2011-06-22 | Novartis AG, 4056 | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| CL2012001399A1 (es) | 2009-12-03 | 2013-03-08 | Novartis Ag | Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion. |
| WO2011067673A2 (en) * | 2009-12-03 | 2011-06-09 | Novartis Ag | Circulation of components during homogenization of emulsions |
| DE102009056884B4 (de) | 2009-12-03 | 2021-03-18 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| CN108042799A (zh) | 2010-07-06 | 2018-05-18 | 诺华股份有限公司 | 阳离子水包油乳液 |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| MX2013003681A (es) | 2010-10-01 | 2013-11-20 | Moderna Therapeutics Inc | Ácidos nucleicos manipulados y métodos de uso de los mismos. |
| SI2624873T1 (sl) | 2010-10-06 | 2020-07-31 | President And Fellows Of Harvard College | Injektabilni, pore-formirajoči hidrogeli za celične terapije - na osnovi materialov |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| ES2685327T3 (es) | 2011-04-28 | 2018-10-08 | President And Fellows Of Harvard College | Armazones tridimensionales macroscópicos preformados inyectables para administración mínimamente invasiva |
| WO2012167230A1 (en) | 2011-06-03 | 2012-12-06 | President And Fellows Of Harvard College | In situ antigen-generating cancer vaccine |
| WO2013006834A1 (en) | 2011-07-06 | 2013-01-10 | Novartis Ag | Oil-in-water emulsions that contain nucleic acids |
| CA2840965C (en) | 2011-07-06 | 2021-03-02 | Novartis Ag | Cationic oil-in-water emulsions |
| CA2845872C (en) * | 2011-08-22 | 2023-03-28 | Nanobio Corporation | Herpes simplex virus nanoemulsion vaccine |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| SI3682905T1 (sl) | 2011-10-03 | 2022-04-29 | Modernatx, Inc. | Modificirani nukleozidi, nukleotidi in nukleinske kisline ter njihove uporabe |
| US20130156849A1 (en) | 2011-12-16 | 2013-06-20 | modeRNA Therapeutics | Modified nucleoside, nucleotide, and nucleic acid compositions |
| WO2013142374A1 (en) | 2012-03-23 | 2013-09-26 | Amirobe, Inc. | Compositions and uses of antimicrobial materials with tissue-compatible properties |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| HK1206601A1 (en) | 2012-04-02 | 2016-01-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of biologics and proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| ES2773895T3 (es) | 2012-04-16 | 2020-07-15 | Harvard College | Composiciones de sílice mesoporosa para modular las respuestas inmunitarias |
| US10286064B2 (en) * | 2012-06-15 | 2019-05-14 | Pds Biotechnology Corporation | Cationic lipid vaccine compositions and methods of use |
| AU2013317805B2 (en) | 2012-09-21 | 2018-07-26 | Pds Biotechnology Corporation | Improved vaccine compositions and methods of use |
| SI2922554T1 (sl) | 2012-11-26 | 2022-06-30 | Modernatx, Inc. | Terminalno modificirana RNA |
| US10258698B2 (en) | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US20160194625A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US10117921B2 (en) | 2013-09-19 | 2018-11-06 | Zoetis Services Llc | Oil-based adjuvants |
| EP2851066A1 (de) * | 2013-09-23 | 2015-03-25 | LTS LOHMANN Therapie-Systeme AG | Fixierung von Impfstoffformulierungen auf Einrichtungen zur epidermalen Immunisierung durch ölige Adjuvantien |
| EP3052106A4 (de) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynukleotide zur codierung immunmodulierender polypeptide |
| SG11201602503TA (en) | 2013-10-03 | 2016-04-28 | Moderna Therapeutics Inc | Polynucleotides encoding low density lipoprotein receptor |
| EP3137105A4 (de) | 2014-04-30 | 2017-12-27 | President and Fellows of Harvard College | Kombinationsimpfstoffvorrichtungen und -verfahren zur abtötung von krebszellen |
| WO2016011226A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP3171895A1 (de) | 2014-07-23 | 2017-05-31 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von intrabodys |
| ES2924988T3 (es) | 2014-10-10 | 2022-10-13 | Univ Michigan Regents | Composiciones con nanoemulsiones para prevenir, inhibir o eliminar una enfermedad alérgica e inflamatoria |
| AU2016206525A1 (en) | 2015-01-16 | 2017-07-13 | United States Of America, As Represented By The Secretary Of Agriculture | Foot-and-mouth disease vaccine |
| HK1247861A1 (zh) | 2015-01-30 | 2018-10-05 | President And Fellows Of Harvard College | 用於癌症治疗的肿瘤周围和肿瘤内部材料 |
| CN114099793A (zh) | 2015-04-10 | 2022-03-01 | 哈佛学院院长等 | 免疫细胞捕获装置及其制备和使用方法 |
| WO2017004250A1 (en) | 2015-06-29 | 2017-01-05 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis |
| EP3324979B1 (de) | 2015-07-21 | 2022-10-12 | ModernaTX, Inc. | Impfstoffe gegen infektionserkrankungen |
| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
| SI3350157T1 (sl) | 2015-09-17 | 2022-04-29 | Modernatx, Inc. | Sestave za doziranje terapevtskih sredstev v celice |
| US11643441B1 (en) | 2015-10-22 | 2023-05-09 | Modernatx, Inc. | Nucleic acid vaccines for varicella zoster virus (VZV) |
| WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
| US20180289792A1 (en) | 2015-10-22 | 2018-10-11 | ModernaTX. Inc. | Sexually transmitted disease vaccines |
| US11612652B2 (en) | 2015-11-13 | 2023-03-28 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
| WO2017099823A1 (en) | 2015-12-10 | 2017-06-15 | Modernatx, Inc. | Compositions and methods for delivery of therapeutic agents |
| PL3394030T3 (pl) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Związki i kompozycje do wewnątrzkomórkowego dostarczania środków |
| PT3394093T (pt) | 2015-12-23 | 2022-05-30 | Modernatx Inc | Métodos de utilização de polinucleotídeos que codificam ligandos ox40 |
| WO2017120612A1 (en) | 2016-01-10 | 2017-07-13 | Modernatx, Inc. | Therapeutic mrnas encoding anti ctla-4 antibodies |
| WO2017136837A1 (en) | 2016-02-06 | 2017-08-10 | President And Fellows Of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
| EP3468530A4 (de) | 2016-06-10 | 2020-03-11 | Clarity Cosmetics Inc. | Nichtkomedogene formuliereungen zur haar- und kopfhautpflege und verfahren zur verwendung |
| EP4606890A3 (de) | 2016-07-13 | 2025-12-03 | President and Fellows of Harvard College | Antigenpräsentierende zellmimetische gerüste und verfahren zur herstellung und verwendung davon |
| KR102638898B1 (ko) | 2016-08-02 | 2024-02-22 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 면역 반응을 조정하기 위한 생체재료 |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| WO2018089851A2 (en) | 2016-11-11 | 2018-05-17 | Modernatx, Inc. | Influenza vaccine |
| EP3544737B1 (de) | 2016-11-28 | 2025-04-23 | Arizona Board of Regents on behalf of Arizona State University | Verfahren im zusammenhang mit tropfenreaktion mit kontinuierlichem fluss |
| MA50335A (fr) | 2016-12-08 | 2020-08-19 | Modernatx Inc | Vaccins à acide nucléique contre des virus respiratoires |
| US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
| WO2018170245A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| EP3596041B1 (de) | 2017-03-15 | 2022-11-02 | ModernaTX, Inc. | Verbindung und zusammensetzungen zur intrazellulären verabreichung von therapeutischen wirkstoffen |
| WO2018170270A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
| DK3596042T3 (da) | 2017-03-15 | 2022-04-11 | Modernatx Inc | Krystalformer af aminolipider |
| US11464848B2 (en) | 2017-03-15 | 2022-10-11 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| ES3020935T3 (en) | 2017-03-15 | 2025-05-23 | Modernatx Inc | Lipid nanoparticle formulation |
| BR112019020781A2 (pt) | 2017-04-06 | 2020-04-28 | Amicrobe Inc | composições e usos de polipeptídeo(s) catiônico(s) sintético(s) antimicrobiano(s) aplicado(s) de forma local com maior desempenho e segurança |
| JP7285220B2 (ja) | 2017-05-18 | 2023-06-01 | モデルナティエックス インコーポレイテッド | 連結したインターロイキン-12(il12)ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子 |
| EP3638678B1 (de) | 2017-06-14 | 2025-12-03 | ModernaTX, Inc. | Verbindungen und zusammensetzungen zur intrazellulären verabreichung von wirkstoffen |
| US10653767B2 (en) | 2017-09-14 | 2020-05-19 | Modernatx, Inc. | Zika virus MRNA vaccines |
| US11911453B2 (en) | 2018-01-29 | 2024-02-27 | Modernatx, Inc. | RSV RNA vaccines |
| US12220486B2 (en) | 2018-03-02 | 2025-02-11 | Saint Joseph's University | Polymer compositions for storage and release of polypeptides |
| US11471884B2 (en) | 2018-04-02 | 2022-10-18 | Dropworks, Inc. | Systems and methods for serial flow emulsion processes |
| EP3853202A1 (de) | 2018-09-19 | 2021-07-28 | ModernaTX, Inc. | Verbindungen und zusammensetzungen zur intrazellulären verabreichung von therapeutischen wirkstoffen |
| JP7526168B2 (ja) | 2018-09-19 | 2024-07-31 | モデルナティエックス インコーポレイテッド | Peg脂質及びそれらの使用 |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| MA53652A (fr) | 2018-09-19 | 2021-07-28 | Modernatx Inc | Lipides peg de haute pureté et leurs utilisations |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| WO2020190750A1 (en) | 2019-03-15 | 2020-09-24 | Modernatx, Inc. | Hiv rna vaccines |
| US12016920B2 (en) | 2019-06-06 | 2024-06-25 | Denka Company Limited | Adjuvant based on peptide nucleic acid |
| JP7638972B2 (ja) | 2019-09-19 | 2025-03-04 | モデルナティエックス インコーポレイテッド | 治療薬の細胞内送達のための分岐状尾部脂質化合物及び組成物 |
| US11679163B2 (en) | 2019-09-20 | 2023-06-20 | Hdt Bio Corp. | Compositions and methods for delivery of RNA |
| EP4034148A4 (de) | 2019-09-23 | 2025-09-10 | Harvard College | Biomaterialbasierter antigenfreier impfstoff und verwendung davon |
| BR112022019124A2 (pt) | 2020-03-23 | 2023-02-14 | Hdt Bio Corp | Composições e métodos para liberação de rna |
| CN111658611B (zh) | 2020-04-13 | 2021-06-01 | 四川大学 | 一种基于微乳的疫苗递送系统及其制备方法和应用 |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| EP4404917A4 (de) | 2021-09-22 | 2025-08-06 | Hdt Bio Corp | Rna-impfstoffe gegen infektionskrankheiten |
| EP4404957A4 (de) | 2021-09-22 | 2025-08-06 | Hdt Bio Corp | Krebstherapiezusammensetzungen und verwendungen davon |
| CA3232566A1 (en) | 2021-09-22 | 2023-03-30 | Hdt Bio Corp. | Dried nanoparticle compositions |
| CA3232719A1 (en) | 2021-09-22 | 2023-03-30 | Steven Gregory REED | Sars-cov-2 rna vaccine compositions and methods of use |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA583561A (en) | 1959-09-22 | H. Edgerton William | Therapeutically valuable esters and methods for obtaining the same | |
| US1565298A (en) | 1925-12-15 | Stop check announcing device for adding machines | ||
| US1573698A (en) | 1922-06-21 | 1926-02-16 | Union Carbide & Carbon Res Lab | Denatured alcohol |
| US2800457A (en) | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
| FR1317586A (de) | 1961-03-17 | 1963-05-08 | ||
| NL280826A (de) | 1962-07-11 | |||
| BE755269A (fr) | 1969-08-25 | 1971-02-01 | Westinghouse Electric Corp | Systeme de regulation d'epaisseur du produit lamine sortant d'un laminoir |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| CA1247080A (en) | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| US4770874A (en) | 1983-08-22 | 1988-09-13 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
| US4772466A (en) | 1983-08-22 | 1988-09-20 | Syntex (U.S.A.) Inc. | Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants |
| US5324513A (en) | 1984-03-07 | 1994-06-28 | Institut Pasteur | Composition useful for the fabrication of vaccines |
| US5171568A (en) | 1984-04-06 | 1992-12-15 | Chiron Corporation | Recombinant herpes simplex gb-gd vaccine |
| EP0175787B1 (de) | 1984-04-06 | 1995-02-15 | Chiron Corporation | Rekombinanter herpes simplex gb-gd impfstoff |
| US5098704A (en) | 1984-06-18 | 1992-03-24 | Chiron Corporation | Hepatitis surface antigen particle vaccine |
| US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| CA1341482C (en) | 1984-10-31 | 2005-05-10 | Paul A. Luciw | Process for preparing fragments of aids-associated retroviruses |
| US4689225A (en) | 1984-11-02 | 1987-08-25 | Institut Merieux | Vaccine for cytomegalovirus |
| US4826957A (en) | 1985-07-12 | 1989-05-02 | New York University | Immunogenic recombinant yeast expression product and method for purifying it |
| US4803070A (en) * | 1986-04-15 | 1989-02-07 | Ribi Immunochem Research Inc. | Immunological emulsion adjuvants for polysaccharide vaccines |
| JP2661044B2 (ja) | 1986-06-17 | 1997-10-08 | カイロン コーポレイション | 肝炎δの診断薬およびワクチン |
| DK341386D0 (da) | 1986-07-18 | 1986-07-18 | Voetman Karin Glassau | Fremgangsmaade og apparat til oprulning af flade dejstykker, f.eks. til roulader |
| EP0289550B1 (de) | 1986-10-20 | 1996-04-10 | Chiron Corporation | Impfstoff zur behandlung von hsv |
| EP0315153B1 (de) | 1987-11-03 | 1994-05-11 | Syntex (U.S.A.) Inc. | Impfstoff-Adjuvans |
| DE3886363T3 (de) | 1987-11-18 | 2004-09-09 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | NANBV-Diagnostika |
| DE68929478T2 (de) | 1988-01-29 | 2004-04-29 | Aventis Pasteur | Rekombinante CMV-Neutralisierungsproteine |
| UA50829C2 (uk) | 1989-03-17 | 2002-11-15 | Чірон Корпорейшн | Очищений поліпептид, що містить антиген вірусу гепатиту с, полінуклеотид, вектор, клітини, система експресії, моноклональне антитіло, препарат поліклональних антитіл, нуклеотидна проба, аналітичні набори, спосіб виявлення нуклеїнових кислот, способи імуноаналізу, вакцина, спосіб одержання антитіл |
| JP2656996B2 (ja) | 1989-05-18 | 1997-09-24 | カイロン コーポレイション | Nanbvの診断用薬 |
| WO1990014837A1 (en) * | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| CH679207A5 (de) | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
| HU220136B (hu) * | 1990-06-29 | 2001-11-28 | Chiron Corp. | Eljárás liposzómákat tartalmazó vakcinakészítmény előállítására |
| US5789573A (en) | 1990-08-14 | 1998-08-04 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2 |
| IL101715A (en) | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
| GB9116610D0 (en) | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
| IT1253009B (it) | 1991-12-31 | 1995-07-10 | Sclavo Ricerca S R L | Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini |
| AU670168B2 (en) | 1992-12-02 | 1996-07-04 | Alkermes Controlled Therapeutics, Inc. | Controlled release growth hormone containing microspheres |
| ATE420171T1 (de) | 1994-07-15 | 2009-01-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| JPH0827018A (ja) | 1994-07-22 | 1996-01-30 | Sanwa Kagaku Kenkyusho Co Ltd | 生理活性ペプチド又は蛋白質を含有する薬剤組成物 |
| US5672584A (en) | 1995-04-25 | 1997-09-30 | The University Of Kansas | Cyclic prodrugs of peptides and peptide nucleic acids having improved metabolic stability and cell membrane permeability |
| US5741776A (en) | 1995-05-22 | 1998-04-21 | Genentech, Inc. | Method of administration of IGF-I |
| AU5979296A (en) | 1995-06-07 | 1996-12-30 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| GB9514285D0 (en) | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
| US5814516A (en) | 1995-10-13 | 1998-09-29 | Lockheed Martin Energy Systems, Inc. | Surface enhanced Raman gene probe and methods thereof |
| US6015710A (en) | 1996-04-09 | 2000-01-18 | The University Of Texas System | Modulation of mammalian telomerase by peptide nucleic acids |
| GB9608803D0 (en) | 1996-04-27 | 1996-07-03 | Univ Newcastle | Mitochondrial dna defects |
| US5912332A (en) | 1996-07-26 | 1999-06-15 | Hybridon, Inc. | Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides |
| US5821060A (en) | 1996-08-02 | 1998-10-13 | Atom Sciences, Inc. | DNA sequencing, mapping, and diagnostic processes using hybridization chips and unlabeled DNA |
| DE19640974A1 (de) | 1996-10-04 | 1998-04-16 | Bayer Ag | Bausteine für DNA/PNA-Cooligomere |
| ATE243761T1 (de) | 1996-10-04 | 2003-07-15 | Dako As | Sonden zur detektion von mycobakterien |
| EP0930893B1 (de) | 1996-10-11 | 2005-04-13 | The Regents of The University of California | Immunostimulierende oligonucleotidekonjugate |
| GB9621367D0 (en) | 1996-10-14 | 1996-12-04 | Isis Innovation | Chiral peptide nucleic acids |
| JP4072206B2 (ja) | 1996-11-05 | 2008-04-09 | クリニカル・マイクロ・センサーズ・インコーポレイテッド | 導電性オリゴマーを介して核酸に連結させた電極 |
| US5800999A (en) | 1996-12-16 | 1998-09-01 | Tropix, Inc. | Dioxetane-precursor-labeled probes and detection assays employing the same |
| EP0991403B1 (de) | 1997-01-30 | 2003-04-02 | Chiron Corporation | Verwendung von mikropartikeln mit adsorbiertem antigen zur stimulierung der immunabwehr |
| KR19980067138A (ko) * | 1997-01-31 | 1998-10-15 | 박원훈 | 유전자 또는 생물학적 활성 약물을 세포내로 효과적으로 전달하는 지방 유제 및 그것의 제조방법 |
| CA2228875A1 (en) | 1997-02-08 | 1998-08-08 | Boehringer Mannheim Gmbh | A method for the preparation of nucleic acid binding compound |
| US5962230A (en) | 1997-02-13 | 1999-10-05 | The University Of Connecticut | Diagnosis and treatment of glaucoma |
| EP1039935A4 (de) | 1997-02-28 | 2005-04-27 | Univ Iowa Res Found | VERWENDUNG VON NUCLEINSÄUREN ENTHALTEND NICHT-METHYLIERTEN CpG-DINUKLEOTIDEN IN DER BEHANDLUNG VON LIPOPOLYSACCHARID-ASSOZIERTEN ERKRANKUNGEN |
| ATE441432T1 (de) | 1997-03-10 | 2009-09-15 | Ottawa Hospital Res Inst | Verwendung von nicht-methyliertem cpg dinukleotid in kombination mit aluminium als adjuvantien |
| DE19712530A1 (de) | 1997-03-25 | 1998-10-01 | Boehringer Mannheim Gmbh | Neue Monomerbausteine zur Markierung von peptidischen Nukleinsäuren |
| US6086900A (en) | 1997-03-26 | 2000-07-11 | Board Of Regents, The University Of Texas Systems | Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes |
| ATE370740T1 (de) | 1997-05-20 | 2007-09-15 | Ottawa Health Research Inst | Verfahren zur herstellung von nukleinsäurekonstrukten |
| AU753172B2 (en) | 1997-06-06 | 2002-10-10 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
| AU731909B2 (en) * | 1997-07-01 | 2001-04-05 | Isis Pharmaceuticals, Inc. | Compositions and methods for the delivery of oligonucleotides via the alimentary canal |
| JP2002509545A (ja) * | 1997-07-08 | 2002-03-26 | カイロン コーポレイション | Dnaワクチンを伴うサブミクロン水中油型エマルジョンの使用 |
| SE9702776D0 (sv) * | 1997-07-22 | 1997-07-22 | Pharmacia & Upjohn Ab | Method of preparing pharmaceutical compositions |
| GB9718901D0 (en) | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
| EP1279401B1 (de) | 1997-09-05 | 2008-01-09 | GlaxoSmithKline Biologicals S.A. | Öl-in-Wasser Emulsionen mit Saponinen |
| DK1042001T3 (da) | 1997-12-16 | 2002-07-08 | Chiron Corp | Anvendelse af mikropartikler kombineret med submikron-(olie-i-vand)-emulsioner |
| US6045816A (en) * | 1998-06-17 | 2000-04-04 | Isp Investments Inc. | Water-based microemulsion of a pyrethroid |
| NZ509853A (en) | 1998-07-29 | 2003-08-29 | Chiron Corp | Microparticles with an adsorbent surface useful for delivering pharmaceuticals |
| JP2002521423A (ja) | 1998-07-31 | 2002-07-16 | コリア インスティチュート オブ サイエンス アンド テクノロージ | 遺伝子又は薬物運搬体としての脂質エマルジョン及び固形脂質微粒子 |
| CA2689696C (en) | 1999-02-26 | 2013-08-06 | Novartis Vaccines And Diagnostics, Inc. | Microemulsions with adsorbed macromolecules and microparticles |
| KR100701569B1 (ko) | 2006-07-10 | 2007-03-29 | 주식회사 경동나비엔 | 응축방지를 위한 저장식 보일러의 열교환기 구조 |
| EP2019117A1 (de) | 2007-07-27 | 2009-01-28 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Optimiertes Reinigungsverfahren für rekombinantes Wachstumsfaktorprotein |
| CN102792149B (zh) | 2010-03-12 | 2015-05-20 | 柯尼卡美能达先进多层薄膜株式会社 | 分子间相互作用的检测方法及其检测装置 |
| JP6136343B2 (ja) | 2012-06-12 | 2017-05-31 | 株式会社リコー | 情報処理システム、情報処理方法、プログラム、及び記録媒体 |
| AT514720B1 (de) | 2013-08-30 | 2016-03-15 | Blum Gmbh Julius | Stellvorrichtung |
| CN104683216B (zh) | 2013-11-29 | 2019-04-12 | 腾讯科技(深圳)有限公司 | 客服信息的转发方法及装置、客服系统 |
| JP6287387B2 (ja) | 2014-03-12 | 2018-03-07 | 株式会社リコー | 液滴吐出装置の液体粘度検出方法、液滴吐出装置の制御方法、液滴吐出装置、及び液滴吐出装置の液体粘度を検出する回路 |
| FR3030069B1 (fr) | 2014-12-16 | 2020-03-20 | Zrc Geneve Sa | Montre a lunette tournante |
| KR102354328B1 (ko) | 2015-09-22 | 2022-01-21 | 삼성전자주식회사 | 영상 표시 장치 및 그 동작 방법 |
| US9680022B1 (en) | 2016-07-12 | 2017-06-13 | United Microelectronics Corp. | Semiconductor device having silicon-germanium layer on fin and method for manufacturing the same |
| JP2020112507A (ja) | 2019-01-16 | 2020-07-27 | 日本電信電話株式会社 | 案内文生成装置、案内システム、案内文生成方法及びプログラム |
-
2000
- 2000-02-09 CA CA2689696A patent/CA2689696C/en not_active Expired - Lifetime
- 2000-02-09 DE DE60020677T patent/DE60020677T2/de not_active Expired - Lifetime
- 2000-02-09 WO PCT/US2000/003331 patent/WO2000050006A2/en not_active Ceased
- 2000-02-09 ES ES00907228T patent/ES2242604T3/es not_active Expired - Lifetime
- 2000-02-09 EP EP05075823.4A patent/EP1574210B1/de not_active Expired - Lifetime
- 2000-02-09 EP EP00907228A patent/EP1156781B1/de not_active Revoked
- 2000-02-09 EP EP10179804A patent/EP2286792A1/de not_active Withdrawn
- 2000-02-09 CA CA2363141A patent/CA2363141C/en not_active Expired - Lifetime
- 2000-02-09 AT AT00907228T patent/ATE297190T1/de active
- 2000-02-09 AU AU28757/00A patent/AU2875700A/en not_active Abandoned
- 2000-02-09 US US09/914,279 patent/US8206749B1/en not_active Expired - Fee Related
- 2000-02-09 JP JP2000600618A patent/JP2002537102A/ja not_active Withdrawn
- 2000-02-09 ES ES05075823.4T patent/ES2579783T3/es not_active Expired - Lifetime
-
2006
- 2006-04-18 US US11/406,144 patent/US8309139B2/en not_active Expired - Fee Related
-
2011
- 2011-10-21 JP JP2011232182A patent/JP6073053B2/ja not_active Expired - Lifetime
-
2012
- 2012-09-14 US US13/618,020 patent/US8771747B2/en not_active Expired - Fee Related
- 2012-09-15 US US13/621,174 patent/US8734832B2/en not_active Expired - Fee Related
-
2014
- 2014-05-28 JP JP2014110216A patent/JP2014169323A/ja not_active Withdrawn
-
2016
- 2016-06-24 JP JP2016125184A patent/JP2016172767A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014169323A (ja) | 2014-09-18 |
| JP2012017344A (ja) | 2012-01-26 |
| US20130195898A1 (en) | 2013-08-01 |
| CA2689696A1 (en) | 2000-08-31 |
| EP1574210A3 (de) | 2007-02-21 |
| WO2000050006A2 (en) | 2000-08-31 |
| CA2363141C (en) | 2010-04-06 |
| EP1574210B1 (de) | 2016-04-06 |
| US20130195923A1 (en) | 2013-08-01 |
| EP2286792A1 (de) | 2011-02-23 |
| WO2000050006A3 (en) | 2001-01-18 |
| CA2689696C (en) | 2013-08-06 |
| AU2875700A (en) | 2000-09-14 |
| US20070116709A1 (en) | 2007-05-24 |
| US8734832B2 (en) | 2014-05-27 |
| DE60020677T2 (de) | 2006-05-04 |
| DE60020677D1 (de) | 2005-07-14 |
| JP6073053B2 (ja) | 2017-02-01 |
| US8309139B2 (en) | 2012-11-13 |
| JP2016172767A (ja) | 2016-09-29 |
| US8771747B2 (en) | 2014-07-08 |
| ES2579783T3 (es) | 2016-08-16 |
| EP1156781B1 (de) | 2005-06-08 |
| ES2242604T3 (es) | 2005-11-16 |
| JP2002537102A (ja) | 2002-11-05 |
| US8206749B1 (en) | 2012-06-26 |
| EP1156781A2 (de) | 2001-11-28 |
| CA2363141A1 (en) | 2000-08-31 |
| EP1574210A2 (de) | 2005-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE297190T1 (de) | Mikroemulsionen mit adsorbierten makromolekülen und mikropartikeln | |
| PT1322287E (pt) | Microparticulas para a administracao de acidos nucleicos heterologos | |
| DE69937571D1 (de) | Mutiertes cholera holotoxin als hilfsmittel | |
| WO2007006939A3 (fr) | Emulsion immuno-adjuvante thermoreversible | |
| MY133780A (en) | Vaccine composition | |
| DE69935598D1 (de) | Impfstoff enthaltend ein iscom, bestehend aus sterol und saponin und frei von zusätzlichen detergenzien | |
| CY1107326T1 (el) | Μικροσωματιδια με απορροφητικες επιφανειες, μεθοδοι κατασκευης αυτων και χρησεις αυτων | |
| AUPP807399A0 (en) | Improved immunogenic lhrh composition and methods relating thereto | |
| BR9906927A (pt) | Proteìnas de neisseria meningitidis | |
| EP1326633A4 (de) | Zusammensetzung mit immunogenen mikroteilchen | |
| EP1741782A3 (de) | Durch Mage Minigene kodierte immunogene Polypeptide und ihre Verwendungen | |
| UY26555A1 (es) | Composición farmacéutica para modulación inmunológica y preparación de vacunas | |
| LU91485I2 (fr) | Vaccin adjuvant grippal dans lequel l'adjuvant estune émulsion huile-dans-eau comprenant du squalèn e, du DL-a-tocophérol et du polysorbate 80 | |
| DE60210456D1 (de) | Solubisierung von kapseln polysacchariden | |
| WO2001068129A3 (de) | Adjuvans für vakzinen | |
| PT98156A (pt) | Um processo de preparacao de uma composicao de vacina | |
| NO331017B1 (no) | Glukan, adjuvanssammensetning omfattende glukanet samt anvendelse av glukanet for fremstilling av en mukosal administrerbar adjuvanssammensetning. | |
| WO2001097841A3 (en) | Qs-21 and il-12 as an adjuvant combination | |
| WO2003051288A3 (en) | Mycobacterial vaccine | |
| ATE310798T1 (de) | Weichspülmittel | |
| WO2000050073A3 (en) | Caulobacter lps immunoadjuvant | |
| WO2000006198A3 (en) | Adjuvant comprising pulmonary surfactant | |
| WO2000069458A3 (en) | Adjuvant combinations for immunization composition and vaccines | |
| WO2002032455A3 (en) | Vaccine | |
| WO2001049320A3 (en) | Use of hemicellulose microparticles as vaccine adjuvant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1156781 Country of ref document: EP |