ATE277596T1 - Topische pharmazeutische zusammensetzung, enthaltend einen cholinergischen wirkstoff oder einen kalziumkanalblocker - Google Patents
Topische pharmazeutische zusammensetzung, enthaltend einen cholinergischen wirkstoff oder einen kalziumkanalblockerInfo
- Publication number
- ATE277596T1 ATE277596T1 AT98907038T AT98907038T ATE277596T1 AT E277596 T1 ATE277596 T1 AT E277596T1 AT 98907038 T AT98907038 T AT 98907038T AT 98907038 T AT98907038 T AT 98907038T AT E277596 T1 ATE277596 T1 AT E277596T1
- Authority
- AT
- Austria
- Prior art keywords
- cholinergic
- act
- pharmaceutical composition
- composition containing
- calcium channel
- Prior art date
Links
- 229940127291 Calcium channel antagonist Drugs 0.000 title 1
- 239000000480 calcium channel blocker Substances 0.000 title 1
- 230000001713 cholinergic effect Effects 0.000 title 1
- 239000012049 topical pharmaceutical composition Substances 0.000 title 1
- 208000016583 Anus disease Diseases 0.000 abstract 3
- 206010002153 Anal fissure Diseases 0.000 abstract 2
- 208000009531 Fissure in Ano Diseases 0.000 abstract 2
- 208000014617 hemorrhoid Diseases 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 210000000436 anus Anatomy 0.000 abstract 1
- NZUPCNDJBJXXRF-UHFFFAOYSA-O bethanechol Chemical compound C[N+](C)(C)CC(C)OC(N)=O NZUPCNDJBJXXRF-UHFFFAOYSA-O 0.000 abstract 1
- 229960000910 bethanechol Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 abstract 1
- 229960001597 nifedipine Drugs 0.000 abstract 1
- 230000000284 resting effect Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9703750.1A GB9703750D0 (en) | 1997-02-24 | 1997-02-24 | Treatment of haemorrhoids |
| GBGB9727238.9A GB9727238D0 (en) | 1997-12-23 | 1997-12-23 | Pharmaceutical composition |
| PCT/GB1998/000575 WO1998036733A2 (en) | 1997-02-24 | 1998-02-23 | Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker |
| US10/214,333 US20040028752A1 (en) | 1997-02-24 | 2002-08-08 | Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277596T1 true ATE277596T1 (de) | 2004-10-15 |
Family
ID=32475044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98907038T ATE277596T1 (de) | 1997-02-24 | 1998-02-23 | Topische pharmazeutische zusammensetzung, enthaltend einen cholinergischen wirkstoff oder einen kalziumkanalblocker |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20040028752A1 (de) |
| EP (3) | EP0969813B1 (de) |
| JP (3) | JP3352095B2 (de) |
| CN (3) | CN1127333C (de) |
| AT (1) | ATE277596T1 (de) |
| AU (1) | AU733047C (de) |
| CA (1) | CA2281755C (de) |
| DE (1) | DE69826644T2 (de) |
| DK (1) | DK0969813T3 (de) |
| ES (1) | ES2224362T3 (de) |
| IL (2) | IL131477A0 (de) |
| PT (1) | PT969813E (de) |
| WO (1) | WO1998036733A2 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE374607T1 (de) | 1994-05-27 | 2007-10-15 | Strakan Int Ltd | Zusammensetzung enthaltend stickstoffoxid- donatoren und methode zur behandlung analer krankheiten |
| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US8119109B2 (en) * | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
| NZ540166A (en) | 2002-10-25 | 2007-06-29 | Foamix Ltd | Cosmetic and pharmaceutical foam |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US20060018937A1 (en) * | 2002-10-25 | 2006-01-26 | Foamix Ltd. | Steroid kit and foamable composition and uses thereof |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US20080317679A1 (en) * | 2002-10-25 | 2008-12-25 | Foamix Ltd. | Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses |
| US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
| US7704518B2 (en) * | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US20060233721A1 (en) * | 2002-10-25 | 2006-10-19 | Foamix Ltd. | Foam containing unique oil globules |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
| US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| US8795693B2 (en) * | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| US20080152596A1 (en) * | 2005-07-19 | 2008-06-26 | Foamix Ltd. | Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof |
| CN100364540C (zh) * | 2006-03-14 | 2008-01-30 | 北京大学 | (2s-顺)-(+)-2,3-二氢-3-羟基-2-(4-甲氧苯基)-1,5-苯并硫氮杂䓬-4(5h)-酮在制备治疗肝炎的药物中的用途 |
| DE102006038292A1 (de) * | 2006-08-16 | 2008-02-21 | Bayer Healthcare Ag | Transdermale Anwendung von Triazinen zur Bekämpfung von Coccidien-Infektionen |
| JP2010502598A (ja) * | 2006-09-01 | 2010-01-28 | モーベルイ・デルマ・アーベー | ジヒドロピリジンカルシウム拮抗剤を含む局部用組成物 |
| US20080260655A1 (en) * | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| US20080206155A1 (en) * | 2006-11-14 | 2008-08-28 | Foamix Ltd. | Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses |
| DK2094079T3 (da) * | 2006-11-24 | 2013-01-02 | Novartis Ag | Sammensætning til fordrivelse og afskrækkelse af utøj |
| US20080292560A1 (en) * | 2007-01-12 | 2008-11-27 | Dov Tamarkin | Silicone in glycol pharmaceutical and cosmetic compositions with accommodating agent |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
| US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
| WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
| WO2009090558A2 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| WO2010125470A2 (en) | 2009-04-28 | 2010-11-04 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
| WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| CA2776471C (en) | 2009-10-02 | 2019-02-12 | Foamix Ltd. | Surfactant-free, water-free, foamable compositions and breakable foams and their uses |
| MX2012005456A (es) * | 2009-11-12 | 2012-06-19 | Acacia Pharma Ltd | Uso de betanecol para el tratamiento de xerostomia. |
| GB201107533D0 (en) * | 2011-05-06 | 2011-06-22 | Acacia Pharma Ltd | Formulaiton |
| AU2013261037A1 (en) * | 2012-05-17 | 2014-12-04 | Contract Pharmaceuticals Limited | Non-ionic vesicle formulations of calcium channel blockers |
| US20140235570A1 (en) * | 2013-02-19 | 2014-08-21 | David Jonathan Hochman | Therapeutic composition for the treatment of perianal disorders |
| RU2592366C2 (ru) * | 2013-07-22 | 2016-07-20 | Общество с ограниченной ответственностью "ХИЛИНГ ФАРМ" | Фармакологическая композиция для лечения проктологических заболеваний (варианты) |
| US9700549B2 (en) | 2013-10-03 | 2017-07-11 | David Wise | Compositions and methods for treating pelvic pain and other conditions |
| MX377365B (es) | 2016-09-08 | 2025-03-10 | Journey Medical Corp | Composiciones y métodos para tratar rosácea y acné. |
| TR201710576A2 (tr) * | 2017-07-19 | 2019-02-21 | Dokuz Eyluel Ueniversitesi Rektoerluegue | Mi̇kroparti̇küler si̇stem i̇çeren anal fi̇ssür tedavi̇si̇ i̇çi̇n bi̇r tampon |
| BR102018008324A2 (pt) * | 2018-04-25 | 2019-11-05 | Laboratorios Ferring Ltda | composição farmacêutica de uso tópico e processo de fabricação de composição farmacêutica de uso tópico |
| CN112423736A (zh) * | 2018-06-01 | 2021-02-26 | 塔凡塔医疗匈牙利公司 | 用于治疗肛门直肠疾病的局部氨氯地平盐 |
| RU2710742C1 (ru) * | 2019-05-14 | 2020-01-10 | Александра Александровна Савосина | Композиция для лечения анальных трещин на основе фелодипина |
| RU2733080C1 (ru) | 2019-12-13 | 2020-09-29 | Александр Евгеньевич Баранников | Фармакологическая композиция для лечения проктологических заболеваний (варианты). |
| CN115337258B (zh) | 2022-07-22 | 2024-10-15 | 上海奥全生物医药科技有限公司 | 一种盐酸地尔硫卓的药物组合物、制备方法及其应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2074627A1 (en) * | 1970-01-13 | 1971-10-08 | Socres | Ppsoriasis treatment compsn |
| JPS6016917A (ja) * | 1983-07-08 | 1985-01-28 | Yamanouchi Pharmaceut Co Ltd | 塩酸ニカルジピンまたはニフエジピンの軟膏剤 |
| JPS60109519A (ja) * | 1983-11-17 | 1985-06-15 | Nippon Shinyaku Co Ltd | ニフェジピン坐剤 |
| US4931279A (en) | 1985-08-16 | 1990-06-05 | Bausch & Lomb Incorporated | Sustained release formulation containing an ion-exchange resin |
| JPS63170316A (ja) | 1986-12-30 | 1988-07-14 | Fujimoto Seiyaku Kk | ニフエジピン経皮吸収外用製剤 |
| JPS63174924A (ja) * | 1987-01-14 | 1988-07-19 | Toko Yakuhin Kogyo Kk | 軟膏基剤および軟膏剤 |
| IT1222395B (it) * | 1987-07-30 | 1990-09-05 | Pierrel Spa | Composizione farmaceutica per somministrazione intranasale comprendente l'ormone ghrh,un agonista colinergico e/o un sale biliare |
| US5084281A (en) * | 1989-02-14 | 1992-01-28 | Dillon Richard S | Method and solution for treating tissue wounds |
| BE1003002A6 (fr) | 1989-03-21 | 1991-10-22 | Coppe Jan | Composition a mettre en oeuvre pour le traitement de la calvitie, et procedes faisant usage de celle-ci. |
| US5162315A (en) * | 1989-05-08 | 1992-11-10 | Rajadhyaksha Vithal J | Penetration enhancers |
| IL92952A (en) | 1990-01-03 | 1994-06-24 | Teva Pharma | R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them |
| US5534520A (en) | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| DE69109297T2 (de) * | 1990-08-13 | 1995-11-09 | David W. Byfield Mass. Yesair | Gemischte lipid-bicarbonat-kolloidale partikel zur abgabe von arzneien und kalorien. |
| US5332576A (en) * | 1991-02-27 | 1994-07-26 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5288505A (en) * | 1991-06-26 | 1994-02-22 | Galephar P.R., Inc., Ltd. | Extended release form of diltiazem |
| SE9102340D0 (sv) * | 1991-08-13 | 1991-08-13 | Astra Ab | Pharmaceutical composition containing carbachol and othercholinergic substances |
| WO1995006466A1 (en) * | 1993-09-01 | 1995-03-09 | Koren Laboratories Pty. Limited | Treatment of anorectal disorders |
| JPH07145061A (ja) | 1993-11-25 | 1995-06-06 | Sekisui Chem Co Ltd | 経皮吸収製剤 |
| US5504117A (en) | 1994-05-27 | 1996-04-02 | Neptune Pharmaceutical Corporation | Pharmacologic preparation for the treatment of anal disorders |
| ATE374607T1 (de) | 1994-05-27 | 2007-10-15 | Strakan Int Ltd | Zusammensetzung enthaltend stickstoffoxid- donatoren und methode zur behandlung analer krankheiten |
| US5654337A (en) * | 1995-03-24 | 1997-08-05 | II William Scott Snyder | Topical formulation for local delivery of a pharmaceutically active agent |
| IT1297886B1 (it) | 1997-02-28 | 1999-12-20 | Carmine Antropoli | Nifedipina per uso topico |
-
1998
- 1998-02-23 WO PCT/GB1998/000575 patent/WO1998036733A2/en active Application Filing
- 1998-02-23 AU AU63024/98A patent/AU733047C/en not_active Expired
- 1998-02-23 EP EP98907038A patent/EP0969813B1/de not_active Revoked
- 1998-02-23 PT PT98907038T patent/PT969813E/pt unknown
- 1998-02-23 ES ES98907038T patent/ES2224362T3/es not_active Expired - Lifetime
- 1998-02-23 DK DK98907038T patent/DK0969813T3/da active
- 1998-02-23 AT AT98907038T patent/ATE277596T1/de active
- 1998-02-23 CN CN98802787A patent/CN1127333C/zh not_active Expired - Fee Related
- 1998-02-23 CN CNB031409091A patent/CN100379423C/zh not_active Expired - Lifetime
- 1998-02-23 CA CA002281755A patent/CA2281755C/en not_active Expired - Lifetime
- 1998-02-23 IL IL13147798A patent/IL131477A0/xx unknown
- 1998-02-23 DE DE69826644T patent/DE69826644T2/de not_active Revoked
- 1998-02-23 EP EP20020015320 patent/EP1249238A3/de not_active Withdrawn
- 1998-02-23 JP JP53641998A patent/JP3352095B2/ja not_active Expired - Lifetime
- 1998-02-23 EP EP02015319A patent/EP1250927A3/de not_active Ceased
- 1998-02-23 CN CNA031411657A patent/CN1480139A/zh active Pending
-
2002
- 2002-05-31 JP JP2002159559A patent/JP2002356422A/ja active Pending
- 2002-05-31 JP JP2002159560A patent/JP2002356425A/ja active Pending
- 2002-08-08 US US10/214,333 patent/US20040028752A1/en not_active Abandoned
-
2006
- 2006-09-17 IL IL178133A patent/IL178133A0/en unknown
-
2011
- 2011-07-08 US US13/178,567 patent/US8318721B2/en not_active Expired - Fee Related
-
2012
- 2012-11-26 US US13/685,023 patent/US8906903B2/en not_active Expired - Fee Related
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