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ATE236131T1 - Optisch aktives 2-nitroimidazolderivat, verfahren zu seiner herstellung und ein intermediat zu seiner herstellung - Google Patents

Optisch aktives 2-nitroimidazolderivat, verfahren zu seiner herstellung und ein intermediat zu seiner herstellung

Info

Publication number
ATE236131T1
ATE236131T1 AT93923039T AT93923039T ATE236131T1 AT E236131 T1 ATE236131 T1 AT E236131T1 AT 93923039 T AT93923039 T AT 93923039T AT 93923039 T AT93923039 T AT 93923039T AT E236131 T1 ATE236131 T1 AT E236131T1
Authority
AT
Austria
Prior art keywords
production
optically active
nitroimidazole derivative
nitroimidazole
derivative
Prior art date
Application number
AT93923039T
Other languages
English (en)
Inventor
Toshimitsu Suzuki
Totsuka-Ku
Azuma Pola Nishio
Original Assignee
Pola Chem Ind Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chem Ind Inc filed Critical Pola Chem Ind Inc
Application granted granted Critical
Publication of ATE236131T1 publication Critical patent/ATE236131T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT93923039T 1992-12-18 1993-10-21 Optisch aktives 2-nitroimidazolderivat, verfahren zu seiner herstellung und ein intermediat zu seiner herstellung ATE236131T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP33903592 1992-12-18
JP1653093 1993-02-03
PCT/JP1993/001519 WO1994014778A1 (en) 1992-12-18 1993-10-21 Optically active 2-nitroimidazole derivative, process for producing the same, and intermediate for producing the same

Publications (1)

Publication Number Publication Date
ATE236131T1 true ATE236131T1 (de) 2003-04-15

Family

ID=26352886

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93923039T ATE236131T1 (de) 1992-12-18 1993-10-21 Optisch aktives 2-nitroimidazolderivat, verfahren zu seiner herstellung und ein intermediat zu seiner herstellung

Country Status (9)

Country Link
US (1) US5532380A (de)
EP (1) EP0632028B1 (de)
JP (2) JP3577079B2 (de)
AT (1) ATE236131T1 (de)
DE (1) DE69332821T2 (de)
DK (1) DK0632028T3 (de)
ES (1) ES2199221T3 (de)
PT (1) PT632028E (de)
WO (1) WO1994014778A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1838305A1 (de) * 2005-01-21 2007-10-03 Richard H. Matthews Radiosensitizer-formulierungen mit nitrohistidinderivaten
JP5297815B2 (ja) * 2007-01-26 2013-09-25 株式会社ポーラファルマ 医薬組成物
CN101541324B (zh) 2007-06-14 2011-06-15 株式会社宝丽制药 医药组合物
CN101642452B (zh) * 2008-08-06 2014-05-28 株式会社宝丽制药 脑肿瘤用放射线敏化剂
CN101805323B (zh) * 2010-03-23 2012-09-26 深圳万乐药业有限公司 一种合成Doranidazole中间体的非对映异构体的方法
JP6071715B2 (ja) * 2013-03-22 2017-02-01 株式会社ポーラファルマ ドラニダゾール構成光学異性体の製造方法
CN111182897A (zh) 2017-10-02 2020-05-19 学校法人庆应义塾 癌干细胞抑制剂

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2314454A (en) * 1938-08-19 1943-03-23 Gen Aniline & Film Corp Production of esters of halogen alcohols
US2377878A (en) * 1941-12-24 1945-06-12 Du Pont Dioxolane-acid halide reaction and product
US2901506A (en) * 1956-12-06 1959-08-25 American Cyanamid Co Pyrolysis of substituted carbonyloxyalkyl halides
NL292912A (de) * 1962-05-18
US3468902A (en) * 1966-06-10 1969-09-23 Hoffmann La Roche 1-substituted-2-nitroimidazole derivatives
CH526506A (de) * 1970-05-27 1972-08-15 Sandoz Ag Verfahren zur Herstellung von 2,2-Bis-(brommethyl)-propandiol-1,3-diacetat
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
JPS58170725A (ja) * 1982-03-31 1983-10-07 Ono Pharmaceut Co Ltd グリセリン誘導体
JPS59139363A (ja) * 1983-01-31 1984-08-10 Kayaku:Kk ２−ニトロイミダゾ−ル誘導体およびその製造法
JPS62283943A (ja) * 1986-05-30 1987-12-09 Taisho Pharmaceut Co Ltd スレイト−ル化合物およびその製造方法
JPS6330491A (ja) * 1986-07-22 1988-02-09 Sankyo Co Ltd 環状ウレタン構造を有する燐酸エステル誘導体
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
JP2626727B2 (ja) * 1990-01-26 1997-07-02 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤
JP2683613B2 (ja) * 1990-01-30 1997-12-03 出光石油化学株式会社 スチレン系樹脂から成る射出成形品

Also Published As

Publication number Publication date
DE69332821D1 (de) 2003-05-08
WO1994014778A1 (en) 1994-07-07
EP0632028B1 (de) 2003-04-02
ES2199221T3 (es) 2004-02-16
US5532380A (en) 1996-07-02
DE69332821T2 (de) 2003-11-13
EP0632028A1 (de) 1995-01-04
JP3577079B2 (ja) 2004-10-13
DK0632028T3 (da) 2003-07-21
PT632028E (pt) 2003-08-29
JP2003321459A (ja) 2003-11-11
EP0632028A4 (de) 1995-03-29

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