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ATE228505T1 - Chinolinderivate - Google Patents

Chinolinderivate

Info

Publication number
ATE228505T1
ATE228505T1 AT99947036T AT99947036T ATE228505T1 AT E228505 T1 ATE228505 T1 AT E228505T1 AT 99947036 T AT99947036 T AT 99947036T AT 99947036 T AT99947036 T AT 99947036T AT E228505 T1 ATE228505 T1 AT E228505T1
Authority
AT
Austria
Prior art keywords
quinoline derivatives
quinoline
derivatives
Prior art date
Application number
AT99947036T
Other languages
English (en)
Inventor
Anders Bjoerk
Stig Joensson
Tomas Fex
Gunnar Hedlund
Original Assignee
Active Biotech Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Active Biotech Ab filed Critical Active Biotech Ab
Application granted granted Critical
Publication of ATE228505T1 publication Critical patent/ATE228505T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT99947036T 1998-04-27 1999-04-26 Chinolinderivate ATE228505T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9801474A SE9801474D0 (sv) 1998-04-27 1998-04-27 Quinoline Derivatives
PCT/SE1999/000676 WO1999055678A1 (en) 1998-04-27 1999-04-26 Quinoline derivatives

Publications (1)

Publication Number Publication Date
ATE228505T1 true ATE228505T1 (de) 2002-12-15

Family

ID=20411103

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99947036T ATE228505T1 (de) 1998-04-27 1999-04-26 Chinolinderivate

Country Status (33)

Country Link
EP (1) EP1073639B1 (de)
JP (1) JP4045069B2 (de)
KR (1) KR100571534B1 (de)
CN (1) CN1113057C (de)
AP (1) AP1293A (de)
AT (1) ATE228505T1 (de)
AU (1) AU747550B2 (de)
BR (1) BR9909925B1 (de)
CA (1) CA2329788C (de)
CZ (1) CZ297439B6 (de)
DE (1) DE69904162T2 (de)
DK (1) DK1073639T3 (de)
EE (1) EE04275B1 (de)
ES (1) ES2188242T3 (de)
HK (1) HK1036618A1 (de)
HR (1) HRP20000726B1 (de)
HU (1) HU227709B1 (de)
ID (1) ID26277A (de)
IL (2) IL138160A0 (de)
IS (1) IS2082B (de)
ME (1) ME00870B (de)
NO (1) NO315606B1 (de)
NZ (1) NZ506641A (de)
OA (1) OA11547A (de)
PL (1) PL190441B1 (de)
PT (1) PT1073639E (de)
RS (1) RS50029B (de)
RU (1) RU2197481C2 (de)
SE (1) SE9801474D0 (de)
TR (1) TR200003061T2 (de)
UA (1) UA60354C2 (de)
WO (1) WO1999055678A1 (de)
ZA (1) ZA200004601B (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0002320D0 (sv) * 1999-10-25 2000-06-21 Active Biotech Ab Malignant tumors
SE0201778D0 (sv) * 2002-06-12 2002-06-12 Active Biotech Ab Process for the manufacture of quinoline derivatives
KR100908655B1 (ko) 2002-11-27 2009-07-21 엘지디스플레이 주식회사 데이터 공급시간의 변조방법과 이를 이용한액정표시장치의 구동방법 및 장치
SE0400235D0 (sv) * 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
SE0401578D0 (sv) * 2004-06-18 2004-06-18 Active Biotech Ab Novel compounds
US7838522B2 (en) 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof
BRPI0516383A (pt) 2004-12-21 2008-09-02 Serono Lab derivados cìclicos de sulfonil amino e o uso dos mesmos
KR20070105326A (ko) 2005-01-31 2007-10-30 라보라뚜와르 세로노 에스. 에이. Ｎ-하이드록시아미드 유도체 및 그것의 용도
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
EA013816B1 (ru) 2005-09-01 2010-08-30 Арес Трейдинг С.А. Лечение неврита зрительного нерва
RS53666B1 (en) * 2005-10-19 2015-04-30 Teva Pharmaceutical Industries Ltd CRYSTALS OF SODIUM LAKVINIMOD AND THE PROCESS FOR OBTAINING THEM
ZA200810790B (en) * 2006-06-12 2010-03-31 Teva Pharma Stable laquinimod preparations
EP2682120B1 (de) 2007-12-20 2016-08-03 Teva Pharmaceutical Industries, Ltd. Stabile Laquinimod-Präparate
ES2633658T3 (es) 2008-09-03 2017-09-22 Teva Pharmaceutical Industries Ltd. Moduladores 2-oxo-1,2-dihidro-quinolina de la función inmunitaria
EP2458992B1 (de) * 2009-07-30 2015-12-16 Teva Pharmaceutical Industries Ltd. Behandlung von morbus crohn mit laquinimod
PL2467372T3 (pl) * 2009-08-10 2017-04-28 Teva Pharmaceutical Industries Ltd. Leczenie zaburzeń związanych z BDNF z zastosowaniem lakwinimodu
PH12012501740A1 (en) 2010-03-03 2012-11-12 Teva Pharma Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
JP2013521305A (ja) * 2010-03-03 2013-06-10 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドを用いるループス関節炎の治療
US8889661B2 (en) * 2010-03-03 2014-11-18 Teva Pharmaceutical Industries, Ltd. Treatment of lupus nephritis using laquinimod
WO2011116091A1 (en) 2010-03-17 2011-09-22 Novartis Ag Dispenser
MX2013000332A (es) * 2010-07-09 2013-02-26 Teva Pharma 5-cloro-4-hidroxi-1-metil-2-oxo-n-fenil-1,2-dihidroquinolina-3-ca rboxamida, sales y usos de la misma.
CA2802006C (en) 2010-07-09 2018-09-25 Active Biotech Ab Method for manufacturing of quinoline-3-carboxamides
EP2597954A4 (de) 2010-07-09 2014-01-01 Teva Pharma Deuterierte n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chlor-1-methyl-2-oxochinolin-3-carboxamid, salze davon und anwendungen dafür
EP2444086A1 (de) 2010-10-22 2012-04-25 Almirall, S.A. Kombinationen mit DHODH-Inhibitoren und COX-Inhibitoren
EP2766020A4 (de) 2011-10-12 2015-04-01 Teva Pharma Behandlung von multipler sklerose mit einer kombination aus laquinimod und fingolimod
EP2811832A4 (de) 2012-02-03 2015-09-23 Teva Pharma Verwendung von laquinimod zur behandlung von patienten mit morbus crohn nach einer fehlgeschlagenen vorhergehenden anti-tnf-therapie
CA2863409A1 (en) 2012-02-16 2013-08-22 Teva Pharmaceutical Industries Ltd. N-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide, preparation and uses thereof
TW201350467A (zh) 2012-05-08 2013-12-16 Teva Pharma Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
BR112015010193A2 (pt) 2012-11-07 2017-07-11 Teva Pharma sais de amina de laquinimod
RU2545056C2 (ru) * 2012-12-10 2015-03-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здавоохранения и социального развития Российской Федерации (ГБОУ ВПО ПГФА Минздравсоцразвития России) Противовоспалительное и анальгетическое средство на основе изопропиламида 1,2-дигидро-1н-2-оксоцинхониновой кислоты
MX2015010296A (es) * 2013-02-15 2016-05-05 Teva Pharma Tratamiento de formas progresivas de esclerosis multiple con laquinimod.
KR20150143499A (ko) 2013-03-14 2015-12-23 테바 파마슈티컬 인더스트리즈 리미티드 라퀴니모드 나트륨의 결정 및 이의 개선된 제조방법
UY36099A (es) 2014-04-29 2016-02-29 Teva Pharma Laquinimod para el tratamiento de pacientes con esclerosis múltiple remitente recurrente (rrms) con un alto grado de discapacidad
MX366837B (es) 2014-09-23 2019-07-26 Active Biotech Ab Quinolinas carboxamidas para usarse en el tratamiento de mielomas multiples.
WO2016078921A1 (en) 2014-11-19 2016-05-26 Active Biotech Ab Quinoline carboxamides for use in the treatment of leukemia
CN114845718A (zh) 2019-12-19 2022-08-02 活跃生物技术有限公司 用于治疗与过度血管形成相关的眼部疾病的化合物
KR20220149579A (ko) 2020-03-03 2022-11-08 액티브 바이오테크 에이비 조합 요법에 사용하기 위한 타스퀴니모드 또는 이의 약학적으로 허용가능한 염
EP4153576A4 (de) * 2020-05-21 2024-06-19 StemSynergy Therapeutics, Inc. Notch-inhibitoren und verwendungen davon
CA3185531A1 (en) 2020-07-23 2022-01-27 Rebekka Katharina Marita SCHNEIDER-KRAMANN S100 proteins as novel therapeutic targets in myeloproliferative neoplasms
US20240091215A1 (en) 2021-01-18 2024-03-21 Active Biotech Ab Tasquinimod or a pharmaceutically acceptable salt thereof for use in the treatment of myelodysplastic syndrome
JP2024520307A (ja) 2021-05-25 2024-05-24 アクティブ バイオテック エイビー 複数のタスキニモド粒子およびその使用
CA3221689A1 (en) 2021-07-02 2023-01-05 Hans Wannman A pharmaceutical product containing tasquinimod and a method for assessing the purity of said product

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
GB9108547D0 (en) * 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives

Also Published As

Publication number Publication date
AP2000001933A0 (en) 2000-12-31
DE69904162D1 (de) 2003-01-09
RU2197481C2 (ru) 2003-01-27
IS2082B (is) 2006-02-15
KR100571534B1 (ko) 2006-04-14
ID26277A (id) 2000-12-14
ME00870B (me) 2008-11-28
HRP20000726A2 (en) 2001-04-30
RS50029B (sr) 2008-11-28
NZ506641A (en) 2002-03-28
YU61200A (sh) 2003-07-07
PL190441B1 (pl) 2005-12-30
ZA200004601B (en) 2002-02-27
NO20005254D0 (no) 2000-10-19
WO1999055678A1 (en) 1999-11-04
CN1113057C (zh) 2003-07-02
HUP0102084A2 (hu) 2001-11-28
CA2329788C (en) 2004-11-23
PT1073639E (pt) 2003-04-30
BR9909925A (pt) 2001-01-09
EP1073639B1 (de) 2002-11-27
HRP20000726B1 (en) 2009-04-30
AU747550B2 (en) 2002-05-16
HK1036618A1 (en) 2002-01-11
PL343420A1 (en) 2001-08-13
HU227709B1 (en) 2011-12-28
AP1293A (en) 2004-08-30
EE200000613A (et) 2002-04-15
DK1073639T3 (da) 2003-03-24
HUP0102084A3 (en) 2002-12-28
CZ20003849A3 (cs) 2001-03-14
NO315606B1 (no) 2003-09-29
OA11547A (en) 2004-05-24
UA60354C2 (uk) 2003-10-15
IL138160A (en) 2006-04-10
SE9801474D0 (sv) 1998-04-27
JP4045069B2 (ja) 2008-02-13
CZ297439B6 (cs) 2006-12-13
TR200003061T2 (tr) 2001-01-22
NO20005254L (no) 2000-12-27
CN1298393A (zh) 2001-06-06
IL138160A0 (en) 2001-10-31
IS5615A (is) 2000-08-31
CA2329788A1 (en) 1999-11-04
DE69904162T2 (de) 2003-08-21
EP1073639A1 (de) 2001-02-07
ES2188242T3 (es) 2003-06-16
AU4301399A (en) 1999-11-16
BR9909925B1 (pt) 2010-09-21
EE04275B1 (et) 2004-04-15
JP2002513006A (ja) 2002-05-08

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