ATE217871T1 - 5,6-dihydropyron derivate als protease inhibitoren und antivirusmitteln - Google Patents
5,6-dihydropyron derivate als protease inhibitoren und antivirusmittelnInfo
- Publication number
- ATE217871T1 ATE217871T1 AT94932030T AT94932030T ATE217871T1 AT E217871 T1 ATE217871 T1 AT E217871T1 AT 94932030 T AT94932030 T AT 94932030T AT 94932030 T AT94932030 T AT 94932030T AT E217871 T1 ATE217871 T1 AT E217871T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- dihydropyron
- protease inhibitors
- antivirus agents
- present
- Prior art date
Links
- QBDAFARLDLCWAT-UHFFFAOYSA-N 2,3-dihydropyran-6-one Chemical class O=C1OCCC=C1 QBDAFARLDLCWAT-UHFFFAOYSA-N 0.000 title abstract 4
- 239000003443 antiviral agent Substances 0.000 title 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 102000004580 Aspartic Acid Proteases Human genes 0.000 abstract 1
- 108010017640 Aspartic Acid Proteases Proteins 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
- C07C321/26—Thiols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15544393A | 1993-11-19 | 1993-11-19 | |
| US08/319,821 US5789440A (en) | 1993-11-19 | 1994-10-12 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
| PCT/US1994/012234 WO1995014011A2 (en) | 1993-11-19 | 1994-10-26 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE217871T1 true ATE217871T1 (de) | 2002-06-15 |
Family
ID=26852339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94932030T ATE217871T1 (de) | 1993-11-19 | 1994-10-26 | 5,6-dihydropyron derivate als protease inhibitoren und antivirusmitteln |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5936128A (de) |
| EP (1) | EP0729463B1 (de) |
| JP (1) | JP3698435B2 (de) |
| AT (1) | ATE217871T1 (de) |
| AU (1) | AU680064B2 (de) |
| BG (1) | BG63012B1 (de) |
| CA (1) | CA2176041A1 (de) |
| CZ (1) | CZ291856B6 (de) |
| DE (1) | DE69430671T2 (de) |
| DK (1) | DK0729463T3 (de) |
| EE (1) | EE9600045A (de) |
| ES (1) | ES2176263T3 (de) |
| FI (1) | FI962021L (de) |
| HR (1) | HRP940936B1 (de) |
| HU (1) | HUT75225A (de) |
| IL (1) | IL111673A (de) |
| MD (2) | MD1560F2 (de) |
| NO (1) | NO315117B1 (de) |
| NZ (1) | NZ275318A (de) |
| PL (1) | PL180634B1 (de) |
| PT (1) | PT729463E (de) |
| RO (1) | RO117850B1 (de) |
| RU (1) | RU2160733C2 (de) |
| SI (1) | SI0729463T1 (de) |
| SK (1) | SK283240B6 (de) |
| TJ (1) | TJ320B (de) |
| WO (1) | WO1995014011A2 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002515730A (ja) * | 1995-10-16 | 2002-05-28 | カイロン コーポレイション | 遺伝子発現を変調する因子のスクリーニング方法 |
| ES2246498T3 (es) | 1995-11-13 | 2006-02-16 | Vitaleech Bioscience N.V. | Aislados antivirales obtenidos de sanguijuelas. |
| US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
| US6087455A (en) * | 1997-12-19 | 2000-07-11 | Shell Oil Company | Process for hydrogenation of macromolecular organic substrates |
| WO2000015634A2 (en) | 1998-09-11 | 2000-03-23 | Warner-Lambert Company | Hiv protease inhibitors |
| DE10030094A1 (de) | 2000-06-19 | 2001-12-20 | Bayer Ag | Phenylsubstituierte 5,6-Dihydro-pyron-Derivate |
| DE10100175A1 (de) * | 2001-01-04 | 2002-07-11 | Bayer Ag | Hetarylsubstituierte Homotetram-und Homotetronsäuren |
| DOP2003000641A (es) | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
| US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| MX2007001527A (es) | 2004-08-18 | 2007-03-27 | Pfizer | Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan. |
| US9012471B2 (en) * | 2008-04-11 | 2015-04-21 | The Trustees Of Columbia University In The City Of New York | Glucose metabolism modulating compounds |
| WO2015070226A1 (en) | 2013-11-11 | 2015-05-14 | Kuality Herbceutics Llc | Kava derived therapeutic compounds and methods of use thereof |
| CN108026084A (zh) * | 2015-05-07 | 2018-05-11 | 夸利蒂赫布丘蒂克斯公司 | 治疗化合物及其使用方法 |
| ES2844184T3 (es) * | 2016-06-14 | 2021-07-21 | Bristol Myers Squibb Co | 4-hidroxi-3-sulfonilpiridin-2(1H)-onas como agonistas del receptor de APJ |
| SG11201903348UA (en) | 2016-10-17 | 2019-05-30 | Genentech Inc | Therapeutic compounds and methods of use thereof |
| GB201707856D0 (en) | 2017-05-16 | 2017-06-28 | Arctic Pharma As | Compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3206276A (en) * | 1961-09-28 | 1965-09-14 | Minerals Engineering Company | Process for recovery of pure v2o5 from vanadium bearing materials |
| US3206476A (en) * | 1962-06-04 | 1965-09-14 | Sterling Drug Inc | 3-substituted-4-hydroxy-6-aryl-2-pyrones and preparation |
| US3818046A (en) * | 1972-12-18 | 1974-06-18 | Dow Chemical Co | Sulfur-containing hydroxy pyrones and alkali metal salts thereof |
| US3931235A (en) * | 1972-12-18 | 1976-01-06 | The Dow Chemical Company | Process for preparing sulfur-containing hydroxy pyrones |
| MA21177A1 (fr) * | 1987-02-11 | 1988-10-01 | May & Baker Ltd | Diones cycliques. |
| EP0403535A1 (de) * | 1988-03-01 | 1990-12-27 | The Upjohn Company | Kumarine zur inhibierung von reverser transcriptase beim menschen |
| JPH03227923A (ja) * | 1990-01-30 | 1991-10-08 | Sawai Seiyaku Kk | ひと免疫不全ウイルス疾患処置剤 |
| JPH07501194A (ja) * | 1991-11-18 | 1995-02-02 | モトローラ・インコーポレイテッド | ユーザ選択可能な防騒音携帯マイクロホン |
| ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
| IL108459A0 (en) * | 1993-02-05 | 1994-04-12 | Opjohn Company | 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses |
-
1994
- 1994-10-26 CZ CZ19961368A patent/CZ291856B6/cs not_active IP Right Cessation
- 1994-10-26 RO RO96-01015A patent/RO117850B1/ro unknown
- 1994-10-26 SI SI9430417T patent/SI0729463T1/xx unknown
- 1994-10-26 EE EE9600045A patent/EE9600045A/xx unknown
- 1994-10-26 AT AT94932030T patent/ATE217871T1/de not_active IP Right Cessation
- 1994-10-26 TJ TJ96000290A patent/TJ320B/xx unknown
- 1994-10-26 HU HU9601349A patent/HUT75225A/hu not_active Application Discontinuation
- 1994-10-26 NZ NZ275318A patent/NZ275318A/xx unknown
- 1994-10-26 RU RU96113141/04A patent/RU2160733C2/ru not_active IP Right Cessation
- 1994-10-26 JP JP51445495A patent/JP3698435B2/ja not_active Expired - Fee Related
- 1994-10-26 AU AU80900/94A patent/AU680064B2/en not_active Ceased
- 1994-10-26 EP EP94932030A patent/EP0729463B1/de not_active Expired - Lifetime
- 1994-10-26 DK DK94932030T patent/DK0729463T3/da active
- 1994-10-26 WO PCT/US1994/012234 patent/WO1995014011A2/en active IP Right Grant
- 1994-10-26 PT PT94932030T patent/PT729463E/pt unknown
- 1994-10-26 MD MD96-0172D patent/MD1560F2/xx not_active IP Right Cessation
- 1994-10-26 SK SK646-96A patent/SK283240B6/sk unknown
- 1994-10-26 CA CA002176041A patent/CA2176041A1/en not_active Abandoned
- 1994-10-26 ES ES94932030T patent/ES2176263T3/es not_active Expired - Lifetime
- 1994-10-26 MD MD96-0172A patent/MD1560G2/ro not_active IP Right Cessation
- 1994-10-26 DE DE69430671T patent/DE69430671T2/de not_active Expired - Fee Related
- 1994-10-26 PL PL94314483A patent/PL180634B1/pl not_active IP Right Cessation
- 1994-11-17 IL IL11167394A patent/IL111673A/xx not_active IP Right Cessation
- 1994-11-17 HR HR940936A patent/HRP940936B1/xx not_active IP Right Cessation
-
1996
- 1996-05-03 BG BG100563A patent/BG63012B1/bg unknown
- 1996-05-13 FI FI962021A patent/FI962021L/fi unknown
- 1996-05-15 NO NO19962018A patent/NO315117B1/no not_active IP Right Cessation
-
1998
- 1998-05-15 US US09/079,689 patent/US5936128A/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE263761T1 (de) | 5,6-dihydropyronderivate als proteaseinhibitoren und antiviralmittel | |
| DE69430671D1 (de) | 5,6-dihydropyron derivate als protease inhibitoren und antivirusmitteln | |
| ATE303993T1 (de) | 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe | |
| MY138860A (en) | Hiv protease inhibitors. | |
| MD960171A (ro) | Derivaţi ai pironei folosiţi ca inhibitori ai proteazei şi agenţi antivirali | |
| DE69518840D1 (en) | N-(3-amino-2-hydroxybutyl)sulfonamid-derivate as hiv-protease-inhibitoren | |
| WO2000015634A3 (en) | Hiv protease inhibitors | |
| ATE231502T1 (de) | Pyron derivate als protease inhibitoren und antivirusmitteln | |
| NO962015L (no) | Pyron-derivater som protease-inhibitorer og antivirus-midler |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0729463 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |