ATE217086T1 - Herstellung von photoprotein konjugaten und verfahren zu ihrer verwendung - Google Patents
Herstellung von photoprotein konjugaten und verfahren zu ihrer verwendungInfo
- Publication number
- ATE217086T1 ATE217086T1 AT94908734T AT94908734T ATE217086T1 AT E217086 T1 ATE217086 T1 AT E217086T1 AT 94908734 T AT94908734 T AT 94908734T AT 94908734 T AT94908734 T AT 94908734T AT E217086 T1 ATE217086 T1 AT E217086T1
- Authority
- AT
- Austria
- Prior art keywords
- conjugates
- present
- photoproteins
- photoprotein
- preparation
- Prior art date
Links
- 102000006830 Luminescent Proteins Human genes 0.000 title abstract 4
- 108010047357 Luminescent Proteins Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 108090001008 Avidin Proteins 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 102000004856 Lectins Human genes 0.000 abstract 1
- 108090001090 Lectins Proteins 0.000 abstract 1
- 108010090804 Streptavidin Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000010382 chemical cross-linking Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000002523 lectin Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1711693A | 1993-02-12 | 1993-02-12 | |
| PCT/US1994/001387 WO1994018342A1 (en) | 1993-02-12 | 1994-02-04 | Preparation of photoprotein conjugates and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE217086T1 true ATE217086T1 (de) | 2002-05-15 |
Family
ID=21780817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94908734T ATE217086T1 (de) | 1993-02-12 | 1994-02-04 | Herstellung von photoprotein konjugaten und verfahren zu ihrer verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5486455A (de) |
| EP (1) | EP0683822B1 (de) |
| JP (1) | JPH08506897A (de) |
| AT (1) | ATE217086T1 (de) |
| AU (1) | AU6171894A (de) |
| DE (1) | DE69430523T2 (de) |
| IL (1) | IL108607A (de) |
| MX (1) | MX9401112A (de) |
| WO (1) | WO1994018342A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4438660A1 (de) * | 1994-10-28 | 1996-05-02 | Boehringer Mannheim Gmbh | Biolumineszenzmarkierte Hapten-Konjugate für den Einsatz in kompetitiven Immunoassays |
| EP0736770A3 (de) * | 1995-04-05 | 1997-05-02 | Anda Biolog Sa | Immunoreaktives Konjugat, Verfahren zu seiner Herstellung, gegen dieses gerichtete Antikörper und sie enthaltende pharmazeutische Zusammensetzung und diagnostische Vorrichtung |
| DE19537952A1 (de) * | 1995-10-12 | 1997-04-17 | Boehringer Mannheim Gmbh | Verfahren zum Nachweis eines Analyten |
| US5876995A (en) * | 1996-02-06 | 1999-03-02 | Bryan; Bruce | Bioluminescent novelty items |
| US5942407A (en) * | 1996-06-25 | 1999-08-24 | Immunomatrix, Inc. | Light-emitting immunoassay |
| US6416960B1 (en) | 1996-08-08 | 2002-07-09 | Prolume, Ltd. | Detection and visualization of neoplastic tissues and other tissues |
| EP1015872B1 (de) | 1996-12-12 | 2005-03-02 | Prolume, Ltd. | Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen |
| DE19652576A1 (de) * | 1996-12-17 | 1998-06-25 | Boehringer Mannheim Gmbh | Niedermolekulare Photoprotein-Konjugate |
| US5876935A (en) * | 1997-01-08 | 1999-03-02 | Dade Behring Inc. | Luminescent specific binding assay |
| WO1998036081A2 (en) | 1997-02-13 | 1998-08-20 | Memorial Sloan-Kettering Cancer Center | Hybrid molecules for optically detecting changes in cellular microenvironments |
| CA2283094A1 (en) * | 1997-02-18 | 1998-08-20 | Oncor, Inc. | Detection of targets with green fluorescent protein and fluorescent variants thereof |
| DE19719465A1 (de) * | 1997-05-07 | 1998-11-12 | Boehringer Mannheim Gmbh | Konservierung von Aequorin-Reagenzien |
| EP1925320A3 (de) | 1998-03-27 | 2008-09-03 | Prolume, Ltd. | Luciferasen, fluoreszierende Proteine, Nukleinsäuren zur Kodierung der Luciferasen und der fluoreszierenden Proteine sowie deren Verwendung zur Diagnose, zum Screening mit hohem Durchsatz und zur Behandlung neuartiger Probleme |
| EP1064360B1 (de) | 1998-03-27 | 2008-03-05 | Prolume, Ltd. | Luciferase, gfp fluoreszenzproteine, kodierende nukleinsaüre und ihre verwendung in der diagnose |
| EP1194781B1 (de) * | 1999-06-18 | 2007-03-07 | Cardiogenics Inc. | Verfahren zur prozessführung chemilumineszenter bindungstests |
| US7109315B2 (en) * | 2000-03-15 | 2006-09-19 | Bruce J. Bryan | Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items |
| US7659078B1 (en) * | 2002-07-17 | 2010-02-09 | University Of Kentucky Research Foundation | Method and kit for determination of prostacyclin in plasma |
| US20080280310A1 (en) * | 2007-05-09 | 2008-11-13 | Louis Panagopoulos | Testing for Blood Group Immunological Reaction Without the Use of Anti-Human Globulin |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4604364A (en) * | 1974-01-04 | 1986-08-05 | Kosak Kenneth M | Bioluminescent tracer composition and method of use in immunoassays |
| GB1578275A (en) * | 1977-06-14 | 1980-11-05 | Maier C | Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids |
| US4396579A (en) * | 1981-08-06 | 1983-08-02 | Miles Laboratories, Inc. | Luminescence detection device |
| US4608246A (en) * | 1983-03-10 | 1986-08-26 | Immucor, Inc. | Testing for a blood group immunological reaction |
| ES8607563A1 (es) * | 1983-10-13 | 1986-06-01 | Univ Georgia Res Found | Un metodo para detectar una interaccion ligante |
| US4665022A (en) * | 1984-02-17 | 1987-05-12 | The Regents Of The University Of California | Bioluminescent assay reagent and method |
| US4927916A (en) * | 1984-04-23 | 1990-05-22 | The General Hospital Corporation | Method of producing fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity using fibrin-specific peptides |
| US4764368A (en) * | 1984-08-29 | 1988-08-16 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| US4657853A (en) * | 1984-09-14 | 1987-04-14 | E. I. Du Pont De Nemours And Company | Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody |
| US4935339A (en) * | 1985-05-07 | 1990-06-19 | Nichols Institute Diagnostics | Delayed solid phase immunologic assay |
| DE3537877A1 (de) * | 1985-10-24 | 1987-04-30 | Geiger Reinhard | Luciferin-derivate und immunoassays unter einsatz derartiger luciferin-derivate |
| GB8603537D0 (en) * | 1986-02-13 | 1986-03-19 | Parker D | Conjugate compound |
| US4916070A (en) * | 1986-04-14 | 1990-04-10 | The General Hospital Corporation | Fibrin-specific antibodies and method of screening for the antibodies |
| DE3714147A1 (de) * | 1987-04-28 | 1988-11-17 | Boehringer Mannheim Gmbh | Immunchemisches verfahren und reagenz zur bestimmung eines polyvalenten antigens in einer fluessigen probe |
| JPS6447379A (en) * | 1987-08-19 | 1989-02-21 | Chisso Corp | Preparation of calcium-dependent oxygenation enzyme |
| US4981979A (en) * | 1987-09-10 | 1991-01-01 | Neorx Corporation | Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity |
| US5094939A (en) * | 1988-07-19 | 1992-03-10 | Fujirebio, Inc. | Chemiluminescence assays using stabilized dioxetane derivatives |
| US4925648A (en) * | 1988-07-29 | 1990-05-15 | Immunomedics, Inc. | Detection and treatment of infectious and inflammatory lesions |
| US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
| US5019393A (en) * | 1988-08-03 | 1991-05-28 | New England Deaconess Hospital Corporation | Biocompatible substance with thromboresistance |
| US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| US5066789A (en) * | 1988-09-30 | 1991-11-19 | Neorx Corporation | Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages |
| JPH02253162A (ja) * | 1989-03-27 | 1990-10-11 | Chisso Corp | 特異的結合能を有する物質と結合したエクオリンを用いる検出法 |
| JPH04502469A (ja) * | 1988-12-22 | 1992-05-07 | ゾマ コーポレイション | ヒンダードカップリング剤および方法 |
| US5134071A (en) * | 1989-02-06 | 1992-07-28 | State University Of New York | Polymerization and copolymerization of proteins |
| JPH03153699A (ja) * | 1989-11-09 | 1991-07-01 | Chisso Corp | 化学結合法により担体に固定化されたエクオリン活性を示す蛋白質 |
| JPH03169897A (ja) * | 1989-11-29 | 1991-07-23 | Chisso Corp | 化学修飾エクオリンとその調製法 |
| US5116944A (en) * | 1989-12-29 | 1992-05-26 | Neorx Corporation | Conjugates having improved characteristics for in vivo administration |
-
1994
- 1994-02-04 DE DE69430523T patent/DE69430523T2/de not_active Expired - Fee Related
- 1994-02-04 WO PCT/US1994/001387 patent/WO1994018342A1/en active IP Right Grant
- 1994-02-04 AT AT94908734T patent/ATE217086T1/de active
- 1994-02-04 JP JP6518303A patent/JPH08506897A/ja active Pending
- 1994-02-04 EP EP94908734A patent/EP0683822B1/de not_active Expired - Lifetime
- 1994-02-04 AU AU61718/94A patent/AU6171894A/en not_active Abandoned
- 1994-02-09 IL IL10860794A patent/IL108607A/en not_active IP Right Cessation
- 1994-02-11 MX MX9401112A patent/MX9401112A/es unknown
- 1994-08-22 US US08/293,648 patent/US5486455A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994018342A1 (en) | 1994-08-18 |
| US5486455A (en) | 1996-01-23 |
| MX9401112A (es) | 1994-08-31 |
| EP0683822A1 (de) | 1995-11-29 |
| IL108607A0 (en) | 1994-05-30 |
| EP0683822B1 (de) | 2002-05-02 |
| JPH08506897A (ja) | 1996-07-23 |
| DE69430523T2 (de) | 2002-11-28 |
| DE69430523D1 (de) | 2002-06-06 |
| IL108607A (en) | 1998-12-06 |
| AU6171894A (en) | 1994-08-29 |
| EP0683822A4 (de) | 1997-11-05 |
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