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ATE143376T1 - Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung

Info

Publication number
ATE143376T1
ATE143376T1 AT90909864T AT90909864T ATE143376T1 AT E143376 T1 ATE143376 T1 AT E143376T1 AT 90909864 T AT90909864 T AT 90909864T AT 90909864 T AT90909864 T AT 90909864T AT E143376 T1 ATE143376 T1 AT E143376T1
Authority
AT
Austria
Prior art keywords
monoclonal antibodies
production
leukocyte adhesion
directed against
antibodies directed
Prior art date
Application number
AT90909864T
Other languages
English (en)
Inventor
James E Hildreth
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Application granted granted Critical
Publication of ATE143376T1 publication Critical patent/ATE143376T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT90909864T 1989-06-02 1990-05-30 Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung ATE143376T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36127189A 1989-06-02 1989-06-02

Publications (1)

Publication Number Publication Date
ATE143376T1 true ATE143376T1 (de) 1996-10-15

Family

ID=23421348

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90909864T ATE143376T1 (de) 1989-06-02 1990-05-30 Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung

Country Status (10)

Country Link
US (4) US5888508A (de)
EP (1) EP0432249B1 (de)
JP (2) JP3048632B2 (de)
AT (1) ATE143376T1 (de)
AU (2) AU645016B2 (de)
CA (1) CA2033347C (de)
DE (1) DE69028684T2 (de)
DK (1) DK0432249T3 (de)
ES (1) ES2095876T3 (de)
WO (1) WO1990015076A2 (de)

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DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
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EP0656789B1 (de) * 1992-08-21 1997-12-17 Genentech, Inc. Verfahren zur behandlung einer durch lfa-1 vermittelten störung
US5821332A (en) * 1993-11-03 1998-10-13 The Board Of Trustees Of The Leland Stanford Junior University Receptor on the surface of activated CD4+ T-cells: ACT-4
US5646251A (en) * 1993-11-05 1997-07-08 The Board Of Trustees Of Leeland Stanford Jr. Univ. Alloreaction-associated antigen (ARAG): a novel member of the immunoglobulin gene superfamily
US6242566B1 (en) 1994-02-10 2001-06-05 Board Of Trustees Of The Leland Stanford Junior University Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
US6867203B2 (en) 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
EP1163003B1 (de) 1999-03-19 2009-08-12 Genentech, Inc. Behandlung von lfa-1 assozieerten krankheiten durch gesteigerte dosen von lfa-1 antagonist
US6582698B1 (en) 1999-03-19 2003-06-24 Genentech, Inc. Treatment method
WO2001051084A1 (en) * 2000-01-14 2001-07-19 Genentech, Inc. Diagnosis and treatment of hepatic inflammatory disorders by inhibiting the binding of lfa-1 to icam-1
WO2001070266A2 (en) 2000-03-17 2001-09-27 Millennium Pharmaceuticals, Inc. Method of inhibiting stenosis and restenosis with a mixture of antibodies anti cd18 and anti ccr2
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
BRPI0511305A (pt) 2004-06-09 2007-12-04 Genentech Inc método de aliviar um granuloma anular ou sarcóide, artigo manufaturado e uso de um antagonista de lfa-1
US8440264B2 (en) * 2006-12-15 2013-05-14 Ford Global Technologies, Llc Method for preparing a brazed surface for receiving a coating
DK3903829T3 (da) 2009-02-13 2023-06-26 Immunomedics Inc Immunkonjugater med en intracellulær spaltelig binding
EP3009455A1 (de) 2009-09-16 2016-04-20 Immunomedics Inc. Klasse-i-anti-cea-antikörper und verwendungen davon
EP2506881B1 (de) 2009-12-02 2024-03-06 Immunomedics, Inc. Kombination aus radioimmuntherapie und antikörper-arznei-konjugaten für verbesserte krebstherapie
JP6024025B2 (ja) 2011-05-02 2016-11-09 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． 少容量投与用のアロタイプ選択抗体の限外濾過濃縮
AU2013302696B9 (en) 2012-08-14 2018-08-09 Ibc Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
CN107753954A (zh) 2012-12-13 2018-03-06 免疫医疗公司 功效改进且毒性降低的抗体与sn‑38的免疫缀合物的剂量
ES2978993T3 (es) 2014-02-21 2024-09-23 Ibc Pharmaceuticals Inc Terapia de enfermedades mediante la inducción de la respuesta inmunitaria a las células que expresan Trop-2
EP3110445A4 (de) 2014-02-25 2017-09-27 Immunomedics, Inc. Humanisierter rfb4-anti-cd22-antikörper
US9580495B2 (en) 2014-06-24 2017-02-28 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
PT3204018T (pt) 2014-10-07 2021-11-12 Immunomedics Inc Uso neoadjuvante de conjugados anticorpo-fármaco
EP3029067A1 (de) 2014-12-01 2016-06-08 Deutsches Krebsforschungszentrum Verwendung von blockierenden Reagenzien zur Verringerung von unspezifischer T-Zellenaktivierung
AU2016252771B2 (en) 2015-04-22 2021-12-16 Immunomedics, Inc. Isolation, detection, diagnosis and/or characterization of circulating Trop-2-positive cancer cells
EP4257134A3 (de) 2015-06-25 2024-01-24 Immunomedics, Inc. Kombination von anti-hla-dr- oder anti-trop-2-antikörpern mit mikrotubuli-inhibitoren, parp-inhibitoren, bruton-kinase-inhibitoren oder phosphoinositol-3-kinase-inhibitoren zur signifikanten verbesserung des therapeutischen ergebnisses bei krebs
EP3316885B1 (de) 2015-07-01 2021-06-23 Immunomedics, Inc. Antikörper-sn-38-immunkonjugate mit einem cl2a-linker
US20250073349A1 (en) 2021-05-10 2025-03-06 Kawasaki Institute Of Industrial Promotion Antibody having reduced binding affinity for antigen
USD1005917S1 (en) * 2021-11-04 2023-11-28 Thor Tech, Inc. Wheel

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US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
JPH01502879A (ja) * 1987-02-26 1989-10-05 ダナ　ファーバー　キャンサー　インスティテュート Ｌｆａ―１のクローニング
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US4797277A (en) * 1987-09-22 1989-01-10 Pharmacia Ab Method for reperfusion therapy
ATE114972T1 (de) * 1987-11-02 1994-12-15 Baylor College Medicine Verwendung von icam-1 oder ihre funktionelle derivate zur behandlung unspezifischer entzündungen.
US5002869A (en) * 1987-11-02 1991-03-26 Dana-Farber Cancer Institute Monoclonal antibody specific to a novel epitope of the LFA-1 antigen of human T lymphocytes
GB8726230D0 (en) * 1987-11-10 1987-12-16 Rosen H Antibodies
US5449760A (en) * 1987-12-31 1995-09-12 Tanox Biosystems, Inc. Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils
US5147637A (en) * 1988-06-07 1992-09-15 The Rockefeller University Method of inhibiting the influx of leukocytes into organs during sepsis or other trauma
ATE125708T1 (de) * 1988-09-28 1995-08-15 Dana Farber Cancer Inst Inc Interzellulare adhäsions-moleküle und deren bindungsliganden.
US5204445A (en) * 1988-10-03 1993-04-20 The Scripps Research Institute Peptides and antibodies that inhibit integrin-ligand binding
US6307025B1 (en) * 1989-04-28 2001-10-23 Biogen, Inc. VCAM fusion proteins and DNA coding therefor
JP3048632B2 (ja) * 1989-06-02 2000-06-05 ザ ジョーンズ ホプキンズ ユニヴァーシティ スクール オブ メディスン 白血球付着レセプターβ鎖に対するモノクローナル抗体と、この抗体の製造方法と、その応用
WO1991002755A1 (en) * 1989-08-18 1991-03-07 La Jolla Cancer Research Foundation Fibulin
US6720141B1 (en) * 1999-11-01 2004-04-13 Interleukin Genetics, Inc. Diagnostics and therapeutics for restenosis

Also Published As

Publication number Publication date
DE69028684T2 (de) 1997-05-22
US20050158315A1 (en) 2005-07-21
DE69028684D1 (de) 1996-10-31
US20010014325A1 (en) 2001-08-16
AU666977B2 (en) 1996-02-29
JP3048632B2 (ja) 2000-06-05
US6187308B1 (en) 2001-02-13
WO1990015076A3 (en) 1991-04-18
EP0432249B1 (de) 1996-09-25
CA2033347C (en) 2000-02-29
DK0432249T3 (da) 1997-02-17
WO1990015076A2 (en) 1990-12-13
JPH04501365A (ja) 1992-03-12
AU5035393A (en) 1994-02-17
JP3288996B2 (ja) 2002-06-04
EP0432249A4 (en) 1992-01-02
AU645016B2 (en) 1994-01-06
EP0432249A1 (de) 1991-06-19
AU5847190A (en) 1991-01-07
JP2000136200A (ja) 2000-05-16
US5888508A (en) 1999-03-30
US6921533B2 (en) 2005-07-26
US7368109B2 (en) 2008-05-06
CA2033347A1 (en) 1990-12-03
ES2095876T3 (es) 1997-03-01

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