ATE178884T1 - Salze von 2-((2,6- dichlorophenyl)amin>phenylacetoxyessigsäure mit organischen basischen kationen - Google Patents
Salze von 2-((2,6- dichlorophenyl)amin>phenylacetoxyessigsäure mit organischen basischen kationenInfo
- Publication number
- ATE178884T1 ATE178884T1 AT95921106T AT95921106T ATE178884T1 AT E178884 T1 ATE178884 T1 AT E178884T1 AT 95921106 T AT95921106 T AT 95921106T AT 95921106 T AT95921106 T AT 95921106T AT E178884 T1 ATE178884 T1 AT E178884T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- dichlorophenyl
- amine
- organic basic
- salts
- Prior art date
Links
- WRYJMEQATCHBRJ-UHFFFAOYSA-N 2-(2-phenylacetyl)oxyacetic acid Chemical compound OC(=O)COC(=O)CC1=CC=CC=C1 WRYJMEQATCHBRJ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001768 cations Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- JDMFXJULNGEPOI-UHFFFAOYSA-N 2,6-dichloroaniline Chemical compound NC1=C(Cl)C=CC=C1Cl JDMFXJULNGEPOI-UHFFFAOYSA-N 0.000 abstract 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- 208000008035 Back Pain Diseases 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010023204 Joint dislocation Diseases 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salts Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
- C07C211/05—Mono-, di- or tri-ethylamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94810382 | 1994-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE178884T1 true ATE178884T1 (de) | 1999-04-15 |
Family
ID=8218277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95921106T ATE178884T1 (de) | 1994-06-29 | 1995-06-28 | Salze von 2-((2,6- dichlorophenyl)amin>phenylacetoxyessigsäure mit organischen basischen kationen |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5708024A (de) |
| EP (1) | EP0767777B1 (de) |
| JP (1) | JPH11505503A (de) |
| AT (1) | ATE178884T1 (de) |
| AU (1) | AU2628895A (de) |
| CA (1) | CA2192682A1 (de) |
| CZ (1) | CZ380596A3 (de) |
| DE (1) | DE69509091T2 (de) |
| DK (1) | DK0767777T3 (de) |
| ES (1) | ES2132672T3 (de) |
| FI (1) | FI965157A0 (de) |
| GR (1) | GR3030625T3 (de) |
| HU (1) | HUT75341A (de) |
| MX (1) | MX9700210A (de) |
| NO (1) | NO965505D0 (de) |
| PL (1) | PL318014A1 (de) |
| WO (1) | WO1996000716A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| GB0007239D0 (en) * | 2000-03-24 | 2000-05-17 | Nycomed Imaging As | Use |
| AR042206A1 (es) | 2002-11-26 | 2005-06-15 | Novartis Ag | Acidos fenilaceticos y derivados |
| KR100749162B1 (ko) | 2005-10-24 | 2007-08-14 | 주식회사 엔지켐 | 아세클로페낙 아미노산염의 제조방법 |
| CN101969867B (zh) | 2008-01-14 | 2013-03-27 | 康文图斯整形外科公司 | 用于骨折修补的装置 |
| RU2012122654A (ru) * | 2009-11-05 | 2013-12-10 | Алкем Лабораториз Лтд. | Стабильная фармацевтическая инъекционная композиция ацеклофенака и способ ее получения |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT368129B (de) * | 1980-06-03 | 1982-09-10 | Gerot Pharmazeutika | Verfahren zur herstellung neuer salze von o-(2,6- dichloranilino)-phenylessigsaeure |
| AT370721B (de) * | 1981-02-24 | 1983-04-25 | Ciba Geigy Ag | Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der |
| CH651821A5 (en) * | 1981-02-18 | 1985-10-15 | Ciba Geigy Ag | Salts of a phenylacetic acid, and a process for their preparation |
| ES520813A0 (es) * | 1983-03-21 | 1984-05-16 | Prodes Sa | Procedimiento para la obtencion del ester del acido 2-(2,6-diclorofenil)amino bencenoacetico con acido glicolico. |
| IT1228242B (it) * | 1986-11-13 | 1991-06-05 | Ricerfarma Srl Milano | Sale del diclofenac con idrossietilpirrolidina e composizioni farmaceutiche che lo contengono |
| IT1250636B (it) * | 1991-07-04 | 1995-04-21 | Ricerche Di Schiena Del Dr Mic | Sale del diclofenac, metodo di preparazione e composizioni farmaceutiche che lo contengono. |
-
1995
- 1995-06-28 ES ES95921106T patent/ES2132672T3/es not_active Expired - Lifetime
- 1995-06-28 MX MX9700210A patent/MX9700210A/es unknown
- 1995-06-28 DK DK95921106T patent/DK0767777T3/da active
- 1995-06-28 CA CA002192682A patent/CA2192682A1/en not_active Abandoned
- 1995-06-28 AT AT95921106T patent/ATE178884T1/de not_active IP Right Cessation
- 1995-06-28 PL PL95318014A patent/PL318014A1/xx unknown
- 1995-06-28 EP EP95921106A patent/EP0767777B1/de not_active Expired - Lifetime
- 1995-06-28 AU AU26288/95A patent/AU2628895A/en not_active Abandoned
- 1995-06-28 HU HU9603590A patent/HUT75341A/hu unknown
- 1995-06-28 WO PCT/IB1995/000524 patent/WO1996000716A1/en not_active Application Discontinuation
- 1995-06-28 US US08/750,811 patent/US5708024A/en not_active Expired - Lifetime
- 1995-06-28 DE DE69509091T patent/DE69509091T2/de not_active Expired - Lifetime
- 1995-06-28 CZ CZ963805A patent/CZ380596A3/cs unknown
- 1995-06-28 JP JP8502986A patent/JPH11505503A/ja active Pending
-
1996
- 1996-12-20 NO NO965505A patent/NO965505D0/no unknown
- 1996-12-20 FI FI965157A patent/FI965157A0/fi not_active Application Discontinuation
-
1999
- 1999-06-30 GR GR990401711T patent/GR3030625T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69509091D1 (de) | 1999-05-20 |
| DE69509091T2 (de) | 1999-09-09 |
| WO1996000716A1 (en) | 1996-01-11 |
| NO965505L (no) | 1996-12-20 |
| EP0767777A1 (de) | 1997-04-16 |
| CZ380596A3 (en) | 1997-08-13 |
| JPH11505503A (ja) | 1999-05-21 |
| US5708024A (en) | 1998-01-13 |
| AU2628895A (en) | 1996-01-25 |
| EP0767777B1 (de) | 1999-04-14 |
| ES2132672T3 (es) | 1999-08-16 |
| GR3030625T3 (en) | 1999-10-29 |
| PL318014A1 (en) | 1997-05-12 |
| FI965157A (fi) | 1996-12-20 |
| DK0767777T3 (da) | 1999-10-25 |
| HUT75341A (en) | 1997-05-28 |
| CA2192682A1 (en) | 1996-01-11 |
| NO965505D0 (no) | 1996-12-20 |
| HU9603590D0 (en) | 1997-02-28 |
| FI965157A0 (fi) | 1996-12-20 |
| MX9700210A (es) | 1998-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |