[go: up one dir, main page]

ATE181731T1 - Isothioharnstoff-derivate als no synthase hemmer - Google Patents

Isothioharnstoff-derivate als no synthase hemmer

Info

Publication number
ATE181731T1
ATE181731T1 AT95933007T AT95933007T ATE181731T1 AT E181731 T1 ATE181731 T1 AT E181731T1 AT 95933007 T AT95933007 T AT 95933007T AT 95933007 T AT95933007 T AT 95933007T AT E181731 T1 ATE181731 T1 AT E181731T1
Authority
AT
Austria
Prior art keywords
pct
synthase inhibitors
sec
isothiourea derivatives
formula
Prior art date
Application number
AT95933007T
Other languages
English (en)
Inventor
James Edwin Macdonald
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10761604&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE181731(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astra Ab filed Critical Astra Ab
Application granted granted Critical
Publication of ATE181731T1 publication Critical patent/ATE181731T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
AT95933007T 1994-09-20 1995-09-20 Isothioharnstoff-derivate als no synthase hemmer ATE181731T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9418912A GB9418912D0 (en) 1994-09-20 1994-09-20 Pharmaceutically active compounds

Publications (1)

Publication Number Publication Date
ATE181731T1 true ATE181731T1 (de) 1999-07-15

Family

ID=10761604

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95933007T ATE181731T1 (de) 1994-09-20 1995-09-20 Isothioharnstoff-derivate als no synthase hemmer

Country Status (11)

Country Link
US (1) US5721247A (de)
EP (1) EP0782567B2 (de)
JP (1) JPH10505862A (de)
AT (1) ATE181731T1 (de)
AU (1) AU3582095A (de)
DE (1) DE69510553T3 (de)
DK (1) DK0782567T3 (de)
ES (1) ES2135769T3 (de)
GB (1) GB9418912D0 (de)
GR (1) GR3031321T3 (de)
WO (1) WO1996009286A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2629795A (en) 1994-12-12 1996-07-03 Chugai Seiyaku Kabushiki Kaisha Aniline derivative having the effect of inhibiting nitrogen monoxide synthase
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
US6028083A (en) * 1997-07-25 2000-02-22 Hoechst Marion Roussel, Inc. Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
US6605607B1 (en) 1998-10-08 2003-08-12 Smithkline Beecham P.L.C. Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents)
WO2001004088A1 (fr) * 1999-07-09 2001-01-18 Chugai Seiyaku Kabushiki Kaisha Procede de preparation de derives d'amiline
HUP0302362A3 (en) * 2000-09-05 2005-05-30 Meditor Pharmaceuticals Ltd Pharmaceutical compositions for headache, migraine, nausea and emesis
KR101052122B1 (ko) 2005-10-25 2011-07-26 시오노기세야쿠 가부시키가이샤 아미노디히드로티아진 유도체
BRPI0811034A2 (pt) 2007-04-24 2014-12-09 Shionogi & Co Derivados de aminodi-hidrotiazina substituídos com um grupo cíclico e seus usos e composições farmacêuticas
US8653067B2 (en) 2007-04-24 2014-02-18 Shionogi & Co., Ltd. Pharmaceutical composition for treating Alzheimer's disease
KR20130018370A (ko) 2008-06-13 2013-02-20 시오노기세야쿠 가부시키가이샤 β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체
US8703785B2 (en) 2008-10-22 2014-04-22 Shionogi & Co., Ltd. 2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity
EP2415756A4 (de) * 2009-03-31 2012-08-29 Shionogi & Co Isothioharnstoffderivate oder isoharnstoffderivate mit bace1-hemmender wirkung
RU2012129168A (ru) 2009-12-11 2014-01-20 Сионоги Энд Ко. Лтд. Производные оксазина
WO2012057248A1 (ja) 2010-10-29 2012-05-03 塩野義製薬株式会社 ナフチリジン誘導体
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
CN103608345A (zh) 2011-04-26 2014-02-26 盐野义制药株式会社 噁嗪衍生物和含有该噁嗪衍生物的bace1抑制剂
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE152027C (de) *
US2050557A (en) * 1930-10-09 1936-08-11 Winthrop Chem Co Inc New therapeutically active ureaand thiourea-derivatives
US2050552A (en) * 1932-08-29 1936-08-11 Dufaycolor Ltd Color photography
WO1995009619A2 (en) * 1993-10-04 1995-04-13 The Wellcome Foundation Limited Substituted urea and isothiourea derivatives as no synthase inhibitors
NL294924A (de) * 1963-07-05
GB1178242A (en) * 1966-02-05 1970-01-21 Wellcome Found Novel Biologically Active Bis-Isothioureas
US4008330A (en) * 1971-09-13 1977-02-15 Nippon Kayaku Kabushiki Kaisha Method for combatting rodents and rodenticidal compositions
US4211867A (en) * 1976-03-19 1980-07-08 Mcneil Laboratories, Incorporated Nitrogen heterocyclic carboximidamide compounds
DD208298A1 (de) * 1982-09-08 1984-05-02 Hackel Goetz Ruediger Verfahren zur herstellung von keratinfaserfaerbepraeparaten
FR2581063B1 (fr) * 1985-04-30 1987-07-17 Chauvin Blache Lab Amino-2 thiazoles n-substitues, leur procede de preparation et leur application en therapeutique
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
GB8908063D0 (en) * 1989-04-11 1989-05-24 Beecham Group Plc Novel compounds
US4988688A (en) * 1989-08-02 1991-01-29 Warner-Lambert Company 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents
JPH08503940A (ja) * 1992-11-27 1996-04-30 ザ ウエルカム ファウンデーション リミテッド 酵素阻害薬
ATE180255T1 (de) * 1993-03-23 1999-06-15 Astra Ab Guanidinderivate mit therapeutischer wirkung
RU2130017C1 (ru) * 1993-08-12 1999-05-10 Астра Актиенболаг Производные амидина, способ их получения и лекарственное средство на их основе, обладающее свойством ингибировать активность синтетазы оксида азота (у)
AU2629795A (en) † 1994-12-12 1996-07-03 Chugai Seiyaku Kabushiki Kaisha Aniline derivative having the effect of inhibiting nitrogen monoxide synthase

Also Published As

Publication number Publication date
AU3582095A (en) 1996-04-09
EP0782567A1 (de) 1997-07-09
WO1996009286A1 (en) 1996-03-28
EP0782567B1 (de) 1999-06-30
GR3031321T3 (en) 1999-12-31
DE69510553T3 (de) 2003-10-02
DK0782567T3 (da) 1999-11-22
US5721247A (en) 1998-02-24
DE69510553D1 (en) 1999-08-05
ES2135769T3 (es) 1999-11-01
JPH10505862A (ja) 1998-06-09
GB9418912D0 (en) 1994-11-09
EP0782567B2 (de) 2002-12-11
DE69510553T2 (de) 1999-12-23

Similar Documents

Publication Publication Date Title
ATE181731T1 (de) Isothioharnstoff-derivate als no synthase hemmer
MX9203053A (es) Derivados de aza nor bornano.
ATE228507T1 (de) Substituierte 6-phenylphenanthridine
FI990419A0 (fi) Typpeä sisältävien hetrosyklisten yhdisteiden fluorialkoksibentsyyliaminojohdannaiset
IL129068A0 (en) Sulfinic acid derivatives and their preparation and use
FI941212A0 (fi) Fuusioituneet trisykliset, typpeä sisältävät heterosykliset yhdisteet
ATE179703T1 (de) Triazolverbindungen und deren verwendung als dopamin-d3-liganden
DK0696281T3 (da) Hidtil ukendte 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazolderivater
NO965094D0 (no) [aÅ-annelerte pyrrolderivater og anvendelse av disse i farmasien
ATE234616T1 (de) Thiadiazolverbindungen als d3 dopaminrezeptorligand
ZA955105B (en) Thiazolidine derivatives their preparation and compositions containing them
BR9408244A (pt) Derivados de azabiciclo[3.2.0]heptano N-substituídos
MX9702203A (es) Derivados de pirazolil-pirazol substituidos, procedimientos para su preparacion y su uso como agentes con accion herbicida.
TW429147B (en) Pharmaceutical composition for the treatment of CNS disorders
ATE207480T1 (de) Substituierte aminoalkylaminopyridine
ZA955052B (en) Pyrrolidine derivatives their preparation and compositions containing them
ATE327235T1 (de) 1,2,5,10-tetrahydropyridazino 4,5-böchinolin-1, 0-dione und ihre anwendung in der behandlung von schmerzen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties