ATE129125T1 - Verfahren zur isolierung von lactoferrin und lactoperoxidase aus milch und milchprodukten. - Google Patents

Verfahren zur isolierung von lactoferrin und lactoperoxidase aus milch und milchprodukten.

Info

Publication number: ATE129125T1
Authority: AT; Austria
Prior art keywords: milk; pct; lactoferrin; lactoperoxidase; eluates
Prior art date: 1992-01-15

Application number

AT93904386T

Other languages

English (en)

Inventor

Klaas Daniel Kussendrager

Marinus Gerardus Cornel Kivits

Albert Bruno Verver

Original Assignee

Campina Melkunie Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-15

Filing date

1993-01-14

Publication date

1995-11-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19860296&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE129125(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-01-14 Application filed by Campina Melkunie Bv filed Critical Campina Melkunie Bv

1995-11-15 Application granted granted Critical

1995-11-15 Publication of ATE129125T1 publication Critical patent/ATE129125T1/de

Links

235000013336 milk Nutrition 0.000 title abstract 6
239000008267 milk Substances 0.000 title abstract 6
210000004080 milk Anatomy 0.000 title abstract 6
238000000034 method Methods 0.000 title abstract 3
102000010445 Lactoferrin Human genes 0.000 title abstract 2
108010063045 Lactoferrin Proteins 0.000 title abstract 2
108010023244 Lactoperoxidase Proteins 0.000 title abstract 2
102000045576 Lactoperoxidases Human genes 0.000 title 1
238000002955 isolation Methods 0.000 title 1
CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 title 1
229940078795 lactoferrin Drugs 0.000 title 1
235000021242 lactoferrin Nutrition 0.000 title 1
229940057428 lactoperoxidase Drugs 0.000 title 1
150000001768 cations Chemical class 0.000 abstract 2
235000018102 proteins Nutrition 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
238000001035 drying Methods 0.000 abstract 1
238000010828 elution Methods 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
239000012266 salt solution Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
- A23C9/146—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by ion-exchange
- A23C9/1465—Chromatographic separation of protein or lactose fraction; Adsorption of protein or lactose fraction followed by elution
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
- A23J1/205—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey from whey, e.g. lactalbumine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/832—Milk; colostrum
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/833—Whey; cheese

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Food Science & Technology (AREA)
Wood Science & Technology (AREA)
Polymers & Plastics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Dairy Products (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
General Preparation And Processing Of Foods (AREA)

AT93904386T 1992-01-15 1993-01-14 Verfahren zur isolierung von lactoferrin und lactoperoxidase aus milch und milchprodukten. ATE129125T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL9200064		1992-01-15

Publications (1)

Publication Number	Publication Date
ATE129125T1 true ATE129125T1 (de)	1995-11-15

Family

ID=19860296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93904386T ATE129125T1 (de)	1992-01-15	1993-01-14	Verfahren zur isolierung von lactoferrin und lactoperoxidase aus milch und milchprodukten.

Country Status (10)

Country	Link
US (1)	US5596082A (de)
EP (1)	EP0620709B1 (de)
AT (1)	ATE129125T1 (de)
CA (1)	CA2128111C (de)
DE (1)	DE69300674T2 (de)
DK (1)	DK0620709T3 (de)
ES (1)	ES2089797T3 (de)
FI (1)	FI111326B (de)
NZ (1)	NZ249235A (de)
WO (1)	WO1993013676A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2183459A1 (en) *	1994-02-16	1995-08-24	Jan H. Nuijens	Isolation of lactoferrin from milk
ES2089970B1 (es) *	1994-03-08	1997-05-01	Univ Zaragoza	Metodo de aislamiento de lactoferrina y otras proteinas lacteas.
JP3112637B2 (ja) *	1994-09-30	2000-11-27	雪印乳業株式会社	骨強化剤
JP2974604B2 (ja) *	1996-01-23	1999-11-10	雪印乳業株式会社	塩基性タンパク質組成物、塩基性ペプチド組成物及びその利用
JP3073439B2 (ja) *	1996-02-08	2000-08-07	雪印乳業株式会社	骨形成促進及び骨吸収防止剤
NL1005677C2 (nl) *	1997-03-27	1998-09-29	Campina Melkunie Bv	Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan.
DE10062056A1 (de) *	2000-12-15	2002-07-04	Henkel Ecolab Gmbh & Co Ohg	Verfahren zur Reinigung von Ionenaustauscher-Kunststoffharzen
EP1584242B1 (de) *	2001-06-01	2010-01-20	Upfront Chromatography A/S	Fraktionierung von proteinhaltigen Mischungen
NZ535784A (en)	2002-03-07	2006-02-24	Upfront Chromatography As	A process of isolating lactoferrin
US20030191193A1 (en) *	2002-04-03	2003-10-09	Jillian Cornish	Lactoferrin
FR2841747B1 (fr) *	2002-07-02	2004-08-20	Cie Laitiere Europeenne	Isolat de proteines de lait et procede pour sa preparation
WO2004082397A1 (en) *	2003-03-21	2004-09-30	Upfront Chromatography A/S	Method for high throughput volumes in the fractionation of bio-molecules by chromatographic systems
JP4263932B2 (ja) *	2003-04-01	2009-05-13	雪印乳業株式会社	ラクトフェリンの製造方法
US20040259770A1 (en) *	2003-06-19	2004-12-23	Rush University Medical Center	Method for determining leukocyte activation
JP3946747B2 (ja) *	2004-02-17	2007-07-18	森永乳業株式会社	ラクトパーオキシダーゼの製造方法
WO2005085287A1 (en) *	2004-03-03	2005-09-15	En-N-Tech, Inc.	Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
AU2007317200B8 (en) *	2006-11-10	2012-02-02	Agriculture Victoria Services Pty Ltd.	Process for the preparation of angiogenin
DK2173770T3 (da)	2007-07-10	2015-06-08	Glanbia Nutritionals Ireland Ltd	Fremgangsmåde til fjernelse af endotoxin fra proteiner
RU2519645C2 (ru)	2008-05-14	2014-06-20	Эгрикалчер Виктория Сервисиз Пти Лтд	Применение ангиогенина или агонистов ангиогенина для лечения заболеваний и нарушений
AU2013204740C1 (en)	2012-05-10	2015-10-01	Agriculture Victoria Services Pty Ltd	Methods of treating cancer using angiogenin or an angiogenin agonist
AU2013204858B2 (en) *	2012-10-08	2015-06-25	Saputo Dairy Australia Pty Limited	Improved process for purifying milk proteins and products thereof
US9661868B2 (en) *	2013-07-16	2017-05-30	Mead Johnson Nutrition Company	Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin
CZ2013885A3 (cs) *	2013-11-15	2015-08-19	Univerzita PalackĂ©ho	Způsob separace syrovátkových proteinů z mléčného média a zařízení k provádění tohoto způsobu
EP3097787B1 (de) *	2015-05-24	2018-11-21	DMK Deutsches Milchkontor GmbH	Verfahren zur gewinnung von lactoperoxidase aus milch
EP3097788B1 (de) *	2015-05-26	2018-10-17	DMK Deutsches Milchkontor GmbH	Verfahren zur gewinnung von lactoferrin aus milch
KR20210091206A (ko)	2018-11-06	2021-07-21	아르헬 프로젝티랜제 인 인제나이어링 디.오.오.	우유, 초유 및 산 또는 스위트 유청으로부터 고도로 정제된 락토페린 및 락토퍼옥시다제를 제조하는 방법
AU2020203454B1 (en) *	2020-05-26	2021-07-22	HPS Tech Pty Ltd	Processing protein
FR3117736B1 (fr) *	2020-12-22	2024-04-05	Savencia	Nouveau procédé de préparation d’un isolat de protéines cationiques de lactosérum et le produit ainsi obtenu

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2505615A1 (fr) *	1981-05-15	1982-11-19	Elf Aquitaine	Procede d'extraction de lactoferrine et d'immunoglobulines du lait
BE901672A (fr) *	1985-02-07	1985-08-07	Oleofina Sa	Procede de purification de proteines du lait et de ses derives.
IE61701B1 (en) *	1986-07-17	1994-11-30	Morinaga Milk Industry Co Ltd	Process for producing bovine lactoferrin in high purity
FR2613368B1 (fr) *	1987-03-10	1989-06-23	Entremont Sa	Procede pour extraire des proteines du lactoserum, par adsorption et elution
SE458818B (sv) *	1987-11-27	1989-05-16	Svenska Mejeriernas Riksforeni	Foerfarande foer utvinning av rena fraktioner av laktoperoxidas och laktoferrin ur mjoelkserum
NZ230031A (en) *	1988-07-27	1991-10-25	Snow Brand Milk Products Co Ltd	Separation of proteins (e.g. lactoferrin) using affinity gel carrier in a rotary column
JP2686831B2 (ja) *	1989-09-22	1997-12-08	雪印乳業株式会社	鉄結合性蛋白質を分離、精製し、採取する方法
JP2974434B2 (ja) *	1990-03-15	1999-11-10	雪印乳業株式会社	分泌性コンポネント含有組成物
JPH05202098A (ja) *	1992-01-29	1993-08-10	Snow Brand Milk Prod Co Ltd	乳質原料から生理活性物質の製造法

1993
- 1993-01-14 AT AT93904386T patent/ATE129125T1/de not_active IP Right Cessation
- 1993-01-14 CA CA002128111A patent/CA2128111C/en not_active Expired - Fee Related
- 1993-01-14 WO PCT/NL1993/000014 patent/WO1993013676A1/en active IP Right Grant
- 1993-01-14 EP EP93904386A patent/EP0620709B1/de not_active Expired - Lifetime
- 1993-01-14 US US08/256,473 patent/US5596082A/en not_active Expired - Fee Related
- 1993-01-14 DE DE69300674T patent/DE69300674T2/de not_active Expired - Fee Related
- 1993-01-14 DK DK93904386.5T patent/DK0620709T3/da active
- 1993-01-14 ES ES93904386T patent/ES2089797T3/es not_active Expired - Lifetime
- 1993-01-14 NZ NZ249235A patent/NZ249235A/en not_active IP Right Cessation
1994
- 1994-07-15 FI FI943368A patent/FI111326B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2128111C (en)	1998-06-16
EP0620709B1 (de)	1995-10-18
NZ249235A (en)	1995-12-21
US5596082A (en)	1997-01-21
FI943368A0 (fi)	1994-07-15
ES2089797T3 (es)	1996-10-01
FI111326B (fi)	2003-07-15
EP0620709A1 (de)	1994-10-26
DE69300674D1 (de)	1995-11-23
CA2128111A1 (en)	1993-07-22
WO1993013676A1 (en)	1993-07-22
FI943368A (fi)	1994-07-15
DE69300674T2 (de)	1996-05-15
DK0620709T3 (da)	1995-12-04

Publication	Publication Date	Title
ATE129125T1 (de)	1995-11-15	Verfahren zur isolierung von lactoferrin und lactoperoxidase aus milch und milchprodukten.
AU649089B2 (en)	1994-05-12	Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals
FR2603581B1 (fr)	1993-08-13	Procede pour isoler et purifier des aminoacides par chromatographie
BG60256B1 (bg)	1994-03-24	Рекомбинантен метод за получаване на лимфотоксин
EP0363126A3 (de)	1991-09-11	Verfahren zur Reinigung von Vitamin K-abhängigen Proteinen
FI883708A0 (fi)	1988-08-09	Menetelmä emäksisten proteiinien eristämiseksi proteiiniseoksista, jotka sisältävät tällaisia emäksisiä proteiineja
DE3672973D1 (de)	1990-08-30	Verfahren zur spezifischen abtrennung von lactose aus milch.
ES8607262A1 (es)	1986-06-01	Esteres de aminoacidos y de peptidos cromogenos
ES8607243A1 (es)	1986-06-01	Esteres de aminoacidos y de peptidos cromogenos
DE69311799D1 (de)	1997-07-31	Tierärztliche überwachung von arzneimittelrückständen in frischfleisch
Huang et al.	1977	Multiple forms of protein phosphatase inhibitors in mammalian tissues
EP0188262A3 (de)	1988-08-03	Verfahren zur Isolierung von Hühnereiweisscystatin, antivirale Agenzien die sie enthalten und seine Verwendung als viraler Protease-Inhibitor
ATE166062T1 (de)	1998-05-15	Verfahren zur reinigung des big-endothelin proteins
Feinstein	1971	Isolation of chicken ovoinhibitor by affinity chromatography on chymotrypsin-Sepharose
ATE53591T1 (de)	1990-06-15	Verfahren zur reinigung von gamma-interferon.
DE3751249D1 (de)	1995-05-24	Protein L und ihre Untereinheiten, mit immunglobulinbindender Aktivität, Verfahren zur Herstellung, Reagenssatz, pharmazeutische Zubereitung und ein Peptococcus-magnus-Stamm.
Ohtsuki et al.	1980	Mouse spleen cell nuclear protein kinases and the stimulating effect of dsDNA on NHP phosphorylation by cyclic AMP-independent protein kinase in vitro
Klapper Jr et al.	1964	Inhibition of peptic digestion of serum albumin by fatty acids
Cole	1960	Ion exchange chromatography of glucagon in urea-containing buffers
EP0244147A3 (de)	1989-04-05	Verfahren zur Reinigung hybrider Proteine
GR3023110T3 (en)	1997-07-30	Process for reactivating denatured protein
ATE165393T1 (de)	1998-05-15	Aktive milchproteinkomponent enthaltende produkten, und verfahren zu ihrer herstellung
AU5995590A (en)	1991-01-31	Separation of anti-metal chelate antibodies
DK0736102T3 (da)	2000-09-04	Fremgangsmåde til fremstilling af peptidprodukter
DE69836226D1 (de)	2006-11-30	Ifn rezeptor 1 bindende proteine, dafür kodierende dna und verfahren zur regulierung der zellulären antwort auf interferone

Legal Events

Date	Code	Title	Description
1996-04-15	UEP	Publication of translation of european patent specification
2003-10-15	REN	Ceased due to non-payment of the annual fee