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ATE128134T1 - Furyl- und thienyl-substituierte taxane als antitumormittel. - Google Patents

Furyl- und thienyl-substituierte taxane als antitumormittel.

Info

Publication number
ATE128134T1
ATE128134T1 AT92308608T AT92308608T ATE128134T1 AT E128134 T1 ATE128134 T1 AT E128134T1 AT 92308608 T AT92308608 T AT 92308608T AT 92308608 T AT92308608 T AT 92308608T AT E128134 T1 ATE128134 T1 AT E128134T1
Authority
AT
Austria
Prior art keywords
furyl
thienyl
tumor agents
substituted taxanes
chem
Prior art date
Application number
AT92308608T
Other languages
English (en)
Inventor
Robert A Holton
Hossain Nadizadeh
Ronald J Biediger
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State filed Critical Univ Florida State
Application granted granted Critical
Publication of ATE128134T1 publication Critical patent/ATE128134T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Polyethers (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT92308608T 1991-09-23 1992-09-22 Furyl- und thienyl-substituierte taxane als antitumormittel. ATE128134T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76380591A 1991-09-23 1991-09-23
US07/862,819 US5227400A (en) 1991-09-23 1992-04-03 Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE128134T1 true ATE128134T1 (de) 1995-10-15

Family

ID=27117340

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92308608T ATE128134T1 (de) 1991-09-23 1992-09-22 Furyl- und thienyl-substituierte taxane als antitumormittel.

Country Status (14)

Country Link
US (1) US5227400A (de)
EP (1) EP0534708B1 (de)
JP (1) JP3217156B2 (de)
AT (1) ATE128134T1 (de)
AU (1) AU649875B2 (de)
CA (1) CA2077621C (de)
DE (1) DE69204951T2 (de)
DK (1) DK0534708T3 (de)
FI (1) FI113267B (de)
GR (1) GR3018481T3 (de)
HU (1) HU215839B (de)
MX (1) MX9205309A (de)
NO (1) NO301070B1 (de)
NZ (1) NZ244455A (de)

Families Citing this family (93)

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US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
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US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US6005138A (en) * 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
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US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
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IL109049A (en) * 1993-03-22 2006-12-31 Univ Florida State Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
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FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
ZA926828B (en) * 1991-09-23 1993-03-15 Univ Florida State Novel alkoxy substituted taxanes and pharmaceutical compositions containing them.

Also Published As

Publication number Publication date
NO301070B1 (no) 1997-09-08
CA2077621C (en) 1999-11-02
DE69204951D1 (de) 1995-10-26
EP0534708B1 (de) 1995-09-20
JPH05239055A (ja) 1993-09-17
US5227400A (en) 1993-07-13
HU215839B (hu) 2001-06-28
NO923677L (no) 1993-03-24
NO923677D0 (no) 1992-09-22
FI924226L (fi) 1993-03-24
NZ244455A (en) 1995-04-27
JP3217156B2 (ja) 2001-10-09
FI924226A0 (fi) 1992-09-21
CA2077621A1 (en) 1993-03-24
MX9205309A (es) 1993-07-01
EP0534708A1 (de) 1993-03-31
FI113267B (fi) 2004-03-31
DK0534708T3 (da) 1996-02-05
HUT62886A (en) 1993-06-28
AU2212292A (en) 1993-03-25
HU9203017D0 (en) 1992-12-28
GR3018481T3 (en) 1996-03-31
AU649875B2 (en) 1994-06-02
DE69204951T2 (de) 1996-02-08

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Legal Events

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