ATE141920T1 - Verfahren zur herstellung von taxan-derivaten - Google Patents

Verfahren zur herstellung von taxan-derivaten

Info

Publication number: ATE141920T1
Authority: AT; Austria
Prior art keywords: stands; iii; general formula; hydroxy function; function protective
Prior art date: 1992-02-07

Application number

AT93904150T

Other languages

English (en)

Inventor

Elie Fouque

Jean-Manuel Mas

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-07

Filing date

1993-02-04

Publication date

1996-09-15

1993-02-04 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1996-09-15 Application granted granted Critical

1996-09-15 Publication of ATE141920T1 publication Critical patent/ATE141920T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
230000001681 protective effect Effects 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical class O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
TUCNEACPLKLKNU-UHFFFAOYSA-N acetyl Chemical group C[C]=O TUCNEACPLKLKNU-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000005840 aryl radicals Chemical class 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000004744 butyloxycarbonyl group Chemical group 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT93904150T 1992-02-07 1993-02-04 Verfahren zur herstellung von taxan-derivaten ATE141920T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9201379A FR2687150B1 (fr)	1992-02-07	1992-02-07	Procede de preparation de derives du taxane.

Publications (1)

Publication Number	Publication Date
ATE141920T1 true ATE141920T1 (de)	1996-09-15

Family

ID=9426424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93904150T ATE141920T1 (de)	1992-02-07	1993-02-04	Verfahren zur herstellung von taxan-derivaten

Country Status (24)

Country	Link
US (1)	US6596880B1 (de)
EP (1)	EP0625147B1 (de)
JP (1)	JP3295879B2 (de)
KR (1)	KR100254167B1 (de)
AT (1)	ATE141920T1 (de)
AU (1)	AU686095B2 (de)
CA (1)	CA2126462C (de)
CZ (1)	CZ283377B6 (de)
DE (1)	DE69304309T2 (de)
DK (1)	DK0625147T3 (de)
ES (1)	ES2090970T3 (de)
FI (1)	FI106959B (de)
FR (1)	FR2687150B1 (de)
GR (1)	GR3020894T3 (de)
HU (1)	HU212577B (de)
MX (1)	MX9300622A (de)
NO (1)	NO305863B1 (de)
NZ (1)	NZ249162A (de)
PL (1)	PL175106B1 (de)
RU (1)	RU2103266C1 (de)
SK (1)	SK280012B6 (de)
TW (1)	TW234122B (de)
WO (1)	WO1993016059A1 (de)
ZA (1)	ZA93823B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6794523B2 (en)	1991-09-23	2004-09-21	Florida State University	Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
CA2100808A1 (en) *	1992-10-01	1994-04-02	Vittorio Farina	Deoxy paclitaxels
ATE253563T1 (de)	1993-02-05	2003-11-15	Bryn Mawr College	Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten
US5948919A (en) *	1993-02-05	1999-09-07	Napro Biotherapeutics, Inc.	Paclitaxel synthesis from precursor compounds and methods of producing the same
US5684175A (en) *	1993-02-05	1997-11-04	Napro Biotherapeutics, Inc.	C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor
EP0700910A1 (de) *	1994-09-06	1996-03-13	Shionogi & Co., Ltd.	Isolierung von Taxol aus Taxus sumatrana
US5580899A (en) *	1995-01-09	1996-12-03	The Liposome Company, Inc.	Hydrophobic taxane derivatives
US5675025A (en) *	1995-06-07	1997-10-07	Napro Biotherapeutics, Inc.	Paclitaxel synthesis from precursor compounds and methods of producing the same
US6107332A (en)	1995-09-12	2000-08-22	The Liposome Company, Inc.	Hydrolysis-promoting hydrophobic taxane derivatives
US6051600A (en) *	1995-09-12	2000-04-18	Mayhew; Eric	Liposomal hydrolysis-promoting hydrophobic taxane derivatives
US5688977A (en) *	1996-02-29	1997-11-18	Napro Biotherapeutics, Inc.	Method for docetaxel synthesis
US5750737A (en) *	1996-09-25	1998-05-12	Sisti; Nicholas J.	Method for paclitaxel synthesis
IL144976A0 (en) *	1999-05-17	2002-06-30	Bristol Myers Squibb Co	A process for the preparation of paclitaxel
HUP0200651A3 (en)	2000-02-02	2002-10-28	Univ Florida State Res Found	C7 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them
HUP0200756A3 (en)	2000-02-02	2005-02-28	Univ Florida State Res Found	C7 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them
US6452025B1 (en)	2001-04-25	2002-09-17	Napro Biotherapeutics, Inc.	Three-step conversion of protected taxane ester to paclitaxel
US20050261367A1 (en) *	2004-03-29	2005-11-24	Howard Murad	Methods for treating dermatological and other health-related conditions in a patient
CN100586940C (zh) *	2007-01-26	2010-02-03	上海百灵医药科技有限公司	紫杉醇和多烯紫杉醇的半合成方法
KR101014438B1 (ko) *	2008-09-26	2011-02-14	동아제약주식회사	탁산 유도체의 제조방법
PL388144A1 (pl)	2009-05-29	2010-12-06	Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością	Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
EP2697211A4 (de) *	2011-04-01	2014-08-13	Shilpa Medicare Ltd	Verfahren zur herstellung von docetaxel und seinem hydrat
EA031986B1 (ru)	2012-04-04	2019-03-29	Галозим, Инк.	Способ и комбинация для лечения солидной раковой опухоли и набор, содержащий комбинацию
JP6427097B2 (ja)	2012-06-15	2018-11-21	ザブリガムアンドウィメンズホスピタルインコーポレイテッドＴｈｅＢｒｉｇｈａｍａｎｄＷｏｍｅｎ’ｓＨｏｓｐｉｔａｌ，Ｉｎｃ．	癌を処置するための組成物および該組成物を製造するための方法
AU2015241198A1 (en)	2014-04-03	2016-11-17	Invictus Oncology Pvt. Ltd.	Supramolecular combinatorial therapeutics
US20190351031A1 (en)	2018-05-16	2019-11-21	Halozyme, Inc.	Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR336841A (fr)	1903-10-29	1904-03-18	James William Mander	Perfectionnements apportés aux instruments employés pour le dessin
FR336840A (fr)	1903-10-29	1904-03-18	Emmanuel Saura	Machine à piston diviseur
FR2629819B1 (fr) *	1988-04-06	1990-11-16	Rhone Poulenc Sante	Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr)	1988-04-06	1990-11-16	Centre Nat Rech Scient	Procede de preparation du taxol

1992
- 1992-02-07 FR FR9201379A patent/FR2687150B1/fr not_active Expired - Fee Related
1993
- 1993-02-04 PL PL93304721A patent/PL175106B1/pl unknown
- 1993-02-04 NZ NZ249162A patent/NZ249162A/en not_active IP Right Cessation
- 1993-02-04 ES ES93904150T patent/ES2090970T3/es not_active Expired - Lifetime
- 1993-02-04 DK DK93904150.5T patent/DK0625147T3/da active
- 1993-02-04 RU RU94040356A patent/RU2103266C1/ru active
- 1993-02-04 JP JP51356393A patent/JP3295879B2/ja not_active Expired - Fee Related
- 1993-02-04 KR KR1019940702713A patent/KR100254167B1/ko not_active IP Right Cessation
- 1993-02-04 HU HU9402289A patent/HU212577B/hu unknown
- 1993-02-04 DE DE69304309T patent/DE69304309T2/de not_active Expired - Lifetime
- 1993-02-04 WO PCT/FR1993/000110 patent/WO1993016059A1/fr active IP Right Grant
- 1993-02-04 MX MX9300622A patent/MX9300622A/es unknown
- 1993-02-04 TW TW082100755A patent/TW234122B/zh not_active IP Right Cessation
- 1993-02-04 CZ CZ941870A patent/CZ283377B6/cs not_active IP Right Cessation
- 1993-02-04 AT AT93904150T patent/ATE141920T1/de active
- 1993-02-04 AU AU35048/93A patent/AU686095B2/en not_active Expired
- 1993-02-04 EP EP93904150A patent/EP0625147B1/de not_active Expired - Lifetime
- 1993-02-04 SK SK930-94A patent/SK280012B6/sk not_active IP Right Cessation
- 1993-02-04 US US08/256,736 patent/US6596880B1/en not_active Expired - Lifetime
- 1993-02-04 CA CA002126462A patent/CA2126462C/fr not_active Expired - Lifetime
- 1993-02-05 ZA ZA93823A patent/ZA93823B/xx unknown
1994
- 1994-08-04 NO NO942895A patent/NO305863B1/no not_active IP Right Cessation
- 1994-08-05 FI FI943643A patent/FI106959B/fi not_active IP Right Cessation
1996
- 1996-08-29 GR GR960401046T patent/GR3020894T3/el unknown

Also Published As

Publication number	Publication date
KR100254167B1 (ko)	2000-05-01
NO942895L (no)	1994-08-04
AU3504893A (en)	1993-09-03
KR950700267A (ko)	1995-01-16
FR2687150A1 (fr)	1993-08-13
WO1993016059A1 (fr)	1993-08-19
TW234122B (de)	1994-11-11
SK93094A3 (en)	1995-04-12
MX9300622A (es)	1993-08-01
JP3295879B2 (ja)	2002-06-24
AU686095B2 (en)	1998-02-05
FI943643A (fi)	1994-08-05
ZA93823B (en)	1993-09-16
DE69304309T2 (de)	1997-01-23
CA2126462A1 (fr)	1993-08-19
JPH07503472A (ja)	1995-04-13
FI106959B (fi)	2001-05-15
NO305863B1 (no)	1999-08-09
PL175106B1 (pl)	1998-11-30
DK0625147T3 (da)	1996-11-11
NO942895D0 (de)	1994-08-04
FI943643A0 (fi)	1994-08-05
US6596880B1 (en)	2003-07-22
SK280012B6 (sk)	1999-07-12
CA2126462C (fr)	2002-07-09
ES2090970T3 (es)	1996-10-16
HU212577B (en)	1996-08-29
GR3020894T3 (en)	1996-11-30
EP0625147A1 (de)	1994-11-23
DE69304309D1 (de)	1996-10-02
CZ283377B6 (cs)	1998-04-15
RU94040356A (ru)	1997-05-27
CZ187094A3 (en)	1994-12-15
EP0625147B1 (de)	1996-08-28
HU9402289D0 (en)	1994-10-28
NZ249162A (en)	1996-10-28
FR2687150B1 (fr)	1995-04-28
RU2103266C1 (ru)	1998-01-27
HUT68773A (en)	1995-07-28

Publication	Publication Date	Title
DE69304309D1 (de)	1996-10-02	Verfahren zur herstellung von taxan-derivaten
FR2678930B1 (fr)	1995-01-13	Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
NO923677L (no)	1993-03-24	Nye furyl- og thienylsubstituerte taksaner og farmasoeytiske preparater som inneholder slike
HUT65618A (en)	1994-07-28	Process for producing benzylidene-carbamoyl-2-pyrrolidone, -4-oxazolidinone, -4-thiazolidinone and -3-isothiazolidinone analogues
DE69332577D1 (de)	2003-01-30	Verfahren zur Herstellung von 13-Ether-Derivaten von Milbemycinen und Zwischenprodukte
RU95113717A (ru)	1996-12-27	Способ получения производных таксана и промежуточные продукты для их получения
ATE167662T1 (de)	1998-07-15	Verfahren zur herstellung eines lignan-derivats
ATE138571T1 (de)	1996-06-15	Verwendung von dioxabicyclo (3.3.0>octane derivaten zur herstellung eines arzneimittels zur hemmung des cholesterinmetabolismus.
EE03071B1 (et)	1998-02-16	Karbasolooni derivaadid ja nende saamise protsess
FR2677023B1 (fr)	1994-02-25	Derives de coumarine hydrosolubles, leur preparation et leur utilisation comme substrat d'enzyme.
DE69300766D1 (de)	1995-12-14	Verfahren zur herstellung von taxanderivaten.
GB8814603D0 (en)	1988-07-27	Intermediates for synthesis of anthocyanidines & processes for their production
ATE967T1 (de)	1982-05-15	Verfahren zur herstellung von xanthonderivaten.

Legal Events

Date	Code	Title	Description
1997-04-15	UEP	Publication of translation of european patent specification