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ATE110773T1 - Verfahren zur züchtung rekombinanter zellen. - Google Patents

Verfahren zur züchtung rekombinanter zellen.

Info

Publication number
ATE110773T1
ATE110773T1 AT88308386T AT88308386T ATE110773T1 AT E110773 T1 ATE110773 T1 AT E110773T1 AT 88308386 T AT88308386 T AT 88308386T AT 88308386 T AT88308386 T AT 88308386T AT E110773 T1 ATE110773 T1 AT E110773T1
Authority
AT
Austria
Prior art keywords
host cell
methods
recombinant cells
polypeptide factor
growing recombinant
Prior art date
Application number
AT88308386T
Other languages
English (en)
Inventor
Jennie P Mather
Axel Ullrich
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE110773T1 publication Critical patent/ATE110773T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT88308386T 1987-09-11 1988-09-12 Verfahren zur züchtung rekombinanter zellen. ATE110773T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9747287A 1987-09-11 1987-09-11

Publications (1)

Publication Number Publication Date
ATE110773T1 true ATE110773T1 (de) 1994-09-15

Family

ID=22263548

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88308386T ATE110773T1 (de) 1987-09-11 1988-09-12 Verfahren zur züchtung rekombinanter zellen.

Country Status (13)

Country Link
US (4) US6232117B1 (de)
EP (1) EP0307247B1 (de)
JP (1) JP2774996B2 (de)
AT (1) ATE110773T1 (de)
AU (1) AU616201B2 (de)
CA (1) CA1307484C (de)
DE (1) DE3851289T2 (de)
DK (1) DK175589B1 (de)
ES (1) ES2064355T3 (de)
IE (1) IE63589B1 (de)
IL (1) IL87737A (de)
NZ (1) NZ226136A (de)
PT (1) PT88479B (de)

Families Citing this family (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
JP3008208B2 (ja) * 1990-06-01 2000-02-14 武田薬品工業株式会社 新規ハイブリドーマ，その製造法および生理活性物質の製造法
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
CA2103583C (en) * 1991-02-08 2009-10-13 Walter D. Funk Recombinant transferrins, transferrin half-molecules and mutants thereof
US5986067A (en) * 1991-02-08 1999-11-16 The University Of Vermont And State Agricultural College Recombinant transferrins, transferrin half-molecules and mutants thereof
US6825037B1 (en) 1991-02-08 2004-11-30 University Of Vermont Recombinant transferrins, transferrin half-molecules and mutants thereof
DE4115722A1 (de) * 1991-05-14 1992-11-19 Boehringer Mannheim Gmbh Serumfreies medium zur kultivierung von saeugerzellen
ATE204606T1 (de) * 1991-12-06 2001-09-15 Genentech Inc Prohormon konvertase transformierte zellen.
US6348327B1 (en) 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
WO1993013196A2 (en) * 1991-12-24 1993-07-08 Genzyme Corporation Method for increasing recombinant protein production
JPH0763363B2 (ja) * 1991-12-25 1995-07-12 萩原 義秀 融合細胞の取得方法
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5708142A (en) 1994-05-27 1998-01-13 Genentech, Inc. Tumor necrosis factor receptor-associated factors
US6656466B1 (en) 1995-06-06 2003-12-02 Genetech, Inc. Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
US5721121A (en) * 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
US5705364A (en) * 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
AUPN442295A0 (en) * 1995-07-26 1995-08-17 Commonwealth Scientific And Industrial Research Organisation Regulated autocrine growth of mammalian cells
ATE242809T1 (de) 1995-09-08 2003-06-15 Genentech Inc Vegf-verwandtes protein
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
US6030945A (en) 1996-01-09 2000-02-29 Genentech, Inc. Apo-2 ligand
US6469144B1 (en) 1996-04-01 2002-10-22 Genentech, Inc. Apo-2LI and Apo-3 polypeptides
US6159462A (en) * 1996-08-16 2000-12-12 Genentech, Inc. Uses of Wnt polypeptides
US5851984A (en) * 1996-08-16 1998-12-22 Genentech, Inc. Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
US6462176B1 (en) 1996-09-23 2002-10-08 Genentech, Inc. Apo-3 polypeptide
US7696327B1 (en) 1997-10-17 2010-04-13 Genentech, Inc. Antibodies to human Toll homologues
US6100076A (en) 1997-01-31 2000-08-08 Genentech, Inc. O-fucosyltransferase
CA2277266A1 (en) 1997-01-31 1998-08-06 Genentech, Inc. O-fucosyltransferase
US6136569A (en) * 1997-02-27 2000-10-24 Genentech, Inc. Method of creating a cDNA library enriched in signal sequences
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US6551799B2 (en) 1999-12-07 2003-04-22 Genentech, Inc. Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
ATE393222T1 (de) 1997-09-18 2008-05-15 Genentech Inc Dcr3 polypeptid, ein tnfr homolog
EP1021542B1 (de) 1997-10-10 2009-03-04 Genentech, Inc. Apo-3 ligand
ES2313756T3 (es) 1997-10-29 2009-03-01 Genentech, Inc. Usos de polipeptido secretado wisp-1 inducido por wnt-1.
IL135607A0 (en) 1997-10-29 2001-05-20 Genentech Inc Wnt-1 inducible genes
US7192589B2 (en) 1998-09-16 2007-03-20 Genentech, Inc. Treatment of inflammatory disorders with STIgMA immunoadhesins
CA2309358A1 (en) 1997-11-21 1999-06-03 Genentech, Inc. A-33 related antigens and their pharmacological uses
NZ527899A (en) 1997-12-03 2004-10-29 Genentech Inc Polypeptides and nucleic acids with homology to acid-labile subunit of insulin-like growth factor
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
IL136326A0 (en) 1997-12-08 2001-05-20 Genentech Inc Human interferon-epsilon: a type i interferon
US6455250B1 (en) * 1997-12-11 2002-09-24 The Regents Of The University Of California Endonuclease compositions and methods of use
WO1999036535A1 (en) 1998-01-15 1999-07-22 Genentech, Inc. Apo-2 ligand
NZ525914A (en) 1998-03-10 2004-03-26 Genentech Inc Novel polypeptides and nucleic acids encoding the same
WO1999049028A1 (en) 1998-03-23 1999-09-30 Genentech, Inc. Method of selection for genes encoding secreted and transmembrane proteins
US7026138B1 (en) 1998-03-23 2006-04-11 Genentech, Inc. Polynucleotides encoding GFRα3
IL138593A0 (en) 1998-03-23 2001-10-31 Genentech Inc GFRα3 AND ITS USES
EP2333069A3 (de) 1998-05-15 2011-09-14 Genentech, Inc. Therapeutische verwendungen von il-17 homologe polypeptide
EP1865061A3 (de) 1998-05-15 2007-12-19 Genentech, Inc. IL-17-homologe Polypeptide und ihre therapeutische Verwendung
EP3112468A1 (de) 1998-05-15 2017-01-04 Genentech, Inc. Il-17-homologe polypeptide und therapeutische verwendung davon
US20020172678A1 (en) 2000-06-23 2002-11-21 Napoleone Ferrara EG-VEGF nucleic acids and polypeptides and methods of use
DK1115863T3 (da) 1998-09-22 2008-03-31 Genentech Inc Ucp4
US7399751B2 (en) * 1999-11-04 2008-07-15 Sertoli Technologies, Inc. Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
US7342102B2 (en) 1998-11-30 2008-03-11 Genentech, Inc. Uncoupling protein 5 (UCP5)
EP1135496B1 (de) 1998-11-30 2010-12-22 Genentech, Inc. Loslösendes protein 5 - ucp5
CA2450402A1 (en) 1998-12-22 2000-06-29 Genentech, Inc. Methods and compositions for inhibiting cancer cell growth comprising pro224
IL143593A0 (en) 1998-12-23 2002-04-21 Genentech Inc Il-1 related polypeptides
US6534061B1 (en) 1999-04-12 2003-03-18 Genentech, Inc. Tumor necrosis factor receptor homologs and nucleic acids encoding the same
DE60043322D1 (de) 1999-06-15 2009-12-24 Genentech Inc Sekretierte und Transmembran-Polypeptide sowie Nukleinsäuren zu deren Kodierung
EP1210411B1 (de) 1999-08-25 2006-10-18 Immunex Corporation Zusammensetzungen und verfahren für verbesserte zellkultur
JP4931310B2 (ja) 1999-10-20 2012-05-16 ジェネンテック， インコーポレイテッド ヘルパーｔ細胞性疾患の治療のためのｔ細胞分化の調節
EP1690872A3 (de) 1999-12-01 2006-08-23 Genentech, Inc. Zusammensetzung und Verfahren zur Diagnose eines Tumors
US7226591B2 (en) 2000-05-22 2007-06-05 Genentech, Inc. Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
DK1897947T3 (da) 1999-12-23 2012-04-10 Genentech Inc IL-17-homologe polypeptider og terapeutiske anvendelser deraf
EP1757311B1 (de) 1999-12-24 2009-02-11 Genentech, Inc. Verfahren und Zusammensetzungen zur Verlängerung der Entsorgungshalbwertszeit von biowirksamen Verbindungen
ATE422369T1 (de) 1999-12-24 2009-02-15 Genentech Inc Verfahren und zusammensetzungen zur verlängerung der entsorgungshalbwertszeit von biowirksamen verbindungen
EP1246917B1 (de) 2000-01-13 2009-03-04 Genentech, Inc. Menschliche stra6 polypeptide
ATE511857T1 (de) 2000-02-16 2011-06-15 Genentech Inc Anti-april monoklonaler antikörper und deren verwendung zur behandlung von immunerkrankungen oder krebs
PL357939A1 (en) 2000-04-11 2004-08-09 Genentech, Inc. Multivalent antibodies and uses therefor
CA2648051A1 (en) 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
EP2275549A1 (de) 2000-06-23 2011-01-19 Genentech, Inc. Zusammensetzungen und Verfahren zur Diagnose und Behandlung von Erkrankungen in Verbindung mit Angiogenese
EP2014298A3 (de) 2000-08-24 2009-10-07 Genentech, Inc. Interleukin-22-Polypeptide, Nukleinsäuren zu deren Codierung und Verfahren zur Behandlung von Bauchspeicheldrüsenerkrankungen
EP1944317A3 (de) 2000-09-01 2008-09-17 Genentech, Inc. Sekretierte und Transmembran-Polypeptide sowie Nukleinsäure zu deren Kodierung
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
ES2361824T3 (es) 2000-12-20 2011-06-22 F. Hoffmann-La Roche Ag Conjugados de eritropoyetina (epo) con polietilenglicol (peg).
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
AU2002254400B2 (en) * 2001-03-23 2007-08-09 Napro Biotherapeutics, Inc. Molecular conjugates for use in treatment of cancer
WO2002099089A1 (en) * 2001-06-04 2002-12-12 Corixa Corporation Compositions and methods for high-level, large-scale production of recombinant proteins
US20070160576A1 (en) 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
JP2004537534A (ja) 2001-06-20 2004-12-16 ジェネンテック・インコーポレーテッド 腫瘍の診断及び治療のための組成物及び方法
EP2311960A3 (de) 2001-08-29 2011-06-01 Genentech, Inc. Bv8-Nukleinsäuren und Polypeptide mit mitogener Aktivität
EP2151244A1 (de) 2001-09-18 2010-02-10 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
US20030228319A1 (en) 2002-04-16 2003-12-11 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
KR100801388B1 (ko) 2002-01-02 2008-02-05 제넨테크, 인크. 종양의 진단 및 치료 방법 및 이를 위한 조성물
US7164002B2 (en) 2002-02-06 2007-01-16 Genentech, Inc. FVIIa antagonists
EP1575480A4 (de) 2002-02-22 2008-08-06 Genentech Inc Zusammensetzungen und verfahren zur behandlung von immunbedingten erkrankungen
WO2004004649A2 (en) 2002-07-08 2004-01-15 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
EP1539228B1 (de) 2002-09-11 2010-12-29 Genentech, Inc. Neue zusammensetzung und verfahren zur behandlung von immunerkrankungen
EP2116616A3 (de) 2002-09-11 2010-03-17 Genentech, Inc. In aktivierten T-Zellen differentiell exprimierte Gene und deren Verwendungen
WO2004024072A2 (en) 2002-09-11 2004-03-25 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
WO2004024097A2 (en) 2002-09-16 2004-03-25 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
EP2500438A3 (de) 2002-09-25 2012-11-28 Genentech, Inc. Neue Zusammensetzungen und Verfahren zur Behandlung von Psoriasis
EP2322200A3 (de) 2002-10-29 2011-07-27 Genentech, Inc. Gestaltungen und Methoden für die Behandlung von immune verwandte Krankheiten
EP1581169A4 (de) 2002-11-08 2008-09-17 Genentech Inc Zusammensetzungen und verfahren zurbehandlung von erkrankungen in verbindung mit natürlichen killerzellen
WO2004047728A2 (en) 2002-11-26 2004-06-10 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
EP1578799B8 (de) * 2002-12-02 2011-03-23 Amgen Fremont Inc. Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
JP4912144B2 (ja) 2003-03-12 2012-04-11 ジェネンテック， インコーポレイテッド 造血促進のためのｂｖ８及び／又はｅｇ−ｖｅｇｆの使用
SI2335725T1 (sl) 2003-04-04 2017-01-31 Genentech, Inc. Visokokoncentrirane formulacije protiteles in proteinov
CA2531022C (en) * 2003-07-03 2014-09-09 Jannette Dufour Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants
PL2784084T5 (pl) 2003-07-08 2024-12-02 Novartis Pharma Ag Przeciwciała antagonistyczne heterologicznych polipeptydów il-17a/f
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
EP2412725A3 (de) 2003-11-17 2012-04-25 Genentech, Inc. Antikörper gegen CD79b zur Behandlung von Tumoren hämatopoetischen Ursprungs
US7858843B2 (en) 2005-06-06 2010-12-28 Genentech, Inc. Gene disruptions, compositions and methods relating thereto
AU2006312014A1 (en) * 2005-11-02 2007-05-18 Wyeth Methods for adapting mammalian cells
US20070231895A1 (en) * 2005-11-02 2007-10-04 Lee Gene W Methods for adapting mammalian cells
WO2007062090A2 (en) 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays
US20070190057A1 (en) 2006-01-23 2007-08-16 Jian Wu Methods for modulating mannose content of recombinant proteins
CA2647277A1 (en) 2006-04-05 2007-11-08 Genentech, Inc. Method for using boc/cdo to modulate hedgehog signaling
WO2008036437A2 (en) 2006-04-19 2008-03-27 Genentech, Inc. Novel gene disruptions, compositions and methods relating thereto
AU2007244683A1 (en) 2006-04-27 2007-11-08 Pikamab, Inc. Methods and compositions for antibody therapy
CA2659990C (en) 2006-08-04 2016-03-22 Prolong Pharmaceuticals, Inc. Polyethylene glycol erythropoietin conjugates
US8623830B2 (en) 2006-09-12 2014-01-07 Beth Israel Deaconess Medical Center, Inc. Compositions containing α-1-antitrypsin and methods for use
BRPI0716680A2 (pt) 2006-11-02 2013-09-24 Daniel J Capon "composto, multÍmero, composiÇço, mÉtodo de afetar a atividade de um alvo, complexo, processo de produÇço do composto, mÉtodo de produÇço de um extensço de aminoÁcidos consecutivos, processo de produÇço de uma extensço de aminoacidos consecutivos , processo para a produÇço de um composto , mÉtodo de produÇço de uma proteina e polipeptÍdeo"
WO2008115039A1 (en) 2007-03-22 2008-09-25 Industry Academic Cooperation Foundation, The Catholic University Of Korea Novel use of ec-sod and method for preparing thereof
US9089564B2 (en) 2007-03-22 2015-07-28 The Catholic University of Korea Industry-Academic Cooperatior Use of EC-SOD for treating angiogenesis-mediated eye diseases
EP2188302B1 (de) 2007-07-09 2017-11-01 Genentech, Inc. Verhinderung der reduktion der disulfidbindung während der rekombinanten herstellung von polypeptiden
HRP20131108T1 (hr) 2007-09-05 2014-01-31 Genentech, Inc. Biološki aktivan arginin koji na c-završetku sadrži peptide
US8030454B2 (en) 2007-12-28 2011-10-04 Genentech, Inc. Anti-hedgehog antibodies
ES2517603T3 (es) 2008-04-07 2014-11-03 Bayer Healthcare, Llc Procedimientos de producción recombinante de glucoproteínas
WO2010021415A1 (en) 2008-08-18 2010-02-25 Seoul National University Industry Foundation Method for controlling cancer metastasis or cancer cell migration by modulating the cellular level of lysyl trna synthetase
KR20130099255A (ko) 2008-09-15 2013-09-05 제넨테크, 인크. 세포 오스몰농도를 조절하기 위한 조성물 및 방법
US8901081B2 (en) 2008-10-10 2014-12-02 Snu R&Db Foundation Uses of GRS proteins or fragments thereof
BRPI0917592B1 (pt) 2008-12-09 2021-08-17 Genentech, Inc Anticorpo anti-pd-l1, composição, artigos manufaturados e usos de uma composição
MX355650B (es) 2009-08-11 2018-04-26 Genentech Inc Produccion de proteinas en medios de cultivo de celulas libres de glutamina.
EP2480569B1 (de) 2009-09-23 2016-04-13 ratiopharm GmbH Verfahren zur reinigung von rekombinantem humanem erythropoietin (epo)
AU2010324686B2 (en) 2009-11-30 2016-05-19 Genentech, Inc. Antibodies for treating and diagnosing tumors expressing SLC34A2 (TAT211 = SEQID2 )
PE20130460A1 (es) 2010-05-03 2013-04-26 Genentech Inc Composiciones y metodos para el diagnostico y tratamiento de tumores
EA030418B1 (ru) 2010-07-12 2018-08-31 ЭйТИР ФАРМА, ИНК. ТЕРАПЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ДЛЯ ЛЕЧЕНИЯ ВОСПАЛИТЕЛЬНОГО ЗАБОЛЕВАНИЯ, ПОЛИПЕПТИД АМИНОАЦИЛ-тРНК-СИНТЕТАЗЫ (AARS)
BR112013003279A2 (pt) 2010-08-13 2016-06-14 Genentech In “métodos para tratar uma doença, método para neutralizar ou bloquear a atividade de il-1ß e/ou il-18, anticorpo, usos de um anticorpo e usos de um anticorpo monoclonal”
WO2012075238A1 (en) 2010-12-02 2012-06-07 Genentech, Inc. Novel receptor-ligand interaction and uses thereof
WO2012088383A2 (en) 2010-12-23 2012-06-28 Genentech, Inc. PILR alpha INTERACTIONS AND METHODS OF MODIFYING SAME
CN102586190B (zh) * 2011-01-11 2014-01-01 北京华安科创生物技术有限公司 高效表达重组人神经生长因子的cho细胞株及其构建方法
DK2751129T3 (en) 2011-11-23 2018-02-05 Cell Biotech Co Ltd Protein P14 with anti-cancer and anti-allergy activity and pharmaceutical composition comprising the same
RU2639564C2 (ru) 2011-12-16 2017-12-21 Браскем С.А. Модифицированные микроорганизмы и способы получения бутадиена с их применением
EP3311847A1 (de) 2012-02-16 2018-04-25 Atyr Pharma, Inc. Histidyl-trna-synthetasen zur behandlung von autoimmun- und entzündungserkrankungen
US9493744B2 (en) 2012-06-20 2016-11-15 Genentech, Inc. Methods for viral inactivation and other adventitious agents
US20130281355A1 (en) 2012-04-24 2013-10-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
PT2841087T (pt) 2012-04-27 2017-11-27 Us Health Antagonistas de fator de crescimento endotelial vascular e métodos para utilização dos mesmos
EP2749569A1 (de) * 2012-12-28 2014-07-02 Annibale Alessandro Puca Variante des BPIFB4-Proteins
SG11201506497SA (en) 2013-03-15 2015-09-29 Glaxosmithkline Ip No 2 Ltd Use of tricarboxylic acid (tca) intermediates to control ammonia generation in cell culture
US10017732B2 (en) 2013-03-15 2018-07-10 Genentech, Inc. Cell culture compositions with antioxidants and methods for polypeptide production
EP2968495B1 (de) 2013-03-15 2019-07-03 Daniel J. Capon Hybrides immunglobulin mit nichtpeptidylverbindung
EP2970921B1 (de) 2013-03-15 2018-09-19 aTyr Pharma, Inc. Histidyl-trna-synthetase-fc-konjugate
EP2829608A1 (de) 2013-07-23 2015-01-28 Universität Bielefeld Verfahren zur Herstellung von rekombinanten Proteinen in Säugerzellen
BR112016006321B1 (pt) 2013-09-23 2022-11-16 Braskem S.A Enzima engenheirada tendo especificidade de substrato aceto acetil-coa e atividade aceto acetil-coa específica de hidrolase, micro-organismo modificado, e, processo de produção de um ou mais produtos a partir de uma fonte de carbono fermentável
HUE065394T2 (hu) 2013-11-15 2024-05-28 Hoffmann La Roche Vírusok inaktiválására szolgáló eljárások környezetbarát detergensek alkalmazásával
LT3110961T (lt) 2014-02-27 2020-02-10 F. Hoffmann-La Roche Ag Ląstelių augimo ir glikozilinimo moduliavimas, gaminant rekombinantinį glikoproteiną
EP4169944A1 (de) 2014-03-14 2023-04-26 Biomolecular Holdings LLC Verfahren zur herstellung von hybridimmunglobulin mit nichtpeptidylverbindung
PE20161326A1 (es) 2014-04-10 2016-12-11 Bayer Healthcare Llc Formulacion en polvo de medio de compuesto y metodo de preparacion de medio liquido para cultivo celular
KR101619863B1 (ko) 2014-05-23 2016-05-24 주식회사 제노포커스 신규 베타-갈락토시다아제
WO2015184327A1 (en) 2014-05-30 2015-12-03 Braskem S.A. Modified microorganisms comprising an optimized system for oligosaccharide utilization and methods of using same
KR101730035B1 (ko) 2015-03-20 2017-04-26 한국과학기술원 L-아스파르트산 유도체를 생산하는 변이미생물 및 이를 이용한 l-아스파르트산 유도체의 제조방법
KR101839595B1 (ko) 2015-04-13 2018-04-26 한국과학기술원 락탐의 제조방법
KR20160141123A (ko) 2015-05-28 2016-12-08 주식회사 제노포커스 고당전이 활성의 베타-갈락토시다제 변이체 및 그 용도
KR101702906B1 (ko) 2015-07-15 2017-02-22 주식회사 제노포커스 신규 알파-1,3-글루카나제
TWI899515B (zh) 2015-08-04 2025-10-01 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
KR101756338B1 (ko) 2016-01-15 2017-07-10 고려대학교 산학협력단 L-시스테인 생산용 변이미생물 및 이를 이용한 l-시스테인의 제조방법
KR102449406B1 (ko) 2016-08-02 2022-09-29 백시넥스 인코포레이티드 백시니아 바이러스/진핵 세포에서 폴리뉴클레오티드 라이브러리를 생산하기 위한 개선된 방법
EP3339444A1 (de) 2016-12-20 2018-06-27 Mabxience Research, S.L. Verfahren zur herstellung eines glycoproteins mit erhöhtem prozentualem anteil an afucosylierten glycanen
US11767520B2 (en) 2017-04-20 2023-09-26 Atyr Pharma, Inc. Compositions and methods for treating lung inflammation
SG11202009542PA (en) 2018-03-29 2020-10-29 Genentech Inc Modulating lactogenic activity in mammalian cells
KR102658830B1 (ko) 2018-08-02 2024-04-19 에스케이이노베이션 주식회사 내열성 탄산무수화효소 변이체 및 이를 포함하는 이산화탄소 포집용 조성물
AR117327A1 (es) 2018-12-20 2021-07-28 23Andme Inc Anticuerpos anti-cd96 y métodos de uso de estos
JP2022514950A (ja) 2018-12-21 2022-02-16 ２３アンドミー・インコーポレイテッド 抗ｉｌ－３６抗体およびその使用方法
KR102346050B1 (ko) 2019-01-25 2022-01-03 주식회사 네오믹스 미백 활성을 갖는 신규 폴리펩타이드 및 이의 용도
JP7586714B2 (ja) * 2019-02-28 2024-11-19 京東方科技集團股▲ふん▼有限公司 網膜色素上皮細胞シート及びその作製方法
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
EP4127153A2 (de) 2020-03-26 2023-02-08 Genentech, Inc. Modifizierte säugetierzellen mit reduzierten wirtszellproteinen
IL297191A (en) 2020-04-15 2022-12-01 Genentech Inc A method for treating the medium before inoculation
JP2023528375A (ja) 2020-05-29 2023-07-04 ２３アンドミー・インコーポレイテッド 抗ｃｄ２００ｒ１抗体及びその使用方法
US20230235040A1 (en) 2020-06-22 2023-07-27 Almirall, S.A. Anti-il-36 antibodies and methods of use thereof
JP2023533217A (ja) 2020-06-24 2023-08-02 ジェネンテック， インコーポレイテッド アポトーシス耐性細胞株
MX2023001440A (es) 2020-08-07 2023-03-06 Genentech Inc Proteinas de fusion del ligando para flt3 y metodos de uso.
JP2023539201A (ja) 2020-08-28 2023-09-13 ジェネンテック， インコーポレイテッド 宿主細胞タンパク質のＣＲＩＳＰＲ／Ｃａｓ９マルチプレックスノックアウト
US20240082387A1 (en) 2020-09-07 2024-03-14 Gi Cell, Inc. Fusion protein comprising coronavirus-derived receptor-binding domain and nucleocapsid protein, and use thereof
KR20220059399A (ko) 2020-11-02 2022-05-10 한국과학기술원 소수성 물질의 생산능이 향상된 재조합 미생물 및 이의 제조를 위한 세포막 엔지니어링 방법
JP2023549809A (ja) 2020-11-16 2023-11-29 エフ． ホフマン－ラ ロシュ アーゲー Ｆａｂ高マンノースグリコフォーム
KR102661294B1 (ko) 2020-12-24 2024-04-30 한국과학기술원 글루타르산 수송체 유전자가 도입된 재조합 미생물 및 이를 이용한 글루타르산의 제조방법
EP4326855A1 (de) 2021-04-19 2024-02-28 Genentech, Inc. Modifizierte säugerzellen
CN117813504A (zh) 2021-06-04 2024-04-02 基因泰克公司 对蛋白质样品中的残留宿主细胞蛋白质的鉴定和定量
CN117916594A (zh) 2021-09-15 2024-04-19 基因泰克公司 代谢组学分析
EP4624488A1 (de) 2022-11-25 2025-10-01 Gil Medical Center Verwendung des fgf5-transkriptvarianten-2-gens und proteins davon zur prävention, hemmung und behandlung von leberfibrose
CN120693406A (zh) 2022-12-12 2025-09-23 基因泰克公司 优化多肽唾液酸含量
WO2025128536A1 (en) 2023-12-14 2025-06-19 Genentech, Inc. Disulfide isoform modulation
WO2025137086A1 (en) 2023-12-20 2025-06-26 Genentech, Inc. Reducing alpha-gal
WO2025221977A1 (en) 2024-04-19 2025-10-23 Genentech, Inc. Method of monitoring and controlling the foam within a vessel
WO2026006162A2 (en) 2024-06-24 2026-01-02 Genentech, Inc. B vitamin modulation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55156591A (en) * 1979-05-23 1980-12-05 Ajinomoto Co Inc Method for stabilizing property of bacteria containing plasmid
US4673649A (en) 1983-07-15 1987-06-16 University Patents, Inc. Process and defined medium for growth of human epidermal keratinocyte cells
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
AU600885B2 (en) 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
EP0163404B1 (de) 1984-05-28 1990-06-27 MITSUI TOATSU CHEMICALS, Inc. Mittel für die Absorption und Entweichung von Wasserdampf
EP0189481B1 (de) 1984-07-13 1991-01-23 Chiron Corporation Insulinähnlicher Wachstumsfaktor II
JPS6328386A (ja) 1986-07-21 1988-02-06 Asahi Chem Ind Co Ltd 細胞培養方法
JP2796547B2 (ja) * 1987-09-11 1998-09-10 ジェネンテク，インコーポレイテッド 組換え細胞培養中でのポリペプチド発現の増大法
JPH01217488A (ja) * 1988-02-26 1989-08-31 Canon Inc 板書記録装置

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AU2212088A (en) 1989-05-25
US6235498B1 (en) 2001-05-22
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DK175589B1 (da) 2004-12-13
CA1307484C (en) 1992-09-15
PT88479A (pt) 1989-07-31
JPH02467A (ja) 1990-01-05
DE3851289D1 (de) 1994-10-06
US6232117B1 (en) 2001-05-15
IL87737A (en) 1993-08-18
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US20010000488A1 (en) 2001-04-26
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US6399331B2 (en) 2002-06-04
ES2064355T3 (es) 1995-02-01
DK506488A (da) 1989-03-12
PT88479B (pt) 1993-05-31
EP0307247B1 (de) 1994-08-31
JP2774996B2 (ja) 1998-07-09
EP0307247A3 (en) 1990-08-22
DE3851289T2 (de) 1995-03-02
IE882768L (en) 1989-03-11

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