[go: up one dir, main page]

ATE107289T1 - Verfahren zur herstellung von 1-phenylimidazolin- 2,5-dion-derivate. - Google Patents

Verfahren zur herstellung von 1-phenylimidazolin- 2,5-dion-derivate.

Info

Publication number
ATE107289T1
ATE107289T1 AT90403725T AT90403725T ATE107289T1 AT E107289 T1 ATE107289 T1 AT E107289T1 AT 90403725 T AT90403725 T AT 90403725T AT 90403725 T AT90403725 T AT 90403725T AT E107289 T1 ATE107289 T1 AT E107289T1
Authority
AT
Austria
Prior art keywords
preparation
formula
image
phenylimidazoline
denote
Prior art date
Application number
AT90403725T
Other languages
English (en)
Inventor
Patrick Seuron
Daniel Varraillon
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Application granted granted Critical
Publication of ATE107289T1 publication Critical patent/ATE107289T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Reinforced Plastic Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT90403725T 1989-12-22 1990-12-21 Verfahren zur herstellung von 1-phenylimidazolin- 2,5-dion-derivate. ATE107289T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8917046A FR2656302B1 (fr) 1989-12-22 1989-12-22 Nouveau procede de preparation de l'anandron et derives de l'anandron.

Publications (1)

Publication Number Publication Date
ATE107289T1 true ATE107289T1 (de) 1994-07-15

Family

ID=9388859

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90403725T ATE107289T1 (de) 1989-12-22 1990-12-21 Verfahren zur herstellung von 1-phenylimidazolin- 2,5-dion-derivate.

Country Status (24)

Country Link
US (1) US5166358A (de)
EP (1) EP0436426B1 (de)
JP (1) JP2836041B2 (de)
KR (1) KR0173307B1 (de)
CN (1) CN1048011C (de)
AT (1) ATE107289T1 (de)
AU (1) AU628699B2 (de)
CA (1) CA2032988C (de)
CZ (1) CZ281655B6 (de)
DE (1) DE69009964T2 (de)
DK (1) DK0436426T3 (de)
ES (1) ES2055382T3 (de)
FI (1) FI103203B1 (de)
FR (1) FR2656302B1 (de)
HU (1) HU207301B (de)
IE (1) IE65510B1 (de)
IL (1) IL96696A (de)
NZ (1) NZ236621A (de)
PL (1) PL164694B1 (de)
PT (1) PT96313B (de)
RU (1) RU1836356C (de)
SK (1) SK278447B6 (de)
UA (1) UA27220C2 (de)
ZA (1) ZA909648B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
US5656651A (en) * 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
FR2741346B1 (fr) * 1995-11-16 1997-12-19 Roussel Uclaf Nouveau procede de preparation de derives phenylimidazolidine
FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
JPH1072446A (ja) * 1996-06-24 1998-03-17 Sumitomo Chem Co Ltd １−置換−ヒダントイン類の製造法
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
IL152719A0 (en) * 2000-06-28 2003-06-24 Bristol Myers Squibb Co Selective androgen receptor modulators and methods for their identification
EP1854798A3 (de) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Kondensierte heterozyklische Succinimid-Verbindungen und Analoga daraus, Modulatoren der nuklearen Hormonrezeptorfunktion
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
PL206962B1 (pl) 2001-12-19 2010-10-29 Bristol Myers Squibb Co Związek heterocykliczny o budowie skondensowanej
JP2007514442A (ja) * 2003-12-19 2007-06-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 前立腺癌治療を評価するための方法および物質
AU2005232526B2 (en) * 2004-02-24 2011-06-23 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
US7709517B2 (en) * 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
LT3100727T (lt) 2006-03-27 2018-12-10 The Regents Of The University Of California Androgeno receptoriaus moduliatorius, skirtas prostatos vėžio ir su androgeno receptoriumi susijusių ligų gydymui
CN101460467B (zh) * 2006-03-29 2012-09-19 加利福尼亚大学董事会 二芳基硫代乙内酰脲化合物
EP2620432A3 (de) 2007-10-26 2013-12-18 The Regents Of the University of California Diarylhydantoinverbindungen
KR101819199B1 (ko) 2010-02-16 2018-01-16 아라곤 파마슈티컬스, 인코포레이티드 안드로겐 수용체 조절제 및 이의 용도
MY180834A (en) 2012-09-26 2020-12-10 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
JP7201694B2 (ja) 2017-10-16 2023-01-10 アラゴン ファーマシューティカルズ，インコーポレイテッド 非転移性去勢抵抗性前立腺癌の治療のための抗アンドロゲン剤

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH166004A (de) * 1934-06-06 1933-12-15 Chem Fab Vormals Sandoz Verfahren zur Darstellung eines Derivates des 5,5-Phenyläthylhydantoins.
US2490813A (en) * 1944-11-29 1949-12-13 Standard Oil Co Continuous process for making aryl amines
US2759002A (en) * 1954-03-24 1956-08-14 Abbott Lab 3-benzyl hydantoin and process
US3134663A (en) * 1957-07-23 1964-05-26 Geigy Chem Corp Herbicidal composition and method employing hydantoins
US3914311A (en) * 1973-06-15 1975-10-21 Du Pont Preparation of aromatic secondary and tertiary amines using a nickel complex catalyst
DE2414613A1 (de) * 1974-03-26 1975-10-16 Bayer Ag 1-aryl-5-alkyliden-2,4-dioxo-imidazolidine
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
CA1138334A (en) * 1977-10-28 1982-12-28 Karl Bernauer Pharmaceutical preparations containing certain urea derivatives
GB1598166A (en) * 1978-05-23 1981-09-16 Lilly Industries Ltd 3,5-disubstituted hydantoin derivatives
US4764625A (en) * 1980-12-12 1988-08-16 Xerox Corporation Process for preparing arylamines
DE3382406D1 (de) * 1982-04-08 1991-10-17 Shell Int Research Neue hydantoine, ihre herstellung und verwendung.

Also Published As

Publication number Publication date
IE65510B1 (en) 1995-11-01
CN1048011C (zh) 2000-01-05
AU6826590A (en) 1991-06-27
RU1836356C (ru) 1993-08-23
US5166358A (en) 1992-11-24
IE904142A1 (en) 1991-07-03
IL96696A (en) 1995-08-31
KR910011799A (ko) 1991-08-07
AU628699B2 (en) 1992-09-17
SK656790A3 (en) 1997-06-04
KR0173307B1 (ko) 1999-02-01
PL288365A1 (en) 1991-09-09
HU207301B (en) 1993-03-29
JPH04103573A (ja) 1992-04-06
PT96313B (pt) 1998-06-30
DE69009964D1 (de) 1994-07-21
FI906366L (fi) 1991-06-23
EP0436426B1 (de) 1994-06-15
CN1052666A (zh) 1991-07-03
DK0436426T3 (da) 1994-07-04
EP0436426A1 (de) 1991-07-10
CA2032988C (fr) 2003-04-29
CZ656790A3 (en) 1996-08-14
JP2836041B2 (ja) 1998-12-14
HU908416D0 (en) 1991-07-29
CZ281655B6 (cs) 1996-12-11
ZA909648B (en) 1992-02-26
FI103203B (fi) 1999-05-14
FI103203B1 (fi) 1999-05-14
ES2055382T3 (es) 1994-08-16
FR2656302A1 (fr) 1991-06-28
NZ236621A (en) 1992-04-28
CA2032988A1 (fr) 1991-06-23
SK278447B6 (en) 1997-06-04
UA27220C2 (uk) 2000-08-15
PT96313A (pt) 1991-09-30
PL164694B1 (pl) 1994-09-30
IL96696A0 (en) 1991-09-16
DE69009964T2 (de) 1994-10-13
FR2656302B1 (fr) 1992-05-07
FI906366A0 (fi) 1990-12-21

Similar Documents

Publication Publication Date Title
DE69009964D1 (de) Verfahren zur Herstellung von 1-Phenylimidazolin-2,5-dion-Derivate.
DE69114637D1 (de) Verbesserte Verfahren zur Herstellung von Zyklopentadienyleisen(II)arenen.
BR8405160A (pt) Compostos sensiveis a luz,mistura sensivel a luz a base dos mesmos e processo para obtencao de tais compostos
DE3761307D1 (de) Herstellung von fibraten.
PT71773A (de) Verfahren zur herstellung von substituierten oxirancarbonsauren
DE69226590D1 (de) Verfahren zur Herstellung von substituierten N-Aryl-1,2,4-Triazolopyrimidin-2-Sulfonamiden
ATE90676T1 (de) Dioxyalkylenaryl-dihydropyridine zwischenprodukte zu ihrer herstellung, verfahren zu ihrer herstellung und ihre verwendung.
DE58907421D1 (de) Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung und ihre Verwendung.
DE69513110D1 (de) Verfahren zur Herstellung von exotherm reagierenden Zusammensetzungen
ATE88202T1 (de) Bismaleimid-siloxane und verfahren zu deren herstellung.
SE8001556L (sv) Tetrahydrobensotiazolylimidazolidinoner
ATE90682T1 (de) Verfahren zur herstellung von cefodizim.
ATE38665T1 (de) Verfahren zur herstellung von 5-perfluoralkyl-5,6-dihydrouracyl-derivaten und verwendbare zwischenprodukte.
ATE23993T1 (de) Verfahren zur herstellung von o,o'dithiobenzamiden.
DE69113323D1 (de) Verfahren zur Herstellung von alpha-Hydroxycarbonsäure amiden.
DE69011901D1 (de) 1-Arylsulfonyl-2-piperidinon-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, ihre Verwendung als Arzneimittel und sie enthaltende Zusammensetzungen.
ATE42542T1 (de) 3-amino-azetidin, seine salze, verfahren zu deren herstellung und zwischenprodukte.
KR850000390A (ko) 치환된 알칸티오카복실산 유도체의 제조방법
DE69612337D1 (de) Verfahren zur Herstellung von Alkylanilin-Verbindungen
ATE11139T1 (de) 2-(n-aryl-n-1,2,3-thiadiazolylcarbonyl)aminobutyrolactone, verfahren zu ihrer herstellung, diese enthaltende fungizide mittel und ihre anwendung als fungizide.
ES528460A0 (es) Procedimiento de preparacion de nuevos deridados de alfa-etibenzol con un grupo amino propanolico sustituido y sus sales de adicion acidas y amonicas cuaternarias.
ATE71618T1 (de) 2-anilino-chinoline, verfahren zu ihrer herstellung und diese enthaltende fungizide.
MX22863A (es) Procedimiento de preparacion de nuevos derivados sustituidos en posicion 15 de la 20,21-dinoreburnamenina.
ES483300A1 (es) Un procedimiento para la preparacion de derivados de benzo- diacepina
DE60001615D1 (de) Verfahren zur Herstellung von trisubstituierten Oxazolen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time