ATA691077A - Verfahren zur herstellung von neuen 9alpha,21- -dihaolgen-11beta, 17alpha-dihydroxy-6alpha- -fluor-16beta-methyl-pregna-1,4- dien-3,20- -dion-verbindungen - Google Patents

Verfahren zur herstellung von neuen 9alpha,21- -dihaolgen-11beta, 17alpha-dihydroxy-6alpha- -fluor-16beta-methyl-pregna-1,4- dien-3,20- -dion-verbindungen

Info

Publication number: ATA691077A
Authority: AT; Austria
Prior art keywords: dihaolgen; 16beta; 9alpha; 6alpha; 11beta
Prior art date: 1976-09-29

Application number

AT691077A

Other languages

English (en)

Other versions

AT363197B (de

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-29

Filing date

1977-09-28

Publication date

1980-12-15

1977-09-28 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1979-02-28 Priority to AT151479A priority Critical patent/AT363204B/de

1979-02-28 Priority to AT0151379A priority patent/AT363203B/de

1979-02-28 Priority to AT0151279A priority patent/AT363202B/de

1980-12-15 Publication of ATA691077A publication Critical patent/ATA691077A/de

1981-07-10 Application granted granted Critical

1981-07-10 Publication of AT363197B publication Critical patent/AT363197B/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT0691077A 1976-09-29 1977-09-28 Verfahren zur herstellung von neuen 9alpha,21-dihalogen-11beta, 17alpha-dihydroxy-6alpha-fluor-16beta-methyl-pregna-1,4-dien-3,20-dion-verbindungen AT363197B (de)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
AT151479A AT363204B (de)	1976-09-29	1979-02-28	Verfahren zur herstellung von mehrfach halogenierten steroiden
AT0151379A AT363203B (de)	1976-09-29	1979-02-28	Verfahren zur herstellung von neuen 9alpha,21-
AT0151279A AT363202B (de)	1976-09-29	1979-02-28	Verfahren zur herstellung von neuen mehrfach halogenierten steroiden

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
LU75903A LU75903A1 (de)	1976-09-29	1976-09-29

Publications (2)

Publication Number	Publication Date
ATA691077A true ATA691077A (de)	1980-12-15
AT363197B AT363197B (de)	1981-07-10

Family

ID=19728370

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT0691077A AT363197B (de)	1976-09-29	1977-09-28	Verfahren zur herstellung von neuen 9alpha,21-dihalogen-11beta, 17alpha-dihydroxy-6alpha-fluor-16beta-methyl-pregna-1,4-dien-3,20-dion-verbindungen
AT0151379A AT363203B (de)	1976-09-29	1979-02-28	Verfahren zur herstellung von neuen 9alpha,21-
AT0151279A AT363202B (de)	1976-09-29	1979-02-28	Verfahren zur herstellung von neuen mehrfach halogenierten steroiden

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
AT0151379A AT363203B (de)	1976-09-29	1979-02-28	Verfahren zur herstellung von neuen 9alpha,21-
AT0151279A AT363202B (de)	1976-09-29	1979-02-28	Verfahren zur herstellung von neuen mehrfach halogenierten steroiden

Country Status (24)

Country	Link
JP (1)	JPS5356652A (de)
AT (3)	AT363197B (de)
AU (1)	AU514200B2 (de)
BE (1)	BE859120A (de)
CA (1)	CA1101410A (de)
CH (9)	CH624967A5 (de)
CY (1)	CY1178A (de)
DD (1)	DD133150A5 (de)
DE (1)	DE2743069C2 (de)
DK (1)	DK146017C (de)
ES (1)	ES462763A1 (de)
FR (1)	FR2366311A1 (de)
GB (1)	GB1563638A (de)
HK (1)	HK16683A (de)
HU (1)	HU175218B (de)
IE (1)	IE46047B1 (de)
IL (1)	IL53012A (de)
KE (1)	KE3258A (de)
LU (1)	LU75903A1 (de)
MY (1)	MY8400092A (de)
NL (1)	NL7710089A (de)
SE (1)	SE436751B (de)
SG (1)	SG3383G (de)
ZA (1)	ZA775800B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL187577C (nl) *	1978-04-05	1991-11-18	Sibla Srl	3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
DE3227312A1 (de) *	1982-07-19	1984-01-19	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
JPH05501115A (ja) *	1990-03-27	1993-03-04	シェリング・コーポレーション	９α―ヒドロキシ　ステロイドの脱水法
US5972922A (en) *	1990-06-11	1999-10-26	Alcon Laboratories, Inc.	Steroids which inhibit angiogenesis
EP1465855A2 (de)	2001-11-29	2004-10-13	Taro Pharmaceuticals U.S.A., Inc.	Verfahren zur herstellung von 6-alpha-fluor-corticosteroiden
US11957753B2 (en)	2010-11-22	2024-04-16	Bausch Health Ireland Limited	Pharmaceutical formulations containing corticosteroids for topical administration
US8809307B2 (en)	2010-11-22	2014-08-19	Dow Pharmaceutical Sciences, Inc.	Pharmaceutical formulations containing corticosteroids for topical administration
US10251895B2 (en)	2015-06-18	2019-04-09	Valeant Pharmaceuticals North America	Topical compositions and methods for treating psoriasis
US11311482B2 (en)	2017-05-12	2022-04-26	Bausch Health Us, Llc	Topical compositions and methods for treating skin diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB898292A (en) *	1959-03-18	1962-06-06	Upjohn Co	Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) *	1970-03-19	1972-02-22	Syntex Corp	Preparation of 21-chloro steroids
US3992422A (en) *	1975-08-14	1976-11-16	Schering Corporation	Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

1976
- 1976-09-29 LU LU75903A patent/LU75903A1/xx unknown
- 1976-12-09 CH CH1549976A patent/CH624967A5/de not_active IP Right Cessation
1977
- 1977-06-08 SE SE7706673A patent/SE436751B/xx not_active IP Right Cessation
- 1977-06-09 DK DK256977A patent/DK146017C/da not_active IP Right Cessation
- 1977-09-14 NL NL7710089A patent/NL7710089A/xx not_active Application Discontinuation
- 1977-09-24 DE DE2743069A patent/DE2743069C2/de not_active Expired
- 1977-09-26 CH CH1172177A patent/CH632279A5/de not_active IP Right Cessation
- 1977-09-27 CY CY1178A patent/CY1178A/xx unknown
- 1977-09-27 FR FR7729043A patent/FR2366311A1/fr active Granted
- 1977-09-27 AU AU29148/77A patent/AU514200B2/en not_active Expired
- 1977-09-27 DD DD7700201226A patent/DD133150A5/de unknown
- 1977-09-27 GB GB40131/77A patent/GB1563638A/en not_active Expired
- 1977-09-27 CA CA287,560A patent/CA1101410A/en not_active Expired
- 1977-09-28 AT AT0691077A patent/AT363197B/de not_active IP Right Cessation
- 1977-09-28 IL IL53012A patent/IL53012A/xx unknown
- 1977-09-28 ZA ZA00775800A patent/ZA775800B/xx unknown
- 1977-09-28 BE BE181243A patent/BE859120A/xx not_active IP Right Cessation
- 1977-09-28 HU HU77CI1774A patent/HU175218B/hu unknown
- 1977-09-28 IE IE1979/77A patent/IE46047B1/en not_active IP Right Cessation
- 1977-09-29 ES ES462763A patent/ES462763A1/es not_active Expired
- 1977-09-29 JP JP11619377A patent/JPS5356652A/ja active Granted
1979
- 1979-02-28 AT AT0151379A patent/AT363203B/de not_active IP Right Cessation
- 1979-02-28 AT AT0151279A patent/AT363202B/de not_active IP Right Cessation
1980
- 1980-11-18 CH CH853880A patent/CH625809A5/de not_active IP Right Cessation
- 1980-11-18 CH CH853780A patent/CH625808A5/de not_active IP Right Cessation
- 1980-11-18 CH CH853980A patent/CH625810A5/de not_active IP Right Cessation
1981
- 1981-10-26 CH CH683081A patent/CH631998A5/de not_active IP Right Cessation
- 1981-10-26 CH CH683181A patent/CH631999A5/de not_active IP Right Cessation
- 1981-10-26 CH CH683281A patent/CH632000A5/de not_active IP Right Cessation
1982
- 1982-01-06 CH CH4682A patent/CH632521A5/de not_active IP Right Cessation
1983
- 1983-01-20 SG SG33/83A patent/SG3383G/en unknown
- 1983-01-21 KE KE3258A patent/KE3258A/xx unknown
- 1983-05-19 HK HK166/83A patent/HK16683A/xx not_active IP Right Cessation
1984
- 1984-12-30 MY MY92/84A patent/MY8400092A/xx unknown

Also Published As

Publication number	Publication date
FR2366311B1 (de)	1982-12-03
JPS6214557B2 (de)	1987-04-02
AT363203B (de)	1981-07-27
CH624967A5 (en)	1981-08-31
CA1101410A (en)	1981-05-19
DE2743069A1 (de)	1978-03-30
HK16683A (en)	1983-05-27
ES462763A1 (es)	1978-05-16
AU514200B2 (en)	1981-01-29
CH625808A5 (en)	1981-10-15
CH625809A5 (en)	1981-10-15
GB1563638A (en)	1980-03-26
IE46047B1 (en)	1983-02-09
DD133150A5 (de)	1978-12-13
DK256977A (da)	1978-03-30
LU75903A1 (de)	1978-05-16
ATA151279A (de)	1980-12-15
ZA775800B (en)	1978-08-30
SE7706673L (sv)	1978-03-30
BE859120A (fr)	1978-03-28
DK146017C (da)	1983-10-24
DK146017B (da)	1983-05-24
KE3258A (en)	1983-03-04
SE436751B (sv)	1985-01-21
CH632000A5 (en)	1982-09-15
ATA151379A (de)	1980-12-15
IL53012A (en)	1982-05-31
CH631998A5 (en)	1982-09-15
FR2366311A1 (fr)	1978-04-28
CH632279A5 (en)	1982-09-30
CH632521A5 (en)	1982-10-15
DE2743069C2 (de)	1987-03-05
HU175218B (hu)	1980-06-28
JPS5356652A (en)	1978-05-23
CY1178A (en)	1983-06-10
CH625810A5 (en)	1981-10-15
AU2914877A (en)	1979-04-05
IE46047L (en)	1978-03-29
CH631999A5 (en)	1982-09-15
NL7710089A (nl)	1978-03-31
AT363197B (de)	1981-07-10
SG3383G (en)	1983-09-09
AT363202B (de)	1981-07-27
MY8400092A (en)	1984-12-31
IL53012A0 (en)	1977-11-30

Publication	Publication Date	Title
AT355571B (de)	1980-03-10	Verfahren zur herstellung von neuen bis -pyridinium-verbindungen
AT357703B (de)	1980-07-25	Verfahren zur herstellung von neuen 9alpha,21- dihalogen-11beta, 17alfa-dihydroxy-6alfa-fluor- 16alfa-methyl-pregna-1,4-dien-3,20-dion-ver- bindungen
ATA348877A (de)	1978-08-15	Verfahren zur herstellung von neuen n- acylierten
AT349634B (de)	1979-04-10	Verfahren zur herstellung von neuen anthra- cyclinglycosiden
AT352279B (de)	1979-09-10	Verfahren zur herstellung von neuen rifamyzin- verbindungen
ATA691077A (de)	1980-12-15	Verfahren zur herstellung von neuen 9alpha,21- -dihaolgen-11beta, 17alpha-dihydroxy-6alpha- -fluor-16beta-methyl-pregna-1,4- dien-3,20- -dion-verbindungen
ATA303477A (de)	1978-11-15	Verfahren zur herstellung von neuen indazolyl- (4-)-oxy-propanolaminen
AT357693B (de)	1980-07-25	Verfahren zur herstellung von neuen ergolen- -derivaten
AT347457B (de)	1978-12-27	Verfahren zur herstellung von neuen indolinospiropyranverbindungen
ATA664176A (de)	1977-10-15	Verfahren zur herstellung von neuen n-alkyl -2,4-dinitro-6- trifluormethyldiphenylaminen
AT352280B (de)	1979-09-10	Verfahren zur herstellung von neuen rifamyzin- verbindungen
AT353411B (de)	1979-11-12	Verfahren zur herstellung von neuen 4- -dedimethylamino-4-arylsulfonamido-5a,6- -anhydrotetracyclinen
AT349489B (de)	1979-04-10	Verfahren zur herstellung von neuen, hydrolyse- stabilen phosphiten von polyalkoholen
AT360647B (de)	1981-01-26	Verfahren zur herstellung von neuen cephalos- porinverbindungen
AT360037B (de)	1980-12-10	Verfahren zur herstellung von neuen substi- tuierten phenylguanidinen
AT353989B (de)	1979-12-10	Verfahren zur herstellung von neuen 11,12- ungesaettigten 9alpha-fluorsteroiden
AT358189B (de)	1980-08-25	Verfahren zur herstellung von neuen aspidosper- midinen
ATA81079A (de)	1980-12-15	Verfahren zur herstellung von neuen 9alpha,21- -dihalogen-11beta,17alpha-dihydroxy-6alpha- -flour-16alpha-methyl-pregna-1,4-dien-3,20- -dion-verbindungen
DD132497A1 (de)	1978-10-04	Verfahren zur herstellung von neuen gona-4,9(10)-dienen
AT356301B (de)	1980-04-25	Verfahren zur herstellung von neuen d-homo- steroiden
ATA81179A (de)	1980-12-15	Verfahren zur herstellung von neuen 9alpha, 21- -dihalogen-11beta, 17alpha-dihydroxy-6alpha- -fluor-16alpha-methyl-pregna-1,4-dien-3-20- -dion-verbindungen
AT356125B (de)	1980-04-10	Verfahren zur herstellung von neuen 1-aryloxy- -2,3-epoxypropanen
AT351515B (de)	1979-07-25	Verfahren zur herstellung von neuen polyenver- bindungen
ATA163077A (de)	1979-01-15	Verfahren zur herstellung von neuen 2-formyl- amino-phenylguanidinen
AT355040B (de)	1980-02-11	Verfahren zur herstellung von neuen veraetherten hydroxy-benzimidazolonen, - -benzoxazolonen, -benzoxazinonen, - chinazolinonen und-chinoxazolinonen

Legal Events

Date	Code	Title	Description
1999-08-15	ELA	Expired due to lapse of time