[go: up one dir, main page]

ATA57097A - Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung - Google Patents

Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung

Info

Publication number
ATA57097A
ATA57097A AT0057097A AT57097A ATA57097A AT A57097 A ATA57097 A AT A57097A AT 0057097 A AT0057097 A AT 0057097A AT 57097 A AT57097 A AT 57097A AT A57097 A ATA57097 A AT A57097A
Authority
AT
Austria
Prior art keywords
production
hydroxyiminoacetamido
aminothiazol
cephem
vinyl
Prior art date
Application number
AT0057097A
Other languages
English (en)
Other versions
AT405283B (de
Inventor
Johannes Dr Ludescher
Hubert Dr Sturm
Siegfried Wolf
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT0057097A priority Critical patent/AT405283B/de
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Priority to CNB988038501A priority patent/CN1139596C/zh
Priority to TR1999/02406T priority patent/TR199902406T2/xx
Priority to CA002283718A priority patent/CA2283718A1/en
Priority to IDW991137A priority patent/ID22536A/id
Priority to SK1343-99A priority patent/SK134399A3/sk
Priority to BR9809745-8A priority patent/BR9809745A/pt
Priority to HU0002987A priority patent/HUP0002987A3/hu
Priority to EP98921425A priority patent/EP0973779B1/de
Priority to IL13175598A priority patent/IL131755A0/xx
Priority to US09/381,947 priority patent/US6350869B1/en
Priority to AU74288/98A priority patent/AU731413B2/en
Priority to AT98921425T priority patent/ATE244249T1/de
Priority to DE69816056T priority patent/DE69816056T2/de
Priority to JP54235898A priority patent/JP3421354B2/ja
Priority to PCT/EP1998/001953 priority patent/WO1998045299A1/en
Priority to KR10-1999-7008984A priority patent/KR100442717B1/ko
Priority to PL98335620A priority patent/PL335620A1/xx
Publication of ATA57097A publication Critical patent/ATA57097A/de
Application granted granted Critical
Publication of AT405283B publication Critical patent/AT405283B/de
Priority to NO994466A priority patent/NO994466L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT0057097A 1997-04-04 1997-04-04 Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung AT405283B (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
AT0057097A AT405283B (de) 1997-04-04 1997-04-04 Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
AT98921425T ATE244249T1 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir
CA002283718A CA2283718A1 (en) 1997-04-04 1998-04-02 Crystalline amine salt of cefdinir
IDW991137A ID22536A (id) 1997-04-04 1998-04-02 Garam amina kristal dari cefdinir
SK1343-99A SK134399A3 (en) 1997-04-04 1998-04-02 Cefdinir in the form of a salt with dicyclohexylamine, a process for its production and its use
BR9809745-8A BR9809745A (pt) 1997-04-04 1998-04-02 Sal cristalino de amina de cefdinir
HU0002987A HUP0002987A3 (en) 1997-04-04 1998-04-02 Dicyclohexyl-amine salt of cefdinir and process for the preparation of the salt and subsequent liberation of the free compound
EP98921425A EP0973779B1 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir
CNB988038501A CN1139596C (zh) 1997-04-04 1998-04-02 头孢地尼的胺盐晶体
US09/381,947 US6350869B1 (en) 1997-04-04 1998-04-02 Crystalline amine salt of cefdinir
AU74288/98A AU731413B2 (en) 1997-04-04 1998-04-02 Crystalline amine salt of cefdinir
TR1999/02406T TR199902406T2 (xx) 1997-04-04 1998-04-02 Kristalli cefdinir amin tuz.
DE69816056T DE69816056T2 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir
JP54235898A JP3421354B2 (ja) 1997-04-04 1998-04-02 結晶性セフジニルアミン塩
PCT/EP1998/001953 WO1998045299A1 (en) 1997-04-04 1998-04-02 Crystalline amine salt of cefdinir
KR10-1999-7008984A KR100442717B1 (ko) 1997-04-04 1998-04-02 세프디니르의 결정성 아민 염
PL98335620A PL335620A1 (en) 1997-04-04 1998-04-02 Crystalline cephdynir and amine salt
IL13175598A IL131755A0 (en) 1997-04-04 1998-04-02 Crystalline amine salt of cefdinir
NO994466A NO994466L (no) 1997-04-04 1999-09-15 Krystallinsk aminsalt av cefdinir

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0057097A AT405283B (de) 1997-04-04 1997-04-04 Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung

Publications (2)

Publication Number Publication Date
ATA57097A true ATA57097A (de) 1998-11-15
AT405283B AT405283B (de) 1999-06-25

Family

ID=3494111

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0057097A AT405283B (de) 1997-04-04 1997-04-04 Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
AT98921425T ATE244249T1 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT98921425T ATE244249T1 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir

Country Status (18)

Country Link
US (1) US6350869B1 (de)
EP (1) EP0973779B1 (de)
JP (1) JP3421354B2 (de)
KR (1) KR100442717B1 (de)
CN (1) CN1139596C (de)
AT (2) AT405283B (de)
AU (1) AU731413B2 (de)
BR (1) BR9809745A (de)
CA (1) CA2283718A1 (de)
DE (1) DE69816056T2 (de)
HU (1) HUP0002987A3 (de)
ID (1) ID22536A (de)
IL (1) IL131755A0 (de)
NO (1) NO994466L (de)
PL (1) PL335620A1 (de)
SK (1) SK134399A3 (de)
TR (1) TR199902406T2 (de)
WO (1) WO1998045299A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
ITMI20020913A0 (it) * 2002-04-29 2002-04-29 Acs Dobfar Spa Nuova forma cristallina del cefdinir
DE60336331D1 (de) 2002-08-13 2011-04-21 Sandoz Ag Ein cefdinir-zwischenprodukt
ITMI20022076A1 (it) * 2002-10-01 2004-04-02 Antibioticos Spa Sali di intermedi del cefdinir.
AU2003276525A1 (en) * 2002-11-15 2004-06-15 Orchid Chemicals And Pharmaceuticals Ltd Novel amorphous hydrate of a cephalosporin antibiotic
ITMI20022724A1 (it) * 2002-12-20 2004-06-21 Antibioticos Spa Sali cristallini del cefdinir.
KR20050121209A (ko) * 2003-03-24 2005-12-26 에이씨에스 도브파 에스. 피. 에이. 7-[2-(2-아미노티아졸-4-일)-2-하이드록시이미노아세트아미도-3-비닐-3-세펨-4-카복실산(신 이성체)의 신규 결정 및이의 제조방법
WO2004104010A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Crystalline form of cefdinir
US20040242556A1 (en) * 2003-06-02 2004-12-02 Ramesh Dandala Novel crystalline form of cefdinir
US20050137182A1 (en) * 2003-06-02 2005-06-23 Ramesh Dandala Novel crystalline form of cefdinir
US20050059819A1 (en) * 2003-09-12 2005-03-17 Duerst Richard W. Cefdinir pyridine salt
US20050059818A1 (en) * 2003-09-12 2005-03-17 Duerst Richard W. Polymorph of a pharmaceutical
US20050113355A1 (en) * 2003-09-12 2005-05-26 Duerst Richard W. Cefdinir pyridine salt
US20050209211A1 (en) * 2004-03-16 2005-09-22 Devalina Law Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir
US20060211676A1 (en) * 2004-03-16 2006-09-21 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060142563A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060142261A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
WO2005090360A1 (en) * 2004-03-19 2005-09-29 Orchid Chemicals & Pharmaceuticals Limited Novel polymorph of cefdinir
US20060069079A1 (en) * 2004-09-27 2006-03-30 Sever Nancy E Stable amorphous cefdinir
US20050245738A1 (en) * 2004-05-03 2005-11-03 Lupin Ltd Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof
WO2006010978A1 (en) * 2004-06-30 2006-02-02 Wockhardt Limited Cefdinir polymorphic forms, and imidazole salt
WO2006006040A2 (en) 2004-07-05 2006-01-19 Orchid Chemicals & Pharmaceuticals Limited News diamine salts of cephalosporin antibiotics and their preparation
WO2006018807A1 (en) * 2004-08-16 2006-02-23 Ranbaxy Laboratories Limited Crystalline forms of cefdinir
ITMI20042231A1 (it) * 2004-11-19 2005-02-19 Antibioticos Spa Cefdinir sale d'ammonio in forma cristallina
MX2007006018A (es) * 2004-11-30 2007-06-07 Astellas Pharma Inc Suspension farmaceutica oral novedosa de cristal de cefdinir.
GB2421024A (en) * 2004-12-07 2006-06-14 Sandoz Ag Cefdinir crystalline form C
WO2006117794A1 (en) * 2005-05-02 2006-11-09 Hetero Drugs Limited A novel crystalline form of cefdinir
EP1899356A1 (de) * 2005-06-15 2008-03-19 Hetero Drugs Limited Cefdinir-verfahren
CN1903860B (zh) * 2005-07-25 2012-01-18 四川抗菌素工业研究所有限公司 溶媒法制备高纯度头孢他美钠工艺及医药用途
JP2008526782A (ja) * 2005-10-31 2008-07-24 テバ ファーマシューティカル インダストリーズ リミティド セフジニルセシウム塩結晶
US20070128268A1 (en) * 2005-12-07 2007-06-07 Herwig Jennewein Pharmaceutical compositions comprising an antibiotic
CN101481383B (zh) 2008-12-31 2012-01-11 杭州奥默医药技术有限公司 头孢地尼酸式复盐化合物及制备方法
TR200909784A1 (tr) * 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Yeni sefdinir tuzları
US8614315B2 (en) 2009-12-25 2013-12-24 Mahmut Bilgic Cefdinir and cefixime formulations and uses thereof
CN101974020B (zh) * 2010-11-19 2012-09-12 苏州中联化学制药有限公司 一种头孢地尼的合成方法
CN102010427B (zh) * 2010-11-19 2012-09-12 苏州中联化学制药有限公司 一种头孢地尼的制备方法
CN103012433B (zh) * 2012-12-13 2015-06-24 珠海保税区丽珠合成制药有限公司 头孢地尼晶型b的制备方法
CN108546270B (zh) * 2017-05-31 2019-11-08 郑州大学第一附属医院 制备头孢地尼的方法
CN107286148B (zh) * 2017-06-20 2019-10-15 广州市桐晖通医药科技有限公司 一种头孢地尼的制备方法及其新的中间体化合物
CN111635419B (zh) * 2020-07-13 2022-05-24 广药白云山化学制药(珠海)有限公司 一种头孢地尼精制母液的处理方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5564M (de) * 1964-03-14 1968-01-02
GB8323034D0 (en) * 1983-08-26 1983-09-28 Fujisawo Pharmaceutical Co Ltd 7-substituted-3-vinyl-3-cephem compounds
ZA885709B (en) 1987-08-19 1989-04-26 Fujisawa Pharmaceutical Co Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid(syn isomer)
SG48415A1 (en) * 1992-02-05 1998-04-17 Biochemie Gmbh Process for the purification of a 3-cephem-4-carboxylic acid derivative
KR960704897A (ko) * 1994-07-22 1996-10-09 에밀리오 마우리 글루타릴 7-아미노세팔로스포란산 유도체 및 이의 제조 방법 (Glutaryl 7-ACA derivatives and processes for obtaining them)
AT403049B (de) * 1995-08-14 1997-10-27 Biochemie Gmbh Abreicherung von 7-adca in 3-vinyl-aca
DE69621649T2 (de) * 1995-12-27 2002-09-19 Hanmi Pharmaceutical Co., Ltd. Verfahren zur herstellung von cefdinir
AT404251B (de) * 1996-08-14 1998-10-27 Biochemie Gmbh Neues kristallines salz von cefixim

Also Published As

Publication number Publication date
JP2000514833A (ja) 2000-11-07
AU731413B2 (en) 2001-03-29
CN1251590A (zh) 2000-04-26
AT405283B (de) 1999-06-25
HUP0002987A3 (en) 2001-04-28
US6350869B1 (en) 2002-02-26
NO994466D0 (no) 1999-09-15
EP0973779B1 (de) 2003-07-02
DE69816056D1 (de) 2003-08-07
CN1139596C (zh) 2004-02-25
JP3421354B2 (ja) 2003-06-30
WO1998045299A1 (en) 1998-10-15
SK134399A3 (en) 2000-05-16
NO994466L (no) 1999-09-15
BR9809745A (pt) 2000-06-20
PL335620A1 (en) 2000-05-08
IL131755A0 (en) 2001-03-19
AU7428898A (en) 1998-10-30
ATE244249T1 (de) 2003-07-15
EP0973779A1 (de) 2000-01-26
KR20010005907A (ko) 2001-01-15
CA2283718A1 (en) 1998-10-15
DE69816056T2 (de) 2004-04-15
TR199902406T2 (xx) 2000-02-21
KR100442717B1 (ko) 2004-08-02
ID22536A (id) 1999-11-04
HUP0002987A2 (hu) 2001-02-28

Similar Documents

Publication Publication Date Title
ATA57097A (de) Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
DE60006298D1 (de) Verfahren zur Herstellung von Kohlendioxid
FI890195A (fi) Foliinihapon tai sen suolojen valmistusmenetelmä
ATE278032T1 (de) Verfahren zur fermentativen herstellung von deacylierten cephalosporinen
FI98067C (fi) Uusia alkyleenidiammoniumdiklavulanaattijohdannaisia, menetelmä niidenvalmistamiseksi samoin kuin niiden käyttö kalvulaanihapon puhdistamiseksi
DE69319296D1 (de) Verfahren zur Reinigung von roher Clavulansäure
ATA57598A (de) Neues salz von 7-(2-(aminothiazol-4yl)-2-
ATE213248T1 (de) Neue kristalline cephem-säureadditionssalze und verfahren zu ihrer herstellung
DE69512639D1 (de) Verfahren zur herstellung von zimtsäurederivaten
DE3678139D1 (de) Neue kristalline salze von aryloxy-propanolaminen, verfahren zu ihrer herstellung und ihre verwendung.
ES2191313T3 (es) Procedimiento para la produccion fermentativa de cefalosporinas desaciladas.
PL238200A1 (en) Process for preparing novel penicillins
PT72421A (de) Verfahren zur herstellung von kristallinen salzen
ATE174919T1 (de) 2-spirocyclopropylcephalosporinderivate und verfahren zu ihrer herstellung
DE10082578D2 (de) Verfahren zur Herstellung von regelmäßigen Nanostrukturen
PT78717B (de) Neue 1-acetonyl-2-(phenylimino)-imidazolidine deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
DE50000029D1 (de) Herstellung von acrylierten flüssigkristallinen Verbindungen
DE60043559D1 (de) Verfahren zur Herstellung von Elektroden
DK215886A (da) 1,3-oxathianderivater
ATA358880A (de) Verfahren zur herstellung von neuen 15-halogen-e- homoeburnanderivaten, von deren saeureadditions- salzen, epimeren und optischen antipoden
ATE267831T1 (de) Kristalle von cephemderivaten und verfahren zu ihrer herstellung
DE60001683D1 (de) Verfahren zur Reinigung von 3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenonsäure
ATE111468T1 (de) Cephalosporinderivate, verfahren zu ihrer herstellung und antibakterielle mittel.
AT387022B (de) Verfahren zur herstellung einer neuen kristallinen form eines cefalosporinderivats
DE69917240D1 (de) Verfahren zur Herstellung von gereinigter Sorbinsäure