ATE278032T1 - Verfahren zur fermentativen herstellung von deacylierten cephalosporinen - Google Patents
Verfahren zur fermentativen herstellung von deacylierten cephalosporinenInfo
- Publication number
- ATE278032T1 ATE278032T1 AT98924209T AT98924209T ATE278032T1 AT E278032 T1 ATE278032 T1 AT E278032T1 AT 98924209 T AT98924209 T AT 98924209T AT 98924209 T AT98924209 T AT 98924209T AT E278032 T1 ATE278032 T1 AT E278032T1
- Authority
- AT
- Austria
- Prior art keywords
- fermentative production
- deacylated
- cephalosporins
- deacylated cephalosporins
- production
- Prior art date
Links
- 238000012262 fermentative production Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- -1 cephalosporin compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201196 | 1997-04-22 | ||
| PCT/EP1998/002460 WO1998048034A1 (en) | 1997-04-22 | 1998-04-22 | Process for the fermentative production of deacylated cephalosporins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE278032T1 true ATE278032T1 (de) | 2004-10-15 |
Family
ID=8228236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98924209T ATE278032T1 (de) | 1997-04-22 | 1998-04-22 | Verfahren zur fermentativen herstellung von deacylierten cephalosporinen |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6518039B2 (de) |
| EP (1) | EP0912754B1 (de) |
| JP (1) | JP2000512511A (de) |
| KR (1) | KR20000022108A (de) |
| CN (2) | CN1224468A (de) |
| AT (1) | ATE278032T1 (de) |
| AU (1) | AU7648898A (de) |
| BR (1) | BR9804857A (de) |
| DE (1) | DE69826604D1 (de) |
| PL (1) | PL330759A1 (de) |
| RU (1) | RU2208644C2 (de) |
| TW (1) | TW565613B (de) |
| WO (1) | WO1998048034A1 (de) |
| ZA (1) | ZA983394B (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
| US7148054B2 (en) | 1997-01-17 | 2006-12-12 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
| US7390619B1 (en) | 1998-02-11 | 2008-06-24 | Maxygen, Inc. | Optimization of immunomodulatory properties of genetic vaccines |
| WO2000009682A1 (en) | 1998-08-12 | 2000-02-24 | Maxygen, Inc. | Dna shuffling of monooxygenase genes for production of industrial chemicals |
| EP1119616A2 (de) | 1998-10-07 | 2001-08-01 | Maxygen, Inc. | Dna shuffling zur herstellung von nukleinsäuren zur mykotoxinentgiftung |
| WO2000028018A1 (en) | 1998-11-10 | 2000-05-18 | Maxygen, Inc. | Modified adp-glucose pyrophosphorylase for improvement and optimization of plant phenotypes |
| US6917882B2 (en) | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
| US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US6961664B2 (en) | 1999-01-19 | 2005-11-01 | Maxygen | Methods of populating data structures for use in evolutionary simulations |
| US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| ATE465459T1 (de) | 1999-01-19 | 2010-05-15 | Maxygen Inc | Durch oligonukleotide-vermittelte nukleinsäuren- rekombination |
| CA2361384A1 (en) | 1999-02-11 | 2000-08-17 | Sun Ai Raillard | High throughput mass spectrometry |
| US6531316B1 (en) | 1999-03-05 | 2003-03-11 | Maxyag, Inc. | Encryption of traits using split gene sequences and engineered genetic elements |
| US7430477B2 (en) | 1999-10-12 | 2008-09-30 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
| US6686515B1 (en) | 1999-11-23 | 2004-02-03 | Maxygen, Inc. | Homologous recombination in plants |
| US7115712B1 (en) | 1999-12-02 | 2006-10-03 | Maxygen, Inc. | Cytokine polypeptides |
| JP2003519495A (ja) | 2000-01-11 | 2003-06-24 | マキシジェン， インコーポレイテッド | 多様性生成およびスクリーニングのための一体化されたシステムおよび方法 |
| JP2004513878A (ja) | 2000-06-23 | 2004-05-13 | マキシジェン， インコーポレイテッド | 新規同時刺激分子 |
| EP1297146A2 (de) | 2000-06-23 | 2003-04-02 | Maxygen, Inc. | Chimäre promotoren |
| US6858422B2 (en) | 2000-07-13 | 2005-02-22 | Codexis, Inc. | Lipase genes |
| CN101555463B (zh) * | 2008-04-08 | 2012-05-30 | 中国科学院上海生命科学研究院湖州工业生物技术中心 | 表达头孢菌素脱乙酰酶的重组大肠杆菌菌株及其构建方法 |
| EP2123772A1 (de) | 2008-04-29 | 2009-11-25 | DSM IP Assets B.V. | Beta-Lactamantibiotikum produzierende Stämme |
| WO2010015624A1 (en) | 2008-08-05 | 2010-02-11 | Dsm Ip Assets B.V. | Adipoyl-7-adca producing strains |
| WO2010015627A2 (en) | 2008-08-05 | 2010-02-11 | Dsm Ip Assets B.V. | Adipoyl-7-adca producing strains |
| CN102369290A (zh) | 2009-04-03 | 2012-03-07 | 帝斯曼知识产权资产管理有限公司 | 发酵工艺 |
| HUE035540T2 (en) | 2010-06-22 | 2018-05-02 | Dsm Sinochem Pharm Nl Bv | Air bubble fermentation process |
| EA023822B1 (ru) | 2011-03-03 | 2016-07-29 | Дсм Синокем Фармасьютикалз Нидерландз Б.В. | Разложение соединений пенициллина |
| WO2015091455A1 (en) | 2013-12-17 | 2015-06-25 | Dpx Holdings B.V. | Bioreactor |
| US10208755B2 (en) | 2014-08-08 | 2019-02-19 | Baker Hughes, A Ge Company, Llc | Magnetic coupling for motor drive shaft of electrical submersible pump |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5671092A (en) * | 1979-11-14 | 1981-06-13 | Kyowa Hakko Kogyo Co Ltd | Optical active cephalosporin analogous derivative |
| DE3172432D1 (en) * | 1980-08-01 | 1985-10-31 | Biochemie Gmbh | New cephalosporin derivatives, their production and their use |
| PT83746B (pt) | 1985-11-15 | 1988-08-17 | Gist Brocades Nv | Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao |
| IE910956A1 (en) | 1990-03-23 | 1991-09-25 | Gist Brocades Nv | A method of modulating the production of secondary¹metabolites |
| US5318896A (en) * | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
| CZ288721B6 (cs) * | 1991-10-15 | 2001-08-15 | Dsm Gist B. V. | Biologický způsob výroby kyseliny 7-aminodeacetylcefalosporanové |
| EP0711348B1 (de) | 1993-07-30 | 2003-03-19 | Dsm N.V. | Prozess zur effizienten produktion von 7-adca via 3-(carboxyethylthio)propionyl-7-adca |
| PL180799B1 (pl) * | 1993-07-30 | 2001-04-30 | Gist Brocades Bv | Sposób wydajnego wytwarzania 7-ADCA poprzez 2-(karboksyetylotio)acetylo-7-ADCA i 3-(karboksymetylotio)-propionylo-7-ADCA |
-
1998
- 1998-04-22 AU AU76488/98A patent/AU7648898A/en not_active Abandoned
- 1998-04-22 AT AT98924209T patent/ATE278032T1/de not_active IP Right Cessation
- 1998-04-22 RU RU99101488/13A patent/RU2208644C2/ru not_active IP Right Cessation
- 1998-04-22 WO PCT/EP1998/002460 patent/WO1998048034A1/en not_active Application Discontinuation
- 1998-04-22 ZA ZA983394A patent/ZA983394B/xx unknown
- 1998-04-22 DE DE69826604T patent/DE69826604D1/de not_active Expired - Lifetime
- 1998-04-22 PL PL98330759A patent/PL330759A1/xx unknown
- 1998-04-22 KR KR1019980710518A patent/KR20000022108A/ko not_active Ceased
- 1998-04-22 CN CN98800523A patent/CN1224468A/zh active Pending
- 1998-04-22 CN CNA2005100823457A patent/CN1706963A/zh active Pending
- 1998-04-22 BR BR9804857A patent/BR9804857A/pt not_active IP Right Cessation
- 1998-04-22 US US09/202,798 patent/US6518039B2/en not_active Expired - Fee Related
- 1998-04-22 EP EP98924209A patent/EP0912754B1/de not_active Expired - Lifetime
- 1998-04-22 JP JP10545045A patent/JP2000512511A/ja active Pending
- 1998-07-10 TW TW087111260A patent/TW565613B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1706963A (zh) | 2005-12-14 |
| PL330759A1 (en) | 1999-05-24 |
| BR9804857A (pt) | 1999-08-24 |
| ZA983394B (en) | 1998-10-30 |
| RU2208644C2 (ru) | 2003-07-20 |
| TW565613B (en) | 2003-12-11 |
| KR20000022108A (ko) | 2000-04-25 |
| US20020037547A1 (en) | 2002-03-28 |
| JP2000512511A (ja) | 2000-09-26 |
| US6518039B2 (en) | 2003-02-11 |
| DE69826604D1 (de) | 2004-11-04 |
| EP0912754A1 (de) | 1999-05-06 |
| CN1224468A (zh) | 1999-07-28 |
| AU7648898A (en) | 1998-11-13 |
| WO1998048034A1 (en) | 1998-10-29 |
| EP0912754B1 (de) | 2004-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |