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AR247816A1 - Procedimiento para la preparacion de derivados del acido piridin-2, 4- y 2, 5-dicarboxilico - Google Patents

Procedimiento para la preparacion de derivados del acido piridin-2, 4- y 2, 5-dicarboxilico

Info

Publication number
AR247816A1
AR247816A1 AR88310032A AR31003288A AR247816A1 AR 247816 A1 AR247816 A1 AR 247816A1 AR 88310032 A AR88310032 A AR 88310032A AR 31003288 A AR31003288 A AR 31003288A AR 247816 A1 AR247816 A1 AR 247816A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
formula
halogen
methyl
Prior art date
Application number
AR88310032A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of AR247816A1 publication Critical patent/AR247816A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PREPARACION DE MEDICAMENTOS DERIVADOS DE ACIDO PIRIDIN-2, 4- Y 2, 5- DICARBOXILICO DE LA FORMULA I', DONDE R1' ES ALQUILO RAMIFICADO O NO, SUSTITUIDO O NO POR ALQUILO, ALCOXI, ALCOXICARBONILO, ALQUILO O DIALQUILAMINO, FENILO, SUSTITUIDO O NO CON ALQUILO, R1' ES FENILO SUSTITUIDO O NO POR HALOGENO, NITRO, ALQUILO, R1' ES 2-OXO-1, 3- DIOXOLILMETILO, SUSTITUIDOS O NO METILO, R1' CUANDO X' ES NITROGENO, SIGNIFICA HIDROGENO, R2' ES HIDROGENO O R1', Y X' ES O O N O SUSTITUIDO CON R3', DONDE R3' ES HIDROGENO, ALQUILO O CONJUNTAMENTE R1' FORMA UN ANILLO PIPERAZINILO SUSTITUIDO O NO CON FENILO O FENILALQUILO, ASI COMO SUS SALES FISIOLOGICAMENTE TOLERABLES, EXCLUIDOS LOS COMPUESTOS DE LOS CUALES X' ES OXIGENO Y R1' Y R2' SIMULTANEAMENTE CON ALQUILO O METILO O ETILO SUSTITUIDO CON FENILO O SIMULTANEAMENTE R1' Y R2' ES UN FENILO SUSTITUIDO EN POSICION 4 CON METOXI, O R1' ES METILO Y R2 HIDROGENO, EN DONDE SE HACE REACCIONAR UN COMPUESTO SELECCIONADO DEL GRUPO DE FORMULA II Y DE FORMULA V; CON U N COMPUESTO DE FORMULA III Y IV, DONDE Y ES HALOGENO O HO, Z ES HALOGENO; Y SI SE DESEA SE HACE REACCIONAR UNA SAL DE METAL ALCALINO DEL ACIDO PIRIDIN- 2, 4 O 2, 5-DICARBOXILICO CON UN HALOGENURO DE LA FORMULA VIII, DONDE Z ES HALOGENO, Y LOS PRODUCTOS DE REACCION EVENTUALMENTE SE TRANSFORMAN EN SUS SALES FISIOLOGICAMENTE TOLERABLES.
AR88310032A 1987-02-10 1988-02-08 Procedimiento para la preparacion de derivados del acido piridin-2, 4- y 2, 5-dicarboxilico AR247816A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873703963 DE3703963A1 (de) 1987-02-10 1987-02-10 Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen

Publications (1)

Publication Number Publication Date
AR247816A1 true AR247816A1 (es) 1995-04-28

Family

ID=6320593

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88310032A AR247816A1 (es) 1987-02-10 1988-02-08 Procedimiento para la preparacion de derivados del acido piridin-2, 4- y 2, 5-dicarboxilico

Country Status (17)

Country Link
EP (1) EP0278452B1 (es)
JP (1) JPS63216870A (es)
KR (1) KR960011371B1 (es)
AR (1) AR247816A1 (es)
AT (1) ATE123022T1 (es)
AU (1) AU600084B2 (es)
DE (2) DE3703963A1 (es)
DK (2) DK168379B1 (es)
ES (1) ES2073393T3 (es)
FI (1) FI91524C (es)
HU (1) HU207295B (es)
IE (1) IE67446B1 (es)
IL (1) IL85361A (es)
NO (1) NO173184C (es)
NZ (1) NZ223431A (es)
PT (1) PT86734B (es)
ZA (1) ZA88897B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3707429A1 (de) * 1987-03-07 1988-09-15 Hoechst Ag Substituierte pyridin-2,4-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
HU202516B (en) * 1987-10-02 1991-03-28 Egyt Gyogyszervegyeszeti Gyar Process for producing (2-thenyl)-thiourea derivatives and yield increasing agents comprising such compounds
DE3924093A1 (de) 1989-07-20 1991-02-07 Hoechst Ag N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
DE3938805A1 (de) * 1989-11-23 1991-05-29 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
DE4020570A1 (de) 1990-06-28 1992-01-02 Hoechst Ag 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung
US5260323A (en) * 1990-06-28 1993-11-09 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
DE4030999A1 (de) * 1990-10-01 1992-04-09 Hoechst Ag 4- oder 5-substituierte pyridin-2-carbonsaeuren, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
YU9492A (sh) * 1991-02-05 1995-03-27 Hoechst Ag. 2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje
CA2085954A1 (en) * 1991-12-24 1993-06-25 Klaus Weidmann Substituted pyridine n-oxides, processes for their preparation, and their use
DE4233124A1 (de) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO1999021860A1 (en) * 1997-10-24 1999-05-06 Fibrogen, Inc. Phenanthroline derivatives
KR100579792B1 (ko) 1998-05-13 2006-05-12 동화약품공업주식회사 신규 2,5-피리딘디카복실산 유도체

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093622A (en) * 1975-05-19 1978-06-06 Zoecon Corporation Pyridine esters of cyclopropane-carboxylic acid
EP0123700A1 (de) * 1983-04-27 1984-11-07 Byk Gulden Lomberg Chemische Fabrik GmbH Substituierte Picolinsäuren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Arzneimittel
DE3432094A1 (de) * 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
US4757071A (en) * 1984-12-14 1988-07-12 Nisshin Flour Milling Co., Ltd. 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases
US4691018A (en) * 1985-05-23 1987-09-01 Chugai Seiyaku Kabushiki Kaisha Pyridine derivatives and their use as anti-allergic agents
GB8702890D0 (en) * 1987-02-10 1987-03-18 Zyma Sa Heterocyclic compounds
DE58908519D1 (de) * 1988-08-04 1994-11-24 Hoechst Ag Verbessertes Verfahren zur Herstellung von N,N-Bis(alkoxyalkyl)-pyridin -2,4-dicarbonsäurediamiden.

Also Published As

Publication number Publication date
FI880554A0 (fi) 1988-02-08
FI880554A (fi) 1988-08-11
NO173184B (no) 1993-08-02
ES2073393T3 (es) 1995-08-16
AU1145088A (en) 1988-08-11
ZA88897B (en) 1988-08-09
DK170245B1 (da) 1995-07-17
IE67446B1 (en) 1996-04-03
IE880350L (en) 1988-08-10
DE3703963A1 (de) 1988-08-18
EP0278452A2 (de) 1988-08-17
PT86734A (pt) 1988-03-01
DK66088D0 (da) 1988-02-09
NO173184C (no) 1993-11-10
NZ223431A (en) 1990-07-26
KR880009935A (ko) 1988-10-05
EP0278452A3 (en) 1989-10-18
FI91524B (fi) 1994-03-31
HU207295B (en) 1993-03-29
DK90992D0 (da) 1992-07-10
PT86734B (pt) 1992-05-29
HUT47249A (en) 1989-02-28
DK90992A (da) 1992-07-10
FI91524C (fi) 1994-07-11
KR960011371B1 (ko) 1996-08-22
DE3853839D1 (de) 1995-06-29
JPS63216870A (ja) 1988-09-09
DK66088A (da) 1988-08-11
NO880556D0 (no) 1988-02-09
DK168379B1 (da) 1994-03-21
IL85361A0 (en) 1988-07-31
ATE123022T1 (de) 1995-06-15
EP0278452B1 (de) 1995-05-24
AU600084B2 (en) 1990-08-02
IL85361A (en) 1993-01-31
NO880556L (no) 1988-08-11

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