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AR247732A1 - Procedimiento para obtener amidas de acido piridin-2, 4- y -2, 5-dicarboxilico - Google Patents

Procedimiento para obtener amidas de acido piridin-2, 4- y -2, 5-dicarboxilico

Info

Publication number
AR247732A1
AR247732A1 AR88310031A AR31003188A AR247732A1 AR 247732 A1 AR247732 A1 AR 247732A1 AR 88310031 A AR88310031 A AR 88310031A AR 31003188 A AR31003188 A AR 31003188A AR 247732 A1 AR247732 A1 AR 247732A1
Authority
AR
Argentina
Prior art keywords
substituted
halogen
hydrogen
preparation
alkyl
Prior art date
Application number
AR88310031A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of AR247732A1 publication Critical patent/AR247732A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PREPARACION DE MEDICAMENTOS QUE SE LLEVAN A UNA FORMA DE ADMINISTRACION APROPIADA AMIDAS DE ACIDO PIRIDIN-2, 4- Y -2, 5-DICARBOXILICO DE FORMULA (I), DONDE R1 ES ALQUILO RAMIFICADO O NO , SUSTITUIDO O NO CON HALOGENO, HO , CN, NH2, -COO-, ALCOXI, ALCOXICARBONILO, ALQUILCARBONILOXI, ALQUILO O DIALQUILAMINO, INDOLIL O FENIL, SUSTITUIDOS O NO, CON HALOGENO, NITRO, ALQUILO O ALCOXI; O R1 ES CICLOALQUILO SATURADO, BENZOCONDENSADO O NO ; O R1 FENILO, NAFTILO O UN ANILLO AROMATICO CON N Y/O O Y/O S, SUSTITUIDO O NO CON HALOGENO, NITRO, CN, ALQUILO O ALCOXI, R2 ES HIDROGENO O R1=R2; R3 ES HIDROGENO O R3=R1, Y R4 ES HIDROGENO O TIENE UNO R4=R1, Y DONDE LOS RADICALES R1 Y R2 Y/O R3 Y R4 JUNTO CON EL N PUEDEN FORMAR UN HETEROCICLICO DE 5, 6 O 7 MIEMBROS SATURADO, PUDIENDO TENER EL ANILLO OTRO N SUSTITUIDO O NO CON FENILO O FENIL-ALQUILO Y SUS SALES FISIOLOGICAMENTE TOLERABLES, EN DONDE SE HACE REACCIONAR UN COMPUESTO DE FORMULA (II); CON UN COMPUESTO DE LA FORMULA (III); DONDE Y ES HALOGENOÑ O HO O CONJUNTAMENTE CON EL GRUPO CARBONILO FORMA UN ESTER ACTIVO O UN ANHIDRIDO MIXTO.
AR88310031A 1987-02-10 1988-02-08 Procedimiento para obtener amidas de acido piridin-2, 4- y -2, 5-dicarboxilico AR247732A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873703959 DE3703959A1 (de) 1987-02-10 1987-02-10 Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen

Publications (1)

Publication Number Publication Date
AR247732A1 true AR247732A1 (es) 1995-03-31

Family

ID=6320590

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88310031A AR247732A1 (es) 1987-02-10 1988-02-08 Procedimiento para obtener amidas de acido piridin-2, 4- y -2, 5-dicarboxilico

Country Status (20)

Country Link
US (1) US5037839A (es)
EP (1) EP0278453B1 (es)
JP (1) JPH0641450B2 (es)
KR (1) KR960011372B1 (es)
AR (1) AR247732A1 (es)
AT (1) ATE116299T1 (es)
AU (1) AU599746B2 (es)
CA (1) CA1334972C (es)
DE (2) DE3703959A1 (es)
DK (1) DK167804B1 (es)
ES (1) ES2067448T3 (es)
FI (1) FI91525C (es)
GR (1) GR3014958T3 (es)
HU (1) HU205905B (es)
IE (1) IE65348B1 (es)
IL (1) IL85362A (es)
NO (1) NO174420C (es)
NZ (1) NZ223433A (es)
PT (1) PT86736B (es)
ZA (1) ZA88896B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512586A (en) * 1987-02-10 1996-04-30 Hoechst Aktiengesellschaft Medicaments based on pyridine-2,4- and 2,5-dicarboxylic acid amides
US5153208A (en) * 1987-02-10 1992-10-06 Hoechst Aktiengesellschaft Pyridine-2,4- and -2,5-dicarboxylic acid amides and their medicinal compositions and methods of use
DE3707429A1 (de) * 1987-03-07 1988-09-15 Hoechst Ag Substituierte pyridin-2,4-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE58908519D1 (de) * 1988-08-04 1994-11-24 Hoechst Ag Verbessertes Verfahren zur Herstellung von N,N-Bis(alkoxyalkyl)-pyridin -2,4-dicarbonsäurediamiden.
DE3924093A1 (de) * 1989-07-20 1991-02-07 Hoechst Ag N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
US5425289A (en) * 1993-10-21 1995-06-20 Snap-On Incorporated Bung tool
DE3928144A1 (de) * 1989-08-25 1991-02-28 Hoechst Ag Zyklische pyridin-2,4- und -2,5-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
DE3931432A1 (de) * 1989-09-21 1991-04-04 Hoechst Ag Pyrimidin-4,6-dicarbonsaeurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3938805A1 (de) * 1989-11-23 1991-05-29 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
ZA91291B (en) * 1990-01-16 1991-09-25 Hoechst Ag Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof
DE4020570A1 (de) 1990-06-28 1992-01-02 Hoechst Ag 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung
US5260323A (en) * 1990-06-28 1993-11-09 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
DE4031000A1 (de) * 1990-10-01 1992-04-09 Hoechst Ag 4- oder 5-substituierte pyridin-2-carbonsaeuren, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
YU9492A (sh) * 1991-02-05 1995-03-27 Hoechst Ag. 2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje
TW199147B (es) * 1991-03-18 1993-02-01 Hoechst Ag
EP0541042A1 (de) * 1991-11-05 1993-05-12 Hoechst Aktiengesellschaft Pyridin-2,4- und 2,5-dicarbonsäureamide und deren Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
CA2085954A1 (en) * 1991-12-24 1993-06-25 Klaus Weidmann Substituted pyridine n-oxides, processes for their preparation, and their use
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
EP0567997A1 (de) * 1992-04-30 1993-11-03 Hoechst Aktiengesellschaft 4- oder 5-(Sulf)imido- und (Sulfon)amidopyridine, sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE4233124A1 (de) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6046219A (en) * 1995-01-20 2000-04-04 Cornell Research Foundation, Inc. Method for the treatment of conditions mediated by collagen formation together with cell proliferation by application of inhibitors of protein hydroxylation
US5789426A (en) * 1995-01-20 1998-08-04 Cornell Research Foundation, Inc. Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation
FR2766187B1 (fr) 1997-07-17 2000-06-02 Rhone Poulenc Rorer Sa Derives de pyrazine, leur preparation et les medicaments les contenant
WO1999021860A1 (en) * 1997-10-24 1999-05-06 Fibrogen, Inc. Phenanthroline derivatives
ATE507205T1 (de) * 2006-12-11 2011-05-15 Genetics Co Inc Aromatische 1,4-di-carboxylamide und deren verwendung

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852519A (en) * 1954-12-27 1958-09-16 Phillips Petroleum Co Method for producing esters of heterocyclic nitrogen carboxylic acids
JPS49277A (es) * 1972-04-18 1974-01-05
DE2803592A1 (de) * 1978-01-27 1979-08-02 Scott Eugene J Van Therapeutisches mittel
DE3174885D1 (en) * 1981-02-03 1986-07-31 Ici Plc Process for the extraction of metal values and novel metal extractants
DE3432094A1 (de) * 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
EP0198202B1 (en) * 1985-03-09 1991-07-17 Mitsubishi Corporation Novel n-cyclohexyl-polycarboxamide compound and derivatives thereof, processes for preparing them, and use of them in preparation of host-guest complexes
GB8702890D0 (en) * 1987-02-10 1987-03-18 Zyma Sa Heterocyclic compounds
DE58908519D1 (de) * 1988-08-04 1994-11-24 Hoechst Ag Verbessertes Verfahren zur Herstellung von N,N-Bis(alkoxyalkyl)-pyridin -2,4-dicarbonsäurediamiden.

Also Published As

Publication number Publication date
KR960011372B1 (ko) 1996-08-22
KR880009936A (ko) 1988-10-06
DK167804B1 (da) 1993-12-20
NO880558D0 (no) 1988-02-09
NO880558L (no) 1988-08-11
FI91525C (fi) 1994-07-11
DE3703959A1 (de) 1988-08-18
ATE116299T1 (de) 1995-01-15
IE880352L (en) 1988-08-10
NO174420C (no) 1994-05-04
EP0278453A3 (en) 1989-10-25
IE65348B1 (en) 1995-10-18
ZA88896B (en) 1988-08-08
CA1334972C (en) 1995-03-28
AU599746B2 (en) 1990-07-26
FI880556A (fi) 1988-08-11
HU205905B (en) 1992-07-28
DK65988D0 (da) 1988-02-09
EP0278453A2 (de) 1988-08-17
PT86736A (pt) 1988-03-01
ES2067448T3 (es) 1995-04-01
PT86736B (pt) 1992-05-29
IL85362A0 (en) 1988-07-31
DK65988A (da) 1988-08-11
JPS63216873A (ja) 1988-09-09
NZ223433A (en) 1990-07-26
NO174420B (no) 1994-01-24
EP0278453B1 (de) 1994-12-28
AU1145288A (en) 1988-08-11
IL85362A (en) 1994-01-25
JPH0641450B2 (ja) 1994-06-01
US5037839A (en) 1991-08-06
FI91525B (fi) 1994-03-31
HUT47250A (en) 1989-02-28
DE3852554D1 (de) 1995-02-09
GR3014958T3 (en) 1995-05-31
FI880556A0 (fi) 1988-02-08

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