AR229101A1 - Procedimiento para obtener una mezcla de la forma a y de la forma b, cristalinas de maleato de 2-amino-3-carbetoxiamino-6-(p-fluor-bencilamino)-piridina - Google Patents

Procedimiento para obtener una mezcla de la forma a y de la forma b, cristalinas de maleato de 2-amino-3-carbetoxiamino-6-(p-fluor-bencilamino)-piridina

Info

Publication number: AR229101A1
Authority: AR; Argentina
Prior art keywords: carbetoxyamine; bencilamino; fluor; amino; procedure
Prior art date: 1980-09-13

Application number

AR286685A

Other languages

English (en)

Spanish (es)

Original Assignee

Degussa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-09-13

Filing date

1981-09-08

Publication date

1983-06-15

1981-09-08 Application filed by Degussa filed Critical Degussa

1983-06-15 Application granted granted Critical

1983-06-15 Publication of AR229101A1 publication Critical patent/AR229101A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AR286685A 1980-09-13 1981-09-08 Procedimiento para obtener una mezcla de la forma a y de la forma b, cristalinas de maleato de 2-amino-3-carbetoxiamino-6-(p-fluor-bencilamino)-piridina AR229101A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3034638		1980-09-13

Publications (1)

Publication Number	Publication Date
AR229101A1 true AR229101A1 (es)	1983-06-15

Family

ID=6111900

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AR286685A AR229101A1 (es)	1980-09-13	1981-09-08	Procedimiento para obtener una mezcla de la forma a y de la forma b, cristalinas de maleato de 2-amino-3-carbetoxiamino-6-(p-fluor-bencilamino)-piridina

Country Status (31)

Country	Link
US (1)	US4481205A (fr)
JP (1)	JPS5781465A (fr)
KR (1)	KR860000585B1 (fr)
AR (1)	AR229101A1 (fr)
AT (1)	AT375924B (fr)
AU (1)	AU541020B2 (fr)
BE (1)	BE890331A (fr)
CA (1)	CA1147736A (fr)
CH (1)	CH646952A5 (fr)
CS (1)	CS226037B2 (fr)
DD (1)	DD201786A5 (fr)
DK (1)	DK159878C (fr)
EG (1)	EG15446A (fr)
ES (1)	ES505423A0 (fr)
FI (1)	FI79531C (fr)
FR (1)	FR2490225B1 (fr)
GB (1)	GB2084138B (fr)
GR (1)	GR75777B (fr)
HU (1)	HU182720B (fr)
IE (1)	IE51547B1 (fr)
IL (1)	IL63801A (fr)
IN (1)	IN155674B (fr)
IT (1)	IT1171520B (fr)
LU (1)	LU83633A1 (fr)
NL (1)	NL189856C (fr)
NO (1)	NO160919C (fr)
PL (1)	PL130030B1 (fr)
SE (1)	SE454693B (fr)
SU (1)	SU1091855A3 (fr)
YU (1)	YU43037B (fr)
ZA (1)	ZA816336B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3416609A1 (de) *	1984-05-05	1985-11-07	Degussa Ag, 6000 Frankfurt	2-amino-3-ethoxycarbonylamino-6-(p-fluor-benzylamino)- pyridin-gluconat und pharmazeutische zubereitungen, die diese substanz enthalten
NO860825L (no) *	1985-03-23	1986-09-24	Degussa	Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin.
JPH0568848U (ja) *	1991-11-18	1993-09-17	京都機械工具株式会社	チューブ絞り器
DE4327516A1 (de) *	1993-08-17	1995-02-23	Asta Medica Ag	Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
DE19625582A1 (de) *	1996-06-27	1998-01-02	Asta Medica Ag	Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen die mit einer unphysiologisch hohen Zellsterberate einhergehen
DE19716984A1 (de) *	1997-04-23	1998-10-29	Asta Medica Ag	Verfahren zur Herstellung von reinem Flupirtin-Maleat und dessen Modifikation A
US6187324B1 (en) *	1998-08-11	2001-02-13	Kabushiki Kaisha Ogi Kogei	Cosmetic composition comprising at least one of Kumazasa extract and medicinal carbon
US6821995B1 (en)	1999-12-01	2004-11-23	Duke University	Method of treating batten disease
DE10327674A1 (de) *	2003-06-20	2005-01-05	Awd.Pharma Gmbh & Co. Kg	Injizierbare Darreichungsform von Flupirtin
US7741358B2 (en) *	2005-04-14	2010-06-22	N.V. Organon	Crystal form of asenapine maleate
US20080279930A1 (en) *	2007-05-07	2008-11-13	Bernd Terhaag	Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
US8501778B2 (en)	2008-06-20	2013-08-06	Nhwa Pharma. Corporation	Aralkyl piperidine derivatives and their uses as antalgic or ataractic agent
CA2738866A1 (fr) *	2008-08-06	2010-02-11	Bionevia Pharmaceuticals, Inc.	Cocristal d'hydrochlorure de flupirtine et d'acide maleique
DE102009023162B4 (de) *	2009-05-29	2011-07-07	Corden PharmaChem GmbH, 68305	Verfahren zur Herstellung von Flupirtin
CN102140077A (zh) *	2010-01-28	2011-08-03	范扶民	氟吡汀a晶型及其制备方法
WO2012004391A1 (fr)	2010-07-09	2012-01-12	K.H.S. Pharma Holding Gmbh	Procédé de préparation de maléate de flupirtine
CN102241626B (zh) *	2011-05-03	2013-07-03	北京华睿鼎信科技有限公司	一种马来酸氟吡汀的合成工艺
WO2013080215A1 (fr)	2011-11-30	2013-06-06	Arch Pharmalabs Limited	Procédé amélioré pour la préparation de flupirtine et des sels pharmaceutiquement acceptables de celle-ci
CN103086963A (zh) *	2013-01-29	2013-05-08	吉林修正药业新药开发有限公司	一种马来酸氟吡汀a晶型化合物及中间体的合成方法
CN104086481B (zh) *	2014-07-18	2016-05-11	四川新斯顿制药股份有限公司	一种马来酸氟吡汀的合成方法
CN111100010A (zh) *	2019-12-30	2020-05-05	山东省越兴化工有限公司	一种对氟苄胺的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1795858C2 (de) *	1968-07-19	1979-01-11	Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt	Benzylaminopyridine
US3969361A (en) *	1972-05-10	1976-07-13	Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler	2-Benzoyl-3-amino-pyridines

1981
- 1981-09-02 US US06/298,886 patent/US4481205A/en not_active Expired - Lifetime
- 1981-09-04 GB GB8126788A patent/GB2084138B/en not_active Expired
- 1981-09-04 IE IE2055/81A patent/IE51547B1/en not_active IP Right Cessation
- 1981-09-08 AR AR286685A patent/AR229101A1/es active
- 1981-09-09 YU YU2157/81A patent/YU43037B/xx unknown
- 1981-09-10 NO NO813082A patent/NO160919C/no unknown
- 1981-09-10 SU SU813332400A patent/SU1091855A3/ru active
- 1981-09-10 IN IN1018/CAL/81A patent/IN155674B/en unknown
- 1981-09-11 GR GR66021A patent/GR75777B/el unknown
- 1981-09-11 ES ES505423A patent/ES505423A0/es active Granted
- 1981-09-11 IL IL63801A patent/IL63801A/xx unknown
- 1981-09-11 ZA ZA816336A patent/ZA816336B/xx unknown
- 1981-09-11 JP JP56143721A patent/JPS5781465A/ja active Granted
- 1981-09-11 CH CH591081A patent/CH646952A5/de not_active IP Right Cessation
- 1981-09-11 BE BE6/47521A patent/BE890331A/fr not_active IP Right Cessation
- 1981-09-11 AU AU75163/81A patent/AU541020B2/en not_active Expired
- 1981-09-11 CA CA000385703A patent/CA1147736A/fr not_active Expired
- 1981-09-11 PL PL1981232999A patent/PL130030B1/pl unknown
- 1981-09-11 CS CS816725A patent/CS226037B2/cs unknown
- 1981-09-11 AT AT0393481A patent/AT375924B/de not_active IP Right Cessation
- 1981-09-11 SE SE8105425A patent/SE454693B/sv not_active IP Right Cessation
- 1981-09-11 HU HU812635A patent/HU182720B/hu not_active IP Right Cessation
- 1981-09-11 LU LU83633A patent/LU83633A1/de unknown
- 1981-09-11 IT IT49272/81A patent/IT1171520B/it active
- 1981-09-11 FI FI812836A patent/FI79531C/fi not_active IP Right Cessation
- 1981-09-11 NL NLAANVRAGE8104211,A patent/NL189856C/xx not_active IP Right Cessation
- 1981-09-11 DK DK404681A patent/DK159878C/da active
- 1981-09-11 DD DD81233226A patent/DD201786A5/de unknown
- 1981-09-11 KR KR1019810003406A patent/KR860000585B1/ko active
- 1981-09-13 EG EG81515A patent/EG15446A/xx active
- 1981-09-14 FR FR8117328A patent/FR2490225B1/fr not_active Expired

Also Published As

Publication number	Publication date
DD201786A5 (de)	1983-08-10
CH646952A5 (de)	1984-12-28
ATA393481A (de)	1984-02-15
NL189856B (nl)	1993-03-16
EG15446A (en)	1986-06-30
GB2084138A (en)	1982-04-07
GR75777B (fr)	1984-08-02
IT1171520B (it)	1987-06-10
DK159878B (da)	1990-12-24
BE890331A (fr)	1982-03-11
NO160919C (no)	1989-06-14
JPS5781465A (en)	1982-05-21
IE51547B1 (en)	1987-01-07
FR2490225A1 (fr)	1982-03-19
ES8206481A1 (es)	1982-08-16
CS226037B2 (en)	1984-03-19
FI79531C (fi)	1990-01-10
ZA816336B (en)	1982-09-29
DK404681A (da)	1982-03-14
ES505423A0 (es)	1982-08-16
IN155674B (fr)	1985-02-23
HU182720B (en)	1984-03-28
CA1147736A (fr)	1983-06-07
US4481205A (en)	1984-11-06
AU7516381A (en)	1982-03-25
YU43037B (en)	1989-02-28
YU215781A (en)	1984-02-29
NL8104211A (nl)	1982-04-01
FI812836L (fi)	1982-03-14
SE8105425L (sv)	1982-03-14
KR830007556A (ko)	1983-10-21
PL130030B1 (en)	1984-07-31
SU1091855A3 (ru)	1984-05-07
FR2490225B1 (fr)	1985-09-06
NO813082L (no)	1982-03-15
IL63801A (en)	1984-10-31
FI79531B (fi)	1989-09-29
IT8149272A0 (it)	1981-09-11
SE454693B (sv)	1988-05-24
AT375924B (de)	1984-09-25
IE812055L (en)	1982-03-13
JPH0259149B2 (fr)	1990-12-11
PL232999A1 (fr)	1982-08-16
LU83633A1 (de)	1982-01-21
NO160919B (no)	1989-03-06
AU541020B2 (en)	1984-12-13
IL63801A0 (en)	1981-12-31
KR860000585B1 (ko)	1986-05-17
DK159878C (da)	1991-05-13
NL189856C (nl)	1993-08-16
GB2084138B (en)	1984-07-25

Publication	Publication Date	Title
AR229101A1 (es)	1983-06-15	Procedimiento para obtener una mezcla de la forma a y de la forma b, cristalinas de maleato de 2-amino-3-carbetoxiamino-6-(p-fluor-bencilamino)-piridina
ES498393A0 (es)	1982-09-16	Procedimiento para la preparacion de una nueva forma de ac- cion retardada a base de dipiridamol
ES518768A0 (es)	1984-03-01	Procedimiento y dispositivo para la fabricacion de una cremallera.
ES504905A0 (es)	1983-02-01	Un procedimiento para la preparacion de una nueva formulacion de bacampicilina.
IT1172196B (it)	1987-06-18	Metodo e materiale sintetico di copertura per trattare una parte le sionata di mucosa orale
ES501610A0 (es)	1982-09-16	Metodo para la preparacion de una espuma de poli-cloruro de vinilo-rigida
ES498055A0 (es)	1982-07-01	Un procedimiento para la preparacion de una piridilanilina
ES504291A0 (es)	1983-01-01	Un procedimiento para la preparacion de benzotio-en y benzofuransulfonamidas.
ES503188A0 (es)	1982-04-16	Un procedimiento para la preparacion de una 1-benzoil-urea 3-sustituida
ES524271A0 (es)	1984-11-16	Un procedimiento para la preparacion de nuevos derivados de daunorrubicina y doxorrubicina.
ES545258A0 (es)	1986-07-16	Procedimiento para distinguir celulas normales de malignas, en una mezcla de las mismas
ES499609A0 (es)	1982-02-01	Un procedimiento para la preparacion de una 3-yodometil-ce- falosporina
ES500897A0 (es)	1982-02-16	Un procedimiento para la preparacion de una mezcla de hidro-carburos
ES501219A0 (es)	1982-09-16	Un procedimiento para la preparacion de una composicion detergente en particulas.
ES506654A0 (es)	1983-01-01	Procedimiento de obtencion de una nueva forma galenica de lametoclopramida
IT8122083A1 (it)	1982-12-02	Nuovi chinossalin-2-il-etenil-chetoni e procedimento per la loro preparazione
ES537783A0 (es)	1985-12-01	Un procedimiento para la preparacion de nuevos 5-hidroxi-2,3-dihidrobenzufuranos sustituidos y analagos.
IT7983403A0 (it)	1979-06-08	Materiale incombustibile eprocedimento per la produzione dello stesso.
MX161366A (es)	1990-09-18	Procedimiento para la preparacion de una formulacion de fotoactivadores solidos y la formulacion obtenida
AR229182A1 (es)	1983-06-30	Unidad de construccion,y metodo para la produccion de una unidad de construccion
ES500412A0 (es)	1982-01-16	Un procedimiento para preparar una pirazolopiridina
ES500494A0 (es)	1982-02-01	Procedimiento y dispositivo para inflamar una mezcla de sin-terizacion
ES488433A0 (es)	1980-12-16	Mejoras en un procedimiento para la produccion de una magne-tita romboedrica sintetica
ES505786A0 (es)	1982-12-01	Un procedimiento para la preparacion de una quinolona
AR228453A1 (es)	1983-03-15	Procedimiento para producir 2,3,5-tricloropiridina