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AR106101A1 - Compuestos bicíclicos como inhibidores de la atx - Google Patents

Compuestos bicíclicos como inhibidores de la atx

Info

Publication number
AR106101A1
AR106101A1 ARP160102881A ARP160102881A AR106101A1 AR 106101 A1 AR106101 A1 AR 106101A1 AR P160102881 A ARP160102881 A AR P160102881A AR P160102881 A ARP160102881 A AR P160102881A AR 106101 A1 AR106101 A1 AR 106101A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
alkoxy
cycloalkyl
thiophenyl
Prior art date
Application number
ARP160102881A
Other languages
English (en)
Inventor
Schmitz Petra
Rudolph Markus
Mattei Patrizio
Hunziker Daniel
Hert Jrme
Di Giorgio Patrick
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR106101A1 publication Critical patent/AR106101A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicación 1: Compuestos de la fórmula (1), en la que: R¹ es fenilo sustituido, (fenilo sustituido)-alquilo C₁₋₆, (fenoxi sustituido)-alquilo C₁₋₆, (fenilo sustituido)-alquenilo C₂₋₆, (fenilo sustituido)-alquinilo C₂₋₆, piridinilo sustituido, (piridinilo sustituido)-alquilo C₁₋₆, (piridinilo sustituido)-alquenilo C₂₋₆, (piridinilo sustituido)-alquinilo C₂₋₆, tiofenilo sustituido, (tiofenilo sustituido)-alquilo C₁₋₆, (tiofenilo sustituido)-alquenilo C₂₋₆, (tiofenilo sustituido)-alquinilo C₂₋₆, dichos fenilo sustituido, (fenilo sustituido)-alquilo C₁₋₆, (fenoxi sustituido)-alquilo C₁₋₆, (fenilo sustituido)-alquenilo C₂₋₆, (fenilo sustituido)-alquinilo C₂₋₆, piridinilo sustituido, (piridinilo sustituido)-alquilo C₁₋₆, (piridinilo sustituido)-alquenilo C₂₋₆, (piridinilo sustituido)-alquinilo C₂₋₆, tiofenilo sustituido, (tiofenilo sustituido)-alquilo C₁₋₆, (tiofenilo sustituido)-alquenilo C₂₋₆ y (tiofenilo sustituido)-alquinilo C₂₋₆ están sustituidos por R³, R⁴ y, R⁵; Y es -OC(O)- o -C(O)-; W es -C(O)-, -S(O)₂- o -CR⁶R⁷-; R² se elige entre los sistemas de anillo B, F, L, M, O, Z, AF, AG, AH, AJ, AN, AO, AP, AQ, AR, AS, AT, AU y AV seleccionados del grupo de fórmulas (2); R³ es halógeno, hidroxi, ciano, alquilo C₁₋₆, alcoxi C₁₋₆, (alcoxi C₁₋₆)-alquilo C₁₋₆, haloalcoxi C₁₋₆, haloalquilo C₁₋₆, hidroxi-alquilo C₁₋₆, cicloalquilo C₃₋₈, (cicloalquilo C₃₋₈)-alquilo C₁₋₆, (cicloalquilo C₃₋₈)-alcoxi C₁₋₆, cicloalcoxi C₃₋₈, (cicloalcoxi C₃₋₈)-alquilo C₁₋₆, alquilamino C₁₋₆, (alquil C₁₋₆)-carbonilamino, (cicloalquil C₃₋₈)-carbonilamino, (alquil C₁₋₆)-tetrazolilo, (alquil C₁₋₆)-tetrazolil-alquilo C₁₋₆ o heterocicloalquil-alcoxi C₁₋₆; R⁴ y R⁵ con independencia entre sí se eligen entre H, halógeno, hidroxi, ciano, alquilo C₁₋₆, alcoxi C₁₋₆, (alcoxi C₁₋₆)-alquilo C₁₋₆; haloalcoxi C₁₋₆, haloalquilo C₁₋₆; hidroxi-alquilo C₁₋₆, cicloalquilo C₃₋₈; (cicloalquilo C₃₋₈)-alquilo C₁₋₆, (cicloalquilo C₃₋₈)-alcoxi C₁₋₆, cicloalcoxi C₃₋₈, (cicloalcoxi C₃₋₈)-alquilo C₁₋₆; (alquil C₁₋₆)-carbonilamino, (cicloalquil C₃₋₈)-carbonilamino, (alquil C₁₋₆)-tetrazolilo, (alquil C₁₋₆)-tetrazolil-alquilo C₁₋₆ y heterocicloalquil-alcoxi C₁₋₆; R⁶ es H o alquilo C₁₋₆; R⁷ es H, alquilo C₁₋₆, halógeno, haloalquilo C₁₋₆ o alcoxi C₁₋₆; R⁹ es halógeno, alquilo C₁₋₆ o alcoxi C₁₋₆; m, n, p y q con independencia entre sí se eligen entre los números 1 y 2; r es el número 1, 2 ó 3; o las sales farmacéuticamente aceptables.
ARP160102881A 2015-09-24 2016-09-22 Compuestos bicíclicos como inhibidores de la atx AR106101A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15186645 2015-09-24

Publications (1)

Publication Number Publication Date
AR106101A1 true AR106101A1 (es) 2017-12-13

Family

ID=54199041

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102881A AR106101A1 (es) 2015-09-24 2016-09-22 Compuestos bicíclicos como inhibidores de la atx

Country Status (20)

Country Link
US (2) US20180208602A1 (es)
EP (1) EP3353180B1 (es)
JP (1) JP6846414B2 (es)
KR (1) KR20180054830A (es)
CN (2) CN115124538A (es)
AR (1) AR106101A1 (es)
AU (1) AU2016328535A1 (es)
BR (1) BR112018006024A2 (es)
CA (1) CA2983782A1 (es)
CL (1) CL2018000596A1 (es)
CO (1) CO2017011151A2 (es)
HK (1) HK1246787A1 (es)
IL (1) IL255570A (es)
MA (1) MA42918A (es)
MX (1) MX2018002217A (es)
PE (1) PE20180461A1 (es)
PH (1) PH12018500408A1 (es)
RU (1) RU2018114289A (es)
TW (1) TW201720824A (es)
WO (1) WO2017050732A1 (es)

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AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
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CN106029667B (zh) 2014-03-26 2019-08-23 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物
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JP6876685B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｔｘ阻害剤としての二環式化合物
RU2724899C2 (ru) 2015-09-24 2020-06-26 Ф. Хоффманн-Ля Рош Аг Новые бициклические соединения в качестве дуальных ингибиторов atx/ca
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CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
WO2018167001A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag Heterocyclic compounds useful as dual atx/ca inhibitors
JOP20190284A1 (ar) 2017-06-14 2019-12-11 Bayer Pharma AG مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس
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