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AR103251A1 - Compuestos policíclicos de carbamoilpiridona y su uso farmacéutico - Google Patents

Compuestos policíclicos de carbamoilpiridona y su uso farmacéutico

Info

Publication number
AR103251A1
AR103251A1 ARP150104261A ARP150104261A AR103251A1 AR 103251 A1 AR103251 A1 AR 103251A1 AR P150104261 A ARP150104261 A AR P150104261A AR P150104261 A ARP150104261 A AR P150104261A AR 103251 A1 AR103251 A1 AR 103251A1
Authority
AR
Argentina
Prior art keywords
group
compounds
cycloalkyl
alkyl
heterocyclyl
Prior art date
Application number
ARP150104261A
Other languages
English (en)
Inventor
Pyun Hyung
Anthony Jung - Morganelli Philip
E Lazerwith Scott
Jin Haolun
Ji Mingzhe
J Cottell Jeromy
R Cai Zhenhong
M Bacon Elizabeth
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR103251A1 publication Critical patent/AR103251A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se revelan compuestos para uso en el tratamiento de la infección por el virus de inmunodeficiencia humana (VIH). Los compuestos tienen la fórmula (1). También se presentan métodos asociados con la preparación y uso de tales compuestos, así como composiciones farmacéuticas que comprenden tales compuestos. Reivindicación 1: Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo, en donde: A se selecciona del grupo que consiste en cicloalquilo monocíclico C₃₋₇ y heterociclilo monocíclico de 4 a 7 miembros; en el que cada cicloalquilo monocíclico C₃₋₇ y heterociclilo monocíclico de 4 a 7 miembros está opcionalmente sustituido con 1 a 5 grupos R⁴; cada R⁴ se selecciona independientemente del grupo que consiste en oxo, metilo, y etilo; o dos R⁴ conectados al mismo átomo de carbono o a átomos de carbono adyacentes forman un cicloalquilo C₃₋₆ fusionado o espiro o anillo heterociclilo de 4 a 6 miembros; R¹ se selecciona del grupo que consiste en H, alquilo C₁₋₄, haloalquilo C₁₋₄ y cicloalquilo C₃₋₆; R² se selecciona del grupo que consiste en hidrógeno, haloalquilo C₁₋₃, y alquilo C₁₋₃; R³ se selecciona del grupo que consiste en fenilo sustituido con al menos 3 grupos R⁵; y cada R⁵ se selecciona independientemente del grupo que consiste en alquilo C₁₋₃ y halógeno.
ARP150104261A 2014-12-23 2015-12-22 Compuestos policíclicos de carbamoilpiridona y su uso farmacéutico AR103251A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462096291P 2014-12-23 2014-12-23

Publications (1)

Publication Number Publication Date
AR103251A1 true AR103251A1 (es) 2017-04-26

Family

ID=55168426

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150104261A AR103251A1 (es) 2014-12-23 2015-12-22 Compuestos policíclicos de carbamoilpiridona y su uso farmacéutico

Country Status (24)

Country Link
US (4) US9522912B2 (es)
EP (2) EP3237416B1 (es)
JP (3) JP6393835B2 (es)
KR (4) KR102020004B1 (es)
CN (2) CN107108643B (es)
AR (1) AR103251A1 (es)
AU (3) AU2015369817B2 (es)
BR (1) BR102015032109A2 (es)
CA (1) CA2969244C (es)
EA (1) EA201791019A1 (es)
ES (1) ES2732482T3 (es)
HK (1) HK1244000B (es)
IL (1) IL252532A0 (es)
MA (1) MA45613A (es)
MX (1) MX2017007814A (es)
NZ (1) NZ732391A (es)
PL (1) PL3237416T3 (es)
PT (1) PT3237416T (es)
SG (1) SG11201704421QA (es)
SI (1) SI3237416T1 (es)
TR (1) TR201909152T4 (es)
TW (2) TWI695003B (es)
UY (1) UY36465A (es)
WO (1) WO2016106237A1 (es)

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