AR096149A1 - Macrociclos como inhibidores de quinasa - Google Patents
Macrociclos como inhibidores de quinasaInfo
- Publication number
- AR096149A1 AR096149A1 ARP140101780A ARP140101780A AR096149A1 AR 096149 A1 AR096149 A1 AR 096149A1 AR P140101780 A ARP140101780 A AR P140101780A AR P140101780 A ARP140101780 A AR P140101780A AR 096149 A1 AR096149 A1 AR 096149A1
- Authority
- AR
- Argentina
- Prior art keywords
- denotes
- phet1
- oconh
- nhcoo
- nhconh
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 2
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 abstract 2
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 abstract 1
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 abstract 1
- DKYBVKMIZODYKL-UHFFFAOYSA-N 1,3-diazinane Chemical compound C1CNCNC1 DKYBVKMIZODYKL-UHFFFAOYSA-N 0.000 abstract 1
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 abstract 1
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 1
- PDQRQJVPEFGVRK-UHFFFAOYSA-N 2,1,3-benzothiadiazole Chemical compound C1=CC=CC2=NSN=C21 PDQRQJVPEFGVRK-UHFFFAOYSA-N 0.000 abstract 1
- KEQTWHPMSVAFDA-UHFFFAOYSA-N 2,3-dihydro-1h-pyrazole Chemical compound C1NNC=C1 KEQTWHPMSVAFDA-UHFFFAOYSA-N 0.000 abstract 1
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 abstract 1
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical compound C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 abstract 1
- GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical compound C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 abstract 1
- WRYCSMQKUKOKBP-UHFFFAOYSA-N Imidazolidine Chemical compound C1CNCN1 WRYCSMQKUKOKBP-UHFFFAOYSA-N 0.000 abstract 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 abstract 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 abstract 1
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- HTFFABIIOAKIBH-UHFFFAOYSA-N diazinane Chemical compound C1CCNNC1 HTFFABIIOAKIBH-UHFFFAOYSA-N 0.000 abstract 1
- YRTCKZIKGWZNCU-UHFFFAOYSA-N furo[3,2-b]pyridine Chemical compound C1=CC=C2OC=CC2=N1 YRTCKZIKGWZNCU-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical compound C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 abstract 1
- -1 isoindolindoline Chemical compound 0.000 abstract 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
- AHHWIHXENZJRFG-UHFFFAOYSA-N oxetane Chemical compound C1COC1 AHHWIHXENZJRFG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 abstract 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
Reivindicación 1: Compuestos de la fórmula (1) en donde X denota N o CH; Y denota Het-diilo o Ar; Q¹ denota (CH₂)ₙ, O(CH₂)ₙ o (CH₂)ₙHet¹-diílo; M denota (CH₂)ₚNR³CO, CONR³, NR³ o CO; Q² denota (CH₂)ₙO o (CH₂)ₙ; B denota Ar o Het-diilo; Het denota furano, tiofeno, pirrol, imidazol, pirazol, oxazol, isoxazol, oxadiazol, tiazol, triazol, tetrazol, piridina, pirimidina, piridazina, pirazina, indol, isoindolindolina, bencimidazol, indazol, quinolina, isoquinolina, benzoxazol, 1,3-benzo dioxol, benzotiofeno, benzofurano, imidazopiridina, dihidroindol, quinoxalina, benzo[1,2,5]tiadiazol o furo[3,2-b]piridina, cada uno de los cuales no está sustituido o está mono- o disustituido con Hal, A, [C(R³)₂]ₚOR³, [C(R³)₂]ₚN(R³)₂, [C(R³)₂]ₚHet¹, NO₂, CN, [C(R³)₂]ₚCOOR³, CON(R³)₂, NR³COA, NR³SO₂A, SO₂N(R³)₂, S(O)ₙA, COHet¹, O[C(R³)₂]ₘN(R³)₂, O[C(R³)₂]ₚHet¹, NHCOOA, NHCON(R³)₂, NHCOO[C(R³)₂]ₘN(R³), NHCOO[C(R³)₂]ₚHet¹, NHCONH[C(R³)₂]ₘN(R³)₂, NHCONH[C(R³)₂]ₚHet¹, OCONH[C(R³)₂]ₘN(R³)₂, OCONH[C(R³)₂]ₚHet¹, CHO, COA, =S, =NR³ y/u =O; Ar denota fenileno, que no está sustituido o que está mono-, di- o trisustituido con Hal, A, [C(R³)₂]ₚOR³, O[C(R³)₂]ₚOR³, [C(R³)₂]ₚN(R³)₂, O[C(R³)₂]ₚN(R³)₂, [C(R³)₂]ₚHet¹, NO₂, CN, [C(R³)₂]ₚCOOR³, O[C(R³)₂]ₚCOOR³, CON(R³)₂, NR³COA, NR³SO₂A, SO₂N(R³)₂, S(O)₂A, COHet¹, O[C(R³)₂]ₚHet¹, NHCOOA, NHCON(R³)₂, NHCOO[C(R³)₂]ₘN(R³)₂, NHCOO[C(R³)₂]ₚHet¹, NHCONH[C(R³)₂]ₘN(R³)₂, NHCONH[C(R³)₂]ₚHet¹, OCONH[C(R³)₂]ₘN(R³)₂, OCONH[C(R³)₂]ₚHet¹, S(O)₂Het¹, CHO y/o COA; Het¹ denota dihidropirrol, pirrolidina, azetidina, oxetano, tetrahidroimidazol, dihidropirazol, tetrahidropirazol, tetrahidrofurano, dihidro piridina, tetrahidropiridina, piperidina, morfolina, hexahidropiridazina, hexahidropirimidina, [1,3]dioxolano, tetrahidropirano o piperazina, que no está sustituido o que está mono- o disustituido con Hal, CN, OH, OA, COOA, CONH₂, S(O)₂A, S(O)₂Ar, COA, A y/u =O; A denota alquilo no ramificado o ramificado con 1 - 10 átomos de C, en donde uno o dos grupos no adyacentes CH y/o CH₂ pueden estar reemplazados por átomos de N, O y/o S y en donde 1 - 7 átomos de H pueden estar reemplazados por F o Cl; R³ denota H o alquilo con 1, 2, 3 ó 4 átomos de C; Hal denota F, Cl, Br o I; n denota 1, 2, 3, 4 ó 5; m denota 1, 2 ó 3; p denota 0, 1, 2, 3 ó 4; y sus solvatos, sales, tautómeros y estereoisómeros farmacéuticamente aceptables, incluyendo sus mezclas en todas las proporciones.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13002393 | 2013-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR096149A1 true AR096149A1 (es) | 2015-12-09 |
Family
ID=48236654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140101780A AR096149A1 (es) | 2013-05-06 | 2014-04-30 | Macrociclos como inhibidores de quinasa |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9861635B2 (es) |
| EP (1) | EP2994471B1 (es) |
| JP (1) | JP6401247B2 (es) |
| CN (1) | CN105164136B (es) |
| AR (1) | AR096149A1 (es) |
| AU (1) | AU2014264973B2 (es) |
| CA (1) | CA2911259A1 (es) |
| ES (1) | ES2637721T3 (es) |
| IL (1) | IL242347B (es) |
| WO (1) | WO2014180524A1 (es) |
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| NZ718190A (en) | 2013-08-23 | 2017-10-27 | Neupharma Inc | Substituted quinazolines for inhibiting kinase activity |
| EP3256475A4 (en) * | 2015-02-13 | 2019-02-13 | Dana-Farber Cancer Institute, Inc. | LRRK2 INHIBITORS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| US10947201B2 (en) * | 2015-02-17 | 2021-03-16 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| US10544106B2 (en) | 2016-08-15 | 2020-01-28 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| PT3559009T (pt) | 2016-12-22 | 2021-05-04 | Calithera Biosciences Inc | Composições e métodos para inibir a atividade da arginase |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| JP2020518673A (ja) | 2017-05-05 | 2020-06-25 | フュージョン・ファーマシューティカルズ・インコーポレイテッド | 二官能性キレートの薬物動態増強及びその使用 |
| BR112019023249A8 (pt) | 2017-05-05 | 2021-02-23 | Centre For Probe Dev And Commercialization | anticorpos monoclonais igf-1r e usos dos mesmos |
| WO2019120267A1 (zh) * | 2017-12-22 | 2019-06-27 | 成都先导药物开发股份有限公司 | 一种咪唑并[1,2-b]哒嗪大环类激酶抑制剂 |
| US11584759B2 (en) | 2018-04-18 | 2023-02-21 | Hitgen Inc. | Macrocyclic kinase inhibitor |
| WO2020027225A1 (ja) | 2018-07-31 | 2020-02-06 | ファイメクス株式会社 | 複素環化合物 |
| KR102163494B1 (ko) * | 2018-10-26 | 2020-10-08 | 한국과학기술연구원 | 단백질 키나아제 저해제인 헤테로방향족 매크로시클릭 유도체 |
| CA3127268A1 (en) * | 2019-01-22 | 2020-07-30 | Merck Patent Gmbh | Heterocyclic derivatives |
| WO2023025912A1 (en) | 2021-08-25 | 2023-03-02 | Alesta Therapeutics BV | Use of gcn2 inhibitors in treating cancer |
| EP4525875A1 (en) * | 2022-05-20 | 2025-03-26 | Merck Sharp & Dohme LLC | Macrocycles as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof |
| WO2024083223A1 (zh) * | 2022-10-21 | 2024-04-25 | 正大天晴药业集团股份有限公司 | 大环类化合物及其医药用途 |
| CN118084923A (zh) * | 2022-11-17 | 2024-05-28 | 中国科学院上海有机化学研究所 | 作为lrrk2激酶抑制剂的环状化合物及其制备方法 |
| WO2024146541A1 (en) * | 2023-01-03 | 2024-07-11 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Macrocyclic compounds as usp1 inhibitors |
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| CN100404536C (zh) | 2003-07-16 | 2008-07-23 | 詹森药业有限公司 | 作为糖原合酶激酶3抑制剂的三唑并嘧啶衍生物 |
| EP1697384B1 (en) * | 2003-12-18 | 2008-04-02 | Janssen Pharmaceutica N.V. | Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents |
| WO2006045828A1 (en) | 2004-10-29 | 2006-05-04 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting bicyclic pyrimidine derivatives |
| MY169441A (en) * | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| US7723340B2 (en) | 2005-01-13 | 2010-05-25 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
| JP2008526926A (ja) | 2005-01-14 | 2008-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | グリコーゲン合成酵素キナーゼ３阻害剤としてのトリアゾロピリミジン誘導体 |
| BRPI0612888B8 (pt) * | 2005-06-30 | 2022-12-27 | Janssen Pharmaceutica Nv | anilino-piridinotriazinas cíclicas como inibidoras de gsk-3, seus usos e composição farmacêutica, intermediário, seu uso e composição farmacêutica |
| ES2506040T3 (es) * | 2005-11-16 | 2014-10-13 | Cti Biopharma Corp. | Derivados de pirimidina ligados a oxígeno |
| AU2009224804B2 (en) * | 2008-03-10 | 2013-12-05 | Janssen Pharmaceutica Nv | 4-aryl-2-anilino-pyrimidines as PLK kinase inhibitors |
| WO2009134624A1 (en) * | 2008-04-28 | 2009-11-05 | Merck & Co., Inc. | Hcv ns3 protease inhibitors |
| JP5844287B2 (ja) * | 2010-02-11 | 2016-01-13 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 第ｘｉａ因子阻害剤としてのマクロ環 |
| TW201206946A (en) * | 2010-07-15 | 2012-02-16 | Bristol Myers Squibb Co | Compounds for the reduction of beta-amyloid production |
| WO2012024234A1 (en) * | 2010-08-18 | 2012-02-23 | University Of Miami | Compositions and methods for inducing cancer cell death |
| CA2809331C (en) * | 2010-08-27 | 2018-09-25 | Merck Patent Gmbh | Triazolopyrazine derivatives |
| RU2622104C2 (ru) * | 2011-09-30 | 2017-06-13 | Онкодизайн С.А. | Макроциклические ингибиторы киназы lrrk2 |
| WO2013045653A1 (en) * | 2011-09-30 | 2013-04-04 | Oncodesign S.A. | Macrocyclic flt3 kinase inhibitors |
| EP2807161B1 (en) * | 2012-01-28 | 2017-10-04 | Merck Patent GmbH | Triazolo[4,5-d]pyrimidine derivatives |
| PL2872515T3 (pl) * | 2012-07-13 | 2017-05-31 | Janssen Sciences Ireland Uc | Puryny makrocykliczne do leczenia infekcji wirusowych |
-
2014
- 2014-04-09 CA CA2911259A patent/CA2911259A1/en not_active Abandoned
- 2014-04-09 AU AU2014264973A patent/AU2014264973B2/en not_active Ceased
- 2014-04-09 ES ES14716758.9T patent/ES2637721T3/es active Active
- 2014-04-09 JP JP2016512234A patent/JP6401247B2/ja not_active Expired - Fee Related
- 2014-04-09 CN CN201480025423.7A patent/CN105164136B/zh not_active Expired - Fee Related
- 2014-04-09 EP EP14716758.9A patent/EP2994471B1/en not_active Not-in-force
- 2014-04-09 WO PCT/EP2014/000942 patent/WO2014180524A1/en active Application Filing
- 2014-04-09 US US14/888,496 patent/US9861635B2/en not_active Expired - Fee Related
- 2014-04-30 AR ARP140101780A patent/AR096149A1/es unknown
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2015
- 2015-10-29 IL IL242347A patent/IL242347B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL242347B (en) | 2018-08-30 |
| EP2994471A1 (en) | 2016-03-16 |
| ES2637721T3 (es) | 2017-10-16 |
| WO2014180524A1 (en) | 2014-11-13 |
| JP2016517894A (ja) | 2016-06-20 |
| AU2014264973A1 (en) | 2015-12-17 |
| CN105164136B (zh) | 2017-12-22 |
| AU2014264973B2 (en) | 2018-01-18 |
| JP6401247B2 (ja) | 2018-10-10 |
| EP2994471B1 (en) | 2017-05-17 |
| CN105164136A (zh) | 2015-12-16 |
| CA2911259A1 (en) | 2014-11-13 |
| US20160166574A1 (en) | 2016-06-16 |
| US9861635B2 (en) | 2018-01-09 |
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