AR089397A1 - Derivados de sulfonilaminopirrolidinona, su preparacion y aplicacion terapeutica - Google Patents
Derivados de sulfonilaminopirrolidinona, su preparacion y aplicacion terapeuticaInfo
- Publication number
- AR089397A1 AR089397A1 ARP120104901A ARP120104901A AR089397A1 AR 089397 A1 AR089397 A1 AR 089397A1 AR P120104901 A ARP120104901 A AR P120104901A AR P120104901 A ARP120104901 A AR P120104901A AR 089397 A1 AR089397 A1 AR 089397A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl group
- alkyl
- groups
- cycloalkyl
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 14
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- -1 -OH Chemical group 0.000 abstract 1
- MAMRCGKAOGCJAM-UHFFFAOYSA-N 1-(sulfonylamino)pyrrolidin-2-one Chemical class O=C1CCCN1N=S(=O)=O MAMRCGKAOGCJAM-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 108010048049 Factor IXa Proteins 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11306733.4A EP2606893A1 (en) | 2011-12-21 | 2011-12-21 | Sulphonylaminopyrrolidinone derivatives, their preparation and their therapeutic application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR089397A1 true AR089397A1 (es) | 2014-08-20 |
Family
ID=47428640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120104901A AR089397A1 (es) | 2011-12-21 | 2012-12-21 | Derivados de sulfonilaminopirrolidinona, su preparacion y aplicacion terapeutica |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9150544B2 (zh) |
| EP (2) | EP2606893A1 (zh) |
| JP (1) | JP6104936B2 (zh) |
| KR (1) | KR20140106703A (zh) |
| CN (1) | CN104136030B (zh) |
| AR (1) | AR089397A1 (zh) |
| AU (1) | AU2012357123B2 (zh) |
| BR (1) | BR112014014869A2 (zh) |
| CA (1) | CA2859575A1 (zh) |
| ES (1) | ES2559854T3 (zh) |
| IL (1) | IL233238A (zh) |
| IN (1) | IN2014CN04861A (zh) |
| MX (1) | MX347620B (zh) |
| RU (1) | RU2014129787A (zh) |
| SG (1) | SG11201403336QA (zh) |
| TW (1) | TWI568727B (zh) |
| UY (1) | UY34543A (zh) |
| WO (1) | WO2013092756A1 (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1307759B1 (it) | 1998-03-31 | 2001-11-19 | Schurr Stahlecker & Grill | Dispositivo per condensare un composito di fibre stirato. |
| DE19838762B4 (de) | 1998-08-26 | 2009-04-16 | Maschinenfabrik Rieter Ag | Spinnmaschine mit einer Vielzahl von Spinnstellen |
| DE102014108210A1 (de) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | Rodentizid |
| CN104557928B (zh) * | 2015-02-14 | 2016-08-24 | 佛山市赛维斯医药科技有限公司 | 一种含二环酰胺结构凝血因子Xa抑制剂、其制备方法及其用途 |
| CN112969698A (zh) * | 2018-11-08 | 2021-06-15 | 葛兰素史密斯克莱知识产权发展有限公司 | 化学化合物 |
| EP4070658A1 (de) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Verwendung von blutgerinnungshemmenden verbindungen als rodentizide |
| CN113264819B (zh) * | 2021-05-25 | 2024-11-05 | 都创(上海)医药开发有限公司 | 一种基于连续流反应技术快速合成3-溴-2-氟苯甲醛的方法 |
| TW202404583A (zh) | 2022-06-08 | 2024-02-01 | 加拿大商再諾製藥公司 | 吡啶胺衍生物及其作為鉀通道調節劑之用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4121947A1 (de) * | 1991-07-03 | 1993-01-07 | Basf Ag | 2-(3-(4-amidino-phenyl))-propionsaeurederivate, ihre herstellung und verwendung |
| US6281227B1 (en) * | 1996-12-13 | 2001-08-28 | Aventis Pharma Deutschland Gmbh | Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds |
| DK0944386T3 (da) * | 1996-12-13 | 2003-01-27 | Aventis Pharma Inc | Sulfonsyre- eller sulfonylamino-N-(heteroaralkyl)-azaheterocyclylamid-forbindelser |
| US6602864B1 (en) * | 1996-12-13 | 2003-08-05 | Aventis Pharma Deutschland Gmbh | Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds |
| IL123986A (en) | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
-
2011
- 2011-12-21 EP EP11306733.4A patent/EP2606893A1/en not_active Withdrawn
-
2012
- 2012-12-19 JP JP2014547988A patent/JP6104936B2/ja not_active Expired - Fee Related
- 2012-12-19 AU AU2012357123A patent/AU2012357123B2/en not_active Ceased
- 2012-12-19 WO PCT/EP2012/076224 patent/WO2013092756A1/en active Application Filing
- 2012-12-19 IN IN4861CHN2014 patent/IN2014CN04861A/en unknown
- 2012-12-19 ES ES12805694.2T patent/ES2559854T3/es active Active
- 2012-12-19 MX MX2014007671A patent/MX347620B/es active IP Right Grant
- 2012-12-19 CN CN201280070270.9A patent/CN104136030B/zh not_active Expired - Fee Related
- 2012-12-19 KR KR1020147019821A patent/KR20140106703A/ko not_active Ceased
- 2012-12-19 EP EP12805694.2A patent/EP2793887B1/en not_active Not-in-force
- 2012-12-19 RU RU2014129787A patent/RU2014129787A/ru not_active Application Discontinuation
- 2012-12-19 SG SG11201403336QA patent/SG11201403336QA/en unknown
- 2012-12-19 BR BR112014014869A patent/BR112014014869A2/pt not_active Application Discontinuation
- 2012-12-19 CA CA2859575A patent/CA2859575A1/en not_active Abandoned
- 2012-12-19 US US14/366,402 patent/US9150544B2/en not_active Expired - Fee Related
- 2012-12-20 TW TW101148829A patent/TWI568727B/zh not_active IP Right Cessation
- 2012-12-21 UY UY0001034543A patent/UY34543A/es not_active Application Discontinuation
- 2012-12-21 AR ARP120104901A patent/AR089397A1/es unknown
-
2014
- 2014-06-18 IL IL233238A patent/IL233238A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014007671A (es) | 2014-11-25 |
| ES2559854T3 (es) | 2016-02-16 |
| CN104136030B (zh) | 2017-03-01 |
| US20140329801A1 (en) | 2014-11-06 |
| EP2793887A1 (en) | 2014-10-29 |
| CN104136030A (zh) | 2014-11-05 |
| WO2013092756A1 (en) | 2013-06-27 |
| EP2793887B1 (en) | 2015-10-21 |
| MX347620B (es) | 2017-05-04 |
| EP2606893A1 (en) | 2013-06-26 |
| JP6104936B2 (ja) | 2017-03-29 |
| CA2859575A1 (en) | 2013-06-27 |
| IN2014CN04861A (zh) | 2015-09-18 |
| US9150544B2 (en) | 2015-10-06 |
| BR112014014869A2 (pt) | 2017-06-13 |
| IL233238A0 (en) | 2014-08-31 |
| JP2015502382A (ja) | 2015-01-22 |
| SG11201403336QA (en) | 2014-07-30 |
| RU2014129787A (ru) | 2016-02-10 |
| TW201331195A (zh) | 2013-08-01 |
| TWI568727B (zh) | 2017-02-01 |
| UY34543A (es) | 2013-06-28 |
| KR20140106703A (ko) | 2014-09-03 |
| IL233238A (en) | 2016-10-31 |
| AU2012357123A1 (en) | 2014-07-10 |
| AU2012357123B2 (en) | 2016-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |