AR077476A2 - Derivados antagonistas del receptor de la vitronectina, procedimiento de preparacion, composiciones farmaceuticas y usos de los compuestos - Google Patents
Derivados antagonistas del receptor de la vitronectina, procedimiento de preparacion, composiciones farmaceuticas y usos de los compuestosInfo
- Publication number
- AR077476A2 AR077476A2 ARP100102568A ARP100102568A AR077476A2 AR 077476 A2 AR077476 A2 AR 077476A2 AR P100102568 A ARP100102568 A AR P100102568A AR P100102568 A ARP100102568 A AR P100102568A AR 077476 A2 AR077476 A2 AR 077476A2
- Authority
- AR
- Argentina
- Prior art keywords
- vitronectine
- receiver
- compounds
- pharmaceutical compositions
- preparation procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicacion 1: Un compuesto de formula (1) en todas las formas isomeras, solas o en mezcla, así como sus sales de adicion fisiologicamente aceptables, en donde G representa 1,2,3,4-tetrahidro-1,8-naftiridin-7-ilo; R1 representa metilo; R2 representa metilo; R3 representa benciloxicarbonilo; y R4 representa OH o t-butoxi.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0214429A FR2847254B1 (fr) | 2002-11-19 | 2002-11-19 | Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077476A2 true AR077476A2 (es) | 2011-08-31 |
Family
ID=32187700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104254A AR042068A1 (es) | 2002-11-19 | 2003-11-18 | Derivados de antagonistas del receptor de la vitronectina, sus procedimientos de preparacion, sus aplicaciones como medicamentos y los compuestos farmaceuticos que contienen |
| ARP100102568A AR077476A2 (es) | 2002-11-19 | 2010-07-15 | Derivados antagonistas del receptor de la vitronectina, procedimiento de preparacion, composiciones farmaceuticas y usos de los compuestos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104254A AR042068A1 (es) | 2002-11-19 | 2003-11-18 | Derivados de antagonistas del receptor de la vitronectina, sus procedimientos de preparacion, sus aplicaciones como medicamentos y los compuestos farmaceuticos que contienen |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US7582640B2 (es) |
| EP (2) | EP2070914B1 (es) |
| JP (1) | JP4567459B2 (es) |
| KR (1) | KR101140752B1 (es) |
| CN (2) | CN101928287A (es) |
| AR (2) | AR042068A1 (es) |
| AT (2) | ATE518842T1 (es) |
| AU (2) | AU2003299330B2 (es) |
| BR (1) | BR0316307A (es) |
| CA (1) | CA2506310C (es) |
| CO (1) | CO5700761A2 (es) |
| CY (1) | CY1112218T1 (es) |
| DE (1) | DE60327712D1 (es) |
| DK (2) | DK2070914T3 (es) |
| ES (2) | ES2325616T3 (es) |
| FR (1) | FR2847254B1 (es) |
| HK (2) | HK1076277A1 (es) |
| IL (2) | IL168136A (es) |
| MA (1) | MA27492A1 (es) |
| MX (1) | MXPA05005340A (es) |
| NO (1) | NO20052491D0 (es) |
| PL (1) | PL376866A1 (es) |
| PT (2) | PT1565467E (es) |
| RU (1) | RU2412185C2 (es) |
| SI (2) | SI2070914T1 (es) |
| TW (1) | TW200412969A (es) |
| WO (1) | WO2004048375A1 (es) |
| ZA (1) | ZA200502850B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2847254B1 (fr) | 2002-11-19 | 2005-01-28 | Aventis Pharma Sa | Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant |
| FR2870541B1 (fr) | 2004-05-18 | 2006-07-14 | Proskelia Sas | Derives de pyrimidines antigonistes du recepteur de la vitronectine |
| US20110189174A1 (en) | 2010-02-01 | 2011-08-04 | Afshin Shafiee | Compositions and methods for treating, reducing, ameliorating, alleviating, or inhibiting progression of, pathogenic ocular neovascularization |
| US20110237605A1 (en) * | 2010-03-26 | 2011-09-29 | Eric Phillips | Molecular Crystal of (4-(1,8-Naphthyridin-2-YL)Piperidin-1-YL)Pyrimidine Derivative |
| CA3109326A1 (en) | 2018-08-17 | 2020-03-05 | Oxurion NV | Integrin antagonists |
| WO2021165206A1 (en) | 2020-02-19 | 2021-08-26 | Oxurion NV | Treatment of dry amd with integrin antagonists |
| CA3183338A1 (en) | 2020-06-29 | 2022-01-06 | Thomas S. Ickovic | Systems, methods, and program products for digital pet identification |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204350A (en) | 1991-08-09 | 1993-04-20 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives |
| US5217994A (en) | 1991-08-09 | 1993-06-08 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives |
| WO1994008577A1 (en) | 1992-10-14 | 1994-04-28 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| AU675689B2 (en) | 1992-12-01 | 1997-02-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| WO1995032710A1 (en) | 1994-05-27 | 1995-12-07 | Merck & Co., Inc. | Compounds for inhibiting osteoclast-mediated bone resorption |
| WO1996000574A1 (en) * | 1994-06-29 | 1996-01-11 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| CA2193966A1 (en) | 1994-06-29 | 1996-01-11 | Fadia El-Fehail Ali | Vitronectin receptor antagonists |
| PL330915A1 (en) | 1996-06-28 | 1999-06-07 | Merck Patent Gmbh | Phenylaniline derivatives as inhibitors of integrin |
| DE19629816A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| DE19653646A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
| US6723727B1 (en) * | 1996-12-20 | 2004-04-20 | Hoechst Aktiengesellschaft | Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them |
| EP0933367A1 (en) * | 1997-12-19 | 1999-08-04 | Hoechst Marion Roussel Deutschland GmbH | Novel acylguanidine derivates as inhibitors of bone resorption and as vitronectin receptor antagonists |
| KR20010034319A (ko) | 1998-01-23 | 2001-04-25 | 아벤티스 파마 도이칠란트 게엠베하 | 골흡수의 억제제 및 세포유착의 억제제로서 신규한술폰아미드 유도체 |
| EP1054871A2 (en) * | 1998-04-01 | 2000-11-29 | Du Pont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
| AU5336299A (en) * | 1998-08-07 | 2000-02-28 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| AU748949B2 (en) | 1999-06-23 | 2002-06-13 | Merck & Co., Inc. | Integrin receptor antagonists |
| EP1065208A1 (en) * | 1999-07-02 | 2001-01-03 | Aventis Pharma Deutschland GmbH | Substituted purine derivatives as inhibitors of cell adhesion |
| EP1065207A1 (en) | 1999-07-02 | 2001-01-03 | Aventis Pharma Deutschland GmbH | Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them |
| US6676750B1 (en) * | 1999-10-05 | 2004-01-13 | Geoffrey John Davies | Growth of diamond clusters |
| DE10042655A1 (de) | 2000-08-31 | 2002-03-14 | Aventis Pharma Gmbh | Verfahren zur Herstellung von Inhibitoren der Zell-Adhäsion |
| FR2847254B1 (fr) | 2002-11-19 | 2005-01-28 | Aventis Pharma Sa | Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant |
| FR2870541B1 (fr) * | 2004-05-18 | 2006-07-14 | Proskelia Sas | Derives de pyrimidines antigonistes du recepteur de la vitronectine |
-
2002
- 2002-11-19 FR FR0214429A patent/FR2847254B1/fr not_active Expired - Fee Related
-
2003
- 2003-11-12 BR BR0316307-5A patent/BR0316307A/pt not_active IP Right Cessation
- 2003-11-12 EP EP09003174A patent/EP2070914B1/fr not_active Expired - Lifetime
- 2003-11-12 AT AT09003174T patent/ATE518842T1/de active
- 2003-11-12 AT AT03799611T patent/ATE431825T1/de active
- 2003-11-12 SI SI200332048T patent/SI2070914T1/sl unknown
- 2003-11-12 US US10/536,028 patent/US7582640B2/en active Active
- 2003-11-12 AU AU2003299330A patent/AU2003299330B2/en not_active Ceased
- 2003-11-12 KR KR1020057009101A patent/KR101140752B1/ko active IP Right Grant
- 2003-11-12 PT PT03799611T patent/PT1565467E/pt unknown
- 2003-11-12 PT PT09003174T patent/PT2070914E/pt unknown
- 2003-11-12 SI SI200331636T patent/SI1565467T1/sl unknown
- 2003-11-12 MX MXPA05005340A patent/MXPA05005340A/es active IP Right Grant
- 2003-11-12 RU RU2005119163/04A patent/RU2412185C2/ru not_active Application Discontinuation
- 2003-11-12 ES ES03799611T patent/ES2325616T3/es not_active Expired - Lifetime
- 2003-11-12 DE DE60327712T patent/DE60327712D1/de not_active Expired - Lifetime
- 2003-11-12 CN CN2009101705723A patent/CN101928287A/zh active Pending
- 2003-11-12 WO PCT/FR2003/003349 patent/WO2004048375A1/fr active Application Filing
- 2003-11-12 PL PL376866A patent/PL376866A1/pl not_active Application Discontinuation
- 2003-11-12 CA CA2506310A patent/CA2506310C/fr not_active Expired - Lifetime
- 2003-11-12 EP EP03799611A patent/EP1565467B1/fr not_active Expired - Lifetime
- 2003-11-12 CN CN2003801088984A patent/CN1738817B/zh not_active Expired - Fee Related
- 2003-11-12 ES ES09003174T patent/ES2369561T3/es not_active Expired - Lifetime
- 2003-11-12 JP JP2004554592A patent/JP4567459B2/ja not_active Expired - Fee Related
- 2003-11-12 DK DK09003174.1T patent/DK2070914T3/da active
- 2003-11-12 DK DK03799611T patent/DK1565467T3/da active
- 2003-11-13 TW TW092131850A patent/TW200412969A/zh unknown
- 2003-11-18 AR ARP030104254A patent/AR042068A1/es unknown
-
2005
- 2005-04-07 ZA ZA200502850A patent/ZA200502850B/en unknown
- 2005-04-19 IL IL168136A patent/IL168136A/en active IP Right Grant
- 2005-05-12 MA MA28281A patent/MA27492A1/fr unknown
- 2005-05-16 CO CO05046617A patent/CO5700761A2/es not_active Application Discontinuation
- 2005-05-23 NO NO20052491A patent/NO20052491D0/no not_active Application Discontinuation
- 2005-11-03 HK HK05109816.8A patent/HK1076277A1/xx not_active IP Right Cessation
-
2008
- 2008-10-03 US US12/245,622 patent/US7763621B2/en not_active Expired - Fee Related
-
2009
- 2009-07-03 HK HK09106005.1A patent/HK1129372A1/xx not_active IP Right Cessation
- 2009-08-24 AU AU2009212779A patent/AU2009212779B2/en not_active Ceased
-
2010
- 2010-05-11 IL IL205693A patent/IL205693A/en active IP Right Grant
- 2010-07-15 AR ARP100102568A patent/AR077476A2/es not_active Application Discontinuation
-
2011
- 2011-11-02 CY CY20111101051T patent/CY1112218T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed, e.g., due to non-payment of fee |