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AR077240A1 - Sulfonamidas heterociclicas, composiciones farmaceuticas de la mismas y su uso en trastornos neurologicos. - Google Patents

Sulfonamidas heterociclicas, composiciones farmaceuticas de la mismas y su uso en trastornos neurologicos.

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Publication number
AR077240A1
AR077240A1 ARP100102268A ARP100102268A AR077240A1 AR 077240 A1 AR077240 A1 AR 077240A1 AR P100102268 A ARP100102268 A AR P100102268A AR P100102268 A ARP100102268 A AR P100102268A AR 077240 A1 AR077240 A1 AR 077240A1
Authority
AR
Argentina
Prior art keywords
alkyl
independently selected
cycloalkyl
heterocycloalkyl
heteroaryl
Prior art date
Application number
ARP100102268A
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English (en)
Original Assignee
Pfizer
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43127233&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR077240(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of AR077240A1 publication Critical patent/AR077240A1/es

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    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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Abstract

Reivindicacion 1: Un compuesto de formula 1, o una sal farmacéuticamente aceptable del mismo, en la que cada R1, cada R2 y cada R7 se selecciona independientemente entre el grupo constituido por hidrogeno, halogeno, hidroxilo, -CF3, -CN, -C(=O)R8, -O-(C=O)-R8, -(NR8)-(C=O)-R8, -(CO)-OR8, -(C=O)-N(R8)2, -OR8, -O(C=O)-OR8, -O-(C=O)-N(R8)2, -NO2, -N(R8)2, -(NR8)-SO2-R8, -S(O)wR8, -SO2(R8)2, alquilo C1-6, arilo C6-10, heteroarilo C1-9, heterocicloalquilo C1-9 y cicloalquilo C3-10; en los que cada uno de dichos alquilo C1-6, arilo C6-10, heteroarilo C1-9, heterocicloalquilo C1-9 o cicloalquilo C3-10 está opcionalmente sustituido independientemente con uno, dos, tres o cuatro R9; w es 0, 1 o 2; m es cero, uno, dos o tres; n es cero, uno, dos o tres; p es cero, uno, dos o tres; q es cero, uno, dos o tres; s es uno y t es uno; o uno de s o t es uno y el otro de s o t es dos; R3 es hidrogeno o alquilo C1-6; cada R4 se selecciona independientemente entre hidrogeno o alquilo C1-6; en los que dicho alquilo C1-6 puede estar opcionalmente sustituido con uno, dos, tres o cuatro halogenos, -CN, o -OR9; o dos grupos R4 sobre el mismo átomo de carbono pueden tomarse juntos para formar un radical oxo (=O) o un espirocicloalquilo C3-6; R5 es hidrogeno o alquilo C1-6; R6 es alquil C1-6-(C=O)-, [alquil C1-6]2N-(C=O)-alquil C1-6-SO2-, cicloalquil C3-10-SO2- o [alquil C1-6]2N-SO2-; donde dichos restos alquilo C1-6 de dicho [alquil C1-6]2N-(C=O)- y [alquil C1-6]2N-SO2- pueden tomarse opcionalmente junto con el átomo de nitrogeno al que están unidos para formar un anillo heterocíclico de cuatro a seis miembros; R8 se selecciona independientemente entre el grupo constituido por hidrogeno, alquilo C1-6, arilo C6-10, heteroarilo C1-9, heterocicloalquilo C1-9 y cicloalquilo C3-10; en los que dicho alquilo C1-6 puede estar opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados independientemente entre hidrogeno, halo, -CN, perfluoroalquilo C1-6, hidroxi, amino, alquilamino C1-6, [alquil C1-6]2amino, alcoxi C1-6, perfluoroalcoxi C1-6, HO-(C=O)-, alquil C1-6-O-(C=O)-, formilo, alquil C1-6-(C=O)-, H2N-(C=O)-, alquil C1-6-(NH)-(C=O)-, [alquil C1-6]2N-(C=O)-, alquil C1-6-(C=O)-O-H(C=O)-NH-, alquil C1-6-(C=O)-NH-, alquil C1-6-(C=O)-[N(alquil C1-6)]-, alquil C1-6-SO2-, alquil C1-6-SO2-NH-, alquil C1-6-SO2-[N(alquil C1-6]-, H2N-SO2-, [alquil C1-6]-NH-SO2- y [alquil C1-6]2N-SO2-; en los que dicho alquilo C1-6 puede estar opcionalmente sustituido adicionalmente con un opcionalmente sustituido arilo C6-10, heteroarilo C1-9, heterocicloalquilo C1-9 o cicloalquilo C3-10; en los que dichos sustituyentes opcionales pueden seleccionarse independientemente entre uno, dos, tres o cuatro radicales seleccionados independientemente entre halogeno, hidroxilo, -CF3, -CN, alquilo C1-3, alcoxi C1-3 y amino; en los que cada uno de dichos sustituyentes R8 arilo C6-10, heteroarilo C1-9, heterocicloalquilo C1-9 o cicloalquilo C3-10 puede estar opcionalmente sustituido adicionalmente con uno, dos, tres o cuatro radicales seleccionados independientemente entre halogeno, hidroxilo, -CF3, -CN, alquilo C1-3, alcoxi C1-3 y amino; cada R9 se selecciona independientemente entre el grupo constituido por halogeno, hidroxilo, -CF3, -CN, -(C-O)R10, -O-(C=O)-R10, -(NR10)-(C=O)-R10, -(C-O)-OR10, -(C=O)-N(R10)2, -OR10, -O-(C=O)-OR10, -O-(C=O)-N(R10)2, -NO2, -N(R10)2, -(NR10)-SO2-R10, -S(O)wR10, -SO2-N(R10)2; R10 se selecciona independientemente entre el grupo constituido por hidrogeno, alquilo C1-6, arilo C6-10, heteroarilo C1-9, heterocicloalquilo C1-9 y cicloalquilo C3-10; en el que dicho alquilo C1-6 puede estar opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados independientemente entre hidrogeno, halo, -CN, perfluoroalquilo C1-6, hidroxi, amino, alquilamino C1-6, [alquil C1-6]2amino, alcoxi C1-6, perfluoroalcoxi C1-6, HO-(C=O)-, alquil C1-6-O-(C-O)-, formilo, alquil C1-6-(C=O)-, H2N-(C=O)-, alquil C1-6-(NH)-(C=O)-, [alquil C1-6]2N-(C=O)-, alquil C1-6-(C=O)-O-, H(C=O)-NH-, alquil C1-6-(C=O)-NH-, alquil C1-6-(C=O)-[N(alquil C1-6)]-, alquil C1-6-SO2-, alquil C1-6-SO-NH-, alquil C1-6-SO2-[N(alquilo C1-6)]-, H2N-SO2-, [alquil (C1-6)]-NH-SO2- y [alquil C1-6]2N-SO2-; en los que dicho alquilo C1-6 también puede estar opcionalmente sustituido adicionalmente con un arilo C6-10, heteroarilo C1-9, heterocicloalquilo C1-9 o cicloalquilo C3-10 opcionalmente sustituido; en los que dichos sustituyentes opcionales pueden seleccionarse independientemente entre uno, dos, tres o cuatro radicales seleccionados independientemente entre halogeno, hidroxilo, -CF3, -CN, alquilo C1-3, alcoxi C1-3 y amino; en los que cada uno de dichos sustituyentes R10 arilo C6-10, heteroarilo C1-9, heterocicloalquilo C1-9 o cicloalquilo C3-10 puede estar opcionalmente sustituido adicionalmente con uno, dos, tres o cuatro radicales seleccionados independientemente entre halogeno, hidroxilo, -CF3, -CN, alquilo C1-3, alcoxi C1-3 y amino; R11 es hidrogeno o alquilo C1-6; el anillo ôAö es arilo C6-10, heteroarilo C1-9, cicloalquilo C4-10 o heterocicloalquilo C1-9; en los que dos de dichos sustituyentes R1 sobre dicho cicloalquilo C4-10 y heterocicloalquilo C1-9 pueden estar unidos opcionalmente al mismo átomo de carbono y pueden tomarse opcionalmente juntos para que sean oxo; el anillo ôBö es arilo C6-10, heteroarilo C1-9, cicloalquilo C4-10 o heterocicloalquilo C1-9; ôXö es -O- o >C(R4)2; ôYö está ausente o es >NR11, -(NR11)-(CO)-, >C=O, -O- o >C(R7)2; y ôZö es -O-, -S-, -(S=O)- o -(SO2)-.
ARP100102268A 2009-06-26 2010-06-25 Sulfonamidas heterociclicas, composiciones farmaceuticas de la mismas y su uso en trastornos neurologicos. AR077240A1 (es)

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