AR074455A1 - Procedimiento para la produccion de vacunas - Google Patents
Procedimiento para la produccion de vacunasInfo
- Publication number
- AR074455A1 AR074455A1 ARP090104651A ARP090104651A AR074455A1 AR 074455 A1 AR074455 A1 AR 074455A1 AR P090104651 A ARP090104651 A AR P090104651A AR P090104651 A ARP090104651 A AR P090104651A AR 074455 A1 AR074455 A1 AR 074455A1
- Authority
- AR
- Argentina
- Prior art keywords
- toxin
- production
- vaccines
- procedure
- culture medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 239000003053 toxin Substances 0.000 abstract 4
- 231100000765 toxin Toxicity 0.000 abstract 4
- 239000001963 growth medium Substances 0.000 abstract 2
- 241000193403 Clostridium Species 0.000 abstract 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 abstract 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 229940068041 phytic acid Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Un procedimiento para la producción de una vacuna contra patógenos bacterianos que producen una toxina AB, como Clostridium, que comprende (a) cultivar el patógeno en condiciones en las que se produce la toxina AB, y recoger el cultivo (b) escindir la toxina AB enzimáticamente in vitro, preferiblemente mediante el uso de hexafosfato de inositol como cofactor, y (c) combinar la composición de la etapa (b) con un vehículo farmacéuticamente aceptable. Reivindicación 3: El procedimiento de la reivindicación 1 o 2, caracterizado porque las células se separan del medio de cultivo tras la recogida, y se escinde la toxina AB en el medio de cultivo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08170591 | 2008-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074455A1 true AR074455A1 (es) | 2011-01-19 |
Family
ID=42022135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104651A Pending AR074455A1 (es) | 2008-12-03 | 2009-12-02 | Procedimiento para la produccion de vacunas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20110243991A1 (es) |
| EP (1) | EP2373332A1 (es) |
| JP (1) | JP2012510497A (es) |
| KR (1) | KR20110100189A (es) |
| CN (1) | CN102238960B (es) |
| AR (1) | AR074455A1 (es) |
| AU (1) | AU2009324180A1 (es) |
| BR (1) | BRPI0922219A2 (es) |
| CA (1) | CA2737403A1 (es) |
| CL (1) | CL2011001284A1 (es) |
| CO (1) | CO6390040A2 (es) |
| MX (1) | MX2011005758A (es) |
| RU (1) | RU2011126602A (es) |
| SG (1) | SG171934A1 (es) |
| TW (1) | TW201026852A (es) |
| UA (1) | UA105508C2 (es) |
| WO (1) | WO2010063693A1 (es) |
| ZA (1) | ZA201101645B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5345532B2 (ja) * | 2006-08-02 | 2013-11-20 | ヨハネス・グーテンベルク−ウニヴェルジテート・マインツ | Ｌｃｔ中毒に対する医薬品 |
| CN106039299A (zh) * | 2007-09-14 | 2016-10-26 | 赛诺菲巴斯德生物制剂有限责任公司 | 含艰难梭菌类毒素a和b的药物组合物 |
| WO2012143902A1 (en) | 2011-04-22 | 2012-10-26 | Wyeth Llc | Compositions relating to a mutant clostridium difficile toxin and methods thereof |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| US8909605B1 (en) | 2013-02-28 | 2014-12-09 | Emc Corporation | Method and system for accelerating data movement using change information concerning difference between current and previous data movements |
| US10226523B2 (en) * | 2013-04-22 | 2019-03-12 | The Board Of Regents Of The University Of Oklahoma | Clostridium difficile vaccine and methods of use |
| CN109865135A (zh) * | 2019-03-18 | 2019-06-11 | 宁波大学 | 一种银鲳美人鱼发光杆菌和灿烂弧菌联合灭活疫苗 |
| KR102376876B1 (ko) * | 2020-04-09 | 2022-03-21 | 대진대학교 산학협력단 | 무독성의 클로스트리디움 디피실 독소단백질-단편 및 이의 용도 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6967088B1 (en) * | 1995-03-16 | 2005-11-22 | Allergan, Inc. | Soluble recombinant botulinum toxin proteins |
| AU722653B2 (en) * | 1995-07-07 | 2000-08-10 | Oravax, Inc | Intranasal vaccination against gastrointestinal disease |
| EP1169456B1 (en) * | 1999-04-09 | 2012-07-11 | Intercell USA, Inc. | Recombinant production of Clostridium difficile Toxin A or Toxin B |
| AU2003299527A1 (en) * | 2002-06-17 | 2004-06-07 | Jimmy D. Ballard | Mutant of clostridium difficile toxin b and methods of use |
| US8852600B2 (en) * | 2006-06-08 | 2014-10-07 | The Rockefeller University | Codon-optimized DNA molecules encoding the receptor binding domains of Clostridium difficile toxins A and B, and methods of use thereof |
| JP5345532B2 (ja) * | 2006-08-02 | 2013-11-20 | ヨハネス・グーテンベルク−ウニヴェルジテート・マインツ | Ｌｃｔ中毒に対する医薬品 |
-
2009
- 2009-12-01 UA UAA201108284A patent/UA105508C2/uk unknown
- 2009-12-01 CA CA2737403A patent/CA2737403A1/en not_active Abandoned
- 2009-12-01 WO PCT/EP2009/066109 patent/WO2010063693A1/en active Application Filing
- 2009-12-01 SG SG2011040409A patent/SG171934A1/en unknown
- 2009-12-01 CN CN200980148516.8A patent/CN102238960B/zh not_active Expired - Fee Related
- 2009-12-01 AU AU2009324180A patent/AU2009324180A1/en not_active Abandoned
- 2009-12-01 JP JP2011538987A patent/JP2012510497A/ja active Pending
- 2009-12-01 EP EP09775142A patent/EP2373332A1/en not_active Withdrawn
- 2009-12-01 MX MX2011005758A patent/MX2011005758A/es not_active Application Discontinuation
- 2009-12-01 BR BRPI0922219A patent/BRPI0922219A2/pt not_active IP Right Cessation
- 2009-12-01 RU RU2011126602/10A patent/RU2011126602A/ru not_active Application Discontinuation
- 2009-12-01 KR KR1020117008708A patent/KR20110100189A/ko not_active Ceased
- 2009-12-01 US US13/126,186 patent/US20110243991A1/en not_active Abandoned
- 2009-12-02 TW TW098141177A patent/TW201026852A/zh unknown
- 2009-12-02 AR ARP090104651A patent/AR074455A1/es active Pending
-
2011
- 2011-03-03 ZA ZA2011/01645A patent/ZA201101645B/en unknown
- 2011-05-31 CL CL2011001284A patent/CL2011001284A1/es unknown
- 2011-06-02 CO CO11068894A patent/CO6390040A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CL2011001284A1 (es) | 2011-09-16 |
| CO6390040A2 (es) | 2012-02-29 |
| CA2737403A1 (en) | 2010-06-10 |
| JP2012510497A (ja) | 2012-05-10 |
| CN102238960B (zh) | 2014-04-23 |
| EP2373332A1 (en) | 2011-10-12 |
| ZA201101645B (en) | 2011-11-30 |
| US20110243991A1 (en) | 2011-10-06 |
| MX2011005758A (es) | 2011-06-28 |
| RU2011126602A (ru) | 2013-01-10 |
| UA105508C2 (uk) | 2014-05-26 |
| AU2009324180A1 (en) | 2010-06-10 |
| CN102238960A (zh) | 2011-11-09 |
| SG171934A1 (en) | 2011-07-28 |
| KR20110100189A (ko) | 2011-09-09 |
| WO2010063693A1 (en) | 2010-06-10 |
| BRPI0922219A2 (pt) | 2018-10-23 |
| TW201026852A (en) | 2010-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |