AR074418A1 - Compuestos de benzonaftiridina, procedimiento de preparacion y su uso en el tratamiento de tumores - Google Patents
Compuestos de benzonaftiridina, procedimiento de preparacion y su uso en el tratamiento de tumoresInfo
- Publication number
- AR074418A1 AR074418A1 ARP090104585A ARP090104585A AR074418A1 AR 074418 A1 AR074418 A1 AR 074418A1 AR P090104585 A ARP090104585 A AR P090104585A AR P090104585 A ARP090104585 A AR P090104585A AR 074418 A1 AR074418 A1 AR 074418A1
- Authority
- AR
- Argentina
- Prior art keywords
- nnr2
- mono
- nhet
- hal
- nhet2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Los compuestos de la fórmula 1 en donde D es Ar o Het1, Het1 es un heterociclo saturado, insaturado o aromático mono- o bicíclico con 1 a 4 átomos de N, O y/o S, que no está sustituido o que puede estar mono-, di- o trisustituido con Hal, A, OA, Ar, OH y/u =O, R1 puede ser en cada caso, de modo independiente entre sí, H, Hal, OA, OH, A, fenilo o CN mono- o polisustituido, Het2 es un heterociclo saturado monocíclico con 1-3 átomos de N y/u O, que no está sustituido o que puede estar mono- o disustituido con =O, R4 puede ser en cada caso, de modo independiente entre sí, H, Hal, OA, OH, A, mono- o polisustituido, X, Y en cada caso, de modo independiente entre sí, están ausentes son -CH2-, -(CH2)2-, -CO- o -CHOH-, en donde sólo puede estar ausente uno de los radicales X o Y, R2, R3 son en cada caso, de modo independiente entre sí, R; R2 y R3 también son juntos una cadena de alquilos C2-6, en donde también un grupo CH2 puede estar reemplazado por O, NH o NA'; A' es alquilo C1-6, o CH2CH2OH, COO(CH2)nAr, (CH2)nAr, (CH2)nHet2, (CH2)nNA2 o Cyc, R5 puede ser H, Hal, NH2, OH, OA o A, R puede ser H, A, Cyc, (CH2)nAr o (CH2)nHet mono- o polisustituido, Z es O, NH, -CH(CONHA)NH-, CH2NHCONH, -CH=CH- o está ausente, Cyc es alquilo cíclico C3-7, A es alquilo lineal o ramificado C1-10, en donde 1-7 átomos de H pueden estar reemplazados por OR, CN, NR2, F y/o Cl y/o en donde uno o dos grupos CH2 no adyacentes pueden estar reemplazados por O, NH, S, SO, SO2 y/o por grupos CH=CH, o es alquilo cíclico C3-7, Ar es fenilo, indanilo, naftilo o bifenilo no sustituido o mono-, di-, tri-, tetra- o pentasustituido con Hal, A, (CR2)nOR, O(CR2)nAr2, (CR2)nNR2, SR, NO2, CN, COOR, CONR2, NRCOA, NRSO2A, SO2NR2, S(O)mA, CO-Het, (CR2)nHet, O(CR2)nNR2, O(CR2)nHet, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)nHet, CR=CRAr2, SO2Het, NHCONH(CR2)nNR2, NHCONH(CR2)nHet, OCONH(CR2)nNR2, CONH(CR2)nHet, CONR(CR2)nNR2, CONR(CR2)nHet y/o COA; Het es un heterociclo mono-, di- o tricíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S, que no está sustituido o que puede estar mono-, di- o trisustituido con Hal, A, Ar2, O(CR2)nAr2, (CR2)nOR, (CR2)nNR2, SR, NO2, CN, COOR, CONR2, NRCOA, NRSO2A, SO2NR2, S(O)qA, CO-Het2, (CR2)nHet2, O(CR2)nNR2, O(CR2)nHet2, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)nHet, NHCONH(CR2)nNR2, NHCONH(CR2)nHet2, OCONH(CR2)nNR2, OCONH(CR2)nHet2, CO-Het2, CHO, COA, =S, =NH, =NA y/u =O; Hal es F, Cl, Br o I; n es 0, 1 o 2, m es 0, 1, 2, 3, 4 o 5, p es 1, 2, 3 o 4, así corno sus sales y estereoisómeros farmacéuticamente aceptables, incluyendo sus mezclas en todas las proporciones. Se pueden utilizar para el tratamiento de tumores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008059578A DE102008059578A1 (de) | 2008-11-28 | 2008-11-28 | Benzo-Naphtyridin Verbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074418A1 true AR074418A1 (es) | 2011-01-19 |
Family
ID=42107404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104585A AR074418A1 (es) | 2008-11-28 | 2009-11-27 | Compuestos de benzonaftiridina, procedimiento de preparacion y su uso en el tratamiento de tumores |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20110230471A1 (es) |
| EP (1) | EP2352733A1 (es) |
| JP (1) | JP2012509916A (es) |
| KR (1) | KR20110095392A (es) |
| CN (1) | CN102227426A (es) |
| AR (1) | AR074418A1 (es) |
| AU (1) | AU2009319421A1 (es) |
| BR (1) | BRPI0921860A2 (es) |
| CA (1) | CA2744833A1 (es) |
| DE (1) | DE102008059578A1 (es) |
| EA (1) | EA201100880A1 (es) |
| IL (1) | IL213052A0 (es) |
| MX (1) | MX2011005531A (es) |
| WO (1) | WO2010060532A1 (es) |
| ZA (1) | ZA201104749B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| WO2013054185A1 (en) * | 2011-10-13 | 2013-04-18 | Pfizer, Inc. | Pyrimidine and pyridine derivatives useful in therapy |
| WO2013070879A1 (en) | 2011-11-10 | 2013-05-16 | Bristol-Myers Squibb Company | Methods for treating spinal cord injury with lpa receptor antagonists |
| MY180688A (en) | 2012-06-13 | 2020-12-07 | Hoffmann La Roche | New diazaspirocycloalkane and azaspirocycloalkane |
| BR112015004111A2 (pt) | 2012-09-25 | 2017-07-04 | Hoffmann La Roche | novos derivados bicíclicos |
| US9518038B2 (en) * | 2012-09-27 | 2016-12-13 | Shandong Yingdong Yinghao Biotechnology, Inc. | Condensation product of theanine derivative and carboxylic acid coumarin derivative, its intermediate, preparation method and use thereof |
| KR20150095888A (ko) | 2012-12-19 | 2015-08-21 | 노파르티스 아게 | 오토탁신 억제제 |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| WO2014133112A1 (ja) * | 2013-03-01 | 2014-09-04 | 国立大学法人東京大学 | オートタキシン阻害活性を有する８－置換イミダゾピリミジノン誘導体 |
| AR095079A1 (es) * | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| BR112015020998B1 (pt) | 2013-03-14 | 2022-10-18 | Galapagos Nv | Compostos e composições farmacêuticas dos mesmos para o tratamento de distúrbios inflamatórios |
| US9951026B2 (en) | 2013-09-17 | 2018-04-24 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| EP3046905A4 (en) | 2013-09-17 | 2017-03-22 | Pharmakea Inc. | Vinyl autotaxin inhibitor compounds |
| EP3049405A4 (en) | 2013-09-26 | 2017-03-08 | Pharmakea Inc. | Autotaxin inhibitor compounds |
| BR112016010221A2 (pt) | 2013-11-22 | 2018-05-02 | Pharmakea Inc | inibidores tetracíclicos de autotaxina. |
| CN110372671B (zh) | 2013-11-22 | 2023-02-21 | 赛博治疗有限责任公司 | 自分泌运动因子抑制剂化合物 |
| WO2015078803A1 (en) | 2013-11-26 | 2015-06-04 | F. Hoffmann-La Roche Ag | NEW OCTAHYDRO-CYCLOBUTA [1,2-c;3,4-c']DIPYRROL-2-YL |
| MY186311A (en) | 2013-12-20 | 2021-07-08 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| AU2015238537B2 (en) | 2014-03-26 | 2019-08-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors |
| AU2015238541B2 (en) | 2014-03-26 | 2019-09-19 | F. Hoffmann-La Roche Ag | Condensed [1,4]diazepine compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| AU2016268250B2 (en) | 2015-05-27 | 2020-08-27 | Sabre Therapeutics Llc | Autotaxin inhibitors and uses thereof |
| CA2992889A1 (en) | 2015-09-04 | 2017-03-09 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
| BR112018006024A2 (pt) | 2015-09-24 | 2020-05-12 | F. Hoffmann-La Roche Ag | Compostos bicíclicos como inibidores de atx |
| BR112018006034A2 (pt) | 2015-09-24 | 2018-10-09 | Hoffmann La Roche | compostos bicíclicos como inibidores de atx |
| CA2991612A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
| CR20180143A (es) | 2015-09-24 | 2018-05-03 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de atx/ca |
| CN110392679B (zh) | 2017-03-16 | 2023-04-07 | 豪夫迈·罗氏有限公司 | 可用作双重atx/ca抑制剂的杂环化合物 |
| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | Ａｔｘインヒビターとしての新規二環式化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3889302T2 (de) * | 1987-12-03 | 1994-10-20 | Mitsubishi Chem Ind | 9-(Acylamino)tetrahydroacridinderivate und wahrnehmungssteigernde Mittel davon als aktiver Wirkstoff. |
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| KR20010014262A (ko) | 1997-06-30 | 2001-02-26 | 닛뽄카야쿠가부시키가이샤 | 신규 나프티리딘 유도체 또는 그 염 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| AU4972900A (en) | 1999-04-08 | 2000-11-14 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
-
2008
- 2008-11-28 DE DE102008059578A patent/DE102008059578A1/de not_active Withdrawn
-
2009
- 2009-11-05 KR KR1020117014790A patent/KR20110095392A/ko not_active Application Discontinuation
- 2009-11-05 US US13/131,696 patent/US20110230471A1/en not_active Abandoned
- 2009-11-05 CN CN2009801476046A patent/CN102227426A/zh active Pending
- 2009-11-05 EP EP09751814A patent/EP2352733A1/de not_active Withdrawn
- 2009-11-05 MX MX2011005531A patent/MX2011005531A/es unknown
- 2009-11-05 EA EA201100880A patent/EA201100880A1/ru unknown
- 2009-11-05 CA CA2744833A patent/CA2744833A1/en not_active Abandoned
- 2009-11-05 BR BRPI0921860A patent/BRPI0921860A2/pt not_active Application Discontinuation
- 2009-11-05 WO PCT/EP2009/007930 patent/WO2010060532A1/de active Application Filing
- 2009-11-05 AU AU2009319421A patent/AU2009319421A1/en not_active Abandoned
- 2009-11-05 JP JP2011537865A patent/JP2012509916A/ja active Pending
- 2009-11-27 AR ARP090104585A patent/AR074418A1/es unknown
-
2011
- 2011-05-22 IL IL213052A patent/IL213052A0/en unknown
- 2011-06-27 ZA ZA2011/04749A patent/ZA201104749B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20110095392A (ko) | 2011-08-24 |
| ZA201104749B (en) | 2012-03-28 |
| EP2352733A1 (de) | 2011-08-10 |
| AU2009319421A1 (en) | 2011-07-14 |
| WO2010060532A1 (de) | 2010-06-03 |
| CN102227426A (zh) | 2011-10-26 |
| JP2012509916A (ja) | 2012-04-26 |
| DE102008059578A1 (de) | 2010-06-10 |
| MX2011005531A (es) | 2011-06-21 |
| CA2744833A1 (en) | 2010-06-03 |
| US20110230471A1 (en) | 2011-09-22 |
| BRPI0921860A2 (pt) | 2015-12-29 |
| EA201100880A1 (ru) | 2012-01-30 |
| IL213052A0 (en) | 2011-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |