AR070487A1 - Derivados de 3- metil- imidazo -( 1,2-b)- piridazina - Google Patents
Derivados de 3- metil- imidazo -( 1,2-b)- piridazinaInfo
- Publication number
- AR070487A1 AR070487A1 ARP090100659A ARP090100659A AR070487A1 AR 070487 A1 AR070487 A1 AR 070487A1 AR P090100659 A ARP090100659 A AR P090100659A AR P090100659 A ARP090100659 A AR P090100659A AR 070487 A1 AR070487 A1 AR 070487A1
- Authority
- AR
- Argentina
- Prior art keywords
- unsubstituted
- formula
- substituted
- compound
- halogen
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 2
- 229910052805 deuterium Inorganic materials 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- YDVJBLJCSLVMSY-UHFFFAOYSA-N carbamoyl cyanide Chemical compound NC(=O)C#N YDVJBLJCSLVMSY-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un proceso para el tratamiento del cuerpo humano o animal, en particular con respecto una enfermedad mediada por la cinasa de tirosina c-Met; al uso de un compuesto de la formula (1) para la fabricacion de un medicamento para el tratamiento de estas enfermedades; a composiciones farmacéuticas que comprenden un compuesto de la formula (1), opcionalmente en la presencia de un componente de combinacion; y a procesos para la preparacion de un compuesto de la formula (1). Reivindicacion 1: Un compuesto de la formula (1) en donde: R1 representa heterociclilo insustituido o sustituido, arilo insustituido o sustituido, cicloalquilo insustituido o sustituido, alquilo insustituido o sustituido, alcoxilo insustituido o sustituido, ciano, carboxamida, o halogeno; R2 representa heterociclilo insustituido o sustituido, arilo insustituido o sustituido; R3 representa H, deuterio, alquilo inferior, y R3' representa H, deuterio, alquilo inferior, halogeno, hidroxilo, o R3 representa halogeno, y R3' representa halogeno, o R3 y R3' representan, junto con el átomo de carbono con el que están unidos, cicloalquilo o vinilo; A1 representa ya sea un enlace directo, un grupo -SO2-, o bien un grupo de formula (2) en donde el enlace marcado * está unido a R1; n representa 0 o 1; m representa 0, 1, 2, 3, 4 o 5; R4 representa H o alquilo insustituido; R5 representa H o alquilo insustituido; R5' representa H o alquilo insustituido; A2 representa O o NR4; o una sal del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08152068 | 2008-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070487A1 true AR070487A1 (es) | 2010-04-07 |
Family
ID=39672115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100659A AR070487A1 (es) | 2008-02-28 | 2009-02-26 | Derivados de 3- metil- imidazo -( 1,2-b)- piridazina |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8822468B2 (es) |
| EP (1) | EP2265614A1 (es) |
| JP (1) | JP5576802B2 (es) |
| KR (1) | KR20100128305A (es) |
| CN (1) | CN102015716B (es) |
| AR (1) | AR070487A1 (es) |
| AU (1) | AU2009218459A1 (es) |
| BR (1) | BRPI0908504A2 (es) |
| CA (1) | CA2717034A1 (es) |
| CL (1) | CL2009000443A1 (es) |
| CO (1) | CO6300957A2 (es) |
| CR (1) | CR11620A (es) |
| DO (1) | DOP2010000263A (es) |
| EA (1) | EA201001365A1 (es) |
| EC (1) | ECSP10010427A (es) |
| IL (1) | IL207434A0 (es) |
| MA (1) | MA32167B1 (es) |
| MX (1) | MX2010009414A (es) |
| NI (1) | NI201000145A (es) |
| PE (1) | PE20091468A1 (es) |
| SM (1) | SMAP201000112A (es) |
| TW (1) | TW200940545A (es) |
| UY (1) | UY31676A1 (es) |
| WO (1) | WO2009106577A1 (es) |
| ZA (1) | ZA201005602B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32049A (es) * | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
| US20110053968A1 (en) | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
| US8389526B2 (en) * | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| WO2011018454A1 (en) | 2009-08-12 | 2011-02-17 | Novartis Ag | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
| MX2012002179A (es) | 2009-08-20 | 2012-03-16 | Novartis Ag | Compuestos heterociclicos de oxima. |
| CU24167B1 (es) | 2009-12-31 | 2016-03-31 | Hutchison Medipharma Ltd | Derivados de triazolopirazinas sustituidas como inhibidores del receptor c-met o hgf para tratar el cáncer |
| US20110195066A1 (en) * | 2010-02-05 | 2011-08-11 | Auspex Pharmaceuticals, Inc. | Quinoline inhibitors of tyrosine kinase |
| EP2588107A1 (en) * | 2010-07-01 | 2013-05-08 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| AR085183A1 (es) | 2010-07-30 | 2013-09-18 | Lilly Co Eli | Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer |
| UY33597A (es) * | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| CA2839958A1 (en) * | 2011-06-22 | 2012-12-27 | Knut Eis | Heterocyclyl aminoimidazopyridazines |
| US9062045B2 (en) | 2011-09-15 | 2015-06-23 | Novartis Ag | Triazolopyridine compounds |
| CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物 |
| CN103122000B (zh) * | 2012-09-03 | 2013-12-25 | 中美冠科生物技术（太仓）有限公司 | 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂 |
| DK2925757T3 (en) | 2012-11-19 | 2018-01-15 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| CN105431148A (zh) | 2013-03-07 | 2016-03-23 | 加利菲亚生物公司 | 混合谱系激酶抑制剂及治疗方法 |
| AR097543A1 (es) * | 2013-09-06 | 2016-03-23 | Lexicon Pharmaceuticals Inc | COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO |
| CN105326793A (zh) * | 2014-08-06 | 2016-02-17 | 中美冠科生物技术（太仓）有限公司 | 一种包含c-Met激酶抑制剂的固体分散体及其制备方法和用途 |
| BR112017012930A2 (pt) * | 2014-12-19 | 2018-01-09 | Janssen Pharmaceutica Nv | derivados de imidazopiridazina como inibidores de pi3kbeta. |
| US10202387B2 (en) * | 2014-12-19 | 2019-02-12 | Janssen Pharmaceutica Nv | Heterocyclyl linked imidazopyridazine derivatives as PI3KB inhibitors |
| RU2770404C2 (ru) * | 2016-09-16 | 2022-04-15 | Гельмгольц Центрум Мюнхен - Дойчес Форшунгсцентрум Фюр Гезундхайт Унд Умвельт (Гмбх) | Ингибиторы traf 6 |
| WO2018115319A2 (en) * | 2016-12-23 | 2018-06-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases |
| WO2018138050A1 (de) | 2017-01-26 | 2018-08-02 | Bayer Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| WO2018237349A1 (en) * | 2017-06-23 | 2018-12-27 | University Of Washington | Inhibitors of typed 1 methionyl-trna synthetase and methods of using them |
| WO2019228940A1 (en) * | 2018-05-28 | 2019-12-05 | F. Hoffmann-La Roche Ag | Novel oxoquinolizine compounds for the treatment and prophylaxis of bacterial infection |
| JP7712932B2 (ja) * | 2019-12-18 | 2025-07-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｌｉｎ２８の阻害剤及びその使用方法 |
| CN119081395B (zh) * | 2024-09-07 | 2025-03-18 | 广东环塑众创实业有限公司 | 一种耐高温尼龙工程塑料及其制备方法 |
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| UA84175C2 (ru) | 2003-11-19 | 2008-09-25 | Аррей Байофарма Инк. | Гетероциклические ингибиторы мэк и их применение |
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| WO2008030744A2 (en) | 2006-09-05 | 2008-03-13 | Board Of Regents, The University Of Texas System | Inhibitors of c-met and uses thereof |
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| PL2081937T3 (pl) | 2006-10-23 | 2013-01-31 | Sgx Pharmaceuticals Inc | Triazolopirydazynowe modulatory kinaz białkowych |
| SI3034075T1 (sl) | 2006-11-22 | 2018-12-31 | Incyte Holdings Corporation | Imidazotriazini in imidazopirimidini kot inhibitorji kinaze |
| AR064420A1 (es) | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
| WO2009011954A2 (en) | 2007-04-27 | 2009-01-22 | Alaka'i Consulting & Engineering, Inc. | Laser spectroscopy system |
| EP2170894A1 (en) | 2007-06-21 | 2010-04-07 | Janssen Pharmaceutica N.V. | Polymorphic and hydrate forms, salts and process for preparing 6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline |
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-
2009
- 2009-02-26 AR ARP090100659A patent/AR070487A1/es unknown
- 2009-02-26 AU AU2009218459A patent/AU2009218459A1/en not_active Abandoned
- 2009-02-26 EA EA201001365A patent/EA201001365A1/ru unknown
- 2009-02-26 CN CN200980114928.XA patent/CN102015716B/zh not_active Expired - Fee Related
- 2009-02-26 PE PE2009000287A patent/PE20091468A1/es not_active Application Discontinuation
- 2009-02-26 CA CA2717034A patent/CA2717034A1/en not_active Abandoned
- 2009-02-26 EP EP09714429A patent/EP2265614A1/en not_active Withdrawn
- 2009-02-26 BR BRPI0908504-1A patent/BRPI0908504A2/pt not_active IP Right Cessation
- 2009-02-26 JP JP2010548110A patent/JP5576802B2/ja not_active Expired - Fee Related
- 2009-02-26 UY UY031676A patent/UY31676A1/es not_active Application Discontinuation
- 2009-02-26 MX MX2010009414A patent/MX2010009414A/es not_active Application Discontinuation
- 2009-02-26 WO PCT/EP2009/052302 patent/WO2009106577A1/en not_active Ceased
- 2009-02-26 KR KR1020107021426A patent/KR20100128305A/ko not_active Ceased
- 2009-02-27 TW TW098106564A patent/TW200940545A/zh unknown
- 2009-02-27 CL CL2009000443A patent/CL2009000443A1/es unknown
- 2009-03-02 US US12/396,137 patent/US8822468B2/en not_active Expired - Fee Related
-
2010
- 2010-08-05 IL IL207434A patent/IL207434A0/en unknown
- 2010-08-05 ZA ZA2010/05602A patent/ZA201005602B/en unknown
- 2010-08-06 CR CR11620A patent/CR11620A/es not_active Application Discontinuation
- 2010-08-27 CO CO10106017A patent/CO6300957A2/es not_active Application Discontinuation
- 2010-08-27 EC EC2010010427A patent/ECSP10010427A/es unknown
- 2010-08-27 NI NI201000145A patent/NI201000145A/es unknown
- 2010-08-27 DO DO2010000263A patent/DOP2010000263A/es unknown
- 2010-09-24 MA MA33198A patent/MA32167B1/fr unknown
- 2010-09-28 SM SM201000112T patent/SMAP201000112A/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010009414A (es) | 2010-09-24 |
| DOP2010000263A (es) | 2010-09-30 |
| CO6300957A2 (es) | 2011-07-21 |
| MA32167B1 (fr) | 2011-03-01 |
| ECSP10010427A (es) | 2010-09-30 |
| EP2265614A1 (en) | 2010-12-29 |
| CA2717034A1 (en) | 2009-09-03 |
| US20090264406A1 (en) | 2009-10-22 |
| BRPI0908504A2 (pt) | 2015-08-11 |
| CN102015716B (zh) | 2014-09-17 |
| IL207434A0 (en) | 2010-12-30 |
| WO2009106577A1 (en) | 2009-09-03 |
| PE20091468A1 (es) | 2009-10-22 |
| UY31676A1 (es) | 2009-09-30 |
| CL2009000443A1 (es) | 2010-09-10 |
| SMAP201000112A (it) | 2010-11-12 |
| JP5576802B2 (ja) | 2014-08-20 |
| EA201001365A1 (ru) | 2011-04-29 |
| TW200940545A (en) | 2009-10-01 |
| NI201000145A (es) | 2011-03-02 |
| ZA201005602B (en) | 2011-04-28 |
| JP2011513279A (ja) | 2011-04-28 |
| KR20100128305A (ko) | 2010-12-07 |
| US8822468B2 (en) | 2014-09-02 |
| AU2009218459A1 (en) | 2009-09-03 |
| CR11620A (es) | 2010-10-08 |
| CN102015716A (zh) | 2011-04-13 |
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