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AR068730A1 - Compuestos de diaril 1,2,4-oxadiazol,composiciones farmaceuticas que los contienen,proceso de preparacion y uso de los mismos como agentes inmunosupresores en el tratamiento de enfermedades autoinmunes y/o inflamatorias cronicas. - Google Patents

Compuestos de diaril 1,2,4-oxadiazol,composiciones farmaceuticas que los contienen,proceso de preparacion y uso de los mismos como agentes inmunosupresores en el tratamiento de enfermedades autoinmunes y/o inflamatorias cronicas.

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Publication number
AR068730A1
AR068730A1 ARP080104332A ARP080104332A AR068730A1 AR 068730 A1 AR068730 A1 AR 068730A1 AR P080104332 A ARP080104332 A AR P080104332A AR P080104332 A ARP080104332 A AR P080104332A AR 068730 A1 AR068730 A1 AR 068730A1
Authority
AR
Argentina
Prior art keywords
atoms
hal
denotes
ocf3
con
Prior art date
Application number
ARP080104332A
Other languages
English (en)
Original Assignee
Serono Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Lab filed Critical Serono Lab
Publication of AR068730A1 publication Critical patent/AR068730A1/es

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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Abstract

Los compuestos son utiles por ejemplo, en el tratamiento de los desordenes autoinmunes, tales como la esclerosis multiple, y otras enfermedades. Reivindicacion 1: un compuesto de la formula (1) donde R1, R2 denotan H, Hal, CF3, OCF3, CN, o NO2, W denota CH o N, Ra es Ar, Het, cicloalquilo que tiene 3-7 átomos, A o NA2, Rb es H, A, Hal, CF3, OCF3, OR3, CN, NO2, (CH2)nN(R3)2, OA, (CH2)nSO2N(R3)2, (CH2)nNR3SO2A, (CH2)nN(SO2A)2, NR3CON(R3)2, NR3COA o (CH2)nSO2R3, Rc denota A, COA, CSA, COOA, CSOA, CON(R3)2 o CSN(R3)2 A es alquilo lineal o ramificado que tiene desde 1 hasta 12 átomos-C, donde uno o más, preferiblemente todos los átomos H pueden estar reemplazados por Hal, especialmente F, o 1 hasta 7 átomos H pueden estar reemplazados por OR3, CN o N(R3)2 y donde uno o más, preferiblemente 1 hasta 7 grupos no adyacentes CH2 pueden estar reemplazados por O, NR3 o S y/o por grupos -CH=CH- o -C=C-, o denota cicloalquilo o cicloalquilalquileno que tiene 3-7 átomos C del anillo; Hal es F, Cl, Br o I, Ar denota un anillo monocíclico o bicíclico, no saturado o aromático carbocíclico que tiene desde 6 hasta 14 átomos de carbono que pueden estar no substituidos o monosubstituidos, disubstituidos o trisubstituidos por Hal, A, CH2OA, CH2N(R3)2, OR3, N(R3)2, NO2, N(SO2Me)2, CN, COOR3, CF3, OCF3, CON(R3)2, NR3COA, NR3CON(R3)2, NR3SO2A, COR3, SO2N(R3)2, SOA o SO2A, fenilo, piridilo -[C(R3)2]-COOR3 y/o -O[C(R3)2]n-, CON(R3)2, Het denota un anillo monocíclico o bicíclico, saturado, no saturado o aromático heterocíclico que tiene 1 N y/o 1 hasta 30 y/o átomos S que pueden estar no substituidos o monosubstituidos, disubstituidos o trisubstituidos por Hal, A, -[C(R3)2]n-Ar, -[C(R3)2]n-cicloalquilo, CH2OA, CH2N(R3)2, OR3, CF3, OCF3, N(R3)2, N(SO2Me)2, NR3CON(R3)2, NO2, CN, -[C(R3)2]n-COOR3, -[C(R3)2]n-CON(R3)2, NR3COA, NR3SO2A, COR3, SO2N(R3)2, SOA, fenilo, piridilo y/o SO2A, R3 es H o A y n es 0, 1, 2, 3, 4, 5, 6, 7 o 8, y los derivados farmacéuticamente aceptables, solvatos, tautomeros, sales y esteroisomeros de los mismos, incluyendo las mezclas de los mismos en todas las proporciones.
ARP080104332A 2007-10-04 2008-10-03 Compuestos de diaril 1,2,4-oxadiazol,composiciones farmaceuticas que los contienen,proceso de preparacion y uso de los mismos como agentes inmunosupresores en el tratamiento de enfermedades autoinmunes y/o inflamatorias cronicas. AR068730A1 (es)

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IL204520A0 (en) 2010-11-30
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