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AR068731A1 - Compuestos de diaril 1,2,4-oxadiazol,composiciones farmaceuticas que los contienen, proceso de preparacion y uso de los mismos como agentes inmunosupresores en el tratamiento de enfermedades autoinmunes y/o inflamatorias cronicas. - Google Patents

Compuestos de diaril 1,2,4-oxadiazol,composiciones farmaceuticas que los contienen, proceso de preparacion y uso de los mismos como agentes inmunosupresores en el tratamiento de enfermedades autoinmunes y/o inflamatorias cronicas.

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Publication number
AR068731A1
AR068731A1 ARP080104333A ARP080104333A AR068731A1 AR 068731 A1 AR068731 A1 AR 068731A1 AR P080104333 A ARP080104333 A AR P080104333A AR P080104333 A ARP080104333 A AR P080104333A AR 068731 A1 AR068731 A1 AR 068731A1
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AR
Argentina
Prior art keywords
hal
coor3
groups
carbon atoms
denotes
Prior art date
Application number
ARP080104333A
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English (en)
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Serono Lab
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Publication date
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Publication of AR068731A1 publication Critical patent/AR068731A1/es

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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

Los compuestos son utiles, por ejemplo, en el tratamiento de trastornos autoinmunes, como, por ejemplo, la esclerosis multiple y otras enfermedades. Reivindicacion 1: Derivado de oxadiazol de formula (1) en donde R1, R2 denotan H, Hal, CF3, OCF3, CN, o NO2, OH, A, OA; S es COOR3, SO2NH2, CON(R3)2 o Z; Q denota X(CH2)m, (CH2)mX(CH2)m o un enlace unico; X es -O-, -NR3-, -COO- o -CONR3-; W denota CH o N; Ra es Ar, Het, NA2, NO2, o si R1 o R2 es Hal, o si Q es (CH2)mX(CH2)m, también es OA; Rb es, A, Hal, OCF3, (CH2)nOH, (CH2)nOA, CN, NO2, N(R3)2, (CH2)nSO2N(R3)2, SO2N(R3)2, (CH2)nNR3SO2A, (CH2)nSO2A, (CH2)nN(SO2A)2, NR3CON(R3)2 o NR3COA, NR3SO2N(R3)2, o si R1 o R2 es Hal, también CF3, OR3; A es un alquilo ramificado o lineal que posee 1 a 12 átomos de carbono, en donde uno o más pueden estar reemplazados por Hal, OR3, COOR3, CN, N(R3)2 o Het y en donde uno o más grupos CH2 no adyacentes pueden estar reemplazados por O, NR3, CO o S y/o por grupos -CH=CH- o -CsC- o grupos cicloalquileno que poseen 3 a 7 átomos de carbono, o denota cicloalquilo o cicloalquilalquileno que posee 3-7 átomos de carbono anulares; Z es una cadena alquilo ramificada o lineal que posee 1 a 12 átomos de carbono, en donde uno o más se encuentran reemplazados por OR3, COOR3, CON(R3)2, CN, SO2A, N(R3)2 o Het y/o en donde uno o más grupos CH2- no adyacentes se encuentran reemplazados por -O-, -COO-, -NR3-, -NBoc-, -CO- o -S-, -SO2- y/o por grupos -CH=CH- o -CsC- o grupos cicloalquileno que poseen 3 a 7 átomos de carbono, o denota cicloalquilo o cicloalquilalquileno que posee 3-7 átomos de C anulares; Hal es F, Cl, Br o I; Ar denota un anillo carbocíclico monocíclico o bicíclico, saturado, insaturado o aromático que posee 6 a 14 átomos de carbono, que pueden estar monosustituidos, disustituidos o trisustituidos por Hal, A, OR3, N(R3)2, NO2, CN, COOR3, CF3, OCF3, CON(R3)2, NR3COA, NR3CON(R3)2, NR3SO2A, COR3, SO2N(R3)2, SOA o SO2A, fenilo, piridil-[C(R3)2]n-COOR3 y/o -O[C(R3)2]n-CON(R3)2, de manera que por lo menos un átomo adyacente al átomo que une el grupo Ar al resto de la molécula porta uno de dichos sustituyentes; Het denota un anillo monocíclico o bicíclico, saturado, o aromático heterocíclico que posee 1 a 4 átomos de N, O y/o S que pueden estar monosustituidos, disustituidos o trisustituidos por Hal, A, -[C(R3)2]n-Ar, -[C(R3)2]n-cicloalquilo, OR3, CF3, OCF3, N(R3)2, NR3CON(R3)2, NO2, CN, -[C(R3)2]-COOR3, -[C(R3)2]n-CON(R3)2, NR3COA, NR3SO2A, COR3, SO2N(R3)2, SOA, fenilo, piridilo y/o SO2A, de manera que por lo menos un átomo adyacente al átomo que une el grupo Het al resto de la molécula porta uno de dichos sustituyentes; R3 es H o A; 2 grupos geminales R3 juntos pueden formar un anillo con el átomo al que se encuentran unidos; n es 0, 1, 2, 3, 4, 5, 6, 7 o 8; y m es 1, 2, 3, 4, 5, 6, 7 o 8; y sus derivados, solvatos, tautomeros, sales y estereoisomeros farmacéuticamente aceptables, que con inclusion de las mezclas en todas sus relaciones.
ARP080104333A 2007-10-04 2008-10-03 Compuestos de diaril 1,2,4-oxadiazol,composiciones farmaceuticas que los contienen, proceso de preparacion y uso de los mismos como agentes inmunosupresores en el tratamiento de enfermedades autoinmunes y/o inflamatorias cronicas. AR068731A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07117921 2007-10-04
US99825407P 2007-10-09 2007-10-09

Publications (1)

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AR068731A1 true AR068731A1 (es) 2009-12-02

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ARP080104333A AR068731A1 (es) 2007-10-04 2008-10-03 Compuestos de diaril 1,2,4-oxadiazol,composiciones farmaceuticas que los contienen, proceso de preparacion y uso de los mismos como agentes inmunosupresores en el tratamiento de enfermedades autoinmunes y/o inflamatorias cronicas.

Country Status (15)

Country Link
US (1) US8202865B2 (es)
EP (1) EP2193125B1 (es)
JP (2) JP6144450B2 (es)
KR (1) KR20100075608A (es)
CN (1) CN101970420B (es)
AR (1) AR068731A1 (es)
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