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AR057300A1 - Estirilsulfonamidas, su obtencion y uso como agentes farmaceuticos - Google Patents

Estirilsulfonamidas, su obtencion y uso como agentes farmaceuticos

Info

Publication number
AR057300A1
AR057300A1 ARP060102005A ARP060102005A AR057300A1 AR 057300 A1 AR057300 A1 AR 057300A1 AR P060102005 A ARP060102005 A AR P060102005A AR P060102005 A ARP060102005 A AR P060102005A AR 057300 A1 AR057300 A1 AR 057300A1
Authority
AR
Argentina
Prior art keywords
alkyl
obtaining
halogenated
stirilsulfonamidas
trifluoromethyl
Prior art date
Application number
ARP060102005A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR057300A1 publication Critical patent/AR057300A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente son sales farmacéuticamente aceptables, formas enantioméricas, diastereoisomeros y racematos, la obtencion de los compuestos anteriores, los medicamentos que los contienen y su fabricacion, así como el uso de los compuestos anteriores para el control o la prevencion de enfermedades, tales como el cáncer. Reivindicacion 1: Un compuesto de la formula (1), en la que: R1, R2 y R3 con independencia entre sí significan hidrogeno, halogeno, alquilo, alcoxi, alquilsulfanilo, alquilo halogenado, alcoxilo halogenado, alquilsulfanilo halogenado, nitro, amino, alquilamino, dialquilamino, ciano, hidroxi o heterociclilo; R4 y R5 con independencia entre sí significan hidrogeno o alquilo; R6 es cloro, bromo, metilo, trifluormetilo o metoxi; R7 es cloro, bromo, fluor, metilo o trifluormetilo; y todas las sales farmacéuticamente aceptables del mismo.
ARP060102005A 2005-05-20 2006-05-18 Estirilsulfonamidas, su obtencion y uso como agentes farmaceuticos AR057300A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05010982 2005-05-20
EP06001007 2006-01-18

Publications (1)

Publication Number Publication Date
AR057300A1 true AR057300A1 (es) 2007-11-28

Family

ID=36607423

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102005A AR057300A1 (es) 2005-05-20 2006-05-18 Estirilsulfonamidas, su obtencion y uso como agentes farmaceuticos

Country Status (13)

Country Link
US (1) US7208526B2 (es)
EP (1) EP1888519A2 (es)
JP (1) JP2008545633A (es)
KR (1) KR100929996B1 (es)
CN (1) CN101268042A (es)
AR (1) AR057300A1 (es)
AU (1) AU2006312801A1 (es)
BR (1) BRPI0611287A2 (es)
CA (1) CA2607982A1 (es)
IL (1) IL186851A0 (es)
MX (1) MX2007014224A (es)
TW (1) TW200720239A (es)
WO (1) WO2007054139A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101675033A (zh) * 2007-05-16 2010-03-17 霍夫曼-拉罗奇有限公司 芳基吡啶基磺酰胺衍生物，它们的制备和作为药剂的应用
MX367335B (es) 2011-04-28 2019-08-15 Celgene Corp Metodos y composiciones que utilizan inhibidores de pde4 para el tratamiento y manejo de enfermedades autoinmunes e inflamatorias.
AR090100A1 (es) 2012-02-21 2014-10-22 Celgene Corp Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
NZ628329A (en) 2013-06-17 2017-12-22 Celgene Corp Formulations of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206142A (en) * 1973-06-11 1980-06-03 Mead Johnson & Company Styrylamidine process
US3983107A (en) * 1973-12-05 1976-09-28 Pfizer Inc. Hypolipidemic alkenesulfonamides
CA1071651A (en) * 1974-04-08 1980-02-12 William L. Matier Styrylamidines
US4157257A (en) * 1976-10-01 1979-06-05 Utsunomiya University Benzenesulfonamide derivatives
JPS5936663A (ja) * 1983-05-27 1984-02-28 Ishihara Sangyo Kaisha Ltd ベンズアミド誘導体及びそれらを含有する除草剤
US5591761A (en) 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
AU4400597A (en) * 1996-10-08 1998-05-05 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives
ES2198598T3 (es) * 1997-01-29 2004-02-01 Pfizer Inc. Derivados de sulfonilurea y su uso en el control de la actividad de la interleuquina-1.
IL133575A0 (en) * 1997-06-27 2001-04-30 Fujisawa Pharmaceutical Co Sulfonamide compounds, a method for producing same and pharmaceutical compositions containing same
DE19742951A1 (de) * 1997-09-29 1999-04-15 Hoechst Schering Agrevo Gmbh Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung
US6410584B1 (en) * 1998-01-14 2002-06-25 Cell Pathways, Inc. Method for inhibiting neoplastic cells with indole derivatives
UA74889C2 (en) 2001-06-06 2006-02-15 Lilly Co Eli Benzoylsulfonamides and sulfonylbenzamidines for the application as antitumour agents
JP2005528320A (ja) * 2001-08-11 2005-09-22 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー 選択的なエストロゲン受容体モジュレーター
AR037097A1 (es) * 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
ATE375978T1 (de) 2002-11-22 2007-11-15 Lilly Co Eli Benzoylsulfonamide als antitumor-mittel

Also Published As

Publication number Publication date
US7208526B2 (en) 2007-04-24
MX2007014224A (es) 2008-02-07
KR20070120195A (ko) 2007-12-21
CA2607982A1 (en) 2007-05-18
KR100929996B1 (ko) 2009-12-07
IL186851A0 (en) 2008-02-09
CN101268042A (zh) 2008-09-17
AU2006312801A1 (en) 2007-05-18
WO2007054139A3 (en) 2008-05-29
BRPI0611287A2 (pt) 2010-08-31
WO2007054139A2 (en) 2007-05-18
JP2008545633A (ja) 2008-12-18
TW200720239A (en) 2007-06-01
EP1888519A2 (en) 2008-02-20
US20060270874A1 (en) 2006-11-30

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal