AR049399A1 - Difenilimidazopirimidina e -imidazol aminas como inhibidores de b-secretasa y metodo de obtencion de los mismos - Google Patents
Difenilimidazopirimidina e -imidazol aminas como inhibidores de b-secretasa y metodo de obtencion de los mismosInfo
- Publication number
- AR049399A1 AR049399A1 ARP050102450A ARP050102450A AR049399A1 AR 049399 A1 AR049399 A1 AR 049399A1 AR P050102450 A ARP050102450 A AR P050102450A AR P050102450 A ARP050102450 A AR P050102450A AR 049399 A1 AR049399 A1 AR 049399A1
- Authority
- AR
- Argentina
- Prior art keywords
- independently
- optionally substituted
- alkyl
- haloalkyl
- alkynyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente provee un compuesto de formula (1) y el uso del mismo para el tratamiento terapéutico, prevencion o alivio de una enfermedad o trastorno caracterizado por depositos beta-amiloides o niveles de beta-amiloides elevados en un paciente. Reivindicacion 1: Un compuesto de formula (1) donde X es N, NO o CR19; Y es N, NO o CR11; Z es N, NO o CR20 con la salvedad que no más de dos de X, Y o Z pueden ser N o NO; R1 y R2 son cada uno independientemente H, CN o un grupo alquilo C1-4 opcionalmente sustituido; R3 y R4 son cada uno independientemente H, o un grupo alquilo C1-4 opcionalmente sustituido o R3 y R4 se pueen tomar juntos para formar un anillo de 3 a 7 miembros que contiene opcionalmente uno o dos hetroátomos seleccionados de O, N o S o R3 se pueden tomar junto con el átomo al cual está unido y un átomo e C adyacente para formar un doble enlace; R5 y R6 son cada uno independientemente H, halogeno, NO2, CN, OR13, NR14R15 o un grupo alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6 o cicloalquilo C3-8, cada uno opcionalmente sustituido, o cuando se encuentran unidos a átomos de C adyacetes r5 y R6 se pueden tomar junto con los átomos a los que se encuentran unidos para formar un anillo de 5 a 7 miembros opcionalmente sustituidos que opcionalmente contienen uno o dos heteroátomos seleccionados de O, N o S; R7, R8, R9, R10, R11, R19 y R20 son cada uno independientemente H, halogeno, NO2, CN, OR16, NR17R18 o un grupo alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6 o cicloalquilo C3-8 cada uno opcionalmente sustituido; m es 0 o 1; n es 0, 1, 2 o 3; ------- es un enlace simple o un doble enlace, con la salvedad de que cuando m es 0 entonces ------ debe ser un enlace simple; R12, R13 y R16 son cada uno independientemente H o un grupo alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8 o arilo; cada uno opcionalmente sustituido; y R14, R15, R17 y R18 son cada uno independientemente h o alquilo C1-4, o un tautomero del mismo, un estereoisomero del mismo o una sal aceptable para uso farmacéutico del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58018704P | 2004-06-16 | 2004-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR049399A1 true AR049399A1 (es) | 2006-07-26 |
Family
ID=34982285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050102450A AR049399A1 (es) | 2004-06-16 | 2005-06-15 | Difenilimidazopirimidina e -imidazol aminas como inhibidores de b-secretasa y metodo de obtencion de los mismos |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7456186B2 (es) |
| EP (1) | EP1758907B1 (es) |
| JP (1) | JP2008503460A (es) |
| KR (1) | KR20070026811A (es) |
| CN (1) | CN1997646A (es) |
| AR (1) | AR049399A1 (es) |
| AT (1) | ATE423121T1 (es) |
| AU (1) | AU2005264917A1 (es) |
| BR (1) | BRPI0512220A (es) |
| CA (1) | CA2578600A1 (es) |
| DE (1) | DE602005012825D1 (es) |
| EC (1) | ECSP067080A (es) |
| ES (1) | ES2321853T3 (es) |
| GT (1) | GT200500157A (es) |
| IL (1) | IL180018A0 (es) |
| MX (1) | MXPA06014792A (es) |
| NO (1) | NO20065847L (es) |
| PA (1) | PA8637201A1 (es) |
| PE (1) | PE20060299A1 (es) |
| RU (1) | RU2006144075A (es) |
| SV (1) | SV2007002146A (es) |
| TW (1) | TW200602048A (es) |
| WO (1) | WO2006009655A1 (es) |
| ZA (1) | ZA200610593B (es) |
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| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| RU2405774C9 (ru) | 2003-12-15 | 2011-03-20 | Шеринг Корпорейшн | Гетероциклические ингибиторы аспартилпротеазы |
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| JP2008528622A (ja) | 2005-02-01 | 2008-07-31 | ワイス | β−セクレターゼのインヒビターとしてのアミノピリジン |
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| WO2006088694A1 (en) | 2005-02-14 | 2006-08-24 | Wyeth | SUBSTITUTED THIENYL AND FURYL ACYLGUANIDINES AS β-SECRETASE MODULATORS |
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| TW200730523A (en) | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
| BRPI0616757A2 (pt) | 2005-09-26 | 2011-06-28 | Wyeth Corp | composto da fórmula i; processo para o tratamento de uma doença ou de um distúrbio associado com a atividade excessiva de bace; processo para a modulação da atividade de bace; processo para o tratamento da doença de alzheimer; e composição farmacêutica |
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-
2005
- 2005-06-14 TW TW094119581A patent/TW200602048A/zh unknown
- 2005-06-14 KR KR1020077000970A patent/KR20070026811A/ko not_active Application Discontinuation
- 2005-06-14 BR BRPI0512220-1A patent/BRPI0512220A/pt not_active IP Right Cessation
- 2005-06-14 CN CNA2005800194504A patent/CN1997646A/zh active Pending
- 2005-06-14 JP JP2007516603A patent/JP2008503460A/ja active Pending
- 2005-06-14 CA CA002578600A patent/CA2578600A1/en not_active Abandoned
- 2005-06-14 MX MXPA06014792A patent/MXPA06014792A/es active IP Right Grant
- 2005-06-14 ES ES05758187T patent/ES2321853T3/es active Active
- 2005-06-14 DE DE602005012825T patent/DE602005012825D1/de active Active
- 2005-06-14 RU RU2006144075/04A patent/RU2006144075A/ru not_active Application Discontinuation
- 2005-06-14 AT AT05758187T patent/ATE423121T1/de not_active IP Right Cessation
- 2005-06-14 EP EP05758187A patent/EP1758907B1/en active Active
- 2005-06-14 WO PCT/US2005/020736 patent/WO2006009655A1/en active Application Filing
- 2005-06-14 AU AU2005264917A patent/AU2005264917A1/en not_active Abandoned
- 2005-06-14 PE PE2005000678A patent/PE20060299A1/es not_active Application Discontinuation
- 2005-06-15 AR ARP050102450A patent/AR049399A1/es unknown
- 2005-06-15 PA PA20058637201A patent/PA8637201A1/es unknown
- 2005-06-15 US US11/152,925 patent/US7456186B2/en not_active Expired - Fee Related
- 2005-06-16 GT GT200500157A patent/GT200500157A/es unknown
- 2005-06-16 SV SV2005002146A patent/SV2007002146A/es unknown
-
2006
- 2006-12-12 IL IL180018A patent/IL180018A0/en unknown
- 2006-12-13 EC EC2006007080A patent/ECSP067080A/es unknown
- 2006-12-15 ZA ZA200610593A patent/ZA200610593B/xx unknown
- 2006-12-18 NO NO20065847A patent/NO20065847L/no not_active Application Discontinuation
-
2008
- 2008-10-07 US US12/246,790 patent/US20090042912A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0512220A (pt) | 2008-02-19 |
| ATE423121T1 (de) | 2009-03-15 |
| RU2006144075A (ru) | 2008-07-27 |
| DE602005012825D1 (de) | 2009-04-02 |
| PE20060299A1 (es) | 2006-05-18 |
| WO2006009655A1 (en) | 2006-01-26 |
| US20050282826A1 (en) | 2005-12-22 |
| ES2321853T3 (es) | 2009-06-12 |
| IL180018A0 (en) | 2007-05-15 |
| JP2008503460A (ja) | 2008-02-07 |
| EP1758907A1 (en) | 2007-03-07 |
| US20090042912A1 (en) | 2009-02-12 |
| ECSP067080A (es) | 2007-05-30 |
| KR20070026811A (ko) | 2007-03-08 |
| PA8637201A1 (es) | 2006-06-02 |
| SV2007002146A (es) | 2007-03-20 |
| CN1997646A (zh) | 2007-07-11 |
| NO20065847L (no) | 2006-12-18 |
| MXPA06014792A (es) | 2007-02-16 |
| TW200602048A (en) | 2006-01-16 |
| EP1758907B1 (en) | 2009-02-18 |
| US7456186B2 (en) | 2008-11-25 |
| AU2005264917A1 (en) | 2006-01-26 |
| CA2578600A1 (en) | 2006-01-26 |
| ZA200610593B (en) | 2009-09-30 |
| GT200500157A (es) | 2006-11-07 |
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