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AR047098A1 - Derivados de arilanilina como agonistas del receptor adrenergico beta2 - Google Patents

Derivados de arilanilina como agonistas del receptor adrenergico beta2

Info

Publication number
AR047098A1
AR047098A1 ARP050100092A ARP050100092A AR047098A1 AR 047098 A1 AR047098 A1 AR 047098A1 AR P050100092 A ARP050100092 A AR P050100092A AR P050100092 A ARP050100092 A AR P050100092A AR 047098 A1 AR047098 A1 AR 047098A1
Authority
AR
Argentina
Prior art keywords
atom
alkyl
attached
6alkylene
nhc
Prior art date
Application number
ARP050100092A
Other languages
English (en)
Inventor
Kinnell Robert Mc
John Jacobsen
Sean Trapp
Daisuke Salto
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of AR047098A1 publication Critical patent/AR047098A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Composiciones farmacéuticas que comprenden dichos compuestos, métodos para utilizar dichos compuestos para tratar enfermedades asociadas con la actividad del receptor adrenérgico b2, y procesos e intermediarios utiles para preparar dichos compuestos. Reivindicacion 1: Un compuesto caracterizado porque es de la formula (1) donde: cada uno de R1, R2, R3, y R4 se selecciona en forma independiente entre H, hidroxi, amino, halo, -CH2OH y -NHCHO, o R1 y R2 juntos se seleccionan entre - NHC(=O)CH=CH, -CH=CHC(=O)NH-, -NHC(=O)S-; y -SC(=O)NH-; uno de R5 y R6 es -[X-C1-6alquilenil]n-NR10R11 o C1-6alquilenil-NR12R13, y el otro de R5 y R6 se selecciona entre H, hidroxi, C1-4alcoxi, y C1-4 alquilo, donde C1-4 alquilo está opcionalmente sustituido con halo, donde cada X se selecciona en forma independiente entre -O-, -NH-, -S-, -NHSO2-, -SO2NH-, -NHC(=O)-, y -C(=O)NH-; cada uno de R10, R11, R12 y R13 es en forma independiente H o C1-4 alquilo; o R10 y R11, junto con el átomo de N al cual están unidos, o R10, junto con el átomo de N al cual está unido y un átomo de C del C1-6alquilenilo adyacente, o R12 y R13, junto con el átomo de N al cual están unidos, o R12, junto con el átomo de N al cual está unido y un átomo de C del C1-6 alquilenilo adyacente, forman un anillo heterocíclico o heteroarilo con entre 5 y 7 átomos en el anillo, y que contiene opcionalmente un heteroátomo adicional seleccionado entre O, N, y S, donde el N está opcionalmente sustituido con -S(O)2-C1- 4alquilo; y n es 1, 2 o 3; y cada uno de R7, R8, y R9 es en forma independiente H o C1-6 alquilo; o una sal o solvato o estereoisomero aceptable para uso farmacéutico del mismo.
ARP050100092A 2004-01-12 2005-01-11 Derivados de arilanilina como agonistas del receptor adrenergico beta2 AR047098A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53578404P 2004-01-12 2004-01-12

Publications (1)

Publication Number Publication Date
AR047098A1 true AR047098A1 (es) 2006-01-04

Family

ID=34806964

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050100092A AR047098A1 (es) 2004-01-12 2005-01-11 Derivados de arilanilina como agonistas del receptor adrenergico beta2

Country Status (20)

Country Link
US (3) US7622467B2 (es)
EP (1) EP1706371B1 (es)
JP (1) JP5041814B2 (es)
KR (1) KR20070000466A (es)
CN (1) CN1910137B (es)
AR (1) AR047098A1 (es)
AT (1) ATE504559T1 (es)
AU (1) AU2005206510A1 (es)
BR (1) BRPI0506823A (es)
CA (1) CA2551821A1 (es)
DE (1) DE602005027307D1 (es)
ES (1) ES2364450T3 (es)
IL (1) IL176549A0 (es)
MA (1) MA28304A1 (es)
NO (1) NO20063620L (es)
NZ (1) NZ548196A (es)
RU (1) RU2370490C2 (es)
TW (1) TW200531692A (es)
WO (1) WO2005070872A1 (es)
ZA (1) ZA200605720B (es)

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Also Published As

Publication number Publication date
CN1910137B (zh) 2010-05-26
NZ548196A (en) 2009-08-28
ATE504559T1 (de) 2011-04-15
MA28304A1 (fr) 2006-11-01
US20120071654A1 (en) 2012-03-22
EP1706371A1 (en) 2006-10-04
EP1706371B1 (en) 2011-04-06
NO20063620L (no) 2006-10-06
JP2007518738A (ja) 2007-07-12
US7994165B2 (en) 2011-08-09
AU2005206510A1 (en) 2005-08-04
JP5041814B2 (ja) 2012-10-03
DE602005027307D1 (de) 2011-05-19
CN1910137A (zh) 2007-02-07
US20050159448A1 (en) 2005-07-21
ES2364450T3 (es) 2011-09-02
RU2370490C2 (ru) 2009-10-20
WO2005070872A1 (en) 2005-08-04
RU2006129312A (ru) 2008-02-20
BRPI0506823A (pt) 2007-05-29
CA2551821A1 (en) 2005-08-04
US7622467B2 (en) 2009-11-24
TW200531692A (en) 2005-10-01
ZA200605720B (en) 2008-09-25
IL176549A0 (en) 2006-10-31
KR20070000466A (ko) 2007-01-02
US20100087410A1 (en) 2010-04-08

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