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AR046143A1 - Composicion farmaceutica que contiene un derivado de tiourea con solubilidad y biodisponiblidad mejoradas - Google Patents

Composicion farmaceutica que contiene un derivado de tiourea con solubilidad y biodisponiblidad mejoradas

Info

Publication number
AR046143A1
AR046143A1 ARP040103851A ARP040103851A AR046143A1 AR 046143 A1 AR046143 A1 AR 046143A1 AR P040103851 A ARP040103851 A AR P040103851A AR P040103851 A ARP040103851 A AR P040103851A AR 046143 A1 AR046143 A1 AR 046143A1
Authority
AR
Argentina
Prior art keywords
derivative
pharmaceutical composition
cyclodextrin
biodisponiblity
tiourea
Prior art date
Application number
ARP040103851A
Other languages
English (en)
Original Assignee
Amorepacific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amorepacific Corp filed Critical Amorepacific Corp
Publication of AR046143A1 publication Critical patent/AR046143A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Una composición farmacéutica que comprende un derivado de tiourea de fórmula (1) o una sal farmacéuticamente aceptable del mismo, una ciclodextrina o su derivado, y, opcionalmente, un aditivo farmacéuticamente aceptable; y una formulación farmacéutica que los comprende, complejo de inclusión, usos, métodos de tratamiento. Reivindicación 1: Una composición farmacéutica que comprende: un derivado de tiourea de fórmula (1), o una sal farmacéuticamente aceptable de la misma; y una ciclodextrina o su derivado, donde: R1 es hidrógeno, flúor, cloro, metoxicarbonilo, carboxilo o hidroxiaminocarbonilo, y R2 es hidrógeno, metoxi, etoxi, propoxi, butoxi, isopropoxi, isobutoxi, neopentoxi, metoximetoxi, o benciloxi. Reivindicación 3: La composición farmacéutica de la reivindicación 1, donde el derivado de tiourea es 1-(4-t-butilbencil)-3-(3-flúor-4-metansulfonilaminobencil)-tiourea. Reivindicación 7: La composición farmacéutica de las reivindicaciones 1 a 6, donde el derivado de ciclodextrina es 2-hidroxipropil-beta-ciclodextrina.
ARP040103851A 2003-10-23 2004-10-22 Composicion farmaceutica que contiene un derivado de tiourea con solubilidad y biodisponiblidad mejoradas AR046143A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20030074274 2003-10-23

Publications (1)

Publication Number Publication Date
AR046143A1 true AR046143A1 (es) 2005-11-23

Family

ID=36581269

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040103851A AR046143A1 (es) 2003-10-23 2004-10-22 Composicion farmaceutica que contiene un derivado de tiourea con solubilidad y biodisponiblidad mejoradas

Country Status (6)

Country Link
US (1) US20070249720A1 (es)
EP (1) EP1680398A4 (es)
JP (1) JP2007509137A (es)
KR (1) KR20050039573A (es)
AR (1) AR046143A1 (es)
WO (1) WO2005040106A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060017571A (ko) * 2004-08-19 2006-02-24 주식회사 태평양 티오우레아 유도체를 함유하는 소양성 또는 자극성피부질환의 예방 또는 치료용 조성물
WO2006098554A1 (en) * 2005-03-16 2006-09-21 Amorepacific Corporation Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
ES2380887T3 (es) 2005-05-13 2012-05-21 Topotarget Uk Limited Formulaciones farmacéuticas de inhibidores de la HDAC
GB0521351D0 (en) * 2005-10-20 2005-11-30 Genomica Sau Modulation of TRPV expression levels
GB0521716D0 (en) 2005-10-25 2005-11-30 Genomica Sau Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases
KR101018819B1 (ko) 2006-02-14 2011-03-04 (주)아모레퍼시픽 티오우레아 유도체를 함유하는 소양성 또는 자극성피부질환의 예방 또는 치료용 외용제 조성물
CA2673483C (en) * 2006-10-20 2014-04-08 Icos Corporation Compositions of chk1 inhibitors
JP5535514B2 (ja) * 2009-04-24 2014-07-02 公立大学法人大阪市立大学 被検物質評価方法
GB201215857D0 (en) 2012-09-05 2012-10-24 Sylentis Sau siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
KR102359439B1 (ko) * 2017-03-31 2022-02-09 (주)아모레퍼시픽 벤조산아마이드 화합물 및 사이클로덱스트린 용해보조제를 포함하는 조성물
CA3111403A1 (en) * 2018-09-17 2020-03-26 Canget Biotekpharma Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4371673A (en) * 1980-07-21 1983-02-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble forms of retinoids
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4596795A (en) * 1984-04-25 1986-06-24 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
IL124436A0 (en) * 1995-12-29 1998-12-06 Boehringer Ingelheim Phaarmace Phenyl thiazole derivatives with anti herpes virus properties
KR100453078B1 (ko) * 2000-08-21 2004-10-15 주식회사 태평양 신규 티오우레아 화합물 및 이를 함유하는 약제학적 조성물
DE60133743T2 (de) * 2000-08-21 2009-07-02 Pacific Corp. Neue thiourea-derivate und pharmazeutische zusammensetzungen die diese enthalten
GB0110901D0 (en) * 2001-05-02 2001-06-27 Smithkline Beecham Plc Novel Compounds
AU2002325381A1 (en) * 2001-07-31 2003-02-24 Bayer Healthcare Ag Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists
JP2003192673A (ja) * 2001-12-27 2003-07-09 Bayer Ag ピペラジンカルボキシアミド誘導体

Also Published As

Publication number Publication date
EP1680398A4 (en) 2007-01-10
WO2005040106A1 (en) 2005-05-06
US20070249720A1 (en) 2007-10-25
JP2007509137A (ja) 2007-04-12
EP1680398A1 (en) 2006-07-19
KR20050039573A (ko) 2005-04-29

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