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AR032409A1 - Metodos para la administracion de analogos de epotilona para el tratamiento de cancer - Google Patents

Metodos para la administracion de analogos de epotilona para el tratamiento de cancer

Info

Publication number
AR032409A1
AR032409A1 ARP020100287A ARP020100287A AR032409A1 AR 032409 A1 AR032409 A1 AR 032409A1 AR P020100287 A ARP020100287 A AR P020100287A AR P020100287 A ARP020100287 A AR P020100287A AR 032409 A1 AR032409 A1 AR 032409A1
Authority
AR
Argentina
Prior art keywords
vial
diluent
mixture
administration
epothilone
Prior art date
Application number
ARP020100287A
Other languages
English (en)
Inventor
Rebanta Bandyopadhyay
Timothy M Malloy
Andrea Panaggio
Krishnaswamy Srinivas Raghavan
Sailesh Amilal Varia
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28678063&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR032409(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR032409A1 publication Critical patent/AR032409A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se revela un proceso de formulacion de determinados análogos de epotilona para la administracion parenteral en el que el análogo se disuelve en una mezcla de al menos 50% en volumen de butanol terciario en agua, la mezcla se liofiliza, el producto liofilizado resultante se empaqueta en un vial con una cantidad suficiente de solvente que comprende etanol anhídro y un surfactante no ionico adecuado en un segundo vial. Todos los pasos se realizan con proteccion contra la luz. En el uso, los contenidos del segundo vial o del vial diluyente se agregan al producto liofilizado y se mezcla para constituir el análogo de epotilona y la solucion resultante se diluye con un diluyente adecuado para producir una solucion para la inyeccion por vía intravenosa que contiene el análogo de epotilona en una concentracion de alrededor de 0.1 mg/ml a alrededor de 0.9 mg/ml. Un surfactante que se prefiere es aceite de ricino polietoxilado y un diluyente que se prefiere es la inyeccion de Ringer tratada con Lactato.
ARP020100287A 2001-01-25 2002-01-25 Metodos para la administracion de analogos de epotilona para el tratamiento de cancer AR032409A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26422801P 2001-01-25 2001-01-25
US29000801P 2001-05-11 2001-05-11

Publications (1)

Publication Number Publication Date
AR032409A1 true AR032409A1 (es) 2003-11-05

Family

ID=28678063

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020100287A AR032409A1 (es) 2001-01-25 2002-01-25 Metodos para la administracion de analogos de epotilona para el tratamiento de cancer

Country Status (25)

Country Link
US (1) US6670384B2 (es)
EP (2) EP1353668B1 (es)
KR (1) KR100851719B1 (es)
CN (1) CN100341505C (es)
AR (1) AR032409A1 (es)
AT (1) ATE389401T1 (es)
BG (1) BG66494B1 (es)
BR (1) BRPI0206509B8 (es)
CY (1) CY1108114T1 (es)
CZ (1) CZ20032021A3 (es)
DE (1) DE60225666T2 (es)
DK (1) DK1353668T3 (es)
EE (1) EE05301B1 (es)
ES (1) ES2304240T3 (es)
HK (2) HK1116339A1 (es)
HU (1) HU229349B1 (es)
IS (1) IS2865B (es)
NO (1) NO20130070L (es)
NZ (1) NZ526870A (es)
PE (1) PE20020734A1 (es)
PT (1) PT1353668E (es)
SK (1) SK288098B6 (es)
TW (1) TWI342211B (es)
UY (1) UY27137A1 (es)
YU (1) YU58203A (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204388B1 (en) * 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
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UA75365C2 (en) 2000-08-16 2006-04-17 Bristol Myers Squibb Co Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon
EP1353667A1 (en) * 2001-01-25 2003-10-22 Bristol-Myers Squibb Company Parenteral formulations containing epothilone analogs
EP1385529A4 (en) 2001-02-20 2007-05-09 Bristol Myers Squibb Co TREATMENT OF REFRACTORY TUMORS USING EPOTHILONE DERIVATIVES
WO2002072085A1 (en) * 2001-03-14 2002-09-19 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
AU2003218107A1 (en) * 2002-03-12 2003-09-29 Bristol-Myers Squibb Company C12-cyano epothilone derivatives
TW200400191A (en) * 2002-05-15 2004-01-01 Bristol Myers Squibb Co Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
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CN101535492A (zh) 2005-02-11 2009-09-16 南加州大学 表达含有二硫键的蛋白质的方法
CN1870631B (zh) * 2005-11-11 2010-04-14 华为技术有限公司 媒体网关的门控方法
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CA2927832C (en) 2010-05-18 2021-03-23 Cerulean Pharma Inc. Cyclodextrin-containing polymer-therapeutic agent conjugates and their use
CA2838387A1 (en) 2011-06-06 2012-12-13 Chevron Phillips Chemical Company Lp Use of metallocene compounds for cancer treatment
PL401116A1 (pl) * 2012-10-09 2014-04-14 Ryszka Florian Farmaceutyczny Zakład Naukowo-Produkcyjny Biochefa Kompozycja dodawana do płynów infuzyjnych
CN107041886A (zh) * 2016-02-06 2017-08-15 北京华昊中天生物技术有限公司 脱环氧埃坡霉素衍生物制剂、制备及其治疗肿瘤的应用
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CA3184960A1 (en) * 2020-09-02 2022-03-10 Li Tang Solid oral formulation of utidelone

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DE69927790T2 (de) 1998-02-25 2006-07-20 Sloan-Kettering Institute For Cancer Research Synthese von epothilonen, ihren zwischenprodukten und analogen verbindungen
US6399638B1 (en) 1998-04-21 2002-06-04 Bristol-Myers Squibb Company 12,13-modified epothilone derivatives
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BR0008331A (pt) 1999-02-18 2002-01-29 Schering Ag Derivados de 16-halogeno-epotilon, processos para a sua preparação e seu emprego farmacêutico
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US20020045609A1 (en) * 2000-05-26 2002-04-18 Gary Ashley Epothilone derivatives and methods for making and using the same

Also Published As

Publication number Publication date
HUP0302726A2 (hu) 2003-11-28
DE60225666D1 (de) 2008-04-30
NO20130070L (no) 2003-09-04
NZ526870A (en) 2005-11-25
IS2865B (is) 2014-02-15
DK1353668T3 (da) 2008-06-30
YU58203A (sh) 2006-08-17
UY27137A1 (es) 2002-08-30
BG108112A (bg) 2004-11-30
BR0206509A (pt) 2004-09-08
SK8562003A3 (en) 2004-07-07
US20020169190A1 (en) 2002-11-14
CY1108114T1 (el) 2014-02-12
CN1496258A (zh) 2004-05-12
EP1938821A2 (en) 2008-07-02
HUP0302726A3 (en) 2007-08-28
ES2304240T3 (es) 2008-10-01
CZ20032021A3 (cs) 2004-05-12
EP1353668A1 (en) 2003-10-22
CN100341505C (zh) 2007-10-10
HK1116339A1 (en) 2008-12-19
SK288098B6 (sk) 2013-07-02
DE60225666T2 (de) 2009-04-16
BG66494B1 (bg) 2015-06-30
PE20020734A1 (es) 2002-08-17
BRPI0206509A8 (pt) 2017-09-19
EP1938821B1 (en) 2016-03-30
BRPI0206509B1 (pt) 2018-10-02
BRPI0206509B8 (pt) 2021-05-25
HK1065946A1 (en) 2005-03-11
US6670384B2 (en) 2003-12-30
TWI342211B (en) 2011-05-21
KR20040048874A (ko) 2004-06-10
PT1353668E (pt) 2008-06-30
EE200300320A (et) 2003-10-15
HU229349B1 (en) 2013-11-28
ATE389401T1 (de) 2008-04-15
EE05301B1 (et) 2010-06-15
IS6891A (is) 2003-07-24
EP1353668B1 (en) 2008-03-19
KR100851719B1 (ko) 2008-08-11
EP1938821A3 (en) 2009-02-18

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